BioE 598 Molecular and Cellular Fundamentals of Bioengineering
http://imaging.bioen.uiuc.edu/yingxiao_wang/classes/
Course Description
To introduce the cutting-edge engineering technologies applied in the molecular and cellular
biology research, i.e. how can the properties of genes, molecules, and cells be monitored,
measured, manipulated, and modeled to advance our understanding of the complex biological
system. Special emphasis will also be placed on how cells interact with each other and external
environment to shed light on the molecular mechanisms governing tissue engineering and
regenerative medicine.
Grade will be based on 40% from five quizzes, 30% from Class Presentation, 30% from final
exam.
Instructors: Yingxiao Wang
Beckman 4261
333-6727
Email: [email protected]
Credit:
4 hours
Meeting Times: MW 9:00-10:50am
Office Hour: Thu 4-5pm Beckman Institute 4261
Location: 3211 DCL
Prerequisite: MCB 150
Proposed Texts: On Line Literature and Notes
Recommended Book: Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P.:
Molecular Biology of the Cell. 4th ed., Garland Science, Taylor & Francis Group, 2002
Exams and Homeworks:
5 Quizzes
In Class Presentation
Final Exam,
Total Points
All quizzes and examinations are cumulative.
40 points
30 points
30 points
100 points
Grading Criteria for Oral Presentation:
1.
Content: Purpose/subject defined clearly, information and logics are self consistent.
2.
Organization: Introduction, Topic, Closing.
3.
Delivery: Poise/Appearance, Body Language, Eye Contact, Voice, Pacing
4.
Awareness of Audience: Persuasion
5.
Quality of Visual Aids: Texts and Figures are clear, not overcrowded,
Content: 12 points. Organization: 12 points. Delivery/Awareness of Audience/Quality of Visual
Aids: 2/2/2 points
Grading:
Week 1 (Jan 14-18)
Week 2(Jan 21-25)
Week 3 (Jan 28-Feb 1)
Week 4 (Feb 4-8)
Week 5 (Feb 11-15)
Week 6 (Feb 18-22)
Week 7 (Feb 25-29)
Week 8 (Mar 3-7)
Week 9 (Mar 10-14)
Week 10 (Mar 17-21)
Week 11 (Mar 24-28)
Letter Grade
A
100-90
B
89-80
C
79-70
D
69-60
F
59-0
The instructors reserve the right to shift the grades slightly based
on score distribution.
Mon
Class rules, Introduction to
the class, Cells and Genomes
(chap 1, recommended text)
MLK Holiday
Wed
Cell Chemistry and Biosynthesis
(chap 2, recommended text)
Proteins
(chap 3, recommended text)
DNA replication, repair,
Quiz 1, DNA,
recombination (chap 5,
Chromosomes, Genomes
(chap 4, recommended text) recommended text)
From DNA to protein
Control of Gene Expression
(chap 6, recommended text) (chap 7, recommended text)
Quiz 2, Cell Membrane and Cell Signaling (chap 15,
recommended text)
Its Functions (chap 10-11,
recommended text)
Cell Signaling (chap 15,
Cytoskeleton (chap 16,
recommended text),
recommended text),
Cell-ECM Adhesion (chap
Cell-Cell Adhesion
19, recommended text),
(chap 19, recommended text),
Biotechnology II (Directed DNA
Quiz 3, Biotechnology I
(chap 8, recommended text) Evolution) Prof. Huimin Zhao
Biotechnology III (chap 9,
Live Cell Imaging of Signaling
recommended text),
Transduction with Fluorescence
Fluorescence Proteins 1-6
Proteins 7-10, Quiz 4
Spring Break
Cell-Environment
Interaction (outside-in)
(Chien-Chun Chen)11, 12
Week 12 (Mar 31-Apr 4) Mechanical Force Effects on
Cellular Functions (James
Eddy)15, 16
Week 13 (Apr 7-11)
Cell and Tissue Engineering,
3D effects
(John Eichorst)19, 20
Cell-Environment Interaction
(inside-out) (Brian Dorvel)13, 14
Cell Effects on Mechanical
Properties of Environment (Sherine
George)17, 18
Cell and Tissue Engineering,
Nanotechnology
(Mark Hwang)21, 22
Week 14 (Apr 14-18)
Cell and Tissue Engineering, Stem Cells, General Concepts
Biomaterials
(Jason Ip)23, 24
Professor Hyun Joon Kong,
Quiz 5
Week 15 (Apr 21-25)
Stem Cells and Cell Signaling Stem Cells and Tissue Engineering
(David Mahr)25, 26
(Aaron Maki)27, 28
Week 16 (Apr 28-May 2) Cell Signaling, migration
(Samantha Polak)29, 30
Cell Signaling, junction
(Yue Zhuo)31, 32
Final Exam: DCL 3211, May 1st, 7-10pm
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