Biogas pilot plant NOW THE BIGGEST IN THE WORLD Page 7 The hunt for e.coli that smell Page 8 The EU Commissioner for Agriculture, Mariann Fischer Boel: “Innovation needed to protect rural life” Page 5 The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement How research fertilises the soil THE TYPICAL agricultural researcher resembles the typical farmer in many ways. Planted firmly in the real world DANISH golfing stars often play on ‘home ground’ and busily engaged in finding solutions to practical problems. Solutions that rest on a solid theoretical and scientific foundation. There is no reason at all to change this. But once in a while, it can be a good thing to make one’s presence felt. Not so much in order to flaunt Denmark is the world’s largest exporter of grass seed. There is particular growth in the export of seed of high quality for lawns and golfing greens. Research is involved in keeping Danish seed production at the leading edge. one’s successes, but rather to make investors, politicians and other stakeholders aware of the huge potential that exists in the agricultural and related sectors. A modern agricultural sector is crucially dependent on research, innovation and dynamic interaction with the rest of society. And we would like Photo: Janne Hansen to play our part in this! Happy reading! Just Jensen, Dean, Faculty of Agricultural Sciences at the University of Aarhus A SPECIAL ADVERTISING SUPPLEMENT FROM www.agrsci.au.dk Phone +45 8999 1900 Fax: +45 8999 1919 e-mail: [email protected] Even though Thomas Bjørn, Søren Hansen and the other top Danish golfing stars travel the world, they have the ‘green, green grass of home’ underfoot far more often than you might think. Denmark is the world’s largest exporter of grass seed. There is particularly strong growth in the export of high-grade seed used for lawns and golfing greens. “Beyond the fact that the market for seed for gardens and golf courses is growing generally, interesting new markets are opening up in the new EU Member States in Eastern Europe, and in China”, says Head of Research Unit Birte Boelt, of the Faculty of Agricultural Sciences in Flakkebjerg. Together with her colleagues at the Zealand research centre, she is involved in laying the foundation for the sector’s future advances. The mild Danish climate is well suited to the production of grass seed. Danish growers account for a full 40 per cent of total grass seed production in the EU. n The Faculty of Agricultural Sciences at the University of Aarhus (DJF) DJF is a new faculty of the University of Aarhus. The faculty has around 900 members of staff, 375 of them scientists. DJF boasts modern laboratories and experimental facilities, including stables, greenhouses and semi-field facilities. Sætningen i linie 4,5 og 6 erstattes med: “In addition, DJF has an area of approximately 1,300 hectares for research, experiments and feed production.” DJS’s turnover in 2006 was 557m, of which 225m is basic state funding while 332m is primarily derived from competitive funding from public funding agencies including EU and from private companies supporting joint research. PRODUCED BY: www.inpress.com · Project Manager: Peter Lundegaard · Editor: Morten Andersen Art Director: Hans-Michael Testmann mDD · Photo: frontpage photo: Peter Eilertsen and Flemming Nielsen. For more information on special advertising supplements, please contact Peter Lundegaard, InPress Denmark, phone +45 70 11 00 13 www.inpress.com THE SHORT DISTANCE from the researcher’s idea to the patient’s cure Basic research does not have to be synonymous years has enabled biotech company Action Phar- progress”, says Søren Nielsen, who himself embod- with elderly, white-bearded scientists studying ma, the Centre’s collaboration partner, to develop ies the value of synergies between basic and ap- some intimate detail of the universe that will never new pharmaceuticals. The new drugs will help pa- plied research. He is a professor at the University of - or in any case only in the very long term - benefit tients with blood clots and type 2 diabetes. Aarhus and Director of the Water and Salt Research the man in the street. “It is crucial to invest in independent basic re- Centre. He is also a Director of Action Pharma A/S, Groundbreaking research in the Water and Salt search, because it is only through that that one where basic research is efficiently converted into Research Centre in Aarhus over just six or seven can create the foundation for new, epoch-making the development of new medicines. Water and salt Research Centre Since 2001, around 60 researchers and technicians at the Water and Salt Research Centre, located at the University of Aarhus, have studied how water is transported across cell membranes via water channels. The researchers are also investigating the role water channels have in various kidney, heart and liver diseases. The expertise at the University led the Danish Natio-nal Research Foundation, to create a separate basic research centre within this research area. The Water and Salt Research Centre was set up with a five-year grant of DKK 40m and, subsequently, a further five-year grant of approximately the same amount. The Director of the Centre is Professor Søren Nielsen. Since the early 1990s, he has worked closely with the Norwegian-American researcher Peter Agre, whose discovery of the water channels (aquaporins) earned him a Nobel Prize in 2003. Peter Agre’s discoveries form the basis for the further research now being undertaken and developed in the Water and Salt Research Centre. “Our task is to conduct basic research, but our daily work also has a long-term focus on how our research can benefit patients”, says Søren Nielsen. Action Pharma Biotech company Action Pharma was founded seven years ago on discoveries made at the Water and Salt Research Centre. The company’s objective is the development of standard products through applied R&D. “Our mission is to capitalise on basic research through Action Pharma A/S, and, to date, things are going exceedingly well,” says CEO Søren Nielsen. A drug which can protect patients against organ failure resulting from blood clots and major surgery is already undergoing clinical trials - i.e. it is being tested on people. Another will be entering clinical trials in the near future and this is a drug to treat type 2 diabetes and obesity. Another four drugs to benefit patients are also under development and co-founders Thomas Jonassen, Action Pharma A/S’s Director of R&D, and Professor Jørgen Frøkiær are full of optimism. “The investors have put more than DKK 100m into the company and the aim is for Action Pharma to become a listed company within a few years and for us to bring a new drug candidate into clinical development every year”, says CFO Jeppe Øvlesen. “We are among the leaders in the development of drugs based on the research done at the Water and Salt Research Centre and at the University of Copenhagen”, concludes Søren Nielsen. www.waterandsalt.au.dk Water and Salt Research Centre http://www.waterandsalt.au.dk Supported by the Danish National Research Foundation Based at the University of Aarhus Network cluster of 8 groups with staff of 60 Research from molecules to clinical medicine Based on research of Nobel Prize winners Peter Agre (Duke Univ.) and Jens Chr. Skou (Aarhus Univ.) ª PhD grants and post.doc. positions open sen ª ª ª ª ª ª www.actionpharma.com. Action Pharma A/S ª www.actionpharma.com ª Based on research from the Universities of Aarhus and Copenhagen ª Pipeline of 8 compounds with 2 in clinical development Investors: ª ª ª ª ª ª Vækstfonden, Denmark InovationsKapital, Sweden Incuba Ventures, Denmark Østjysk Innovation, Denmark Total investment: approx. DKK 120m Drug development positions open The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement Milk that heals Patients with chronic gastric infection may be able to protect themselves by drinking milk. Foto: Flemming Nielsen This is the perspective of a research project which the Faculty of Agricultural Sciences is undertaking in collaboration with the patients’ association for colitis and Crohn’s disease, Viborg Hospital and Arla Foods. Many people have the impression that it is beneficial to drink milk if you have a gastric ulcer, and the scientific literature actually contains descriptions of how certain protein fragments in milk may have a beneficial effect in healing the gastrointestinal tract. Through a four-year project, researchers will now try to identify the chemicals with a view to converting them into socalled ‘functional food’ which will not only be satiating but also healing. n Quality and environment are keywords SAMSON AGRO A/S is Northern Europe’s largest manufacturer of agricultural machinery capable of handling natural fertiliser from stable to field. A dedicated focus on quality, reliability, research and the environment makes SAMSON the leader in its field FOR FARM CONTRACTORS and large-scale farms worldwide, SAMSON in Viborg, Denmark is the company they turn to for the best in machinery and equipment for outdoor handling of manure. SAMSON manufactures a comprehensive product range of mixers, slurry tankers, computer equipment, spreaders, incorporators & injectors and equipment for professional users who demand flexibility and reliability. ”Quality is a keyword in all our products. We want to have the best products on the market and we believe we can get the price for the quality we represent. The crucial point is that our machinery will not be parked up at any time during the peak season, but in operation around the clock,” emphasises Povl Yde Hove, Sales and Marketing Manager, SAMSON AGRO. SAMSON’s solid manure spreaders are famous worldwide and are among the most imitated machines. Some 80 manufacturers have copied the SAMSON spreader. But we don’t get worked up about that. ”Our spreaders are the most reliable product on the market and 2 - 3 times more efficient than any other make, and quality, user-friendliness and reliability are what matter most to us – and are what make our products more pricey than competitor versions. But this added investment is recouped in just under a year – which makes for a very convincing selling point,” comments Povl Yde Hove. SAMSON manufactures machinery and equipment designed for intensive, multi-year use incorporating cutting-edge technology that benefits the environment. ”Denmark is a leader in environmental responsibility, and that puts pressure on us as a manufacturer. That pressure suits us down to the ground because it spurs us to build firstclass products that help to protect the environment,” says Povl Yde Hove. In terms of dosing, precision and servicing, SAMSON is also the leader. SAMSON AGRO A/S was formed in 1999 by the merger of four companies: Samson, UM, JOS and SAK. Projected turnover this year: DKK 300 million/EUR 40 million. The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement Innovation TO PROTECT RURAL LIFE Photo: Peter Ejlertsen As Commissioner for Agriculture, Mariann Fischer Boel is the top politician responsible for 40 per cent of the Union’s total budget, equating in 2006 to some 55 billion Euro. Text: Morten Andersen The EU Commissioner for Agriculture Mariann Fischer Boel: “Only through strong agricultural and food research can Europe compete”. FOR MOST PEOPLE, the word innovation evokes industry, but, going forward, it will equally come to set the agenda in agriculture in the EU countries. As the EU’s Commissioner for Agriculture, Denmark’s Mariann Fischer Boel, puts it: “When we are convened in the WTO and negotiating on the EU’s behalf, it is clear that there are some major players emerging. Take a country like Brazil which is undergoing an explosive development in the production of food. They simply have advantages in the way of a favourable climate, low wages and more lax environmental requirements that we will never be able to compete with. So, we have to be more inventive”. “We need to create products which, in terms of quality, are second to none. We can only do that by having strong agricultural and food research, and, with a European perspective at that. If each of the Member States does its own thing, the effect gets diluted.” The problem is not only relevant for the old EU countries: “The new Member States in Eastern and Central Europe are feeling the effects of global competition. They are already in the process of increasing their efficiency. For example, by establishing herds of pigs to tie in with maize cultivation. The fact is, you earn more from your maize, when you pass it through a pig!” Rural life As Commissioner for Agriculture, Mariann Fischer Boel is the top politician responsible for 40 per cent of the Union’s total budget, equating last year to some 55 billion Euro. This figure illustrates the continuing huge importance of agriculture in Europe. But for her, the future of agriculture is not just about economics. ¢ The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement ¢ “It is also about securing a future for rural life in the EU countries. I am therefore pleased to see that innovation is now featuring as one of the instruments of the EU’s policy on rural development”. Innovative agricultural projects and businesses can receive subsidies from a fund which forms part of the EU’s rural development policy. “Now, I know full well that innovation and research are not the same thing. But agricultural research alone cannot produce the results. There must also be a stratum of innovative companies in both agricultural improvement and in production itself, which are capable of applying the results of the research. A future in bioenergy As an example of a promising new development, Mariann Fischer Boel mentions biogas and other types of bioenergy: “There is huge potential for agriculture in becoming a supplier to the energy sector. We saw barely a year ago how vulnerable we are in Europe, when the Russians closed their natural gas pipeline. It is therefore obvious – including in the political debate – that we need to engage in energy research and develop new sources of energy”. “ The fact is, you earn more from your maize, when you pass it through a pig! support the use of 2nd generation biofuels, i.e. biofuels which are not made from primary materials such as wheat, potatoes and maize, but rather from straw or other “Materials unsuitable for human food” The programme has just been launched and runs until 2013. The structure of the agricultural sector is well suited to the improvements required, according to the EU Commissioner for Agriculture: “I am certain we will see many small and medium-sized enterprises within both agricultural improvement and production putting in tenders. Again, something that will generate growth and development in the rural areas.” n This is a development that Europe is giving a push-start. In the EU’s 7th Framework Programme for research, 2.2 billion Euro are earmarked for research into energy. Some of this money will be used to EAST JUTLAND – a growth area for biotech and medico East Jutland Innovation A/S has been an essential partner in the founding and development of more than 20 successful biotech and medico start-ups in Aarhus, Denmark since 1998. These companies have attracted more than 50 million euro for their further growth. East Jutland Innovation A/S (Danish name: Østjysk Innovation A/S) aims to help establish start-up companies based on research results from the University and University Hospital in Aarhus, Denmark. Target areas include medical technology, pharmaceutical products, biotechnology, diagnostics and contract research. East Jutland Innovation invests seed capital independently or on behalf of the Danish Ministry of Science, Technology and Innovation in new, innovative and research-related companies. “We can see that growth in biotech and medico companies has been so strong, because we dare to take the risk to invest during the very early phase in a new company’s life,” says Lars Stigel, Managing Director of East Jutland Innovation A/S. “It is a pleasant surprise that so many start-ups have spun out from medical research. Several are on the way to become successful companies that have turned research into business,” says Lars Stigel. East Jutland Innovation A/S of Aarhus, Denmark, is one of seven government certified innovation centres that invests state and private risk capital in the start-up phase of new research-based companies. Here are a few examples of some of the 20 medical research businesses in the company’s portfolio: www.boreanpharma.com Borean Pharma is a leading Danish biotech company focused on drug discovery and development. www.actionpharma.com Has developed a compound that prevents major organ damage in connection with blood clots and similar complications. www.recepticon.com The company develops special receptor antagonists, which can prevent a drug’s side effects on the kidneys. www.molegro.com Has developed a new and more precise software technology for molecular docking. www.ownresearch.dk This company offers contract research for companies within the pharmaceutical i ndustry that develop drugs against depression. www.he-dk.com Health Equipment Denmark develops and distributes medico equipment. Its first product is a clip used to fixate tubes to the patient during dialysis and other treatments. The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement The foundation stone has been laid that will place Denmark on the world map as a leader in biogas. The world’s largest biogas plant for research Text: Morten Andersen “Our own projects, students and educational activities will take up some of the potential, but there will also be ample opportunity for taking on projects for companies, and providing a springboard for the Danish biogas adventure”, says Søren A. Mikkelsen. The Xergi A/S company, owned by Aktieselskabet Schouw & Co. and Hedeselskabet A/S, is the primary contractor for the plant, which is scheduled for completion in the spring of 2007. The installation will consist of four bioreactors and a complete operating plant capable of producing 850,000 cubic metres of methane per annum. This could meet the electricity needs of 800 single family homes and the heating needs of 200 houses. n WITH A CAPACITY equivalent to the electricity requirements of 800 households, a new plant being built at Foulum near Viborg “will be the world’s largest biogas plant for research.” “The plant is an important factor in placing Denmark on the world map as a leader in biogas and environmental technology. With a plant of this size, we are getting a focal point which may produce a crucial breakthrough”, says Vice-Dean Søren A. Mikkelsen of the Faculty of Agricultural Sciences (DJF). The fact that DJF is responsible for the plant means that the facilities will be open to anyone with an interest in developing biogas technology. For example, companies can test their apparatus – and, what is more, obtain scientific proof that the equipment works. From slurry to gas We all know about biogas from the process that, for example, occurs at the bottom of a lake in the absence of oxygen. Organic material – leaves, twigs and dead animals – is broken down by microorganisms primarily of methane, which is also the main component of natural gas. ”In recent years, requirements regarding agricultural recycling of nutrients, particularly nitrogen, have become more stringent.” This means that farmers are looking for means of increasing the availability of nitrogen and thus its use. This presents an obvious opportunity for converting slurry and manure into biogas. Especially if electricity and heating can be sold, to achieve a sound overall economy. Photo: Flemming Nielsen, Agro Media and partially converted into biogas. Biogas consists The Faculty of Agricultural Sciences at University of Aarhus – Special Advertising Supplement THE HUNT Odour nuisance needs to be controlled if agriculture is to continue to develop. Techniques from agricultural research also have applications in industry. Text: Morten Andersen E.COLI IS the best known bacterium in the world. Every day, countless laboratory technicians search for it in samples of drinking and bathing water. “We are not especially scared of the e.coli bacterium in itself. We look for it because it is a good, practical indicator of faecal contamination in the water. Similarly, we would very much like to find an indicator for unpleasant odours”, says LugtTekt A/S Director, Anders Peter Adamsen. “We haven’t yet found one single indicator, but we have isolated around a dozen different chemicals which are key. This is a good starting point for tackling the problems.” The company provides consultancy on preventing and removing odours which cause a nuisance to farmers and their neighbours. LugtTek is involved in a wide range of development projects in collaboration with the Faculty of Agricultural Sciences and farming organisations. “There’s never been a lot of prestige involved in dealing with farm excrement. But it is becoming increasingly clear that obnoxious smells need to be controlled if the business is going to keep on developing”, says Anders Peter Adamsen. Depending on the actual circumstances, the company, located in the Agro Business Park and a neighbour of the Faculty Photo: Flemming Nielsen for the e.coli of smell He stops obnoxious agricultural smells. Anders Peter Adamsen, LugtTek. of Agricultural Sciences, will propose different solutions, from changing the composition of livestock feed, through adding specific chemicals to the slurry and manure, to direct cleansing of the air in the animal houses. In addition to agricultural suppliers, the Director notes an increasing number of industrial companies among his customers: “A number of companies have problems with smells, even if, in the nature of things, they don’t like to talk too loudly about it. More and more frequently, companies are coming to us out of a sense of timely concern. They want to change their production in a specific manner and ensure that this does not create problems with odour.” “So we can say that the methods we have developed in collaboration with agricultural researchers have also found other applications.” n Carrots beat cancer That carrots have a preventive effect against cancer is nothing new in itself, but Danish researchers now think they have found one of the key chemicals in carrots which produce the effect. At one time it was thought that it was beta-carotene, which gives carrots their orange colour, that had the can- cer-inhibiting effect. However this has been refuted. Researchers at the Faculty of Agricultural Sciences at the University of Aarhus and the University of Southern Denmark have now demonstrated that the effect actually derives from the natural compound falcarinol. This discovery offers hope that carrots with a higher content of falcarinol and related compounds can be developed in order to achieve an optimal anticarcinogenic effect. n
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