Tuesday, March 6, 2012
Open to entry- Protein Networks from yesterday
Homework:
1) Cell Transport retakes in tutorial- LAST DAY
2) Quiz on Protein Pathways/Protein Structure- FRI
3) Serotonin Pathway worksheet- due on Block Day
“Coat Color in Labrador Retrievers”
Cocoa
Midnight
Guiding Question:
“How does variation exist between
organisms?”
Read: “Coat Colors in Labrador Retrievers” to help you
answer this question.
Vocab to know for reading.
• Pigment = A substance, such as chlorophyll or
melanin, that produces a characteristic color in
plant or animal tissue.
• Skin and Hair pigments are produced in cells called
melanocytes.
• Synthesize = to put together.
Labrador (dog) pigmentation
Tyrosine
tyrosinase
What will be the
dog’s coat color?
BLACK
Yellow pigment
Dopaquinone
TRP-2
Brown pigment
TRP-1
Boxes = metabolites
Arrows = enzymes that change
the metabolites
Black pigment
What would happen if the enzyme TRP
– 1 was missing?
Yellow pigment
Tyrosine
tyrosinase
Dopaquinone
TRP-2
Brown pigment
TRP-1
Boxes = metabolites
Arrows = enzymes that change
the metabolites
Black pigment
What color is the dog’s coat? Brown
So what would happen if the enzymes
TRP – 1 and TRP-2 were both missing?
Yellow pigment
Tyrosine
tyrosinase
Dopaquinone
TRP-2
Brown pigment
TRP-1
Boxes = metabolites
Arrows = enzymes that change
the metabolites
Black pigment
What color is the dog’s coat? Yellow
Make an entry:
Entry 17: Protein Pathways Practice3/6/12
See attached
Pigment Metabolic Network for the
Imaginary Bioflower
Blue Flower
Purple Flower
Where is the variation in these flowers? Blue and Purple Flowers (Color)
Bioflowers
A colorless starting molecule is converted by
enzyme X to blue pigment. Next, enzyme Y
converts the blue pigment to purple pigment.
1a.Diagram of the pathway. (include a key)
Blue Pigment
Colorless Compound
X
Purple Pigment
Y
1b.Give an explanation for a blue flower.
Enzyme Y not available or not working
“Roundbuds”
Roundbuds
In another type of wildflower, the roundbud, red pigment is
synthesized from a white precursor by enzyme Q.
1.
Draw the enzyme pathway for the roundbud.
It was believed that all roundbuds were red until a
knowledgeable, observant teenager discovered a meadow
full of white-flowered roundbuds.
2. Using your knowledge of the synthesis pathway for red
pigment, give an explanation for the white roundbud
variety.
2a. Draw Enzyme Pathway
Red Pigment
White Precursor
Q
In another type of wildflower, the roundbud, red
pigment is synthesized from a white precursor
by enzyme Q.
2b. It was believed that all roundbuds were red until a
knowledgeable, observant teenager discovered a
meadow full of white-flowered roundbuds.
Enzyme Q is not working- therefore no
conversion to red pigment.
2b. Using your knowledge of the synthesis
pathway for red pigment, give an explanation
for the white roundbud variety.
White Precusor
Red Pigment
Q
YELLOW PIGMENT IS CONVERTED BY ENZYME Z
INTO BROWN PIGMENT
• YELLOW CAN ALSO BE CONVERTED BY ENZYME W
INTO RED PIGMENT
• BROWN PIGMENT IS CONVERTED BY ENZYME X
INTO BLACK PIGMENT
• BROWN CAN ALSO BE CONVERTED BY ENZYME Y
INTO ORANGE
YELLOW
PIGMENT
Z
W
BROWN
PIGMENT
RED
PIGMENT
X
Y
BLACK
PIGMENT
ORANGE
PIGMENT
• Yellow= no Z or W
• Brown= no X or Y, W
• RED= no Z
Chupacabra Coat Color
#3. Fancy flowers
a.
RED
S
RED-WHITE
SPOTS
b. Red with white spots
c. No spots, red only
T
RED-BLUE
SPOTS
a. 1,2
b. A,B, C, D
c. All
except F
d. 1, 3
#4
A
1
B
2
D
3
C
4
E
5
F
Make an entryEntry 18: Human Metabolic
Networks- 3/6/12
Substrate Enzyme Product
Add to last question on back:
How is a MAO inhibitor used to treat
depression?