Inhibition of NO Synthesis Induces Inflammatory Changes
and Monocyte Chemoattractant Protein-1 Expression in
Rat Hearts and Vessels
by Hideharu Tomita, Kensuke Egashira, Mayuko Kubo-Inoue, Makoto Usui,
Masamichi Koyanagi, Hiroaki Shimokawa, Motohiro Takeya, Teizo Yoshimura, and
Akira Takeshita
Arterioscler Thromb Vasc Biol
Volume 18(9):1456-1464
September 1, 1998
Copyright © American Heart Association, Inc. All rights reserved.
Photomicrographs of Masson’s trichrome–stained coronary arteries (A, B, and C) and
myocardium (D, E, and F) from a control rat (A and D), a rat receiving L-NAME for 3 days (B and
E), and a rat receiving L-NAME for 28 days (C and F).
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
A, Time course of inflammatory cell infiltration into vascular and myocardial areas in L group.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
Immunohistochemical localization of ED1 (A), CD3 (B), α-SM actin (C), PCNA (D), and
nonimmune IgG (E) in coronary arteries after 3 days of L-NAME treatment.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
Immunohistochemical localization of MCP-1.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
A, Expression of cardiac MCP-1 and GAPDH mRNA in control group rat and during course of LNAME treatment.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
A, Expression of cardiac mRNA for MCP-1 and GAPDH mRNA in control group rat, rat receiving
L-NAME for 3 days, and rat receiving L-NAME and l-arginine for 3 days.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
A, Expression of mRNA for MCP-1 and GAPDH mRNA in kidney of control group rat and rat
receiving L-NAME for 3 days.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.
NOx production (in nmol · h−1 · mg−1) from aortas in control, L, D, and L+L-arg groups.
Hideharu Tomita et al. Arterioscler Thromb Vasc Biol.
1998;18:1456-1464
Copyright © American Heart Association, Inc. All rights reserved.