Dr Mohd Afzal
Department of Chemistry
Aligarh Muslim University
Aligarh–202002–Up (India)
Phone: +91–9897542558
[email protected]
Research Interest:
My particular area of interest includes molecular drug design, synthesis of organic
pharmacophore as biocompatible ligand and their further coordination transition and nontransition metal ion in order to develop new metal based cancer chemotherapeutic agents
and their characterization by spectroscopic, analytical technques. In vitro nucleic acid
(DNA and RNA)/protein binding, nuclease, protease and Topoisomerase (I and II)
inhibition studies of cancer chemotherapeutic drug, drug metabolism, distribution delivery
of chemotherapeutic drug through HPLC and other spectroscopic techniques.
Apart from these, presently i am working on MOF's, Kinetic delivery of Nano
encapsulated cancer chemotherapeutic drug.
Project Fellow: “Synthesis and characterization of saccharide based transition metal
complexes, electrochemistry and their pharmacokinetic studies”
Patents
:“Novel anti–proliferative complex and a method for preparation
thereof"
:“New heterobimetallic CuII–SnIV based cancer chemotherapeutic agent”
Scholarship and awards:
 Senior Research Fellow Award From Council of Scientific & Industrial Research
(CSIR), India
 Young scientist award from Indian council of chemist for the best paper
presentation.
 UGC Research fellowship award from government of India.
Academic Record:
2008–2014: Ph.D. Chemistry, Aligarh Muslim University Aligarh–India.
Advisor: Professor Sartaj Tabassum
Thesis: “Synthesis of new metal complexes and their interaction with CT DNA”.
2006–2008: M.Sc Chemistry, Aligarh Muslim University, Aligarh.
2003–2006: B.Sc (Hons) Chemistry, Aligarh Muslim University, Aligarh.
1
Technical Background:
 Gel electrophoresis (Agarose and SDS–PAGE)
 CHN analyser
 UV visible spectrophotometer (UV 1700 pharma spec)
 Spectrofluorophotometer (RF – 5301 PC)
 Circular dichroism (Jasco J–815–CD)
 Western blotting
 PCR
 DNA Isolation
 HPLC
 ELISA
 Confocal Imagine
Research Experiences:
 Bioinorganic Chemistry
 Synthesis of Metal Complexes
 Topoisomerase (I and II) Inhibition assay
 Binding Studies and Nuclease of Metal–Complexes with DNA
 Binding Studies and Protease activity of Metal–Based with HSA
Country visited:
2013– Germany 63rd LINDAU Nobel laureate meetings held at INSELHALLE,
LINDAU, (31st May–5th June, 2013).
2011– Canada 3rd Georgian Bay CanBIC International conference on Bioinorganic
chemistry held at Stocky centre Parry Sound, Ontario (31st May–4th June, 2011).
Online International Publications (20):
1. 5–[(E)–(2–Hydroxybenzylidene)amino]–1H–1,3–benzimidazole–2(3H)–thione.
Zishan Tabassum, Othman Sulaiman, Mohd. Afzal, Madhukar Hemamalini and
Hoong–Kun Fun, Acta Crystallographica Section E. (2011). E67, o144–o145.
2. Molecular drug design, synthesis and crystal structure determination of CuII–SnIV
heterobimetallic core: DNA binding and cleavage studies.
Farukh Arjmand, Shazia Parveen, Mohd. Afzal, Loic Toupet and Taibi Ben
Hadda, European Journal of Medicinal Chemistry., 49 (2012) 141–150.
3. Molecular drug design, synthesis and structure elucidation of new specific target
peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor.
Sartaj Tabassum, Waddhaah M. Al–Asbahy, Mohd. Afzal, Farukh Arjmand,
Vivek Bagchi, Dalton Transaction., (2012), 41, 4955–4964.
4. Synthesis, characterization and interaction studies of copper based drug with
Human Serum Albumin (HSA): spectroscopic and molecular docking
investigations.
Sartaj Tabassum, Waddhaah M. Al–Asbahy, Mohd. Afzal, Farukh Arjmand,
Journal of Photochemistry and Photobiology B: Biology., (2012), 114, 132–
139.
2
5. Interaction and Photo–induced Cleavage Studies of Copper based
Chemotherapeutic Drug with Human Serum Albumin: Spectroscopic and
Molecular Docking Study.
Sartaj Tabassum, Waddhaah M. Al–Asbahy, Mohd. Afzal, Farukh Arjmand, and
Rizwan Hasan Khan, Molecular. BioSystem., (2012), 8, 2424–2433.
6. DNA binding and cleavage studies of new sulfasalazine–derived dipeptide Zn(II)
complex: Validation for specific recognition with 5′–TMP.
Sartaj Tabassum, Waddhaah M. Al–Asbahy, Mohd. Afzal, Manal Shamsi, Farukh
Arjmand. Journal of luminescence., (2012), 132, 3058–3065.
7. Synthesis, characterization, biological studies (DNA binding, cleavage,
antibacterial and topoisomerase I) and molecular docking of copper(II)
benzimidazole complexes.
Farukh Arjmand, Shazia Parveen, Mohd. Afzal, Mohd. Shahid, Journal of
Photochemistry and Photobiology B: Biology., (2012), 114, 15–26.
8. New heterobimetallic CuII–Sn2IV complex as potential topoisomerase I inhibitor:
in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines.
Sartaj Tabassum, Mohd. Afzal, Farukh Arjmand, Journal of Photochemistry and
Photobiology B: Biology., 115 (2012) 63–72.
9. Enantiomeric specificity of biologically significant Cu(II) and Zn(II) chromone
complexes towards DNA.
Farukh Arjmand, A. Jamsheera, Mohd. Afzal, Sartaj Tabassum, Chirality 24
(2012) 977–986.
10. Synthesis and characterization of copper(II)/zinc(II)–based potential
chemotherapeutic compounds: their biological evaluation viz. DNA binding
profile, cleavage and antimicrobial activity.
Sartaj Tabassum, Ahmad Asim, Farukh Arjmand, Mohd. Afzal, Vivek Bagchi,
European Journal of Medicinal Chemistry., 58 (2012) 308–316.
11. New modulated design and synthesis of Quercetin–CuII/ZnII–Sn2IV scaffold for
potential chemotherapeutic application: in vitro DNA binding profile, DNA
cleavage pathway and Topo–I activity.
Sartaj Tabassum, Mehvash Zaki, Mohd. Afzal, Farukh Arjmand, Dalton
Transaction., 2013, 42, 10029–10041.
12. Chiral discrimination of metal–based chemotherapeutics Co(II), Cu(II) and Zn(II)
towards the ultimate drug target–DNA.
Farukh Arjmand, Shazia Parveen, Sabiha Parveen, Mohd. Afzal, Chemistry &
Biology Interface, (2013), 3, 3, 137–145.
13. New modulated design, docking and synthesis of carbohydrate–conjugate
heterobimetallic CuII–SnIV complex as potential topoisomerase II inhibitor: In
vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines.
Sartaj Tabassum, Mohd. Afzal, Farukh Arjmand, European Journal of
Medicinal Chemistry., 74 (2014) 694–702.
3
14. Synthesis and Structure Elucidation of a Cobalt(II) Complex as Topoisomerase I
Inhibitor: in vitro DNA Binding, Nuclease and RBC Hemolysis.
Musheer Ahmad, Mohd. Afzal, Sartaj Tabassum, Bożena Kalińska, Jerzy
Mrozinski, and Parimal K. Bharadwaj, European Journal of Medicinal
Chemistry, 58 (2012) 308–316.
15. Synthesis and characterization of Cu(II)–Based Anticancer Chemotherapeutic
Agent targeting Topoisomerase Iα: In vitro DNA binding, pBR322 Cleavage,
Molecular Docking Studies and cytotoxicity against human cancer cell lines.
Mehvash Zaki, Mohd. Afzal, Farukh Arjmand, European Journal of Medicinal
Chemistry, 74 (2014) 509–523.
16. In vitro DNA binding, pBR322 plasmid cleavage, molecular modeling study of
chiral benzothiazole–valine derivatives to evaluate their enantiomeric biological
disposition for therapeutic target DNA.
Rahman Alizadeh, Mohd Afzal, Farukh Arjmand, Spectrochimica Acta Part A,
131 (2014) 625–635.
17. Design and synthesis of new Zn(II) nalidixic acidDACH based Topo−II
inhibiting molecular entity: Chemotherapeutic potential validated by its in vitro
binding profile, pBR322 cleavage activity and molecular docking studies with
DNA and RNA molecular targets.
Farukh Arjmand, Imtiyaz Yousuf, Mohd. Afzal, Loic Toupet, Inorganica
Chimica Acta, Inorganica Chimica Acta, 421 (2014) 26–37
18. Synthesis and crystal structure determination of copper(II)–complex: In vitro
DNA and HSA binding, pBR322 plasmid cleavage, cell imaging and cytotoxic
studies
Sartaj Tabassum, Mehvash Zaki, Musheer Ahmad, Mohd Afzal, Saurabh
Srivastav, Saripella Srikrishna and Farukh Arjmand, European Journal of
Medicinal Chemistry, 83 (2014) 141–154
19. Synthesis and structure elucidation of a copper(II) Schiff–base complex: In vitro
DNA binding, pBR322 plasmid cleavage and HSA binding studies
Sartaj Tabassum, Musheer Ahmad, Mohd. Afzal, Mehvash Zaki, and Parimal K.
Bharadwaj, Journal of Photochemistry and Photobiology B: Biology (Accepted)
20. Synthesis, structure elucidation and DFT studies of a new coumarin derived
Zn(II) complex: In vitro DNA/HSA binding profile and pBR322 cleavage
pathway
Ruchi Singh, Mohd. Afzal, Mehvash Zaki, Musheer Ahmad , and Sartaj
Tabassum, Parimal K. Bharadwaj, RSC Advances (Accepted)
21. Nuclear blebbing of biologically active organoselenium complex towards human
cervical cancer cell (HeLa): In vitro DNA/HSA binding, cleavage and cell
imaging studies
Masood Ahmad Rizvi, Mehvash Zaki, Mohd. Afzal, Manoj Mane, Manjeet
Kumar, Bhahwal Ali Shah, Saurabh Srivastav, Saripella Srikrishna, Ghulam
Mustafa Peerzada and Sartaj Tabassum, European Journal of Medicinal
Chemistry, (Accepted)
4
Communicated:
 In vitro DNA and HSA binding, pBR322 plasmid cleavage, molecular modeling
study of new copper(II) Schiff–base complex: Validation of a specific
chemotherapeutic agent for human cervical tumor cell line (SiHa).
Sartaj Tabassum, Musheer Ahmad, Mohd. Afzal, Mehvash Zaki, Ruchi Singh,
Raja Das, Pankaj Poddar, Parimal K. Bharadwaj., Journal of Photochemistry and
Photobiology B: Biology
Conferences:
1. Presented poster entitled “Design and synthesis of copper–based anticancer
chemotherapeutic agent: In vitro binding studies with CT–DNA and 5′–GMP’’ by
Mohd. Afzal, at 12th CRSI–RSC National Symposium in Chemistry 2010 held at
IICT–Hyderabad (4–7th February).
2. Attend the National Symposium on Recent Trends in Chemical Sciences at
Aligarh Muslim University, Aligarh, (22–25th February, 2010).
3. Attend the National Symposium on Recent Trends in Enzyme technology,
Toxicology and Bioinformatics at Aligarh Muslim University, Aligarh, (3rd
March, 2010).
4. Attend the National Seminar on “Plant Biotechnology: Advances, Impact and
Relevance” at Aligarh Muslim University, Aligarh, (20th March, 2010).
5. Attend the National Symposium on “Current Trends in Biochemical, Biomedical
and Environmental Sciences” at Aligarh Muslim University, Aligarh, (22nd
February, 2011).
6. Presented poster entitled “Synthesis and characterization of chemotherapeutic
agent and its binding studies with Human Serum Albumin” at International
conference on chemistry: Frontiers and challenges held at Aligarh Muslim
University, Aligarh, (5–6th March, 2011).
7. Presented poster entitled “Design, docking and synthesis of heterobimetallic CuII–
Sn2IV complex as topoisomerase I inhibitor” at 3rd Georgian Bay CanBIC
International conference on Bioinorganic chemistry held at Stocky centre Parry
Sound, Ontario, Canada (31st May–4th June, 2011).
8. Presented poster entitled “Design, docking and Synthesis of glycoconjugate
heterobimetallic CuII–SnIV complex as topoisomerase I inhibitor: in vitro DNA
binding, cleavage and cytotoxic activity against different human cancer cell lines”
at 3rd Asian Conference on Coordination Chemistry held at Habitat Centre, New
Delhi, India (17–20th October, 2011).
9. Presented poster entitled “De novo design, synthesis, spectroscopic
characterization and DNA–binding studies of new sulfasalazine–derived dipeptide
Zn(II) complex: Validation for specific recognition with nucleotides and DNA
cleavage studies” at 17th International conference on “Expanding Horizons in
Chemical and Biological Sciences: Innovations Crossroads” held at School of
Chemical Sciences, Solapur University, Solapur (21st–24th January, 2012).
10. Presented poster entitled “Biologically active copper(II) and zinc(II) complexes:
synthesis, X–ray crystal structure, in vitro DNA binding, cleavage studies and
antimicrobial activity” at 14th CRSI–RSC National Symposium in Chemistry held
at CSIR–NIIST, Thiruvananthapuram, India (2–5 February, 2012).
11. Presented
poster
entitled
“Interaction
studies
of
5–[(E)–(2
Hydroxybenzylidene)amino]–1 H–1,3–benzimidazole–2(3H)–thione with DNA
and HSA using biophysical and molecular docking investigations” at APA
5
International Congress on Advances in Human healthcare Systems held at
Habitat Centre, New Delhi, India (20–23 February, 2012).
Permanent Details:
Father Name
AT and Po
District
Pin Code
State
Passport No
Date of Birth
Sex
:
:
:
:
:
:
:
:
Md Aslam
Jalkoura
Khagaria
851222
Bihar
H0747581
05–March–1984
Male
Academic Referees
[1] Prof. Sartaj Tabassum (supervisor)
Department of Chemistry
Aligarh Muslim University
India–202002
Email: [email protected]
[2] Prof. Farukh Arjmand
Department of Chemistry
Aligarh Muslim University
India–202002
Email: [email protected]
6