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Book Synopsis
Side Reactions in Peptide
Synthesis, based on the
author’s academic and
industrial experience, and
backed by a thorough review
of the current literature,
provides analysis of, and
proposes solutions to, the
most frequently encountered
side reactions during peptide
and peptidomimetic
synthesis. This valuable
handbook is ideal for
research and process
chemists working with
peptide synthesis in diverse
settings across academic,
biotech, and pharmaceutical
research and development.
While peptide chemistry is
increasingly prevalent,
common side reactions and
their causes are often poorly
understood or anticipated,
causing unnecessary waste of
materials and delay. Each
chapter discusses common
side reactions through
detailed chemical equations,
proposed mechanisms (if
any), theoretical background,
and finally, a variety of
possible solutions to avoid or
alleviate the specified side
reaction. Provides a
systematic examination on
how to troubleshoot and
minimize the most frequent
side reactions in peptide
synthesisGives chemists the
background information and
the practical tools they need
to successfully troubleshoot
and improve resultsIncludes
optimization-oriented
analysis of side reactions in
peptide synthesis for
improved industrial process
development in peptidyl API
(active pharmaceutical
ingredient) production
Answers the growing, global
Book details
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Author : Yi Yang
Pages : 376 pages
Publisher : Academic
Press 2015-09-22
Language : English
ISBN-10 : 0128010096
ISBN-13 :
9780128010099
need for improved, replicable
processes to avoid impurities
and maintain the integrity of
the end product.Presents a
thorough discussion of
critical factors in peptide
synthesis which are often
neglected or underestimated
by chemists Covers solid
phase and solution phase
methodologies, and provides
abundant references for
further exploration