U78-5672
ID:434500-5
A 4-year-old girl had persistent hematuria
(microscopic) found by routine urinalysis.
Patient has been symptom free. Been
investigated with no good information revealed.
Probable diagnosis Focal glomerulonephritis.
IF
•
•
•
•
•
IgG –Negative.
IgA –Negative.
IgM –Negative.
C3 –Negative.
Fibrinogen –Negative.
Interpretation
• The minimal findings are compatible with
“idiopathic (essential) hematuria” or with “benign
familial hematuria”.
• Persistent “fetal type glomeruli” are a feature of
early cases of “Alport’s syndrome”, these can be
seen in infantile kidneys with persistent fetal
lobulation of the cortex.
• The absence of focal proliferative changes in
glomeruli mitigates against a diagnosis of focal
glomerulonephritis.
DIAGNOSIS
• Needle biopsy of kidney showing a few
persistent “fetal Glomeruli” renal glomeruli
and occasional red cell casts within renal
tubules.
EM82-5343
Glomerulonephritis (open renal biopsy).
IF
•
•
•
•
•
IgG – Negative.
IgA – Negative.
IgM – Negative.
C3 – Negative.
Properdin – Negative.
DIAGNOSIS
• Probable “Progressive Hereditary Nephritis”
(Alport’s syndrome).