Joint Meeting
Neurotoxicity Society and
International Neurotoxicology Association
Hotel Slaviero Essential Florianópolis Ingleses – Acquamar
Florianópolis, Brazil
Dear Conference Participants,
Welcome to the 2017 Joint Meeting of the Neurotoxicity Society and the International
Neurotoxicology Association. We value your participation in this meeting. Your contributions to the
discussions of recent advancements in neurotoxicology. From such interactions and scientific
exchanges across the two societies we hope to build upon the framework to chart the future of
neurotoxicity research. We hope you enjoy and find intellectually fulfilling this confluence of
scientists that have been brought together from around the world as we all learn of the latest
research and advances in neurotoxicology. Many people have worked with considerable effort to
bring us all together. We thank them all.
Best regards,
Gustavo Ferreira, Ph.D.
Co-Chair Conference Host Committee
Universidade Federal do Rio de Janeiro
Rio de Janeiro, Brasil
Maria-Trinidad Herrero, MD, MPhil, Ph.D.
President, Neurotoxicity Society
University of Murcia, Spain
Alexandra Latini, Ph.D.
Co-Chair Conference Host Committee
Universidade Federal de Santa Catarina
Florianópolis, SC, Brasil
Edward D. Levin, Ph.D.
President, International Neurotoxicology Association
Duke University, Durham, NC, USA
May 20
16:00-17:30 Registration
Florianópolis Room
17:00-17:30: Opening remarks and welcome from the Presidents and Local Hosts
17:30-18:30: Jacob Hooisma Keynote Lecture: Parkinson’s disease: At the intersection of genes and environment
J. Timothy Greenamyre, M.D., Ph.D., University of Pittsburgh, PA, USA. [email protected]
18:30-19:30: Reception (ticket required)
May 21
Florianópolis Room
8:00-9:00: Workshop
Agilent Technologies Workshop on Mitochondrial Bioenergetics
Carolyn Dazzo Gouchoe, Ph.D., Natalia Romero, Ph.D.
Diets, Mitochondria and the Brain;
Alicia J. Kowaltowski, M.D., Ph.D., University of São Paulo, São Paulo, Brazil.
9:10-10:30 Neuroinflammation and Neurodegeneration
Chair: Patrícia F. Schuck Ph.D., Universidade do Extremo Sul Catarinense. Criciúma, Brazil. [email protected]
Neuroinflammation in systemic inflammatory diseases
Felipe Dal Pizzol, Ph.D., [email protected]
Influence of a physiologically relevant brain oxygen tension on mitochondrial respiratory impairment in inflammatory microglia
Evan Bordt, University of Maryland, Baltimore, MD, USA. [email protected]
Administration of branched-chain amino acids alters the balance between pro- and anti-inflammatory cytokines, and induces cerebral
oedema, and blood-brain barrier breakdown
Emilio Luis Streck, PhD - Universidade do Extremo Sul Catarinense. Criciúma, Brazil. [email protected]
Cognitive deficit and neuroinflammation in phenylketonuria: is there a link?
Patrícia F. Schuck Ph.D., Universidade do Extremo Sul Catarinense. Criciúma, Brazil. [email protected]
10:30 – 11:00: Break
11:00-12:10: Neuroinflammation: Reaction and Regulation
Chair: Rommy Von Bernhardi R., Ph.D., Pontificia Universidad Católica de Chile, Santiago, Chile. [email protected]
Increased neuroinflammation and neurodegenerative changes secondary to age-associated changes of Scavenger-A as a novel
pathophysiological mechanism for Alzheimer’s disease.
Rommy Von Bernhardi R., Ph.D., Pontificia Universidad Católica de Chile, Santiago, Chile. [email protected]
Inhibition of inflammasome activation by neopterin
Roberta de Paula Martins, Ph.D., Universidade Federal de Santa Catarina, Florianópolis, Brazil. [email protected]
Can neurotoxic metals influence an inflammatory response or serve as an inflammasome trigger?
G. Jean Harry, Ph.D., NIEHS, Research Triangle Park, NC, USA. [email protected]
12:10 – 13:10: Lunch
13:10-14:30: NeuroInflammation and Viral Infection in the Process of Neuropathology
(Sponsored by International Society for Neurochemistry)
Chairs: Italo Mocchetti, Ph.D., Georgetown University, Washington, DC, USA. [email protected]
G. Jean Harry, Ph.D., NIEHS, Research Triangle Park, NC, USA.
Mechanisms of Zika infection, toxicity, and pathogenesis within the human nervous system.
Eliseo Eugenin, Ph.D., Rutgers, The State University of New Jersey, Newark, NJ, USA. [email protected]
Retroviruses and neurodegeneration
Joseph Steiner Ph.D., National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA. [email protected]
Chemokines and neurodegeneration in HIV-1 infection
Marcus Kaul, Ph.D., University of California, San Diego, CA, USA. [email protected]
Neurotoxicity of HIV protein gp120
Italo Mocchetti, Ph.D., Georgetown University, Washington, DC, USA. [email protected]
14:30 – 15:00: Break
15:00-16:00: Antibiotics Action In Neurological Diseases: In Vivo and In Vitro Advancing Mechanistic Understanding
Chairs: Elaine Del-Bel, Ph.D., USP-Ribeirao Preto-Brazil, Sao Paulo, Brazil. [email protected]
Rita Raisman-Vozari, Ph.D., INSERM Paris, Paris, France. [email protected]
A study on the inflammatory reaction in the L-DOPA-induced dyskinesia in a Parkinson’s disease rat model
Mariza Bortolanza, Ph.D., USP-Ribeirao Preto, Sao Paulo, Brazil. [email protected]
A study on the protective role of doxycycline upon dopaminergic neurons in Parkinson’s Disease rodent model
Elaine Del-Bel, Ph.D., USP-Ribeirao Preto-Brazil, Sao Paulo, Brazil. [email protected]
Role of doxycline in neuroinflammation and protein aggregation
Rita Raisman-Vozari, Ph.D., INSERM Paris, Paris, France. [email protected]
16:00 – 17:00: Regulated Necrosis and Associated Non-Apoptotic Mechanisms in Neurotoxicity
Chair: Michael A. Collins, Ph.D. Loyola University Chicago, IL, USA. [email protected]
Binge alcohol and brain neuronal necrosis
Michael A. Collins, Ph.D., Stritch School of Medicine, Maywood IL, USA. [email protected]
Programmed necrosis in photoreceptors: Implications for AMD and other retinal degenerations
Demetrios G. Vavvas, M.D., Ph.D., Harvard Medical School, Boston MA, USA. [email protected]
Cellular senescence as an alternative programmed pathway in brain cells under stress: potential role in Parkinson’s Disease (PD).
Julie K. Andersen, Ph.D., Buck Research Institute for Age Research, Novato CA, USA. [email protected]
May 21
Ingleses Room
9:10-10:30: Advances in the Neurotoxicology of Abused Drugs
Chairs: Yousef Tizabi, Ph.D., Howard University. Washington, DC, USA. [email protected]
Emmanuel Onaivi, Ph.D., William Paterson University, Wayne NJ, USA. [email protected]
Behavioral and neurobiological effects of low and high alcohol dose
Yousef Tizabi, Ph.D., Howard University. Washington, DC, USA. [email protected]
Leading to drug addiction: participation of ethanol metabolizing enzymes in the increased voluntary ethanol intake in perinatally-leadexposed rats
Miriam B Virgolini, Ph.D., Universidad Nacional de Córdoba. Argentina. [email protected]
3,4-methylenedioxymethamphetamine: abuse potential and neurodegenerative effects
Nicola Simola, Ph.D., University of Cagliari, Cagliari, Italy. [email protected]
Neurobiology of compulsive behaviors: Translational tools in addiction
Emmanuel Onaivi, Ph.D., William Paterson University, Wayne, NJ, USA. [email protected]
10:30-11:00: Break
11:00-12:10: Neurotoxicity of New Psychoactive Substances: From molecular target to clinical toxicology
Chairs: Laura Hondebrink, Ph.D., University Medical Center Utrecht. Utrecht, The Netherlands. [email protected]
Remco H.S. Westerink, Utrecht University. Utrecht, The Netherlands. [email protected]
Introduction on new psychoactive substances (NPS): occurrence, prevalence of use and their primary mode of action
Laura Hondebrink Ph.D., University Medical Center Utrecht. Utrecht, The Netherlands. [email protected]
Neurotoxicity screening for acute effects of new psychoactive substances (NPS) on neuronal activity using cortical neurons and human
iPSC-derived neurons grown on microelectrode array (mwMEA) plates
Remco Westerink Ph.D., Utrecht University, Utrecht, The Netherlands. [email protected]
Overview of desired and unwanted (acute toxicity) effects following NPS exposure in humans
David Wood, MD, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners, and School of Medicine and Life
Sciences, King's College London, London, UK. [email protected]
12:10 – 13:10 Lunch
13:10-14:30 Platform Session 1
Chair: Emilio Streck, Ph.D., UNESC [email protected]
The place of epigenetics in the effect of alcohol on brain plasticity
Laurence Lanfumey, Ph.D., Centre of Psychiatry and Neuroscience, Sainte Anne Hospital, Paris, France.
[email protected]
Cholesterol metabolism in adult neural stem cells: Impaired adult hippocampal neurogenesis in an animal model of familial
hypercholesterolemia
Daiane F. Engel, Ph.D., Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
[email protected]
Role of hypothalamic HIF-1 complex in the regulation of energy homeostasis
Joana M. Gaspar, Ph.D., University of Campinas, Campinas, SP, Brazil. [email protected]
14:30-15:00: Break
15:00-15:40 Platform Session 1 (continued)
Chair: Emilio Streck, Ph.D., UNESC [email protected]
Isovitexin rich fraction of Passiflora actinia extract provides cognitive improvement and neuroprotection after cerebral ischemia in mice
Simone Molz, Ph.D., Pharmacy School, Contestado University, Canoinhas, SC, Brazil. [email protected]
Restoration of cognitive performance in mice carrying a deficient allele of 8-oxoGuanine DNA glycosylase by x-ray irradiation
Tim Hofer, Ph.D., Norwegian Institute of Public Health, Oslo, Norway. [email protected]
15:40-17:00: Different Aspects of Adverse Effects on the CNS of Stress-Related Factors Such as Glutamate and Ammonia
Chairs: Marta C. Antonelli, Ph.D., Universidad de Buenos Aires. Buenos Aires, Argentina. [email protected]
Arne Schousboe, D.Sc, University of Copenhagen. Copenhagen, Denmark. [email protected]
Hepatic encephalopathy and hyperammonemia lead to altered brain energy metabolism, GABAergic neurotransmission and behavioral
deficits in the animal model of bile duct-ligation.
Renata Leke, Ph.D., University of Göteborg. Göteborg, Sweden. [email protected]
Metabotropic glutamate receptors and neurodegeneration
Ferdinando Nicoletti, M.D., University of Catania, Catania, Italy. [email protected]
Maternal behavior, glutamate and oxytocin balance in the perinatal stress rat model
Stefania Maccari, Ph.D., University of Lille 1, France, University of Rome, Italy. [email protected]
Glutamate metabolism impairment in a rat model of prenatal restraint stress.
Marta C. Antonelli, Ph.D., Universidad de Buenos Aires, Buenos Aires, Argentina. [email protected]
17:30 – 19:30: Poster Session (The listing of posters is at the end of the program.)
20:00 – 22:00: Dinner (ticket required)
May 22
Florianópolis Room
8:30-10:10: Emerging Neurotoxicological Mechanisms in Parkinsonian Neurodegeneration: Advances in Models and Concepts
Chairs: Anumantha Kanthasamy Ph.D., Iowa State University, Ames, USA. [email protected]
Marcel Leist, Ph.D., University of Konstanz, Konstanz, Germany. [email protected]
Mechanisms of α-synuclein aggregation and cell-to-cell transmission of neurotoxic protein oligomers through the exosomal pathway
Anumantha Kanthasamy Iowa State University, Ames, USA. [email protected]
Blocking mitochondrial fission is protective against dopaminergic neurodegeneration
Kim Tieu, Ph.D. Florida International University, USA. [email protected]
Mechanisms of alpha-synuclein protein aggregates induced neuroinflammation in neurotoxicity models
Arthi Kanthasamy, Ph.D., Iowa State University, Ames, IA, USA. [email protected]
Impaired mitochondrial transport and proteasome function in human dopaminergic neurodegeneration
Marcel Leist, Ph.D., University of Konstanz, Konstanz, Germany. [email protected]
Dysregulation of metal transporters in dopaminergic neurodegeneration
Michael Aschner, Ph.D., Albert Einstein College of Medicine, New York, USA. [email protected]
10:10-10:40 Break
10:40-12:00: Mechanisms for Neurodegeneration, Neuroprotection and Treatment in Parkinson´s Disease: 1
Chair:
Juan Segura-Aguilar, Ph.D., University of Chile. Santiago, Chile. [email protected]
Aminochrome as preclinical model for Parkinson´s disease
Juan Segura-Aguilar, Ph.D., University of Chile. Santiago, Chile. [email protected]
Epigenetic changes and brainstem dysfunction in neuropsychiatric disorders – AD/PD/Anx
Harry W.M. Steinbusch, Ph.D., Maastricht University, Maastricht, The Netherlands. [email protected]
Mechanisms of neuroprotection and immunomodulation of phytoestrogens: application for Parkinson disease in perspective
Silvia Costa, Federal University of Bahia, Bahia, Brazil. [email protected]
Superimposed control by ATP and adenosine of behavioral dysfunction in animal models of Parkinson’s Disease
Rodrigo A. Cunha, M.D., University of Coimbra, Coimbra, Portugal. [email protected]
12:00-13:00: Lunch
13:00-14:20 Mechanisms for Neurodegeneration, Neuroprotection and Treatment in Parkinson´s Disease: 2
Chairs: Rui Daniel Prediger, Ph.D., Universidade Federal de Santa Catarina. Florianópolis, Brazil. [email protected]
Maria Trinidad Herrero, M.D., Ph.D., University of Murcia. Murcia, Spain. [email protected]
Neuroprotective role of full--length human cerebral dopamine neurotrophic factor (CDNF) against α-synuclein oligomers
Débora Foguel, Ph.D., Universidade Federal do Rio de Janeiro, Rio de Janiero, Brazil. [email protected]
Physical activity improves the effects of antiinflammatory treatment in Parkinson’s Disease
María Trinidad Herrero, M.D., Ph.D., University of Murcia, Murcia, Spain. [email protected]
Norepinephrine upregulates the expression of tyrosine hydroxylase and protection against 6-hydrodopamine toxicity in
dopamine neurons.
Meng-Yang Zhu, Ph.D., East Tennessee State University, Johnson City, TN, USA. [email protected]
Depression in Parkinson's disease: Neurobiology and new therapeutic agents
Rui Daniel Prediger, Ph.D., Federal de Santa Catarina, Florianópolis, Brazil. [email protected]
14:20 – 15:40 Platform Session 2
Chair: Oddvar Myhre, Ph.D., Norwegian Institute of Public Health, Oslo, Norway. [email protected]
Molecular signatures of Parkinson’s, Alzheimer’s and bipolar diseases: Altered regulons, molecular targets and innovative therapeutic
interventions
Fábio Klamt, Ph.D., Laboratory of Cellular Biochemistry, Federal University of Rio Grande do Sul, Brazil. [email protected]
Genetic susceptibility to neurodegeneration in Amazon: apolipoprotein E genotyping in vulnerable populations exposed to mercury
Maria Elena Crespo-López, Ph.D., Universidade Federal do Pará, Belém-PA, Brazil. [email protected]
Color vision impairments at low-level methylmercury exposure of an Amazonian population at the Madeira River - Brazil
Cláudia Feitosa-Santana, Ph.D., Hospital Israelita Albert Einstein, São Paulo, Brazil. [email protected]
Advances in Understanding the Mechanism of Dioxin Induced Neurotoxicity
Li Xu, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences,
Chinese Academy of Sciences, Beijing, China. [email protected]
May 22
Ingleses Room
8:50-10:10 Developing an Integrated Testing Strategy Using In Vitro Data to Screen and Prioritize Compounds with High
Throughput / High Content Methods: 1
Chairs: Tim Shafer, Ph.D., US-Environmental Protection Agency. Research Triangle Park, NC, USA. [email protected]
David Reif, Ph.D., North Carolina State University, Raleigh, NC, USA. [email protected]
Analytical methods to distill useful information from high-throughput screening of chemicals
David Reif Ph.D., North Carolina State University, Raleigh, NC, USA. [email protected]
Screening the ToxCast Phase II library for acute neurotoxicity using cortical neurons grown on multi-well microelectrode array
(mwMEA) plates
Jenna Strickland, Ph.D., Michigan State University, East Lansing, MI, USA. [email protected]
Using developing cortical cultures on microelectrode arrays to identify and prioritize compounds based on changes in network formation
Tim Shafer, Ph.D., US-Environmental Protection Agency. Research Triangle Park, NC, USA. [email protected]
Towards in vitro DT/DNT testing: Assaying chemical susceptibility in early differentiating NT2 cells
Sepideh Abolpour Mofrad, Ph.D., Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
[email protected]
10:10-10:40: Break
10:40-12:00 Developing an Integrated Testing Strategy Using In Vitro Data to Screen and Prioritize Compounds with High
Throughput / High Content Methods: 2
Chair: Anna Price, Ph.D., Institute for Health and Consumer Protection, European Commission JRC, Ispra, Italy.
[email protected]
Applications of human induced pluripotent stem cell (3D) models for neurotoxicity testing
Anke Tukker, MSc, Utrecht University, Utrecht, The Netherlands. [email protected]
A 3D human brain organotypic model to study developmental neurotoxicology
David Pamies, Ph.D., Center for Alternatives to Animal Testing, John Hopkins University, Baltimore MD, USA.
[email protected]
Creating a developmental neurotoxicity (DNT) testing roadmap for regulatory purposes
Anna Price, Ph.D., Institute for Health and Consumer Protection, European Commission JRC. Ispra, Italy.
[email protected]
Discussion of Session 1 & 2: In vitro evaluations for neurotoxicity assessment and testing
12:00-13:00: Lunch
13:00-13:40: Platform Session 3
Chair: Julie Andersen, Buck Institute for Age Research, Novato CA, USA. [email protected]
The role of chemical speciation for manganese disrupting cross-talking pathways in cerebellar granule cells and its implication for a
putative adverse outcome pathways (AOP) relevant for manganese-induced neurotoxicity and neurodegeneration
Raúl Bonne Hernández, Ph.D., Federal University of São Paulo, Brazil. [email protected]
Biosafety assessment of nanostructured materials by using co-cultures of neurons and astrocytes
2
Christina Suñol, Ph.D., IIBB-CSIC-IDIBAPS-CIBERESP; ICMAB-CSIC. Barcelona. Spain. [email protected]
st
13:40-15:20 Physiological Assessment of Sensory Toxicity and the Role in Human Risk Assessment in the 21 Century
Chairs: Jordi Llorens, Ph.D. Universitat de Barcelona, Barcelona, Spain. [email protected]
William K. Boyes, Ph.D., US-Environmental Protection Agency, Research Triangle Park, USA. [email protected]
Vestibular function assessment in humans and in animals exposed to ototoxic compounds
Jordi Llorens, Ph.D., Universitat de Barcelona, Barcelona, Spain. [email protected]
Membrane fluidity does not explain how solvents act on the middle-ear reflex. Physiological consequences for exposures to noise.
Pierre Campo, Ph.D., Institut National de Recherche et de Sécurté, Vandoeuvre-les-Nancy, France. [email protected]
Visual impact of occupational exposure to mercury
Dora F. Ventura, Ph.D., Universidade de Sao Paulo, Sao Paulo, Brazil. [email protected]
st
Evaluating visual system toxicity in relation to human risk assessments in the 21 century.
William K. Boyes, Ph.D., US-Environmental Protection Agency, Research Triangle Park, USA. [email protected]
16:00-21:00: Florianópolis Tour and Dinner (ticket required)
May 23
Florianópolis Room
8:30-10:10: Mitochondria-related Metabolism Leading to Neurodegeneration and Neuroprotection
Chair: Gustavo C. Ferreira, Ph.D., Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. [email protected]
Arne Schousboe, D.Sc, University of Copenhagen. Copenhagen, Denmark. [email protected]
Mechanisms of neurotoxicity at physiological O2
Brian Polster, Ph.D., University of Maryland School of Medicine, Baltimore MD, USA. [email protected]
Disruption of mitochondrial functions caused by the major fatty acids accumulating in long-chain fatty acid oxidation defects
Moacir Wajner, Ph.D., Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. [email protected]
Carnosine, a possible suppressor of neurotoxicity?
Alan Hipkiss, Ph.D., University of Birmingham, Birmingham, UK. [email protected]
Astrocyte dysfunction in experimental models of glutaric acidemia type I
Silvia Olivera-Bravo, Ph.D, Instituto de Investigaciónes Biológicas Clemente Estable, Montevideo, Uruguay.
[email protected]
Mitochondrial DNA damage as a peripheral biomarker for human rotenone exposure
Laurie Sanders Ph.D., Duke University, Durham, NC, USA. [email protected]
10:10-10:30: Break
10:30-12:10: Neuroprotective and/or Neurotoxic Roles of SUMOylation in Neurodegenerative Diseases
Chairs: Jeremy Henley, Ph.D., University of Bristol. Bristol, UK. [email protected]
Dean Pountney, Ph.D., Griffith University, Southport, Queensland, Australia. [email protected]
Mechanisms and consequences of neuronal protein SUMOylation in health and disease
Jeremy Henley, Ph.D., University of Bristol. Bristol, UK. [email protected]
SUMO and mitochondrial dysfunction
Helena Cimarosti, Ph.D., University of Santa Catarina, Florianópolis, Brazil. [email protected]
SUMOylation, aging and autophagy in neurodegeneration
Dean Pountney, Ph.D., Griffith University, Southport, Queensland, Australia. [email protected]
Exogenous guanosine to modify SUMOylation – focus on Alzheimer and Parkinson’s diseases
Camila Zanella, University of Santa Catarina, Florianópolis, Brazil. [email protected]
12:10-13:30 Lunch and Business Meetings
13:30-15:00: Metabolic Derangements Predisposing to Neurotoxicity and Neurodegenerative Disease
Chairs: Andreza Fabro de Bem, Ph.D., Federal University of Santa Catarina. Florianópolis, Brazil. [email protected]
Alexandra Latini, Ph.D., Federal University of Santa Catarina. Florianópolis, Brazil. [email protected]
Hypothalamic dysfunction in obesity
Lício Velloso, Ph.D., University of Campinas, Campinas, Brazil. [email protected]
Hypercholesterolemia as a risk factor for neurocognitive impairments
Andreza Fabro de Bem, Ph.D., Federal University of Santa Catarina, Florianópolis, Brazil. [email protected]
Chronic hyperglycemia promotes hippocampal REST epigenetic gene inactivation with cognitive impairment and neurotoxicity
Alexandra Latini, Ph.D., Federal University of Santa Catarina, Florianópolis, Brazil. [email protected]
A single dose of glucocorticoid affects synaptic plasticity markers in the human limbic system
Roger Walz, M.D., Ph.D., Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
15:00-15:30: Break
15:30 – 17:00: Joint Student Award Symposium
Chair: Remco H.S. Westerink, Utrecht University. Utrecht, The Netherlands. [email protected]
Hypoxia-inducible factor-1α (HIF-1α) binds to HIF-response elements on the promoter region of candidate genes in the genome rat
under hypoxic conditions: A bioinformatics study
Emmanuel Casanova Ortiz, University of Chile, Santiago, Chile. [email protected]
Small molecules alter manganese toxicity in Caenorhabditis elegans
Tanara V. Peres, Albert Einstein College of Medicine, Bronx, NY, USA. [email protected]
The effects of early environmental enrichment and PACAP in a rat model of Parkinson’s disease.
Adel Jungling, University of Pecs Medical School, Pecs, Hungary. [email protected]
17:30-19:00: Soccer Game
19:30-24:00: Awards Dinner (ticket required)
May 23
Ingleses Room
8:30-10:10: Advancing Mechanistic Understanding of Neurotoxic Contributors to Autism
(Sponsored by the National Institute for Environmental Health Sciences)
Chair: Edward D. Levin, Ph.D., Duke University, Durham, NC, USA. [email protected]
What we have learned about mechanisms for ASD etiology by studying risk and protective factors
Rebecca J. Schmidt, Ph.D., University of California, Davis, CA, USA. [email protected]
Developmental neurotoxicity of traffic-related air pollution: studies with diesel exhaust in mice
Rachel (Yu-Chi) Chang Ph.D., University of Washington, Seattle, WA, USA. [email protected]
Traffic related air pollution and autism spectrum disorder: A population based nested case-control study in Israel
Marc Weisskopf, Ph.D., Sc.D., Harvard University School of Public Health, Cambridge, MA, USA. [email protected]
Environmental toxins and neural-glial interactions in autism
Staci Bilbo, Ph.D., Harvard University School of Medicine, Cambridge, MA, USA. [email protected]
Persisting impairment of neurobehavioral function in zebrafish caused by early developmental exposure to disrupting retinoic acid
receptor and vitamin D signaling
Edward D. Levin, Ph.D., Duke University Medical Center, Durham, NC, USA. [email protected]
10:10-10:30 Break
10:30-12:10: Long-lasting Effects of Early Development Challenge on Brain and Behavior
Chairs: Sandra Ceccatelli, Ph.D., Karolinska Institutet, Stockholm, Sweden. [email protected]
Michael Aschner, Ph.D., Albert Einstein College of Medicine, Bronx, NY, USA. [email protected]
Developmental exposure to excess glucocorticoids alters neuronal differentiation and induces long-term behavioral changes
Sandra Ceccatelli, Ph.D., Karolinska Institutet, Stockholm, Sweden. [email protected]
Long lasting neurotoxic effects of MDMA administration during adolescence
Micaela Morelli Ph.D., University of Cagliari, Cagliari, Italy. [email protected]
Interruption of oxygen at delivery and permanent vulnerability to recurrent metabolic insults: in vitro and in vivo experiments
Mario Herrera-Marschitz, Ph.D., University of Chile, Santiago, Chile. [email protected]
Low-level embryonic exposure to flame retardants and related compounds causes neurobehavioral impairment in larval and
adult zebrafish
Lilah Glazer Ph.D., Duke University, Durham, NC, USA. [email protected]
Lead exposure of children in China: Current status and prevention
Jingyuan Chen, M.D., Ph.D. School of Public Health, Fourth Military Medical University, Xi’an, China. [email protected]
12:10-13:30: Lunch and Business Meetings
13:30-15:00: Neurodevelopmental Effects of Chemical Exposure
Chair: Micaela Morelli Ph.D., University of Cagliari, Cagliari, Italy.
Effects of developmental alcohol exposure on neuronal plasticity and multisensory integration in the cortex
Alexandre Medina de Jesus, University of Maryland Medical Center, Baltimore, MD, USA. [email protected]
Enduring neurotoxic effects of perinatal exposures to pesticides in mice
Marcelo Farina Ph.D., Universidade Federal de Santa Catarina, Florianópolis, Brazil. [email protected]
Exposure to domoic acid during a critical period of neurodevelopment alters myelin sheath formation and leads to behavioral deficits
J.M. Panlilio, Woods Hole Center for Oceans and Human Health, Woods Hole, MA, USA. [email protected]
Histopathological and behavioral alterations caused by chronic intrastriatal hypoxanthine administration in striatum of young rats
,
Helena Biasibetti-Brendler Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. [email protected]
Poster Presentations
1
Vinpocetine, a phosphodiesterase inhibitor, mitigates hyperactivity and memory/ learning deficits in mice exposed to nicotine
and ethanol during the period equivalent to human gestation
Yael Abreu-Villaça, Anna C. Carvalho-Graça, Gabriela Skinner, Bruna M. Lotufo, Vitor H. S. Duarte-Pinheiro, Alex C. Manhães and
Claudio C. Filgueiras
Laboratorio de Neurofisiologia, Departamento de Ciencias Fisiologicas, Universidade do Estado do Rio de Janeiro (UERJ), Brazil.
[email protected]
2
Rifampicin suppresses alpha-synuclein induced microglial activation and improve neuron survival against inflammation
1,2
1
3
4
1
4
3
Leonardo Acuña , Sabah Hamadat , Natalia Corbalán , Florencia González , Jeremy Rocca , Rosana Chehín , Dulce Papy ,
1
1
1
Patrick Michel , Julia Sepúlveda * and Rita Raisman *
1
Institut du Cerveau et de la Moelle Epinière-ICM, Hôpital de la Pitié-Salpêtrière. Paris France.
2
Instituto de Patología Experimental (CONICET-UNSa). Salta, Argentina.
3
Université Paris Est Créteil, Université Paris Est, Créteil, France.
4
Instituto Superior de Investigaciones Biológicas (CONICET-UNT). Tucumán, Argentina.
[email protected]
3
Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce
differential cytotoxic effects in bovine brain microvessel endothelial cells.
1*,
1
1
1
2
3
3
1
Syed Ali H. Rosas-Hernandez , E. Cuevas , S.M. Lantz , K.C. Rice , B.M. Gannon , W.E. Fantegrossi and M.G. Paule
1
National Center for Toxicological Research/FDA, Jefferson, AR, USA.
2
NIDA/NIAAA, Bethesda, MD, USA.
3
University of Arkansas Medical School, Little Rock, AR, USA.
[email protected]
4
The flavonoid 4,5,7–trihydroxyflavone is a neuroprotective agent against neuroinflamation and dopaminergic degeneration
induced by aminochrome
1
1
1
1
1
Fillipe M. de Araujo , Rafael S. Ferreira , Cleonice Creusa dos Santos , Tácio L.R.S. Rodrigues , Juliana Helena C. e Silva ,
2
2
1
1
1
Juciano Gasparotto , Daniel Pens Gelain , Cleide S. Souza , Ramon S. El-Bachá , Maria de Fátima D. Costa , José Claudio M.
2
3
1
1
Fonseca , Juan Segura-Aguilar , Silvia L. Costa and Victor Diogenes A. Silva
1
Federal University of Bahia, Salvador, Bahia, Brazil.
2
Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
3
University of Chile, Santiago, Chile.
[email protected]
5
Isolated human populations and mercury exposure: blood mRNA of S100B protein as a possible biomarker of intoxication
1
2
2
Gabriela de Paula Fonseca Arrifano , María Jiménez Moreno , Rosa Del Carmen Rodriguez Martin-Doimeadios , Marcus Augusto
1
1
1
1
3
de Oliveira , José Rogério Souza Monteiro , Ricardo Souza Paraense , Camila Rodrigues Machado , Marcelo Farina , Barbarella
1
1
1
Macchi , José Luiz Martins do Nascimento and Maria Elena Crespo Lopez
1
Universidade Federal do Pará, Brazil.
2
Universidad de Castilla-La Mancha, España.
3
Universidade Federal de Santa Catarina, Brazil.
[email protected]
6
Atorvastatin-promoted neuroprotection against glutamate toxicity depends on GluN2B subunit of of N-methyl-D-aspartate
receptors (NMDAR)
L.B. Binder, N.F. Marques, L.C. Constantino and C.I. Tasca
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
[email protected]
7
Effects of combined exposure to low-frequency noise and CS2 on hearing and balance
Maria Carreres-Pons, Monique Chalansonnet, Thomas Venet, Aurélie Thomas, Jordi Llorens, Pierre Campo
Institut National de Recherche et de Sécurité. Rue du Morvan. CS 60027. F-54519 Vandœuvre Cedex. France
[email protected]
8
Chronic administration of L-tyrosine alters oxidative stress parameters in brain of rats supplemented with omega-3 fatty acids
1,2
1,2
1,2
1,2
1
1
Milena Carvalho-Silva , Lara M. Gomes , Letícia J. Teixeira , Joyce Rebelo , Fernanda Malgarin , Maria L. Gomes , Bruna K.
1,3
1
3
1,2
Ferreira , Patrícia F. Schuck , Gustavo C. Ferreira and Emilio L. Streck
1
University of Southern Santa Catarina, Criciúma, S.C., Brazil.
2
National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, R.S., Brazil.
3
Federal University of Rio de Janeiro, Rio de Janeiro, R.J., Brazil.
[email protected]
9
Hypoxia-inducible factor-1α (HIF-1α) binds to HIF-response elements on the promoter region of candidate genes in the
genome rat under hypoxic conditions: A bioinformatics study
Emmanuel Casanova Ortiz, Pablo Báez, Luis Valenzuela, Rodrigo Assar, Katherine Marcelain Cubillos and Mario Herrera-Marschitz
University of Chile, Santiago, Chile.
[email protected]
10
Mechanisms mediating paraquat and maneb-induced toxicity in neural stem cells
1
2
1
2
Dirleise Colle , Marilena Raciti , Marcelo Farina and Sandra Ceccatelli
1
Federal University of Santa Catarina, Florianópolis, Brazil.
2
Karolinska Institutet, Stockholm, Sweden.
[email protected]
11
Poly [adp-ribose] polymerase-1 (parp-1) is important in adult brain neuroinflammation and neurotoxicity instigated by alcohol
M.A. Collins, D.E. Kouzoukas, N.F. Tajuddin, J.A. Schreiber, H.-Y. Kim*, S. Kaja and E.J. Neafsey
Loyola University Chicago, Stritch School of Medicine, Maywood IL USA; and *NIAAA, Bethesda MD USA.
[email protected]
12
Antitumoral evaluation of triterpenes in glioblastoma cells
1
1
1
L.N. Comunello , D. Diedrich , S.C.B. Gnoatto , M.S.L. Pereira²; D.L. de Oliveira² and G. Gosmann¹.
1
Laboratório de Fitoquímica e Síntese Orgânica (LaFiS), Faculdade de Farmácia. Porto Alegre, RS, Brazil.
2
Laboratório de Neuroquímica Celular (NeuroCell), Departamento de Bioquímica, UFRGS. Porto Alegre, RS, Brazil.
[email protected]
13
Involvement of GluN2B subunit containing N-Methyl-D-Aspartate (NMDA) receptors and phosphatidylinositol-3 kinase (PI3K)
pathway in the mechanism of NMDA preconditioning
1
2
1
3
4
1
Leandra C. Constantino , Fabiana K. Ludka , Luisa Binder , Samuel Vandresen-Filho , Giordano G. Viola and Carla I. Tasca
1
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
2
Curso de Farmácia, Universidade do Contestado, Canoinhas, SC, Brazil.
3
Universidade Federal de Mato Grosso do Sul, Cuiabá, MT, Brazil.
4
Universidade Federal de Sergipe, Campus São Cristóvão, Brazil.
[email protected]
14
+
2+
Motor deficits, loss of nigral dopaminergic neurons and gliosis in transgenic A53T +/- mice: role of Na -Ca exchanger
isoforms
1
3
3
3
3
3
Giulia Costa , Maria Josè Sisalli , Katia Omura , Rossana Sirabella , Lucio Annunziato , Antonella Scorziello and
1,2
Micaela Morelli
1
University of Cagliari, Cagliari, Italy.
2
National Research Council of Italy, Institute of Neuroscience, Cagliari, Italy.
3
School of Medicine, "Federico II" University of Naples, Italy.
[email protected]
15
Attenuation of sickness behavior and neuroinflammation and neuroplasticity improvement in the hippocampus of aged mice:
The role of exercise training
Karine Mathilde Campestrini Dallagnol, Rodrigo Augusto da Silva, Aline Pertile Remor, Rui Prediger, Alexandra S Latini and
Aderbal S Aguiar Jr.
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil..
[email protected]
16
Neurotoxic effect of As, Pb, and Mn – mixture developmental exposure: Impaired the learning and memory with NMDA
receptor and postsynaptic signaling proteins in hippocampus of rats
Lalit P Chandravanshi, Anamika, Richa Gupta* and Surendra K Trigun
Department of Zoology, Banaras Hindu University, Varanasi, India.
*CSIR- Indian Institute of Toxicology Research, India.
[email protected]
17
Methylmercury enhances SP1 nuclear localization concurrent with diminished Fyn gene expression in primary rat
cortical astrocytes
Megan Culbreth and Michael Aschner
Albert Einstein College of Medicine, Bronx, NY, USA.
[email protected]
18
Tributyltin (TBT) chronic exposure impairs object recognition memory in female mice
Igor Ferraz da Silva, Eduardo Merlo, Jones Bernardes Graceli and Lívia Carla de Melo Rodrigues.
Federal University of Espírito Santo, Espírito Santo, Brasil.
[email protected]
19
GluN2B-containing NMDAR antagonism reduce short-term neurodegeneration and inflammation induced by early life
status epilepticus
1
1
2
2
1
Natã Sehn da Rosa , Cássio Morais Loss , Régis Gemerasca Mestriner , Léder Leal Xavier and Diogo Losch de Oliveira
1
Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil.
2
Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
[email protected]
20
C elegans as in vivo model for test quinolinic acid neurotoxic effects
Tássia L. da Silveira, Daniele C. Zamberlan, Marina L. Machado, Thayanara C. Silva, Leticia P. Arantes and Felix A. A. Soares.
Federal University of Santa Catarina, Florianópolis, Brazil.
[email protected]
21
The flavonoid 4,5,7–trihydroxyflavone is a neuroprotective agent against neuroinflamation and dopaminergic degeneration
induced by aminochrome
1
1
1
1
1
Fillipe M. de Araujo , Rafael S. Ferreira , Cleonice Creusa dos Santos , Tácio L.R.S. Rodrigues , Juliana Helena C. e Silva ,
2
2
1
1
1
Juciano Gasparotto , Daniel Pens Gelain , Cleide S. Souza , Ramon S. El-Bachá , Maria de Fátima D. Costa , José Claudio M.
2
3
1
1
Fonseca , Juan Segura-Aguilar , Silvia L. Costa and Victor Diogenes A. Silva
1
Federal University of Bahia, Salvador, Bahia, Brazil.
2
Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
3
University of Chile, Santiago, Chile.
[email protected]
22
Hospitalization rates for Parkinson’s disease and pesticide use in Brazil
1
2
3
4
Aline de Souza Espindola Santos , Noa Krawczyk , Jaime Lima and Armando Meyer
1
Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
2
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
3
Federal University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
[email protected]
23
Elucidation of the molecular signature of Parkinson's disease – altered regulons, molecular targets and innovative
therapeutics interventions
Daiani Machado de Vargas, Marco Antônio De Bastiani and Fábio Klamt
Universidade Federal do Rio Grande do Sul, Brazil.
[email protected]
24
6-Hydroxydopamine decreases brain aldehyde dehydrogenase 2 (ALDH2) expression: Implications for neurotoxicity in a
Parkinson´s disease model
1
1
1
1
2
Romina Deza-Ponzio *, Macarena L. Herrera *, Natalia A. Marchese , Osvaldo M. Basmadjian , María José Bellini , Víctor A.
1
1
1
Molina , Miriam B. Virgolini and Claudia B. Hereñú *Equally contribution
1
Depto. Farmacología-FCQ-UNC-CONICET-Córdoba, Córdoba, Argentina.
2
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP)- FCM-UNLP-CONICET-La Plata, Buenos Aires, Argentina.
[email protected]
25
Prenatal hypoxia-ischemia causes loss of retinal ganglion cells followed by pupillary light reflex alteration in rats
G.M. Diniz-Taveira; Fonseca, L.S.; Oliveira, M.H.N.; Tenorio, F.; Barradas, P.C. and Krahe, T.E.
Rio de Janeiro State University, Rio de Janeiro, Brazil.
[email protected]
26
Methylmercury induces oxidative stress and rock-1 activation in primary astroglial cells
1
2
1
Alessandra Antunes dos Santos , Aaron B. Bowman and Michael Aschner
1
Albert Einstein College of Medicine, New York, USA.
2
Vanderbilt University Medical School, Nashville, TN, USA.
[email protected]
27
Agmatine improves behavioral impairments observed in an animal model of the attention deficit hyperactivity disorder
Angela P. França, Marissa G. Schamne, Bruna S. de Souza, Thiago Corrêa, José E. da Silva Santos, Geison S. Izídio and
Rui D. Prediger.
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
[email protected]
28
Evaluation of neurochemical, inflammatory and behavioral parameters in hyperphenylananic female rats
1
1
Maria Luiza Gomes ; Jotele Fontana Agostini ; Michele Garcez¹; Monique Michels¹; Franciele Vuolo¹; Felipe Dal Pizzol¹; Josiane
2
Budni¹; Gustavo da Costa Ferreira ; Emilio Luis Streck¹; Patrícia Fernanda Schuck¹
2
¹Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ,
Brazil. [email protected]
29
Prenatal infection affects inhibitory synaptic function and plasticity: role of endocannabinoids
1,2
1
Zhiling Guo , Bin Zhao
1
Chinese Academy of Sciences, Beijing, China.
2
McGill University, Montreal, QC, Canada.
[email protected]
30
Cognitive impairment in an experimental model of Parkinson´s Disease
1
1
1
1
1
Macarena Lorena Herrera *, Romina Deza-Ponzio *, Osvaldo M. Basmadjian , Victoria B. Occhieppo , Victor A.Molina , María
2
1
José Bellini , Claudia B. Hereñú *equally contribution
1
Instituto de Farmacología Experimental de Córdoba (IFEC)- Depto. Farmacología-FCQ-UNC-CONICET-Córdoba, Argentina.
2
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP)- FCM-UNLP-CONICET-La Plata, Buenos Aires, Argentina.
[email protected]
31
Repeated 5-day administration of L-BMAA, microcystin-LR, or as mixture, in adult C57BL/6 mice - lack of adverse
cognitive effects
1
1
2
2
1
Tim Hofer , Dag Marcus Eide , Synne Kleiven , Hans Christian Utkilen and Oddvar Myhre
1
Norwegian Institute of Public Health, Oslo, Norway.
2
University College of Southeast Norway, Bø, Norway.
[email protected]
32
Effects of postnatal enriched environment in a model of Parkinson’s disease in adult rats
Adel Jungling, Dora Reglodi, Zsofia Nozomi Karadi, Gabor Horvath and Jozsef Farkas, Balazs Gaszner and Andrea Tamas
University of Pecs Medical School, Pecs, Hungary.
[email protected]
33
The effects of early environmental enrichment and PACAP in aging rat model of Parkinson’s disease
1
1
2
1
2
1
Adel Jungling , Dora Reglodi , Gabor Maasz , Gabor Horvath , Zsolt Priger and Andrea Tamas
1
University of Pecs Medical School, Pecs, Hungary.
2
Balaton Limnological Institute, MTA-CER, Tihany, Hungary.
[email protected]
34
Protein SUMOylation in models of Parkinson’s disease
1
1
1,
2
2
1
Stella C. Junqueira , Ana C. Guerra de Souza , Izi I. Floriano Kevin A. Wilkinson , Jeremy M. Henley , Rui D. Prediger and
1
Helena Cimarosti
1
Federal University of Santa Catarina, Florianópolis, Brazil.
3
University of Bristol, UK.
[email protected]
35
Novel non-estrogenic endpoints of phenolic metabolites toxicity in fish: Using zebrafish as a model for study
Nessrin Kheirallah and Tamer El-Sayed Ali
Alexandria University, Alexandria, Egypt.
[email protected]
36
Assessing the role of the intermediate filament (nanofilament) protein nestin in poststroke plasticity
1
1
2
1
Renata Leke , Ulrika Wilhelmsson , Andras Nagy and Milos Pekny
1
University of Gothenburg, Sweden.
2
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
[email protected]
37
Correlation between oxide nitric synthase and catalase in neonatal brain exposed to perinatal asphyxia
Lespay-Rebolledo C; Perez-Lobos R; Tapia-Bustos A; Vío V; Bustamante D; Morales P and Herrera-Marschitz M
University of Chile, Santiago, Chile.
[email protected]
38
Persisting effects of separate and combined nicotine and benzo-a-pyrene exposure during gestation on motor, emotional and
cognitive functions in rats
Edward D. Levin, Marty Cauley, Andrew Hawkey, Corrine Wells, Shaqif Junaid, Leah Yao and Zachary Spiera
Duke University, Durham, NC, USA.
[email protected]
39
Impairment of spatial working memory and biochemical changes induced by direct crack-cocaine inhalation and cocaine
pyrolysis product, anhydroecgonine methyl ester (AEME)
1
1
1
1
1
2
Ingryd FS Lipaus , Elisa F Gomes , Thais B Oliveira , Cleciane W Martins , Andrezza M Araújo , Evandro C Lebarch , Josideia B
2
2
3
3
1
1
Mendonça , Fabricio S Pelição , Patrícia F Schuck , Fernanda Malgarin , Ester M Nakamura-Palacios and Lívia CM Rodrigues
1
Universidade Federal do Espírito Santo, Brazil.
2
Polícia Civil do Estado do Espírito Santo, Brazil.
3
Universidade do Extremo Sul Catarinense, Brazil.
[email protected]
40
Molecular mechanisms of neurotoxicity induced by chlorpyrifos and chlorpyrifos-oxon in HT22 cells
Mark William Lopes, Aline Aita Naime, Dirleise Colle and Marcelo Farina
Federal University of Santa Catarina, Florianópolis, Brazil.
[email protected]
41
Influence of early life NMDAR antagonism and early life GluN2B-containing NMDAR antagonism on adult behavior:
Interaction with rearing environments
Cássio Morais Loss, Natã Sehn da Rosa, Natividade de Sá Pereira, Fabrício Figueiró, Giordano Gubert Viola and
Diogo Losch de Oliveira
Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil.
[email protected]
42
Triton WR-1339 exerts cellular impairment and depressive-like behavior
Fabiana Kalyne Ludka, Andreia Gapski, Amanda Catarina Borba, Idilaine Custódio and Simone Molz
Universidade do Contestado, Canoinhas, Brazil.
[email protected]
43
Guanosine prevents olfactory impairment and mitochondrial disruption induced by intranasal MPTP infusion
N.F. Marques, T.B. Sampaio, L.B. Binder, L.C. Constantino, J.M. Mack, R.D. Prediger and C.I. Tasca
Federal University of Santa Catarina, Florianópolis, Brazil.
[email protected]
44
Intranasal administration of sodium dimethyldithiocarbamate induces persistent motor deficits related to Parkinson’s disease
in mice that are prevented by melatonin treatment
Josiel Mileno Mack, Tainara de Menezes Moura, Débora Lanznaster, Carla Inês Tasca, Alcir Luiz Dafre and Rui Daniel Prediger.
Universidade Federal de Santa Catarina, Florianópolis, Brazil.
[email protected]
45
Short-time forebrain glutamate uptake impairment related to reduction of GFAP expressing cells after kainic acid induced
epileptic seizures in adult zebrafish.
1
1
1
1
1
1
Luana Moro , Ben Hur Marins Mussulini , Adriana Vizuete , Suelen Baggio , Emerson Santos , Gabriela Lazzarotto , Letícia
1
1
1
1
1
Pettenuzzo , Renato Dutra Dias , Maria Elisa Calcagnotto , Diogo Losch de Oliveira , Diogo Onofre Gomes de Souza , Javier S.
2
3
Burgos and Eduardo Pacheco Rico .
1
Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
2
Parque Tecnológico de Ciencias de la Salud, Granada, Spain.
3
Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
[email protected]
46
Brain metabolic preference shifts under prolonged epileptic seizure episodes in adult zebrafish pentylenetetrazole model
Ben Hur Marins Mussulini, Gabriela Lazzarotto, Ivi Juliana Bristot, Renato Dutra Dias and Fabio Klamt, Diogo Losch de Oliveira.
Federal University of Rio Grande do Sul, , Porto Alegre, RS, Brazil.
[email protected]
47
Neurotoxicity in rats exposed to exhaust emissions from biodiesel fuels – the FuelHealth project
2
2
2
3
4,5
1,2
Oddvar Myhre , Pål Amdal Magnusson , Johan Øvrevik , Joanna Gromadzka-Ostrowska , Anna Lankoff and Renate Valand
1
Oslo and Akershus University College of Applied Sciences, Norway.
2
Norwegian Institute of Public Health, Norway.
3
Warsaw University of Life Sciences, Poland.
4
Center for Radiobiology and Biological Dosimetry, Poland.
5
Jan Kochanowski University, Poland.
[email protected]
48
Effects of flavonoid agathisflavone on differentiation of rat bone marrow mesenchymal stem cells
Ravena Nascimento¹ ² and Silvia Lima Costa²
¹ Universidade Estadual de Feira de Santana, Feira de Santana, Bahia, Brazil.
²Laboratório de Neuroquímica e Biologia Celular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
[email protected]
49
New insights in neuronal protection against methylmercury-induced cytotoxicity and proposed new targets for
upcoming research
Nair Olguín, Marie-Lena Müller, Eduard Rodríguez-Farré and Cristina Suñol
IIBB-CSIC-IDIBAPS-CIBERESP, Barcelona, Spain.
[email protected]
50
Monocrotaline pyrrole from Crotalaria retusa induces glial response and behavioral changes in adult Wistar rats
1
1
2,
1
1
2
Joana L. Oliveira , Adriana L. Silva , Roberto F. Almeida Rejane Santana , Eduardo Moreira Trindade , Adriano M. Assis ,
2
1
1
Diogo Onofre G. Souza , Victor Diogenes A. Silva and Silvia L. Costa
1
Federal University of Bahia, Salvador, Bahia, Brazil.
3
Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
[email protected]
51
Towards new solutions against mercury intoxication in Amazon: Pre-clinical results of Euterpe oleracea (açaí)
1
1
1
1
1
Ricardo O. Paraense , Ericks Soares , José Rogério Souza-Monteiro , Gabriela Arrifano , Camila R. Machado , Luciana C.
1
1
1
2
1
Imbiriba , Cristiane do Socorro Ferraz Maia , Hervé Rogez , Marcelo Lima and Maria Elena Crespo Lopez
1
Universidade Federal do Pará, Brazil.
2
Instituto Evandro Chagas, Brazil.
[email protected]
52
Involvement of the endocannabinoid system on neuroinflammation in the prefrontal cortex and hippocampus of adolescent
rats submitted to chronic binge alcohol
2
2
2
Renan Pelição¹, Paula MQ Bellozzi , Isabel VA Lima , Soraya W Saliba , Ester M Nakamura-Palacios¹, Antonio Carlos Pinheiro
2
2
2
Oliveira , Alline C Campos , Antonio L Teixeira , Lívia CM Rodrigues¹.
1
Universidade Federal do Espírito Santo, Brazil.
2
Universidade Federal de Minas Gerais, Brazil.
[email protected]
53
Small molecules alter manganese toxicity in Caenorhabditis elegans
1
2
2
1
Tanara V. Peres , Kyle Horning , Aaron B. Bowman and Michael Aschner
1
Albert Einstein College of Medicine, Bronx, NY, USA.
2
Vanderbilt University Medical Center and Vanderbilt University, Nashville, TN, USA.
[email protected]
54
The effects of guanosine in neural proliferation, neurogenesis and antidepressant-like behavior in adult mice
Tetsade Piermartiri, Beatriz Santos, Fernanda Barros, Rui D Prediger and Carla I Tasca
Universidade Federal de Santa Catarina, Florianópolis, Brazil.
[email protected]
55
Interruption of oxygen at delivery and permanent vulnerability to recurrent metabolic insults: In vitro and in vivo experiments
R. Perez-Lobos, C. Lespay-Rebolledo, E. Palacios, A. Tapia-Bustos, V Vío, D Bustamante, P. Morales and M. Herrera-Marschitz.
University of Chile, Santiago, Chile.
[email protected]
56
Vulnerability of basal ganglia to metabolic insults following perinatal asphyxia: Metabolic impairment and
nicotinamide protection
1,2
1
1
1
1
1
1
R. Pérez-Lobos R , C. Lespay-Rebolledo , A. Tapia-Bustos , V. Vío , D. Bustamante , P. Morales and M. Herrera-Marschitz.
1
University of Chile; Santiago, Chile.
2
Universidad Andrés Bello, Santiago, Chile.
[email protected]
57
Alteration of the PAC1 receptor expression in the basal ganglia of MPTP-induced parkinsonian macaque monkeys
1
1,2 A.
1
3
3
3
1
D. Reglodi , M. Feher , Tamas , A.L. Gil-Martinez , E. Fernandez-Villalba , M.T. Herrero and B. Gaszner
1
University of Pecs, Pecs, Hungary.
2
"Kaposi Mór" Teaching Hospital, Kaposvar, Hungary.
3
University of Murcia, Murcia, Spain.
[email protected]
58
Effects of sulfasalazine administration on nociceptive responses in rats following intranasal MPTP administration, an animal
model of Parkinson´s disease
Katiane Roversi, Sérgio J. Macedo-Júnior, Juliano Ferreira, Alexandra Latini and Rui D. Prediger
Universidade Federal de Santa Catarina, Florianópolis, Brazil.
[email protected]
59
Noradrenaline replacement in prefrontal cortex restores both short- and long-term recognition memory impairments induced
by locus coeruleus lesion in rats
Tuane Bazanella Sampaio, Marina Aparecida Magnini Portes, Tayná Schuh and Rui Daniel Prediger.
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
[email protected]
60
Aminochrome induces glial activation and neuronal degeneration in primary culture from rat CNS
1
1
1
1
1
1
Cleonice C. Santos , Fillipe M. Araújo , Rafael S. Ferreira , Vanessa B. Silva , Juliana H. C. Silva , Maria S. Grangeiro ,
1
1
1
2
1
Érica Patricia L. Pereira , Cleide S. Souza , Silvia L. Costa , Juan Segura-Aguilar and Victor Diogenes A. Silva
1
Federal University of Bahia, Salvador, Bahia, Brazil.
2
University of Chile, Santiago, Chile.
[email protected]
61
Agmatine reverses emotional impairments in the intranasal MPTP model of Parkinson’s disease – the role of neurotrophic
factors and neuroinflammation
Marissa G. Schamne, Bruna Soares de Souza, Tainara Menezes Moura and Rui Daniel Prediger
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
[email protected]
62
Levodopa improves fatigue tolerance in reserpine-treated mice – an animal model of Parkinson disease
1
1
2
2
1
Débora da Luz Scheffer , Roberta de Paula Martins , Catherine Ward Nick Andrews Aderbal Silva Aguiar Junior and
1
Alexandra Latini
1
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
2
Harvard Medical School, Boston, USA.
[email protected]
63
SUMOylation profiles in an animal model of epilepsy
Leticia Coelho Silva, Mark W. Lopes, Roger Walz and Helena Cimarosti
Federal University of Santa Catarina, Florianópolis, Brazil.
[email protected]
64
Neural cell death induced by piperidine alkaloids from Prosopis juliflora (Mesquite) leaves involves programmed cell death via
caspase-9 activation and autophagy
1
2
2
1
1;
Victor Diogenes A. Silva , Carlos Cuevas , Patricia Muñoz , Cleonice Creusa dos Santos , Fillipe M. de Araujo
1
1
1
1
2
1
Rafael S. Ferreira , Juliana Helena C. e Silva , Érica N. Soares , Eudes S. Velozo , Juan Segura-Aguilar and Silvia L. Costa .
1
Federal University of Bahia, Salvador, Bahia, Brazil.
2
University of Chile, Santiago, Chile.
[email protected]
65
Physical exercise attenuates cortical neuroinflammation induced by lipopolysaccharide in mice
1
Ananda Staats, Roberta de Paula Martins, Lívia Maria, Karina Ghisoni, Lucila Silv , Rui Daniel Prediger, Alexandra Latini and
Aderbal Aguiar Jr.
Federal University of Santa Catarina, Florianópolis, Brazil.
[email protected]
66
Acute and long-term effects of intracerebroventricular administration of α-ketoisocaproic acid on oxidative stress parameters
1,2
1,2
1,2
1
1
3
Emilio L. Streck , Luciane Taschetto , Giselli Scaini , Hugo G. Zapelini , Ândrea C. Ramos , Monique Michels , Felipe Dal3
1
3
Pizzol , Patrícia F. Schuck and Gustavo C. Ferreira
1
University of Southern Santa Catarina, Criciúma, SC, Brazil.
2
National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, RS, Brazil.
3
Federal University of Rio de Janeiro, Rio de Janeiro, R.J., Brazil.
[email protected]
67
Perinatal asphyxia induces changes in oligodendrocytes phenotype in telencephalon of rat brain
1
1
1
1
1
2
A. Tapia-Bustos , R. Perez-Lobos , C. Lespay-Rebolledo , V. Vío , D. Bustamante , A. Lamaison, B. Villafranca. F. Ezquer , M.
1
1
Herrera-Marschitz and P. Morales .
1
University of Chile, Santiago, Chile.
2
Universidad del Desarrollo, Santiago, Chile.
[email protected]
68
Metabotropic glutamate receptors as prognostic markers in Glioblastomas
Chairini C. Thome, Mery S. L. Pereira., Marco A. Debastiani., Fábio Klamt. and Diogo L. de Oliveira.
Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
[email protected]
69
Effects of hearing isolation on the development of ultrasonic vocalization in rat pups
Hiromi Wada, Ph.D.
Hokkaido University, Sapporo, Japan.
[email protected]
70
Effect of acute and chronic administration of L-tyrosine on working memory in young rats
1
1,2
1,2
1,2
1,2
1
Leticia B. Wessler , Milena Carvalho-Silva , Lara M. Gomes , Letícia J. Teixeira , Joyce Rebelo , Gislaine Z. Reús , Airam B.
1
1
1
1
1,2
Moura , Danyela Matos , João Quevedo , Patrícia F. Schuck , Emilio L. Streck
1
University of Southern Santa Catarina, Criciúma, SC, Brazil.
2
National Institute of Science and Technology in Translational Medicine (INCT-TM), Porto Alegre, R.S, Brazil.
[email protected]
71
Antidyskinetic effect of acute guanosine administration in reserpinized mice.
1
2
1,2
Massari, C.M. ; Lanznaster, D. ; Tasca C.I. .
1
Programa de Pós-Graduação em Bioquímica, Departamento de Bioquímica, Universidade Federal de Santa Catarina,
2
Florianópolis, Brasil; Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis,
Brasil;
72
Alterations on the gene expression on cerebellar thyroid hormone homeostasis in perinatally rats exposed by glyphosatebased herbicide
Costa Reis LT; Souza JS; Romano RM; Romano AR; Chiamolera MI; Giannocco G; Dias da Silva MR; Amaral da Silva VD;
Costa SL; Cunha Lima ST.
Universidade Federal da Bahia, Laboratório de Biotecnologia e Bioprospecção,
Instituto de Biologia, Salvador, Bahia, Brazil.
Laboratório de Endocrinologia Molecular e Translacional, Departamento de
Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Departamento de Farmácia, Universidade Estadual do Centro-Oeste, Guarapuava
Paraná, Brazil.
Laboratório de Neuroquímica e Biologia Celular, Departamento de Bioquímica e
Biofísica, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
73
Brain bioenergetics in rats with acute hyperphenylalaninemia
Agostini JF; Dimer NW; Ferreira BK; Gomes ML; Kist LW; Malgarin F; Carvalho-Silva M; Gomes LM; Rebelo J; Silva Frederico
MJ; Mena Barreto Silva FR; Rico ER; Bogo MR; Streck EL; Ferreira GC; Schuck PF.
Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
74
Carnosine alters redox homeostasis in cultured primary cortical astrocytes
Ferreira BK; Diniz FC; Oliveira-Bravo S; Barbeito L; Streck EL; Shuck PF; Melo Reis RA; Ferreira GC.
Laboratório de Neuroenergética e Erros Inatos do Metabolismo, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade
Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Cellular and Molecular Neurobiology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Montevideo, Uruguay.
Neurodegeneration Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay.
Laboratório de Bioenergética, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma,
SC, Brazil.
Laboratório de Erros Inatos do Metabolismo, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul
Catarinense, Criciúma, SC, Brazil.
Laboratório de Neuroquímica, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro , Rio de
Janeiro, Brazil.
75
Colonic inflammation is accompanied by glial alterations in 6-OHDA mouse model of Parkinson’s disease
Thomasi B; Valdetaro L; Mussauer A; Nascimento G; Fernandes AC; Serfaty CA; Campello P; Melibeu A; Ribeiro MG; Moura
Neto V; Tavares Gomes AL.
UFF (Universidade Federal Fluminense), Instituto de Biologia; Departamento de Neurobiologia Laboratório da Interação NeuroGlial.
UFRJ (Universidade Federal do Rio de Janeiro), Instituto de Ciências Biomédicas, Laboratório de morfogênese celular.
Instituto Estadual do Cérebro Paulo Niemeyer.
76
Doxycycline can efficiently switch alpha-synuclein early aggregation oligomers into non-toxic species: repurposing an old
drug as neuroprotector
Lizarraga FG; Socias B; Avila C; Barbosa L; Andres B; Diaz JS; Elaine DB; Fernandez C; Papy-Garcia D; Chehin R; RaismanVozari R.
Universidad Nacional de Tucuman/CONICET, INSIBIO, S.M. de Tucuman, Argentina.
Instituto de Física da Universidade de São Paulo, IFUSP, São Paulo, Brazil.
Max Planck Laboratory for Structural Biology- Chemistry and Molecular Biophysics of Rosario, MPLbioR- UNR-MPIbpC,
Rosario, Argentina.
Institut Du Cerveau Et De La Moelle Epinière ICM and CNRS- Unité Mixte De Recherche- Sorbonne Universités, ICM-CNRS,
Paris, France.
Faculty of Odontology of Ribeirão Preto, USP, Ribeirão Preto-, Brazil.
Laboratoire Croissance- Réparation et Régénération Tissulaires CRRET, Université Paris Est Créteil-CRRET, Créteil, France.
77
Effect of nanocapsules with naringin and naringenin against brain damage induced by streptozotocin in mice
Budel RG; Ferreira CF; Guerino BC; Biacchi KB; Borin DB; Raffin RP; Boeck CR.
Postgraduate Program in Nanosciences, Centro Universitário Franciscano, Santa Maria – RS, Brazil.
78
NAC decreases both dopaminergic cell death and inflammatory changes in old-Parkinsonian mice
Gil-Martinez AL; Cuenca L; Estrada C; Fernandez-Villalba E; Trinidad Herrero M.
Clinical & Experimental Neuroscience, School of Medicine, Institute of Aging Research. University of Murcia, Murcia, Spain.
79
Opposing roles for ascorbic acid and glutathione in the chick embryonic retina
Freitas HR; Faria RX; Braga Ferreira LG; Cussa Kubrusly RC; Ferreira GC; Melo Reis RA.
Laboratory of Neurochemistry, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro,
RJ, Brazil.
Laboratory of Toxoplasmosis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
Laboratory Neuropharmacology, Dept. Physiology and Pharmacology, Federal Fluminense University, Niterói, Brazil.
Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
80
Running for REST: the effects of exercise in the hippocampus of aged mice
Campestrini Dallagnol KM; Silva RA; Remor AP; Prediger R; Latini AS; Aguiar Junior AS.
Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, CCB – UFSC, Florianópolis – SC.
Laboratório Experimental de Doenças Neurodegenerativas (LEXDON).
81
Tnf-alpha plays a role in neuroplasticity mediated by microglia activation after monocular enucleation
Chagas LS; Trindade P; Serfaty CA.
Instituto de Biologia, Universidade Federal Fluminense.
D’or Institute for Research and Education, Brasil.
82
Toxicity evaluation of nanoparticles with simvastatin in hippocampal slices from rats and C. elegans
Guerino BC; Moreira MP; Machado ML; Antunes Soares FA; Ourique AF; Boeck CR.
We appreciate the support of the meeting from:
Conselho Nacional de Pesquisa e Desenvolvimento Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
National Institute for Environmental Health Sciences
International Society for Neurochemistry
American Society for Neurochemistry
Springer Publishing Company
Agilent/Seahorse
Elsevier
Axion BioSystems
Cellular Dynamics International
Mimetas
Alesco
Axol Bioscience