Features of the pathways of Ag processing
Feature
Class II MHC Pathway
Composition
of MHC
Types of APC
Responsive T cell
Source of Ags
Enzymes responsible
For peptide degradation
Molecules involved in
Transport of peptides and
Loading of MHC molecules
Class I MHC Pathway
Features of the pathways of Ag processing
Feature
Class II MHC Pathway
Composition
of MHC
Types of APC
alpha/beta chains
DC, MO, B cells (endothelial)
Class I MHC Pathway
alpha/beta 2-m
All nucleated
Responsive T cell
CD4 T cells
CD8 T cells
Source of Ags
Exogenous
Endogenous
Enzymes responsible
For peptide degradation
Endosomal and lysosomal
proteases
Cytosolic
proteasome
Molecules involved in
Transport of peptides and
Loading of MHC molecules
Invariant chain (Ii), HLA-DM
TAP
Viral immune evasion
Kuby Figure 8-8