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Book Synopsis
Molecular Pharmacology of
Cell Regulation Series
Editor: M.D. Houslay This
important Series provides
topical, in depth and
authoritative reviews on all
aspects of the molecular
mechanisms of cell
regulatory processes. It
attempts to unravel the
molecular structures,
properties and functions of
systems which provide
putative targets for the next
generation of drugs. It will,
therefore, be of major interest
to biochemists,
pharmacologists, molecular
pathologists,
endocrinologists, cell
biologists and research
clinicians working on the
fundamental description of
how cells regulate their own
and each other’s activity, on
the development of novel
therapeutic agents and on
analyses of pathological
changes and genetic lesions.
Volume 2 Cyclic Nucleotide
Phosphodiesterases:
Structure, Regulation and
Drug Action Edited by J.
Beavo Department of
Pharmacology, University of
Washington, USA and M.D.
Houslay Institute of
Biochemistry, University of
Glasgow, UK Cyclic
nucleotide
phosphodiesterases play a
vital role in cell regulation as
the enzymes which mediate
the degradation of important
second messenger molecules.
For the first time, this book
brings together the latest
available information and
opinion on the different
species of phosphodiesterases
and their isoenzymes. It
includes sections on their
Book details
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Author :
Pages : 358 pages
Publisher : Wiley 199011
Language : English
ISBN-10 : 0471927074
ISBN-13 :
9780471927075
identification, purification,
structure and properties; the
organisation of their
encoding genes; regulation of
phosphodiesterase activity in
visual transduction, hormonal
activation, cellular
differentiation and
pathological states; and the
mode of action of selective
inhibitors of
phosphodiesterases and their
therapeutic use in conditions
such as congestive heart
failure.