Pericyte recruitment during vasculogenic tube assembly
stimulates endothelial basement membrane matrix
formation
by Amber N. Stratman, Kristine M. Malotte, Rachel D. Mahan, Michael J. Davis, and
George E. Davis
Blood
Volume 114(24):5091-5101
December 3, 2009
©2009 by American Society of Hematology
Recruitment of pericytes to the ablumenal surface of EC-lined tubes within vascular guidance
tunnels using a new model of EC-pericyte tube coassembly in 3D collagen matrices.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Extracellular deposition of basement membrane components is observed only when EC are
cocultured with pericytes during EC-pericyte tube coassembly.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Pericyte recruitment to microvascular tubes during vasculogenesis in quail CAMs correlates
with basement membrane matrix assembly.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Up-regulation of fibronectin, nidogen-1, laminin isoforms, and perlecan occurs selectively in ECpericyte cocultures to regulate EC basement membrane assembly.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Selective induction and functional requirement of integrins with affinity for basement membrane
matrices during EC-pericyte tube coassembly.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Fibronectin matrix assembly is required for vascular basement membrane formation during ECpericyte tube coassembly.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology
Pericyte TIMP-3 regulates basement membrane formation during EC-pericyte coassembly events
within vascular guidance tunnels during tube remodeling and maturation events.
Amber N. Stratman et al. Blood 2009;114:5091-5101
©2009 by American Society of Hematology