제목
iNKT cells regulate IL4 homeostasis
초록
Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4
(IL-4) early during infection. However, indirect evidence suggests they may produce this
immunomodulatory cytokine in the steady state. Through intracellular staining for
transcription factors, we have defined three subsets of iNKT cells (NKT1, NKT2 and
NKT17) that produced distinct cytokines; these represented diverse lineages and not
developmental stages, as previously thought. These subsets exhibited substantial
interstrain variation in numbers. In several mouse strains, including BALB/c, NKT2 cells
were abundant and were stimulated by self ligands to produce IL-4. In those strains,
steady-state IL-4 conditioned CD8+ T cells to become ‘memory-like’, increased serum
concentrations of immunoglobulin E (IgE) and caused dendritic cells to produce
chemokines. Thus, iNKT cell–derived IL-4 altered immunological properties under normal
steady-state conditions.
약력
1996 – 1998
1998 – 2002
2003 – 2007
2007 – 2010
2010 – Present
1.
2.
3.
4.
5.
6.
7.
8.
Premedical School, Seoul National University
M.D., Seoul National University, College of Medicine
Resident in Pathology, Seoul National University Hospital
Ph.D. in Immunology, Seoul National University, College of Medicine
Post-doctoral fellow, University of Minnesota, MN, USA
Lee et. al., Lineage specific effector signatures are shared amongst NKT, ILC, 
and helper T cells. J Immunol. 2016
Lee et. al., Tissue specific distribution of iNKT cells impacts their cytokine response.
Immunity, 2015
Lee et. al., Steady-state production of IL-4 modulates immunity in mouse strains
and is determined by lineage diversity of iNKT cells. Nat Immunol. 2013
Lee et. al., Sclerodermatous chronic graft-versus-host disease induced by host T
cell-mediated autoimmune process. Immunol Cell Biol. 2012
Lee et. al., Alternative memory in the CD8 T cell lineage. Trends Immunol. 2011
Lee et. al., MHC class II–restricted PLZF expressing CD4+ T cells convert CD8+ T
cells into an innate phenotype. J Immunol. 2011
Lee et. al., Generation of PLZF+ CD4+ T cells via MHC class II–dependent
thymocyte–thymocyte interaction is a physiological process in humans. J Exp Med.
2010
Lee et. al., MHC class II-dependent T–T interactions create a diverse, functional
and immunoregulatory reaction circle. Immunol Cell Biol. 2009