Multiple myeloma cells catalyze hepatocyte growth factor
(HGF) activation by secreting the serine protease HGFactivator
by Esther P.M. Tjin, Patrick W.B. Derksen, Hiroaki Kataoka, Marcel Spaargaren, and
Steven T. Pals
Blood
Volume 104(7):2172-2175
October 1, 2004
©2004 by American Society of Hematology
MM cells proteolytically convert HGF into its active form and express the serine protease HGFA.
(A) MM cells convert HGF into its active form.
Esther P.M. Tjin et al. Blood 2004;104:2172-2175
©2004 by American Society of Hematology
HGFA mediates HGF conversion by MM cells.
Esther P.M. Tjin et al. Blood 2004;104:2172-2175
©2004 by American Society of Hematology