MUSC i2b2
Jean Craig, Biomedical Informatics
Signe Denmark, Office of Clinical Research
Katie Kirchoff, Biomedical Informatics
Learning Objectives
• What is i2b2?
• Data in i2b2
• How to use i2b2: demonstration
• How to gain access & i2b2 resources
• Brief overview of other feasibility tools & consultation
service
What is i2b2?
•
Informatics for Integrating Biology & the Bedside
•
•
•
Analytic Query Tool
Open Source
i2b2.org
•
•
•
NIH-funded National Center for Biomedical Computing
Established in 2004
Based at Partners HealthCare System
What is i2b2?
•
Enables researchers to query clinical data for discovery
research
•
Platform adopted by many national and international CTSA
networks and healthcare centers
•
Data is structured to feed TriNetX
MUSC i2b2 Project
•
Patient counts for feasibility
•
Limited data sets for analysis
•
•
De-identified patient and visit data
Dates of service
MUSC i2b2 Project
•
Populated from data stored in the Research Data Warehouse
(RDW)
•
Data is currently updated monthly
•
TriNetX is a subset of the data available in MUSC i2b2
MUSC i2b2 Project
MUSC i2b2 Project – Data
MUSC i2b2 Demo
i2b2.musc.edu
MUSC i2b2
If query times out, can access in the menu
Reload previously run queries
Shared query library
How to gain access to i2b2
•
User management policy follows the same policy as the
Research Query Tool
•
Who can access MUSC i2b2?
› MUSC faculty and sponsored staff members have access
› All non-faculty users must be sponsored by a MUSC faculty
member;
› Email completed Sponsorship
Form to [email protected]
› Access is granted within 1-2 business days.
› http://academicdepartments.musc.edu/bmic/DataRequest.ht
ml
i2b2 Resources
• RDW/MUSC i2b2 Data Dictionary
• i2b2 FAQ
• i2b2 Plug-in Guide
Feasibility Tools & Consultation
• Self-service tools for de-identified
patient counts
• Need help navigating the selfservice tools? SCTR provides free
Self-Service Research Data &
Feasibility consultations
• Honest Broker services for
identified data & de-identified
queries
• Epic and MUSC CDW report builds
for research
• Queries related to regional and
national data networks
SlicerDicer
This tool allows de-identified query access to all patients available in Epic
(Ambulatory 5/2012, Emergency 11/2012, Inpatient 7/2014)
SlicerDicer Access
• Complete training in MyQuest:
• Epic SlicerDicer for Research (25 mins)
• Once you complete the training in MyQuest, email Paul
Powers [email protected] to enable your access
• Additional available training in MyQuest:
• Epic RPT050 Overview of SlicerDicer (5 mins)
• Epic RPT051 Creating Populations in SlicerDicer (5 mins)
• Epic RPT052 Comparing Populations in SlicerDicer (10 mins)
TriNetX: Data-Driven Clinical Trial Design & Recruitment
Real world data network of providers and pharma
August 2016 Go live at MUSC
Epic encounter data since 7/1/2014 currently populated in TriNetX
Which self-service tool do I choose?
MUSC Self-Service Feasibility Tools
MUSC i2b2
User friendly interface
Requires MUSC Faculty
sponsorship
TriNetX (consult
service)
Epic SlicerDicer
X
X
X
CDW Research
Query tool
X
Training Required
Provide aggregate counts
X
X
X
X
X
Query by demographics
X
X
X
X
Query by medication
orders
X
X
X
X
Query by labs
Query by Diagnosis
Use Sequential Criteria
X
X
X
X
X
X
X
X
X
X
X
Data available only after
7/2014
X
X
X
Query on Cancer registry
data
X
X
Query based on encounter
location
X
Create a query to share
with an honest broker for
recruitment patient list
X
Export a de-identified
limited data set
X
X
X
Which self-service tool do I choose?
Do you need to receive
more than aggregate
counts of patients?
Yes
No
Do you need information
counts for MUSC patients
only
No
Will you need to receive
identifiable data?
No
Yes
HSSC i2b2
(Includes MUSC,
Greenville Health System,
Palmetto Health,
Spartanburg Regional
Healthcare System)
Do you need data prior to
2014
No
No
SlicerDicer
Will you need data prior to
2014
Yes
Do you need cancer
registry data or to filter by
procedures?
Yes
Research Query Tool
No
MUSC I2B2
Will you need data only on
your own clinical patients?
Yes
Research Data Request
Yes
No
Research Data Request
Will you need data prior to
2014?
Yes
Will you need cancer
registry data or need to
filter by procedures?
MUSC i2b2
No
SlicerDicer
Yes
Research Data Request
843-792-8300
[email protected]
sctr.musc.edu
Data Preparatory to Research Requests
Can be requested without IRB approval HIPAA Privacy rule preparatory to
Research Provision
› 45 CFR 164.512(i)(1)(ii)
The following attestation much be agreed upon and adhered to with regards
to the received data
› Because you selected "Preparatory to Research requiring identifiers", you must
agree that:
› (A) Use or disclosure is sought solely to review protected health information
as necessary to prepare a research protocol or for similar purposes
preparatory to research;
› (B) No protected health information is to be removed from the covered entity
by the researcher in the course of the review; and
› (C) The protected health information requested is the MINIMUM level
necessary for assessment of the feasibility of this research project