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(The FASEB Journal. 2008;22:1062.3.)
© 2008 FASEB
1062.3
Three Tropical Plants with Hepatoprotective properties
Onyekachi Ogbonnaya Iroanya1, Joy Elizabeth Okpuzor2 and Herbert O Mbagwu3
1
Dept of Cell Biology ang Genetics
Department of Cell Biology and Genetics
3
Department of Pharmacology, University of Lagos, Lagos, Nigeria
2
ABSTRACT
The use of medicinal plants is becoming increasingly popular among all social classes in our
society. The lower socioeconomic class cannot afford the high cost of orthodox treatment; the
only alternative to remain in good health is the use of medicinal plants which abounds in their
surrounding to treat all types of diseases. The study aims to substantiate the claims made by the
traditional healers on the use of a mixture of Gongronema latifolia, Ocimum gratissimum and
Vernonia amygdalina in the treatment of liver problems.
The mixture showed no toxicity when administered orally or intraperitoneally to Wistar albino
rats. Aqueous extract of the mixture was evaluated against Acetaminophen induced acute
hepatotoxicity in Wistar rats. The animals were divided into six groups with each group
containing ten animals. Three doses of the extract (2000, 4000, 8000 mg\kg) were fed to the rats
for four days at 24 hours interval.
At a dose of 8000 mg\kg body weight there was a significant change in the level of Alkaline
Phosphatase (21.3± 3.8), Aspartate Aminotransferase (23.3±2.3) and Alanine Aminotransferase
(18 ±1.1) when compared to positive (19.7 ± 0.3, 23.7 ± 1.2 and 23.7 ± 1.2) and normal (25 ±
2.1, 22.3 ± 1.9 and 23.7 ± 1.2) control values. These results indicate a significant
hepatoprotective effect against liver damage induced by Acetaminophen.
We therefore, provide a scientific rationale for the traditional use of the mixture in the
management of liver diseases.
Table of Contents
This Article
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FASEB J. March 2008 22 (Meeting Abstract Supplement) 1062.3
1.
» Meeting Abstract
- Classifications
1.
o
Mode of Action of Bioactive Natural Products
- Services
1.
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Copyright © 2013 by the Federation of American Societies for Experimental Biology
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Print ISSN: 0892-6638
Online ISSN: 1530-6860