Prof. Dr. Ismanizan Ismail
Director / Principal Research Fellow
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Plant Molecular Biotechnology
Our research group focuses on plant cell biotechnology especially on secondary metabolite content through green
CONTACT INFORMATION
technology. The concept and activities are based on integrated multidisciplinary of life sciences and engineering
Tel: +603 8921 4546
with the knowledge, skill and technology of all research disciplines. We emphasize on the use of in -vitro culture for
Fax: +603 8921 3398
production of hairy roots lines which combine the
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structural analysis for activities of targeted molecules.
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The fact that hairy roots culture do produce new and
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difference metabolites as compared to normal roots
has allowed further exploration of their potential
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application. We put our effort on characterizing those
EDUCATION
molecules through Nuclear Magnetic Resonans (NMR), combining molecular biology, chemistry and biomedical
BSc (UKM), PhD (Edinburgh)
analysis to understand the structures-activities relation (SAR). We also work closely with the engineering to
develop optimum cultivation conditions and
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enhanced recovery of targeted molecules. The
ADDRESS
group also work on the regulation of gene
Institute of Systems Biology
expression in relation to plant respond toward
Universiti Kebangsaan Malaysia
plant stresses. Our initial study with F-box protein
43600 UKM Bangi, Malaysia
involves in Ubiquitin E3 ligase mechanism has
http://www.inbiosis.ukm.my
suggested the involvement of miRNA molecules.
Consequently, we have identified a few miRNA candidates known to be potentially related to F-box protein. The
regulatory roles of miRNA in plant stresses has aspired us to explore further miRNA-transcription factor coexpression networking. As the regulation of gene expression in plant lately has taken to another step involving
transcription factors as a ‘master regulatory’, the
involvement of miRNAs in plant genes regulation is
inspiring. As one of our goals, the research efforts
devoted to draw the comprehensive view of
miRNA-Transcription factors (miRNTF) network.
The linkage and relation between F-box protein,
miRNTF and their target transcripts in various plant stresses are our focus research activities.
In order to
understand and analyse the roles of this small RNA molecules throughout the plant gene networking, extensive
studied through bioinformatics tools competent for network analysis as well as sufficient experimental activities for
realiable analytical results will be carried out.
miR-164a
miR-395
miR-2107