Europass Curriculum Vitae Personal information First name(s) / Surname(s) Address(es) Lidia CREMER 103 Splaiul Independentei, sector 5, Bucharest, Romania Telephone(s) 40 21 3069298; 40 21 5287298 Fax(es) 40 21 3069298; 40 21 5287298 E-mail Nationality Date of birth Gender Mobile: 40 722851689 [email protected] Romanian 23.08.1955 Female Desired employment / Research Fellow / Partner responsible Occupational field Work experience Dates Occupation or position held Main activities and responsibilities 2006 - present Head of Immunomodulation Laboratory - Name and address of employer Dates Occupation or position held Main activities and responsibilities Name and address of employer Type of business or sector Page 1/8- Curriculum vitae of CREMER Lidia Specific research activities in immunology, immunochemistry, biochemistry, molecular biology Management and Administration of Immunomnodulation Laboratory; training, directing and coordination of research activity in the group (researchers, new graduates employees, technicians). Writing up scientific proposals and papers Project director and project responsible in national (CEEX, NUCLEU, PN II, CNCSIS, BIOTECH) and international projects (co-operations) Budget authority for acquisition of research equipment, reagents, consumables, services, participation in scientific meetings etc “Cantacuzino” National Institute of Research and Development for Microbiology and Immunology (Cantacuzino NIRDMI), 103 Splaiul Independentei, 050096 Bucharest, Romania 1986 – 2006 Researcher : Junior researcher, Senior researcher (3rd degree, 2nd degree), Immunology Department - Research on modern strategies approacing the pathogenesis of autoimmune/inflammatory diseases, by modulating pro and anti-inflammatory cytokine network and using natural/synthetic compounds - In vivo studies for testing the anti-tumoral capacity (melanoma) of natural/synthetic compounds - Cytotoxicity/viability tests performed on normal and tumoral cell lines - Identifying active compounds in modulation of antibody production in vivo - Identifying the modulatory capacity of some compounds on endotoxic shock induced by LPS - Identifying and monitoring the activities of compounds with anti-inflammatory and immunosuppressive properties, which are purified from medicinal plants, by applying cellular and molecular biology tests, in order to intimate their action and to enlarge their applicability - Modern methods for testing the efficacy of anti-inflammatory drugs prescribed in the therapy of acute and chronic inflammatory diseases - Writing up scientific proposals and papers “Cantacuzino” National Institute of Research and Development for Microbiology and Immunology, 103 Splaiul Independentei, 050096 Bucharest, Romania Research and Development. Management: (a) Strategic management, (b) Research activity management, (c) Research project management. For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 Dates Occupation or position held Main activities and responsibilities Name and address of employer Type of business or sector 1979 – 1986 Chemist Dyes testing Sintofarm S.A., 22 Ziduri intre Vii, sector 2, 023324 Bucharest, Romania Industry Education and training Dates Title of qualification awarded Principal subjects/occupational skills covered Name and type of organisation providing education and training Dates Title of qualification awarded Principal subjects/occupational skills covered Name and type of organisation providing education and training Dates Title of qualification awarded Principal subjects/occupational skills covered Name and type of organisation providing education and training 1992 – 1997 PhD in Medicine - Medical Biochemistry Proinflammatory cytokines and free oxygen radicals: vegetal extracts able to regulate the synthesis / activity of these mediators of inflammation “Carol Davila” University of Medicine and Pharmacy, Bucharest 1978 – 1979 Postgraduation training / Research qualification (Master equivalent degree) Physical Chemistry University of Bucharest 1974 – 1978 University degree in Chemistry Chemistry University of Bucharest, Faculty of Chemistry Personal skills and competences Mother tongue(s) Other language(s) Self-assessment Specify mother tongue Romanian English, French, Spanish Understanding European level (*) Listening Reading Speaking Spoken interaction Writing Spoken production English Language French Language C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient C2 Proficient Spanish Language B2 Independent user B2 Independent user A2 Basic A1 Basic A1 Basic Social skills and competences Page 2/8- Curriculum vitae of CREMER Lidia Team work: I have worked in research groups in immunology Leader work: I am a research group leader since 2006 at “Cantacuzino” NIRDMI For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 Technical skills and competences ELISA, immunoblotting, chemiluminometry, fluorimetry, modern colorimetric techniques, cell cultures, cells isolation and stimulation, in vitro cell cytotoxicity/proliferation techniques, small laboratory animals immunization methods. Completed postgraduated courses with diplomas: 1986 – Basic Immunology Course, Bucharest, Romania 1988 – IUIS International Immunology Course "The deviated Immune Response", Poiana Brasov, Romania 1988 - IUIS International Immunology Course "Regulation of Immunity", Polczyn Zdroj, Poland 1990 – NATO/FEBS Summer School "Cellular Regulation by Protein Phosphorylation", La Londe, France 1995 - First Balcanic Symposium of FACS users, Varna, Bulgaria 1996 - EFIS International Immunology Symposium “Signals and Signal Processing in the Immune System", Tihany, Hungary 2000 - John Humphrey Course "Self-Tolerance and Self-Recognition", Sinaia, Romania 2001 - Posgraduate training “From Cellular & Molecular Biology to XXIst century medicine”, Bucharest, Romania Other completed training courses with diplomas: 2006 - Prerequisites of ISO / CEI 17025:2005 - reference for the accreditation of attempt / calibration laboratories, RENAR 2007 - Validation of attempt / analysis methods. Practical aspects and computer tools, FiaTest 2007 - Uncertainty measuring evaluation in attempt laboratories. Case studies and applications, FiaTest Computer skills and competences Artistic skills and competences Driving licence Microsoft Office (Excel, PowerPoint, Word); MS Outlook; Adobe Photoshop; Internet; etc) Photography I hold a driving licence (B category) Additional information Patents: Method for determining double stranded or single stranded anti-DNA antibodies. Authors: G.Szegli, M.Stefanescu, L.Cremer, V.Enache, Patent No.95732/1988-OSIM (1988) Member in scientific organizations: Member of the Romanian Society for Immunology, since 1987 Nominations: 2010. Research projects evaluation expert awarded by the Ministry of Research, Bucharest. Teaching activity: Lecturer – Basic Immunology Workshop, organized annually by the Romanian Society for Immunology (2003 - 2009) Long-term expert (Technical expert - Quality management, inter-laboratories comparison) in the project “Professional and organizational forming of employees in the immunology laboratories, by initiating efficient technologies and quality management”, financed by the European Social Fund (Human Resources) POSDRU/81/3.2/S/59497 (2010-2013) Annex List of published and communicated papers (mainly 2008-2011) Page 3/8- Curriculum vitae of CREMER Lidia For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 Annex List of published and communicated papers (mainly 2008-2011) a) No. 1 2 3 Publications in scientific journals with ISI quotation Title Identification of anti-idiotypic antibodies to anti-phosphotyrosine antibodies in human sera Assessment of two synthesized curdlan derivatives as possible antioxidants and/or modulators of human PMN cells respiratory burst The antioxidant effects of some progressively purified fractions from Helleborus purpurascens b) No. Authors Maria Stefanescu, Cristiana Matache, A.Onu, C.Cristescu, Lidia Cremer, G.Szegli L. Cremer, A-R Lupu, M.M.Badulescu, G.Mocanu, D.Mihai, A.Calugaru, N.S.Apetrei, M.Moscovici, G.Szegli N.S. Apetrei, A-R Lupu, A.Calugaru, F.Kerek, G.Szegli, L.Cremer Publications in scientific journals indexed in other international databases Title Authors 1 The novel arthritis drug substance MCS-18 attenuates the antibody production in vivo 2 Local analgesic drug “MCS-18” provides high survival rates in septic-shock mice F.Kerek, G.Szegli, L.Cremer, A-R Lupu, S.Durbaca, A.Calugaru, A.Herold, D.L. Radu F.Kerek, A.Babes, L.Cremer, A-R Lupu, C.Coman, A.Calugaru, G.Szegli 3 Effects of cold plasma on B16 and COLO320 tumoral cells A-R Lupu, N.Georgescu, A.Calugaru, L.Cremer, G.Szegli, F.Kerek 4 Recognition and control of Dectin-1 receptors and TLR-2 by Curdlan –like biopolymers and purified natural extracts Novel antirheumatic drug “MCS-18” involved in TLR signaling A.Calugaru, L.Cremer, A-R Lupu, M.M. Badulescu, N.S.Barzu, F.Kerek, G.Szegli A-R Lupu, L.Cremer, G.Szegli, A.Calugaru, M.M.Badulescu, N.S.Barzu, M-L Flonta, F.Kerek A-R Lupu, L.Cremer, F.Kerek, A.Calugaru, N.S.Barzu, C.Coman, ML Flonta, G.Szegli A-R Lupu, L.Cremer, F.Kerek, A.Calugaru, M.M.Badulescu, M-L Flonta, G.Szegli C.C. Surdu-Bob, C.Coman, A.Calugaru, L.Cremer, M.Badulescu, E.Vlase 5 6 The role of natural compound D161 in neurogenic inflammation 7 New natural compound MCS-18, a TLR-2 antagonist able to down-regulate inflammation-related pain In vivo and in vitro studies on the efficiency and toxicity of SBCC implant particles on B16 melanoma 8 c) No. 1 Publications in scientific journal with peer-review Title Study of apoptosis induced by cytostatics and vegetal extracts on human endothelial cell line Page 4/8- Curriculum vitae of CREMER Lidia Authors N.S.Bârzu, M.M.Bădulescu, A-R Lupu, L.Cremer , G.Szegli, F.Kerek, A.Calugaru Journal (with ISI quotation) Autoimmunity, 15, 181-186 (1993) Romanian Biotechnological Letters, Vol. 15, No. 6, 5718-5728, (2010) Romanian Biotechnological Letters, Vol. 16, No. 6, 6673-6682 (2011) Journal (indexed in other databases) Acta Microbiologica et Immunologica Hungarica, 55 (1), 15-31, (2008) Shock, 29 (Supplement 1), 110, (2008) Proceeding of 4th International Congress on Cold Atmospheric Pressure Plasmas: Sources and Applications – CAPPSA (2009) European Journal of Immunology, Vol.39, No.S1, S77, 2009 European Journal of Immunology, Vol.39, No.S1, S77, 2009 European Journal of Pain, Vol 13, Suppl 1, Sept 2009 European Journal of Pain, Vol 13, Suppl 1, Sept 2009 Poceedings of The 4th European Conference for Clinical Nanomedicine, The Great Strides towards the Medicinie of the Future (2011) Journal (with peer-review) Roum.Arch.Microbiol.Im munol., Vol.67, Nr.1-2, pag.5-9 (2008) For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 2 The modulation of reactive oxygen species production from human polymorphonuclear cells by curdlan derivatives as Dectin-1 agonists/antagonists M.M.Bădulescu, A-R Lupu, L.Cremer, A.Calugaru, N.S.Apetrei, M. Moscovici, G.Mocanu, G. Szegli Roum.Arch.Microbiol.Im munol., Vol.68, Nr.2, pag.63-68 (2009) 3 The effects of cold atmospheric plasma jets on B16 and COLO320 tumoral cells A-R Lupu, N.Georgescu, A.Calugaru, L.Cremer, G.Szegli, F.Kerek 4 Recognition and modulation of Dectin-1 and TLR-2 receptors by curdlan derivatives and purified natural extracts 5 Curdlan derivatives able to enhance cytostatic drugs activity on tumoral cells 6 Efectele curdlanului si ale derivatilor sai asupra sepsisului indus la soareci 7 The effect of some curdlan derivatives on Dectin-1 expression and cytokine production in human peripheral blood mononuclear cells Implant microparticles – a new concept for non-invasive cancer therapy A.Calugaru, L. Cremer, A-R Lupu, M.M.Badulescu, N.S.Apetrei, M.Moscovici, G.Mocanu, D.Mihai, F.Kerek, G.Szegli M.M.Badulescu, N.S.Apetrei, A-R Lupu, L.Cremer, G.Szegli, M.Moscovici, G.Mocanu, D.Mihai, A.Calugaru C.Coman, E.Vlase, L.Cremer, A-R Lupu, N.S.Apetrei, A.Calugaru, G.Mocanu, D.Mihai, M.Moscovici, G.Szegli N.S.Apetrei, A.Calugaru, M.M.Badulescu, A-R Lupu, M.Moscovici, G.Mocanu, D.Mihai, G. Szegli, L.Cremer C.C. Surdu-Bob, C.Coman, A.Calugaru, L.Cremer, M.Badulescu, E.Vlase N.S.Apetrei, A.Calugaru, F.Kerek, M.Panteli, I.Rasit, L.Cremer, G.Szegli, A-R Lupu Roum.Arch.Microbiol.Im munol., Vol.68, Nr.3, pag. 136-144 (2009) Roum.Arch.Microbiol.Im munol., Vol.68, Nr.3, pag.119-124, (2009) 8 9 Cells A highly purified vegetal fraction able to modulate HMGB1 and to attenuate septic shock in mice Roum.Arch.Microbiol.Im munol., Vol.68, Nr.4, pag.11-16, (2009) Revista Romana de Medicina Veterinara, Nr.4, 89-96, (2010) Roum.Arch.Microbiol.Im munol., Vol.69, Nr.2, pag.61-66, (2010) Roum.Arch.Microbiol.Im munol., Vol.70, Nr.1, pag.37-41, (2011) Roum.Arch.Microbiol.Im munol., Vol.70, Nr.3, pag.114-123, (2011) d) No. 1 2 3 4 Papers presented in international scientific conferences with program committee Title Authors Scientific conference (International conference with program committee) Analgesic and anti-inflammatory A-R Lupu, L.Cremer, Sepsis 2008 compound MCS -18 provides high F.Kerek, A.Calugaru, survival rates in septic-shock mice C.Coman, A.Babes, G.Szegli Local analgesic drug “MCS-18” F.Kerek, A.Babes, International Shock Congress provides high survival rates in L.Cremer, septic-shock mice A-R Lupu, C.Coman, A.Calugaru, G.Szegli High pressure liquid B.Burghelea, Al 31- lea Congres Mondial al Viei chromatography (HPLC) and A.Kontek, si Vinului si a 6-a Adunare oxygen radical absorbance R.Campeanu, Generala a O.I.V. capacity (ORAC), standardized G.Caraene, methods complying with EU A-R Lupu, R.Porumb, regulations concerning bioactive L.Cremer, products obtained from grape A.Tudorache seeds Pharmacological evaluation of a B.Burghelea, International Symposium on New total grape seed polyphenolic G.Neagu-Caraene, Researches in Biotechnology extract as ingredient in functional R.Campeanu, food products complying with EU L.Cremer, regulation concerning natural V.Vulturescu, bioactive products G.Radulescu, C.Nichita, R.Albulescu, R.Porumb, A.R.Lupu, G.Szegli Page 5/8- Curriculum vitae of CREMER Lidia For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 Year, town, country 19-22 Nov. 2008, Granada, Spania 28 Iun – 2 Iul 2008 Cologne, Germania 15-20 Iun 2008, Verona, Italia 20-21 noiembrie 2008, Bucuresti 5 Immunosuppressive and antiinflammatory activities of MCS18, a compound isolated from a total Helleborus purpurascens extract 6 MCS-18 and D161 – TLR antagonists or negative regulators of TLR intracellular signaling? 7 The modulation of free oxygen radicals production from human polymorphonuclear cells by Dectin-1 and TLRs agonists/antagonists 8 The modulation of IL-10 and TNFalpha released by activated human PBMC in the presence of natural and derived beta-glucans 9 Novel antirheumatic drug MCS-18 involved in TLR signaling 10 Recognition and control of Dectin1 receptors and TLR-2 by Curdlan–like biopolymers and purified natural extracts 11 The role of natural compound D161 in neurogenic inflammation 12 New natural compound MCS-18, a TLR-2 antagonist able to downregulate inflammation-related pain 13 Studies regarding the efficacy of “Natural SOD” and its fractions on PMN cells of patients with rheumatic diseases 14 In vivo and in vitro studies on the efficiency and toxicity os SBCC implant particles on B16 melanoma 15 Clinical, histopathological and immunohistochemical correlation in ovarian cancer Page 6/8- Curriculum vitae of CREMER Lidia A-R Lupu, N.Georgescu, L.Cremer, N.S.Barzu, M.M.Badulescu, A.Calugaru, C.Coman, E.Vlase, G.Szegli, F.Kerek A-R Lupu, L.Cremer, F.Kerek, A.Calugaru, M.M.Badulescu, M-L Flonta, G.Szegli M.M. Badulescu, A-R Lupu, L.Cremer, A.Calugaru, N.S.Barzu, M.Moscovici, G.Szegli N.S.Apetrei, L.Cremer, M.M.Badulescu, A-R Lupu, A.Calugaru, M.Moscovici, G.Szegli A-R Lupu, L.Cremer, G.Szegli, A.Calugaru, M.M.Badulescu, N.S.Barzu, M-L Flonta, F.Kerek A.Calugaru, L.Cremer, A-R Lupu, M.M.Badulescu, N.S.Barzu, F.Kerek, G.Szegli A-R Lupu, L.Cremer, F.Kerek, A.Calugaru, N.S.Barzu, C.Coman, M-L Flonta, G.Szegli A-R Lupu, L.Cremer, F.Kerek, A.Calugaru, M.M.Badulescu, M-L Flonta, G.Szegli A-R Lupu, L.Cremer, A.Herold, M.Cristea, MM.Badulescu, N.S.Barzu, A.Calugaru, G.Szegli C.C.Surdu-Bob, C.Coman, A.Calugaru, L.Cremer, M.Badulescu, E.Vlase A.Badulescu, Fl.Badulescu, C.Popescu, L.Cremer, A.Anastasiu 8th EFIS Tatra Immunology Conference Iunie 2008, Strbske Pleso, Slovacia TRIPR Conference „Innate immunity and the pathogenesis of rheumatic diseases” 6-8 Mai 2009, Genova, Italia TRIPR Conference „Innate immunity and the pathogenesis of rheumatic diseases” 6-8 Mai 2009, Genova, Italia TRIPR Conference „Innate immunity and the pathogenesis of rheumatic diseases” 6-8 Mai 2009, Genova, Italia The 2nd European Congress of Immunology Sept. 2009, Berlin, Germania The 2nd European Congress of Immunology Sept. 2009, Berlin, Germania Pain in Europe VI, 6th Congress of the European Federation of IASP®, Chapters (EFIC) Sept. 2009, Lisabona, Portugalia Pain in Europe VI, 6th Congress of the European Federation of IASP®, Chapters (EFIC) Sept. 2009, Lisabona, Portugalia TRIPR Conference „Biological Agents and Emerging Treatments in the Management of Rheumatic Diseases” 27-30 Mai 2010, Genova, Italia The 4th European Conference for Clinical Nanomedicine 23-25 Mai 2011, Basel, Elvetia 8th Congress of the European Society of Gynecology 8-11 Sept. 2011, Copenhaga, Danemarca For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 e) No. 1 2 3 4 5 6 7 8 9 10 11 Communicated papers in national presented in national conferences with program committee Title Authors Scientific conference Year, town (National conference with program committee) Efectul unor extracte naturale M.M.Badulescu, A 38a Conferinta Nationala de 2008, Busteni asupra producerii de radicali liberi A-R Lupu, L.Cremer, Imunologie de oxigen in celule stimulate la N.S.Barzu, A.Călugaru, nivelul receptorilor TLR si Dectin 1 F.Kerek, M.Moscovici, G.Szegli Inhibarea activitatii fosfatidilinozitol N.S.Barzu, L.Cremer, A 38a Conferinta Nationala de 2008, Busteni 3-kinazei de catre fractiuni A.Calugaru, Imunologie vegetale izolate si purificate din A-R Lupu, Helleborus purpurascens M.M.Badulescu, F.Kerek, G.Szegli Activitatile antiinflamatoare ale A-R Lupu, L.Cremer, Al IV-lea Simpozion “Acad. 26-28 martie compusilor MCS-18a si MCS-18d N.S.Barzu, Nicolae Cajal” 2008, Bucuresti izolati dintr-un extract total de M.M.Badulescu, Helleborus purpurascens A.Calugaru, C.Coman, E.Vlase, G.Szegli, F.Kerek Effect of Curdlan type biopolymers A.Calugaru, L.Cremer, A 39a Conferinta Nationala de 2009, and some natural extracts on A-R Lupu, Imunologie Calimanesti Dectin-1 and TLRs M.M.Badulescu, N.S.Apetrei, F.Kerek, G.Szegli The capacity of some beta-glucan M.MBadulescu, A 39a Conferinta Nationala de 2009, biopolymers to modulate reactive A-R Lupu, L.Cremer, Imunologie Calimanesti oxygen species production from A.Calugaru, N.S.Barzu, human polymorphonuclear cells M.Moscovici, G.Mocanu, G.Szegli Cold atmospheric plasma jects – a A-R Lupu, A 39a Conferinta Nationala de 2009, new medical device acting on N.Georgescu, Imunologie Calimanesti tumoral cells A.Calugaru, L.Cremer, G.Szegli, F.Kerek MCS-Ab162 and D161 – possible A-R Lupu, L.Cremer, 5th „Gheorghe Marinescu” Oct. 2009, therapeutic agents in F.Kerek, A.Calugaru, Symposium of the National Bucharest neuroimmune diseases C.Coman, E.Vlase, Neuroscience Society of Romania M.M.Badulescu, N.S.Apetrei, M-L Flonta, G.Szegli Enhancement of some cytostatic N.S.Apetrei, A 40a Conferinta Nationala de 2010, Sibiu drugs activity on tumor cell lines M.M.Badulescu, Imunologie using curdlan derivatives L.Cremer, A-R Lupu, M.Moscovici, G.Mocanu, D.Mihai, G.Szegli, A.Calugaru The modulation of IL-10 and TNF- N.S.Apetrei, L.Cremer, Conferinta Internationala Anuala 23-25 alpha cytokines activities by highly A.Calugaru, a SRBBM Septembrie purified vegetal extracts and M.M.Badulescu, 2010, Bucuresti Curdlan derivatives in human A-R Lupu, activated PBMCs F. Kerek , D.Mihai, G.Mocanu , M.Moscovici, G.Szegli Preliminary studies on human A-R Lupu, The annual International 23-25 sept PMN cells activation by T.Popescu, Conference of the RSBMB 2010, Bucuresti TiO2−based nanopowders M.M.Badulescu, L.Cremer, L.Diamandescu, D.Tarabasanu-Mihaila Inhibition of induced mouse B16 A.Calugaru, A 40a Conferinta Nationala de 2010, Sibiu melanoma by metal C.C Surdu-Bob, Imunologie microspherical particles L.Cremer, M.Badulescu, C.Coman Page 7/8- Curriculum vitae of CREMER Lidia For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628 12 A highly purified fraction from Helleborus purpurascens able to modulate HMGB1 release in human tumor cells and to attenuate septic shock in mice 13 The antioxidant effects of some progressively purified vegetal extracts Page 8/8- Curriculum vitae of CREMER Lidia N.S.Apetrei, A.Calugaru, A-R Lupu, M.Panteli , I.Rasit, M.Moscovici, F.Kerek, G.Szegli, L.Cremer N.S. Apetrei, A-R- Lupu, A.Calugaru, F.Kerek, G.Szegli, L.Cremer A 41a Conferinta Anuala de Imunologie 2011, Timisoara Conferinta Internationala Anuala a SRBBM 2011, Craiova For more information on Europass go to http://europass.cedefop.europa.eu © European Communities, 2003 20060628
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