Case studies
Tisseos® is a bi-layered, synthetic, biocompatible and fully resorbable membrane for
Guided Bone Regeneration (GBR) and Guided Tissue Regeneration (GTR) applications.
Bilayered structure for optimal barrier effect
Specially designed bilayered structure prevents (gingival) epithelial tissue ingrowth on one side
(smooth fascia of dense layer) while promoting cell infiltration and guided bone healing on the other
(matt fascia with non-woven microfibers).
BILAYERED STRUCTURE
Next generation synthetic resorbable membrane
SYNTHETIC
Synthetic – today’s alternative choice:
• Medical-grade Polylactic-Glycolic Acid provides excellent
biocompatibility. A 100% biodegradable polymer, PLGA has a long
history of successful use in a variety of medical applications and
devices such as resorbable sutures, pins, screws etc, and over
many decades
• Unlike bovine or porcine derived membranes, Tisseos® is free
from animal derivatives. Our biocompatible synthetic membrane
avoids the risk of transmission of animal pathogens.
• Widens treatable patient group: Tisseos® synthetic membranes
are suitable for patients who avoid animal by-products for
cultural reasons or lifestyle choices.
26 wks
Graph shows the Tisseos® membrane resorption time
over a 6 month period.
The barrier function of Tisseos® membrane remains intact for the
first 4 weeks.
Optimal bone and tissue regeneration are both guaranteed thanks to
the slow, fully controlled resorption over 6 months, avoiding any
Histologie of subcutis implants in rats of the
synthetic PLGA Tisseos® membrane after 4, 8, 16
and 26 weeks (Coloration au trichrome de
Masson; x100 barre=250 μm).
need for second stage surgery for membrane removal.
RESORBABLE
16 wks
8 wks
4 wks
PLA
• Supple but strong
EASY TO USE
• Easy to cut
• Tear resistant for tacking and suturing
• Sticks only to bone
• Does not stick to soft tissue or instruments
• Once wet Tisseos® respects the form and shape that you create
15x20
15x25
20x30
• Available in 4 sizes
30x40
• Quickly soaks up biological fluids on the micro-fiber side
• Can be used without prior humidification
1
Clinical case study
Dr. HOORNAERT Alain, Nantes, France
Initial clinical situation
Alveolar ridge after opening of
the gingiva
Filling of the bone defect with
biomaterial
Bone regeneration
using Tisseos® membrane
and a biomaterial
Positioning the Tisseos®
membrane
Gingival healing after 8 days
Clinical situation after 4 months
showing successful vertical and
lateral bone augmentation
Postoperative x-ray
Key benefits of Tisseos®
•
A major advantage of Tisseos® is its easy surgical
handling when compared to collagen membranes.
When placed on the bone, the microfibre layer
soaks up the blood and it attaches easily to the
bone.
•
The membrane can easily be repositioned on the
bone defect for optimal placement to cover the
biomaterial.
•
When suturing, the dense layer (smooth side of the
membrane) slides easily over the gingival tissue
without disturbing the bone filling biomaterial.
Insertion of 2 implants
Exposure of implants
Control x-ray
•
Both the dental surgeon and the patient benefit
from shorter surgical times and improved
operational comfort.
Final restoration
2
Clinical case study
Dr. HOORNAERT Alain
Nantes, France
Socket preservation and
bone ridge augmentation
using Tisseos® membrane
and a biomaterial
Initial clinical situation
Bone crest after opening of the
gingiva
Positioning of Tisseos®
membrane
Gingiva healing at 8 days
Clinical situation after 4 months
showing vertical and horizontal
bone augmentation
Filling of the defect with biomaterial
Postoperative view
Why correct vestibular bone
defects?
Insertion of 3 implants
CT-scan before surgery
(prior to implantation)
Alveolar bone resorption after tooth extraction cannot
be avoided. In the anterior maxillary bone, resorption is
observed on the vestibular side and can negatively
impact the placement of the implant in two ways:
•
The axis of the dental implant may be misplaced
•
The implant may be visible when smiling
Using a dental membrane allows you to overcome such
problems.
Placement of covering screws
Temporary prosthetics
restoration
3
Clinical case study
Drs. BRAY Estelle and L’ENFANT Benoit,
Nantes, France
Initial clinical situation
Allogenic bone graft
Alveolar ridge after 4 months
Alveolar ridge regeneration
following allogenic bone
grafting
Insertion of 2 implants
Prosthetics rehabilitation showing the vertical defect
CT-scans
Resorption of the allogenic bone graft
using Tisseos® membrane
and a biomaterial
Predictable vertical bone
regeneration
Resorption of allogenic bone graft is difficult to predict.
Placement of Tisseos® membrane and filling of the defect with a biomaterial
Guided bone regeneration using Tisseos® and biomaterial
allows you to augment bone vertically in a more predictable
way.
Healing at 8 days
Healing at 2 ½ months
Temporary prosthetics restoration
4
Clinical case study
Dr. MORLOCK Jean-François
Tours, France
Clinical situation
before tooth extraction
Dental alveole and bone ridge
Filling with biomaterial
Socket preservation
using Tisseos® membrane
and a biomaterial
Covering with Tisseos®
membrane
Healing at 28 days
X-ray at 6 months
Healing at 5 days
Socket preservation
•
After tooth extaction, the alveolar bone resorbs,
compromising the insertion of implants.
•
Filling of the alveole with biomaterial limits the
bone resorption.
•
Tisseos® membrane covers the biomaterial until
bone healing is complete.
Re-entry at 6 months
Insertion of 2 implants
Final restoration
5
Cilinical case study
Dr. HOORNAERT Alain
Nantes, France
Bone augmentation with
immediate implantation
using Tisseos® membrane
and a biomaterial
Initial clinical situation
Preoperative cone beam scans
Insertion of implant
Covering with Tisseos® membrane
Alveolar ridge
Filling with biomaterial in the
fenestration
Healing at 1 month
Post-surgical view
Key features of Tisseos®
X-ray
Final restoration
•
The insertion of a dental implant for a screwretained prosthetic may lead to a vestibular
dehiscence when the maxillary bone profile is not
favorable.
•
The use of Tisseos® and a biomaterial at the apex of
the implant allows you to prevent such dehiscence.
•
The ease of handling of Tisseos® saves time in such
types of surgery.
6
Clinical case study
Dr. EVANNO Charles,
Liré, France
Initial clinical situation
Alveolar ridge after opening of
the gingiva
Implant with exposed turns
Placement of Tisseos®
membrane
Dehiscence coverage
Filling with the biomaterial
Repositioning of the membrane
Palatal insertion
Sutures
X-ray
using Tisseos® membrane
and a biomaterial
What to do in case of
membrane exposure?
•
When filling a large defect, it may be difficult to close the
gingival tissue without tension. The membrane may then
become exposed during the gingival healing.
•
If exposed, Tisseos® membrane maintains its physical
integrity, prevents leakage of the biomaterial and
prevents infection of the site.
•
The healing of the gingiva is favoured by the guided
tissue regeneration properties of the Tisseos®
membrane.
•
After exposure, the gingival tissue will heal and close in
2 weeks without losing the barrier effect.
•
Mouth wash with antiseptic solution and local application
of a Chlorhexidine gel are recommended in case of
membrane exposure.
Membrane exposure at day 8
Gingival healing at day 16
Placement of the cover screw
at 1 month
Prosthetics restoration
7
Clinical case study
Dr. THERY Laurent,
La Chapelle sur Erdre, France
Initial clinical situation
Pre-operative situation
Dehiscence coverage
using Tisseos® membrane
and a biomaterial
Bone defect
Filling with biomaterial
Positioning of Tisseos® membrane
Insertion of the implant
Resorption of Tisseos®
membrane
Sutures
Gingival healing at 10 days
The opening of the site after 4 months allows visualization
of the complete regeneration of the bone crest over 4
turns of the implant previously exposed, as well as the
complete resorption of the membrane.
Re-entry after 4 months
8
Clinical case study
Dr. THERY Laurent
La Chapelle sur Erdre, France
Bone grafting with bone
bank
Surgical template
and Tisseos® membrane
Preparation of the graft
according to the template
Grafts in situ
Sutures
Healing at 10 days
Positioning Tisseos® membrane
IRS UN, 8 quai Moncousu, 44000 Nantes, France
Phone : + 33 228 08 00 37 - Fax : + 33 228 08 00 39
[email protected]
www.biomedical-tissues.com
Tisseos® dental membrane is a class III medical device (CE0459) manufactured by Biomedical Tissues.
For safe operation, Tisseos® membrane must be used in accordance with the instructions for use. (Legal notice M15B01B 2015-10)
Tisseos® - PL15MD006