ALAN SOLOMON: CURRICULUM VITAE Title: American Cancer Society Clinical Research Professor Professor of Medicine and Head, Human Immunology & Cancer Program University of Tennessee Graduate School of Medicine, Knoxville, TN Birth Date: May 16, 1933 Citizenship: United States (born New York, NY) Wife: Andrea G. Cartwright Children: David A. Solomon Joseph A. Solomon William (Woody) Cartwright Michael A. Cartwright Step Children: Office: University of Tennessee Graduate School of Medicine 1924 Alcoa Highway Knoxville, TN 37920 Tel: (865)·305·9167 Fax: (865)·305·6865 E-mail: [email protected] Home: GATOP 2705 Riverside Drive Knoxville, TN 37914 Tel: (865) 524-5087 Fax: (865) 523-3627 E-mail: [email protected] Education: Bucknell University Lewisburg, PA 1949-1953 BS Duke University School of Medicine Durham, NC 1953-1957 BSM, MD Senior Assistant Surgeon, USPHS Senior Surgeon, Inactive Reserve, USPHS 1960-1962 1962-1983 Diplomat: National Board of Medical Examiners 1958 (Biology) Military Status: Board Certification: 1 Grants and Awards: Honors: Diplomat: American Board of Internal Medicine Medical Licensure (active): Tennessee 1964 1966- Special Fellowship National Institute of Arthritis and Metabolic Diseases National Institutes of Health, USPHS 1963-1965 USPHS Research Grant R01 CA-08354 Principal Investigator 1965-1966 American Cancer Society Research Grant T-420 Principal Investigator 1967-1973 National Science Foundation Research Grant GB-6036 Principal Investigator 1967-1973 Research Career Development Award CA-21229 National Cancer Institute 1968-1972 USPHS Research Grant R01 CA-15173 Co-Principal Investigator 1974-1977 American Cancer Society Research Grant IM-430 Principal Investigator 1985-1991 USPHS Research Grant R01 CA-10056 Principal Investigator 1966-2012 American Cancer Society Clinical Research Professorship 1992-2003 USPHS Research Grant R21 CA-76630 Principal Investigator 1998-2000 USPHS Research Grant R21 CA-82609 Principal Investigator 1999-2001 USPHS (NCI) Rapid Access to Intervention Development (RAID) Biologic Projects Award 049 1999-2000 Alpha Omega Alpha Duke University School of Medicine 1956 2 C.V. Mosby Award for Scholastic Excellence Duke University School of Medicine 1957 First Prize, Essay for Fourth Year Medical Students New England Journal of Medicine 1957 Dr. Daniel Stats Memorial Award Editorial Board, Journal of the Mount Sinai Hospital 1961 Fellow, American College of Physicians 1968 Second Prize, Henry L. Moses Award Montefiore Hospital, NY 1970 Physician's Recognition Award American Medical Association 1971 Third Prize, Henry L. Moses Award Montefiore Hospital, NY 1972 President's Club University of Tennessee 1981 The Davison Club Duke University School of Medicine 1981 First Prize, Henry L. Moses Award Montefiore Hospital, NY 1983 Laszlo Memorial Lecturer Montefiore Hospital, NY 1984 The Founders' Society Duke University 1987 Professor of Medicine Citation in Recognition of Extraordinary Leadership and Service University of Tennessee Medical Center 1989 Who's Who in America, 4th Edition Second Prize (Clinical Category), Henry L. Moses Award Montefiore Hospital, NY First Prize (Clinical Category) Henry L. Moses Award 1995 2000 3 2001 Montefiore Hospital, NY Excellence and Leadership in Basic Science and Research Award University of Tennessee Graduate School of Medicine Professional Organizations: 2005 First Prize (Basic Science Category) Henry L. Moses Award Montefiore Hospital, NY 2009 American Federation for Clinical Research 1962-1996 American Association for Cancer Research 1963- New York County and State Medical Societies 1963-1966 American Medical Association 1963-1995 Society for the Study of Blood 1964-1966 American Society of Hematology 1964- American Association for Advancement of Science 1965- Central Society for Clinical Research 1967-1990 American College of Physicians (Fellow) 1967- American Association of Immunologists 1968- Knoxville Academy of Medicine 1968- Tennessee Medical Association 1968- Sigma Xi 1968-1980 Southern Society for Clinical Investigation 1968-1978 American Society for Clinical Investigation 1971- American Association for Cancer Education 1977-1982 American Society of Clinical Oncology 1977- International Society of Hematology 1980-1998 International Society for Experimental Hematology 1981-1995 Clinical Immunology Society 1988-2000 American Society for Investigative Pathology 2002 - 4 Professional Assignments Since 1966: Tutor, Immunology Seminar University of TennesseeOak Ridge Graduate School of Biomedical Sciences 1968 Institutional Research Grant Committee American Cancer Society, University of Tennessee 1968-1970 Faculty Council University of Tennessee Memorial Research Center 1968-1975 Transfusion Committee University of Tennessee Memorial Research Center and Hospital 1969-1972 Library Committee University of Tennessee Memorial Research Center and Hospital 1970-1972 Southeastern Cancer Study Group Regional Representative, Admissions Committee Duke University School of Medicine 1970- 1980 1970-1991 Subcommittee on Nomenclature of Human Immunoglobulins International Union of Immunologic Societies 1971-1973 Chairman Institutional Research Grant Committee American Cancer Society University of Tennessee Memorial Research Center 1971-1974 Seminar Chairman University of Tennessee Memorial Research Center 1971-1974 Graduate Faculty Department of Microbiology 1971-1988 Subcommittee on Multiple Myeloma Southeastern Cancer Study Group 1971-1980 Project Coordinator East Tennessee Cancer Research Center 1972-1974 5 Special Medical Committee Comprehensive Health Planning, Knoxville Academy of Medicine 1973-1974 Consulting Staff (Hematology/Oncology) East Tennessee Chest Disease Hospital 1974-1978 Research Participation Committee University of Tennessee-Knoxville 1974-1977 President Knoxville-Oak Ridge Associated Researchers and Clinicians in Cancer 1974-1977 Board of Directors American Cancer Society - Knox County Unit 1974-1996 Professional Education Committee American Cancer Society - Knox County Unit 1974-1990 Membership Committee American Association of Immunologists 1974-1977 Secretary Scientific Review Committee East Tennessee Cancer Research Center 1974-1977 Chairman Liaison Committee to the East Tennessee Cancer Research Center, Knoxville Academy of Medicine 1975-1977 Subcommittee on Tumor Immunology Southeastern Cancer Study Group 1975-1978 Continuing Medical Education Committee Knoxville Academy of Medicine 1975-1978 Clinical Cancer Committee University of Tennessee Medical Center at Knoxville 1975-1980 Consultant Human Cancer Diagnostics and Therapeutics Unit, Cancer and Toxicology Program, Biology Division, Oak Ridge National Laboratory 1976-1983 Medical Director 1977-2004 6 Baptist Regional Cancer Center Baptist Hospital of East Tennessee Chairman Oncology Committee Baptist Regional Cancer Center 1977-1990 Consultant Center for Mechanistic Biology and Biotechnology Argonne National Laboratory 1977- Advisory Panel The American Board of Medical Laboratory Immunology 1978-1980 Research Committee Tennessee Heart Association 1978-1979 Consultant Clinical Cancer Program Project Review Committee National Cancer Institute National Institutes of Health 1978-1979 Credentials Committee, Medical Staff East Tennessee Baptist Hospital 1978-1980 Treasurer Knoxville Society of Internal Medicine 1979-1980 Clinical Cancer Program Project Review Committee National Cancer Institute National Institutes of Health 1979-1982 Chairman Program Project Review Committee National Cancer Institute National Institutes of Health 1982-1983 Institutional Review Committee East Tennessee Baptist Hospital 1979-1982 Special Committee on Blood Banks Knoxville Academy of Medicine 1980-1982 Committee on Medicine and Religion Knoxville Academy of Medicine 1980-1982 7 Consultant Health and Safety Research Division Nuclear Division, ORNL 1980-1983 Ad Hoc Subcommittee on Program Project Review National Cancer Advisory Board 1982-1983 Board of Scientific Counselors Division of Cancer Biology, Diagnosis, and Centers National Cancer Institute, National Institutes of Health 1993-1995 Advisory Board University of Tennessee Research Corporation 1991-2002 Professional Advisory Board The Wellness Community—National 1993-2000 Editorial Board Amyloid: The Journal of Protein Folding Disorders 1993- AAI Committee on Public Affairs American Association of Immunologists 1993-1995 Cancer Center Program Strategic Planning Task Force University of Tennessee Medical Center Knoxville, TN 1994-1995 Counselor The Henry Kunkel Society, Rockefeller University Hospital New York, NY 1997-2001 Scientific Advisory Board, International Myeloma Foundation 1998- Research Targeting Advisory Group, American Cancer Society 1998 Harry & Elsa Jiler American Cancer Society International Visiting Scientist Committee, Chairman University of Tennessee Graduate School of Medicine 1998-2002 Scientific Advisory Board Multiple Myeloma Research Foundation 2000-2004 ` 8 Medical Advisory Board Amyloidosis Research Foundation 2004- Invited Participation in Scientific Conferences since 1992: Mechanisms in B-Cell Neoplasia Conference 4/21-23/92 sponsored by the National Cancer Institute's Laboratory of Genetics, Division of Cancer Biology, Diagnosis and Centers Bethesda, MD Site-Visit Chairman, National Cancer Institute 4/29-30/92 Special Review Committee, Clinical Cancer Program Project Grant, Bethesda, MD American Cancer Society Cancernet Support Group Park West Hospital Knoxville, TN 5/12/92 83rd Annual Meeting of the American Association for Cancer Research San Diego, CA 5/20-23/92 25th Annual Meeting and Exposition, The American Society of Nephrology Baltimore, MD 11/15-18/92 Methodist Medical Center Staff and CME Committee Oak Ridge, TN 4/13/93 Introductory Speaker, VII International Symposium on Amyloidosis Kingston, Ontario, Canada 7/11-15/93 IVth International Workshop on Multiple Myeloma Mayo Foundation Rochester, MN 10/2-5/93 Molecular Approaches to Cancer Immunotherapy, American Association for Cancer Research Asheville, NC 11/7-11/93 Markey Cancer Center Seminar Series, Chandler Medical Center, Lexington, KY 11/12/93 9 5th International Conference on Lymphocyte Activation and Immune Regulation Newport Beach, CA 2/4-6/94 Conference on Immunoglobulin Gene Expression in Development and Disease, sponsored by The New York Academy of Sciences Montreal, Quebec, Canada 7/13-17/94 36th Annual Meeting and Exposition, The American Society of Hematology Nashville, TN 12/3-5/94 9th International Congress of Immunology, San Francisco, CA 7/23-29/95 Session Chairman on "Major Amyloidoses", FASEB Summer Research Conference on "Amyloid and Other Abnormal Assembly Processes" Copper Mountain, CO 8/20-25/95 Vth International Workshop on Multiple Myeloma La Baule, France 9/10-13/95 Guest Lecturer commemorating the retirement of Shiro Saito, MD, Dean and Professor of Medicine, First Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan 3/23/96 The Louisiana State University Medical Center Seminar Series Shreveport, LA 4/1/96 American Cancer Society Cancernet Support Group Knoxville, TN 4/16/96 Internal Medical Ground Rounds, University of Arkansas for Medical Sciences Little Rock, AR 4/18/96 The Henry Kunkel Society Meeting The Rockefeller University New York, NY 5/2-3/96 VI International Workshop on Multiple Myeloma 6/14-18/97 10 Boston, MA FASEB Summer Research Conference on "Amyloid and Other Abnormal Assembly Processes" Copper Mountain, CO Presentations (Since 1991): 7/13-18/97 Center for the Study of Emerging Diseases, International Workshop on Conformational Diseases, Ein-Boqeq, Dead Sea, Israel 11/8-12/98 ACS Professors Meeting White Planes, NY 10/10/99 FASEB Summer Research Conference on “Amyloid and Other Protein Assembly Processes” Copper Mountain, CO 6/11-15/00 Henry Kunkel Society Meeting Rockefeller University New York, NY 5/2-3/01 VIIIth International Myeloma Workshop Banff, Alberta, Canada 5/4-8/01 IX International Amyloid Symposium Budapest, Hungary 7/15-21/01 FASEB Summer Research Conference on “Amyloids and Other Protein Assembly Processes” Snowmass, CO 6/15-19/02 9th Conference on Cancer Therapy with Antibodies and Immunoconjugates Princeton, NJ 10/24-26/02 ACS Professor Meeting Key Biscayne, FL 10/30-11-1/03 X International Amyloid Symposium Tours, France 4/18-22/04 Protein Folding Disorders & Protein Therapeutics San Diego, CA 1/11-12/05 “Human Light-Chain-Associated Diseases: Myeloma (Cast) Nephropathy, Light-Chain 3/26/91 11 Deposition Disease, and Amyloidosis” Medical Grand Rounds University of Tennessee Medical Center “Multiple Myeloma: Recent Advances in Diagnosis and Treatment” Cancer Committee Multidisciplinary Conference University of Tennessee Medical Center 1/16/92 “Malignant Lymphoma” American Cancer Society-Cancernet Group Park West Hospital, Knoxville, TN 5/12/92 “Experimental Model of Human Light-ChainAssociated Renal and Systemic Diseases” 25th Annual Meeting and Exposition The American Society of Nephrology Baltimore, MD 11/16/92 “Multiple Myeloma: Diagnosis and Treatment” Methodist Medical Center Staff and CME Committee Oak Ridge, TN 4/13/93 “Research Being Conducted in The Human Immunology & Cancer Program at UTMC/K” Board of Directors American Cancer Society Knox County Unit Knoxville, TN 6/29/93 “Heavy-Chain-Associated Amyloidosis (AH Amyloidosis)” VIIth International Symposium on Amyloidosis Kingston, Ontario, Canada 7/11-15/93 “Multiple Myeloma and Related Diseases: 11/12/93 Clinical and Pathologic Implications of Monoclonal Immunoglobulins” Markey Cancer Center Seminar Series University of Kentucky Chandler Medical Center Lexington, KY “Plasma Cell Neoplasms and Amyloidosis” Medical Residents Conference University of Tennessee Medical Center Knoxville, TN 1/21/94 “Immunoglobulin Pathophysiology in 4/16/94 12 B-Cell Malignancies” American Cancer Society Research Professors' Meeting Santa Cruz, CA “Clinical Implications of Light-Chain Deposition” Medical Grand Rounds University of Tennessee Medical Center Knoxville, TN 9/13/94 “Update on Light-Chain-Related Diseases” Medical Residents Conference University of Tennessee Medical Center Knoxville, TN 11/18/94 “Light-Chain Amyloidosis and Deposition Diseases” FASEB Summer Research Conference on "Amyloid and Other Abnormal Assembly Processes" Copper Mountain, CO 8/22/95 Poster: “Immunoglobulin Kappa Light Chain Framework One (FR1) Peptide is Fibrillogenic” Co-authored with Th. A. Niewold, C. Murphy, and J. Wood, FASEB Summer Research Conference on "Amyloid and Other Abnormal Assembly Processes" Copper Mountain, CO 8/20-25/95 Poster: “Quantitation and Characterization of the Binding of Thioflavin T (THT) and Congo Red (CR) to Peptide Fibrils” Co-authored with J. S. Wall, Th. A. Niewold, and C. Murphy, FASEB Summer Research Conference on "Amyloid and Other Abnormal Assembly Processes" Copper Mountain, CO 8/20-25/95 “Pathologic Ramifications of Immunoglobulin Deposition in Multiple Myeloma and Related Diseases” Vth International Workshop on Multiple Myeloma La Baule, France 9/12/95 “Human Light-Chain-Associated Renal and Systemic Diseases: Myeloma (Cast) Nephropathy, Light-Chain Deposition Disease, and AL Amyloidosis” Medicine Grand Rounds University of Tennessee Medical Center Knoxville, TN 10/24/95 13 “Multiple Myeloma” Healthline, Channel 12 Knoxville, TN 11/10,17/95 “Clinical and Experimental Features of the Human 3/23/96 Renal and Systemic Light-Chain-Associated Diseases” Guest Lecture commemorating the retirement of Shiro Saito, MD Dean and Professor of Medicine First Department of Internal Medicine School of Medicine The University of Tokushima, Japan “Clinical and Experimental Features of the Human Renal and Systemic Light-Chain-Associated Diseases” The Louisiana State University Medical Center Seminar Series Shreveport, LA 4/1/96 “Facts About Leukemia, Lymphoma, Multiple Myeloma, and Hodgkin's Disease-1995 Update” American Cancer Society Cancernet Support Group Knoxville, TN 4/16/96 “Clinical and Experimental Features of the Human Renal and Systemic Light-Chain-Associated Diseases” Internal Medical Grand Rounds University of Arkansas for Medical Sciences, Little Rock, AR 4/18/96 “Clinical and Experimental Features of the Human Renal and Systemic Light-Chain-Associated Diseases” The Kunkel Society Meeting The Rockefeller University New York, NY 5/2/96 “The Role of Aredia (Pamidronate) in Multiple Myeloma and Metastatic Lytic Lesions” Chiron Therapeutics Knoxville, TN 9/11/96 "Clinical and experimental features of the Human Renal and Systemic Light-Chain-Associated Diseases" Guest Lecturer, Neuroscience Therapeutics Seminar Parke-Davis Ann Arbor, MI 2/17/97 14 ”Myeloma Update” Arizona Cancer Center Tucson, AZ 4/16-19/98 "Comparison of Recombinant 6 VL Proteins8/7 -11/98 Chemical and Thermal Stability Correlates with Fibrillogenesis Potential" VIII International Symposium on Amyloidosis Mayo Clinic Rochester, MN “Light Chain-Associated Conformational Diseases” International Workshop on Conformational Diseases The Center for the Study of Emerging Diseases Ein-Boqeq, Israel 10/8-12/98 “Light Chain-Associated Conformational Diseases” Advances in Immunology University of Tennessee Medical Center Knoxville, TN 1/27/99 “Immunotherapy in Patients with Light Chain Associated (AL) Amyloidosis: Antibody-Mediated Resolution of Pathologic Deposits” Development Therapeutic Program Division of Cancer Treatment and Diagnosis National Cancer Institute Frederick, MD 6/99 “Advances in the Diagnosis and Treatment of Amyloid-Associated Diseases: Collaboration between the Universities of Uppsala and Tennessee” Guest Lecturer Uppsala University Uppsala, Sweden 8/30/99 Poster: “Extramedullary Production of AL Amyloid Precursor Proteins” VIIth International Workshop on Multiple Myeloma Stockholm, Sweden 9/1-5/99 “Antibody-Mediated Resolution of Light ChainAssociated (AL) Amyloid Deposits” FASEB Summer Research Conference on “Amyloid and Other Protein Assembly Processes” Copper Mountain, CO 6/11-15/00 15 “Primary (AL) Amyloidosis: Diagnostic, Prognosis and Therapeutic Strategies” Keynote Lecturer 7/15-21/01 IXth International Symposium on Amyloidosis Budapest, Hungary “Primary (AL) Amyloidosis: Diagnostic, Prognostic, and Therapeutic Strategies” Department of Pathology University of Tennessee Medical Center, Knoxville Knoxville, TN 8/17/01 “Immunotherapy of Patients with Primary (AL) Amyloidosis: Antibody-Mediated Resolution of Pathologic Deposits” Drug Development Group Division of Cancer Treatment and Diagnosis National Cancer Institute Rockville, MD 4/3/02 “Primary Amyloidosis” Department of Medicine Grand Rounds University of Tennessee Medical Center, Knoxville Knoxville, TN 7/30/02 “Immunotherapy in Primary (AL) Amyloidosis using Amyloid-Reactive Monoclonal Antibodies” Guest Lecturer 9th Conference on Cancer Therapy with Antibodies and Immunoconjugates Princeton, NJ 8-24-02 “Amyloid: The Curse of Old Age” University of Tennessee Science Forum University of Tennessee Knoxville, TN 9-26-03 “The Amyloidoses: A Medical Curse “ Council of Scientific Writers Knoxville, TN 10-26-03 “Amyloid-Reactive Antibodies as Novel Immunotherapeutic Agents for Patients with Primary (AL) Amyloidosis” 10-30-03 16 American Cancer Society Professors Meeting Key Biscayne, FL Appointments: “Immunotherapy in Systemic Primary (AL) Amyloidosis using Amyloid-Reactive Monoclonal Antibodies” Forum, University of Tennessee Department of Biochemistry Molecular Biology Knoxville, TN 2-25-04 “Immunotherapy in AL Amyloidosis” Xth International Symposium on Amyloid and Amyloidosis Tours, France 4-21-04 “Amyloid-Reactive Antibodies as Novel Immunotherapeutic and Imaging Agents for Patients with Primary (AL) Amyloidosis” Hematology/Medical Oncology Grand Rounds Memorial Sloan-Kettering Cancer Center New York, NY 10-26-04 “Demonstration of the Efficacy of Passive Immunotherapy of Peripheral Amyloid Diseases in Animal Models” San Diego, CA 1-11-05 “War on Amyloid: Diagnostic and Therapeutic Strategies” Internal Medicine Ground Rounds The University of Tennessee Graduate School of Medicine Knoxville, TN 4-11-06 Intern Mount Sinai Hospital, NY 1957-1958 Assistant Resident in Medicine (Dr. L. Leiter) Montefiore Hospital, NY 1958-1959 Assistant Resident in Medicine (Dr. A. B. Gutman) Mount Sinai Hospital, NY 1959-1960 Clinical Associate Metabolism Service (Dr. J.L. Fahey) National Cancer Institute, National Institutes of Health 1960-1962 17 Chief Resident in Medicine (Dr. A. B. Gutman) Mount Sinai Hospital, NY 1962-1963 Research Assistant in Hematology (Dr. L. R. Wasserman) Mount Sinai Hospital, NY 1963-1965 Guest Investigator (Dr. H. G. Kunkel) and Assistant Physician The Rockefeller University, NY 1963-1965 Assistant Attending Hematologist Mount Sinai Hospital, NY 1965-1966 Associate Physician and Guest Investigator The Rockefeller University, NY 1965-1966 Associate Research Professor University of Tennessee Memorial Research Center and Hospital Knoxville, TN 1966-1969 Research Professor University of Tennessee Memorial Research Center and Hospital Knoxville, TN 1970-1978 Clinical Professor Department of Medicine, Clinical Education Center University of Tennessee Center for Health Sciences Knoxville, TN 1972-1980 Professor of Medical Biology Department of Medical Biology, Memorial Research Center University of Tennessee Center for Health Sciences Knoxville, TN 1978-1980 Professor of Medicine Department of Medicine University of Tennessee Center for Health Sciences Knoxville, TN 1981- Head, Human Immunology & Cancer Program Department of Medicine University of Tennessee Medical Center Knoxville, TN 1988- 18 Guest Investigator Argonne National Laboratory Argonne, IL 1990- American Cancer Society Clinical Research Professor 1992- Hospital Staff Appointments (Knoxville, TN): Active Medical Staff Department of Medicine University of Tennessee Medical Center 1966- Active Medical Staff Department of Medicine (Hematology/Oncology) Baptist Hospital of East Tennessee 1975- Courtesy Medical Staff Department of Medicine (Hematology/Oncology) Fort Sanders Regional Medical Center 1975-2000 Courtesy Medical Staff Department of Medicine (Hematology/Oncology) East Tennessee Children's Hospital 1975-1993 Courtesy Medical Staff Department of Medicine (Hematology/Oncology) St. Mary's Medical Center 1976-1998 Other Assignments and Honors: Board of Visitors, College of Nursing University of Tennessee 1997- Board of Visitors University of Tennessee Department of Religious Studies 2004- Advisory Board, Clarence Brown Theater University of Tennessee 2000- James L. Clayton Award, Knoxville Museum of Art Knoxville, TN 2007 19
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