CURRICULUM VITAE: ASRAR B. MALIK
Distinguished Professor of Pharmacology
and Head of Department
The University of Illinois College of Medicine
835 S. Wolcott Ave., Chicago, IL 60612
Phone (312) 996-7635
FAX (312) 996-1225
e-mail [email protected]
MARITAL STATUS:
Married with 2 children
CITIZENSHIP:
U.S.
DEGREES:
B.Sc. (Hons.)
Departments of Anatomy and Cell Biology
and of Physiology, Faculties of Science
and Medicine, University of Western
Ontario, London, Canada
1968
M.Sc.
Department of Physiology, Faculty
of Medicine, University of Toronto, Toronto
1969
Ph.D.
Department of Physiology, Faculty of
Medicine, University of Toronto, Toronto
1971
HONORS and AWARDS
Ontario Graduate Fellowship, University of Toronto
1969-1971
Brennan Summer Fellowship, University of Toronto
1970
Fellow of Research Institute of Hospital for Sick Children, Toronto, Canada
1968-1971
Wiggers Travel Award, The Albany Medical College
1979
Research Career Development Award, National Institutes of Health
1977-1982
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Max Starkman Visiting Professor, University of Toronto
1983
MERIT Award from NIH National Health, Lung and Blood Institute
1987-1997
Research Triangle Pulmonary Scholar (Duke University
and Burroughs-Wellcome)
1987
Inaugural Distinguished Faculty Lecture, The Albany Medical College
of Union University
1988
Fogarty International Center Award
1989
John B. Hickam Visiting Professor, University of
Indiana School of Medicine
1991
Distinguished Visiting Professor, Japanese Thoracic Society
1996
University of Illinois Scholar
1999-2002
100th Anniversary Commemoration Lecture of Doctoral Program
2000
Department of Physiology, University of Toronto
Appointment as Distinguished Professor (Univ. of Illinois appointment)
2001-present
Plenary Lecture, 50th Anniversary Japanese Anesthesiology Society
2003
Distinguished Research Achievement Award, American Thoracic Society
2007
Dickinson Richards Plenary Lecture, American Heart Association
2008
Scientific Advisory Board at Max Planck Institute for Cardiovascular
Lung Research
2008-2014
ACADEMIC APPOINTMENTS
Demonstrator in Physiology, Faculty of Medicine, Department of Physiology
Faculty of Medicine, University of Toronto
1968-1971
Demonstrator in Cell Biology and Anatomy Department of Histology,
Faculty of Medicine, University of Toronto
1970
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Instructor in Physiology, Washington University School of Medicine, St. Louis
1971-1973
Associate Staff, Research Division, Jewish Hospital of St. Louis,
Washington University School of Medicine
1972-1973
Assistant Professor of Physiology, The Albany Medical College
of Union University
1974-1977
Associate Professor of Physiology, The Albany Medical College
of Union University
1977-1980
Graduate Faculty, Department of Physiology, The Albany Medical College
of Union University
1974-1993
Professor of Physiology and Cell Biology, The Albany Medical College
of Union University
1980-1993
Professor of Biomedical Engineering (Adjunct), Rensselaer Polytechnic
Institute, Troy, New York
1983-1993
Professor of Biomedical Sciences (Molecular Pathogenesis Program)
School of Public Health Sciences, State University of New York at Albany
1987-1993
Senior Scientific Staff, Rush-Presbyterian-St. Luke's Medical Center, Chicago
1993-1995
Professor and Chairman, Department of Pharmacology,
Rush Medical College/Rush-Presbyterian-St. Luke's Medical Center, Chicago
1993-1995
Professor and Head, Department of Pharmacology, University of Illinois
College of Medicine, Chicago
1996-present
Distinguished Professor of Pharmacology
(appointment by Chancellor)
2001-present
CENTER APPOINTMENTS
Director of Center for Lung and Vascular Biology
Director of the Center for the Development of Stem Cell Therapies
for Human Disease
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2006-present
2007-present
SOCIETY MEMBERSHIPS
American Physiological Society
American Society of Pharmacology and
Experimental Therapeutics
American Thoracic Society
New York Academy of Sciences
American Heart Association (Cardiopulmonary
Council)
New York Heart Association
American Association for the Advancement of Science
International Society of Thrombosis and Hemostasis
New York State Lung Association
Chicago Heart Association
Chicago Lung Association
American Society of Cell Biology
Biophysical Society
American Society of Biochemistry and Molecular
Biology
TEACHING
Physiology and Histology Courses; Medical and Dental, University of Toronto
Physiology (lectures in Pulmonary and Cardiovascular Sections - Medicine I), The Albany Medical College
Cardiovascular Medicine - Medicine II, Albany Medical College
Scientific Basis for Medical Practice - Medicine II, Albany Medical College
Advanced Cardiovascular Physiology (Graduate Course Director), Albany Medical College
Cardiovascular Pharmacology (Lecturer), Department of Pharmacology, Albany Medical College
Cardiopulmonary Physiology, Nurse Anesthetists Course, Albany Medical College
Cardiopulmonary Physiology, Department of Biomedical Engineering, Rensselaer Polytechnic
Institute/ Albany Medical College, Conjoint Program
Medical Pharmacology, Rush Medical College
Medical Pharmacology, University of Illinois College of Medicine
Graduate Course Vascular Biology and Pharmacology, Department of Pharmacology, University of Illinois
Principles of Molecular Medicine, University of Illinois College of Medicine
Post-Graduate Pulmonary Pathophysiology Course, Pulmonary Residents and Fellows, University of
Illinois College of Medicine
Integrative Physiology Course, University of Illinois College of Medicine
Stem Cell Graduate Course, University of Illinois College of Medicine
EDITOR-IN-CHIEF
American Journal of Physiology (Lung Cellular and Molecular Physiology)
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2000-2005
EDITORIAL BOARD APPOINTMENTS
American Journal of Physiology (Heart and Circulation)
Journal of Applied Physiology
Federation Proceedings (Consulting Editor)
Journal of Critical Care Medicine
Circulation Research
Applied Cardiopulmonary Physiology
Microvascular Research
American Journal of Physiology (Lung Cell and Molecular Physiology)
1978-1987
1984-1996
1983, 1986
1985-1996
1986-1992
1995-1998
1988-1994
1989-1997
1992-1997
Pulmonary Pharmacology
Shock
1992-1997
1996-2006
EDITORIAL/CONSULTING REVIEWER
Circulation Research
Microvascular Research
American Journal of Physiology (Heart and
Circulation)
American Journal of Physiology (Cell Physiology)
American Journal of Physiology (Lung Cell and
J. Membrane Biology
American Journal of Respiratory Cell and
Molecular Biology
Journal of Cellular Physiology
In Vitro: Cellular and Developmental Biology
Cytometry
Molecular Physiology)
Life Sciences
Journal of Applied Physiology
Lung
Experimental Lung Research
American Review of Respiratory Disease
Canadian Journal of Physiology and
Pharmacology
Proceedings of Society of Experimental Biology
Pharmacological Research
Chest
Journal of Tissue Culture Methods
Toxicology and Applied Pharmacology
Molecular Pharmacology
J.A.M.A.
Atherosclerosis and Thrombosis
Journal of Immunology
Pharmacological Reviews
and Medicine
FASEB Journal
Biotechniques
Biophysica Biochemia Acta
Critical Care Medicine
European Journal of Pharmacology
Journal of Cell Biology
J. Physiology
Circulation
Pflugers Achives
Blood
Microcirculation
Endothelium
Science
Nature Medicine
Physiological Reviews
Journal of Immunology
Journal of Clinical Investigation
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Journal of Cell Science
Molecular Cell Biology
Journal of Biological Chemistry
FEBS Letters
Molecular Biology of Cell
Nature
J. Neurochemistry
Nature Drug Discovery Reviews
NIH STUDY SECTION AND OTHER ADVISORY COMMITTEE APPOINTMENTS:
Cardiovascular-Pulmonary Study Section member (CVA), National Institutes of Health, 1979-1983.
Respiratory and Applied Physiology Review Group (RAP), National Institutes of Health, 1981-1983.
Heart, Lung and Blood Research Committee A, National Institutes of Health, 1985-1989.
Heart, Lung and Blood Research Committee A (Health Reviewer Reserve) National Institutes of
Health, 1989-1993.
Pulmonary Diseases Advisory Committee (PDAC), National Heart, Lung and Blood Institute, NIH,
1992-1994.
Central Veteran's Administration, Washington, DC, Basic Sciences Review Group, 1992-1996.
Surgery, Anesthesiology, and Trauma (SAT) Study Section, National Institutes of Health, 1999-2003.
Lung Injury, Repair, and Remodeling Study Section (LIRR), National Institutes of Health, 2004-2008
Ad hoc member, Cardiovascular-Pulmonary Study Section (CVA), National Institutes of Health, 19781979.
National Institutes of Health, Specialized Centers of Research (SCOR) and Program Projects for
National Institutes of General Medical Sciences, National Institutes of Neurological and
Communicative Disorders, National Institute of Diabetes, Digestive and Kidney Diseases, and
National Heart, Lung and Blood Institute (1978- present)
National Institutes of Heath, Pulmonary Vascular SCORs and other SCORs (consultant) 1980-2003
Medical Research Council of Canada, Special Consultant, 1982-present. Executive Committee,
Cardiopulmonary Council, American Heart Association, 1983-1985.
American Lung Association - Research Programs Consultant, l983.
Veteran's Administration Research Committee (Pulmonary, Cardiovascular and Career Awards) Grants
Reviewer, 1983-present.
Province of Ontario, PSI Biomedical Research Review, l983.
Consultant to Research Programs (Department of Medicine, Pulmonary Division) University of
California, San Diego, l983.
National Institutes of Health, Clinical Sciences II Study Section - Postdoctoral Training, 1984.
External Examiner, Doctorate Thesis, University of Toronto, Institute of Medical Sciences, Faculty of
Medicine, 1984.
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Consultant on High Altitude Pulmonary Edema and Acute Mountain Sickness, Himalayas and Hindu
Kush, Ayub Medical College, Abbotabad, Pakistan (with Mountain Warfare Division, US
Government and Pakistan Army), July 1984.
Canadian Heart Foundation Consultant Reviewer, 1985.
National Science Foundation, Grants Reviewer, 1986-present.
Program Committee of Scientific Assembly on Respiratory Structure, Function and Metabolism, Section
on Pulmonary Circulation, American Thoracic Society, l984-85.
Clinical Investigator Award Review Committee, National Heart, Lung and Blood Institute, l985.
Coonsultant, Chicago Lung Association, 1986.
Consultant, US-Spain Joint Committee for Scientific and Technological Cooperation, 1986.
Consultant, Lung and Vascular Research Programs, University of Texas at Tyler, 1986.
Cardiovascular D Review Committee, American Heart Association, Dallas, 1986-1990.
Nominations Committee, Cardiopulmonary Council, American Heart Association, 1986-1988.
Program Review Committee for National Meeting, American Heart Association, 1987.
Representative of Program Project Review "Committee A" on National Heart, Lung and Blood Institute
Council Meeting, 1987.
International Advisory Board, Medical Principles and Practice, 1987-present
External Ph.D. Thesis Reviewer, Gothenberg University, Goteberg, Sweden, 1987.
Consultant, Alberta Heritage Foundation, 1988-present
Consultant, High Altitude Sickness, The Army Medical College, through Fogarty Institute, Rawalpindi,
Pakistan, 1989.
Visiting Scholars of Fogarty International Institute, National Institutes of Health (Dr. Ashima Anand,
All-India Institute of Medical Sciences, Jan., l988; Professor Serikov, Leningrad University,
April 1989; Professor A.S. Paintal, F.R.S., Director General, Indian Council of Medical
Research, April, 1991).
Founding Member and Governing Council Committee of The New York State Lung Research Institute,
American Lung Association of New York State 1985-1989 (developed by-laws).
Chairman, Governing Council of the New York State Lung Research Institute, New York State Lung
Association, 1989- 1993.
Member of the Executive Board of New York State Lung Association, l989-1993.
Consultant, Fond Nationale Suisse de la Recherche Scientifique, l990, 1991.
Consultant, Ontario Thoracic Society, Ottawa, Canada, 1990
NASA Advisory Panel on Biomedical Sciences, 1990-1995.
Scientific Advisor, Corvas International Corp., La Jolla, California, 1991-1996.
Ph.D. Advisory Committee, Dept. of Physics (with Professor Ivar Giaever), Rensselaer Polytechnic
Institute, 1991.
Program Review for The Wellcome Trust, London, England, 1991.
7
Consultant, Baldacci Laboratories, Pisa, Italy, 1991-1994.
Co-Chair of Workshop "Pathogenesis of Lung Disease in Sickle Cell Hemoglobinopathies", National
Heart, Lung and Blood Institute, NIH, 1992.
Grants and Program Reviewer for New York State Heart Association, l992-1995.
Pulmonary Disease Advisory Committee (PDAC), NHLBI, 1992-1996.
Veteran's Administration, Washington, DC, Basic Science Review Group, 1992-1996.
British Columbia Medical Research Grants Reviewer, 1992-present
M.D. Thesis Opponent, Thesis of Dr. Katrina Saldeen, University of Linkoping, Sweden, 1992.
Consultant, Doody Medical Publishers, Oak Park, IL 1993-1999.
Co-Chair of Workshop "In Vivo Cell Biology", National Heart, Lung and Blood Institute, NIH, 1993
Ph.D. Advisory Committee for Dr. Aftab Ahmad, University of Punjab, Pakistan, 1995
American Heart Association (Chicago Chapter) Research Council, 1993-1997
Ph.D. Thesis Committee, Department of Pharmacology, The University of Illinois, Chicago, IL 1994
Executive Council of Great Lakes Chapter of American Society of Pharmacology and Experimental
Therapeutics, 1994-1998
Ad hoc Member, Lung Pathobiology (LPB) Study Section, February, 1995-2003
Sponsor for Visiting Scholar, Burroughs-Wellcome Foundation and FASEB, Sir John Vane, June, 1995.
Consultant, Andaris Inc., Nottingham, UK, 1995-1999.
Chairman of Special Emphasis Panel Pulmonary Vascular Biology, NHLBI, Bethesda, March, 1995.
British Columbia Lung Association, Grants Review, 1995, 1996, 1997, 1998, 1999, 2004
President, Great Lakes Chapter of American Society of Experimental Pharmacology and Therapeutics,
1995-1996.
Consultant, Red Cell Inc., San Francisco, 1995.
Consultant, The Aga Khan University Medical College, Search Committee for Chair of Physiology and
Pharmacology, Karachi, Pakistan, 1996.
Ad hoc Member Surgery, Anesthesiology and Trauma (SAT) Study Section (NIH), 1997-1999.
Member, Surgery, Anesthesiology, and Trauma (SAT) Study Section (NIH), 2000-2004.
Program Review Committee, Sickle Cell SCOR grant applications (NIH) 1997.
Grant Review, The Arthiritis and Rheumatism Council, United Kingdom (1997).
Chairman of NIH Special Emphasis Panel, Etiology of Cardiovascular Complications in HIV Infection
(1997, 1998, 1999).
Member, Acute Lung Injury/ARDS Parent Committee, NHLBI SCOR Applications (1998).
Review Panel on NIH Minority Research Training Programs, Chairman, December, 1999; as Member,
November 2001.
ex officio member of Steering Committee of Respiration Section, American Physiological Society ,
2000-2006
Parent Committee for Pathobiology of Lung Fibrotic Disease SCOR Applications (2001)
8
Special Emphasis Panel, Proteomics Initiative, NHLBI, June 2002
Consultant, Osesterreichische Nationalbank Jubilaumsfonds, Vienna, 2002
Board of Directors, Schweppe Foundation, Chicago, 2002-present
Review Panel, SCCORs in Translational Research in Acute Lung Injury, NHLBI, March 2003
Consultant Polium Biotech, 2003
Consultant, Fonds zur Forderung der wissenschaftlicten Forschung (Austria), 2004, 2006
Chair, Vascular Biology Biology Review Panel 1, American Heart Association (National) 2004-2005
National Center for Research Resources, Special Emphasis Panel, NIH, 2004
Technology Centers for Networks and Pathways (NIH Roadmap, Special Emphasis Panel), NIH 2004
Consultant, Consiglio Nazionale delle Ricerche, Rome, Italy 2005
Program Reviewer Alberta Heritage Foundation for Medical Research, 2005
Surgery, Anesthesiology, Trauma (SAT) NIH Study Section Ad hoc Member 2005, 2007
Review of NIH Education Project Training Applications (Minority Institutions) 2005
Member Lung Injury and Repair (LIRR) Study NIH Section, 2004-2008
Grant Reviewer, Israel Science Foundation, 2006
Award Selection Committee for the Earl Benditt Award, NAVBO, 2006-2009
Swiss Medical Research Foundation, 2007
Member NIH F10 Fellowship Study Section, 2007
NHLBI T32 Institutional Training Grant Special Emphasis Panel, 2008
Board of Scientific Counselors, National Institute of Dental and Craniofacial Research, NIH, 2008
On-site External Review Panel Meeting, University of Texas Health Science Center at Tyler, 2009
Irish Medical Research Council, 2009
NHLBI Program Project Grant, Special Emphasis Panel, Bethesda, MD, 2009
INSTITUTIONAL SERVICE
The Albany Medical College
Admissions Committee: Six Year Medical (B.S./M.D.) Program, 1974-1977.
Occupational Safety and Health Committee, l976-1982.
Graduate Studies Committee, Department of Physiology, 1974-1975.
Coordinator, Intradepartment Research Seminars, l976-1977, 1979-1980.
Chairman, Department of Physiology Library Committee, 1977-1978.
Education Committee, 1977-1979.
Chairman, Faculty Search Committee, Department of Physiology, 1979.
Search Committee, Chairman of Medicine, 1980-1981.
Committee on Research Involving Human Subjects, 1980-1982.
Clinical Research Studies Center Advisory Committee, 1981-1985.
Vice Chairman, Department of Physiology, 1982-1985.
9
Standing Search Committee Appointed by President, Albany Medical Center (for recruitment of department
chairmen and senior faculty at Albany Medical Center), 1985-1989.
Search Committee for Chairman of Surgery, 1985-1986.
Research Advisory Committee 1987-1993.
Search Committee, Chairman of Pathology, 1988.
Chairman, Theobald Smith Lecture 1988-1990.
Search Committee, Chairman of Medicine, l989.
Committee for Theobald Smith Lectureship, 1986-1993.
Chairman, Theobold Smith Lecture Committee 1988-1990.
Search Committee, Chairman of Medicine, 1989.
Admissions Committee: Six Year Medical Program (BS/MD), 1990-1993.
Search Committee, Chairman of Pathology, 1990
Dean's Advisory Committee on Research at The Albany Veteran's Administration Hospital, 1988-1991.
Department of Physiology and Cell Biology Faculty Search Committee, l992.
Rush-Presbryterian-St. Luke’s Medical Center
Advisory Committee for New Research Building, Rush-Presbyterian-St. Luke's Medical Center, 19931995.
Rush-Cook County Research Oversight Committee, 1994.
Subcommittee on Faculty Tracks, Rush Medical College, 1994.
Search Committee, Chairman of Anatomy, 1994
Committee on Departmental Reviews, Rush Medical College, 1994-1995.
Committee on Senior Faculty Appointments and Promotions, Rush Medical College 1994-1995.
University of Illinois
President’s Retreat for Strengthening Communication between University of Illinois and the People of
Illinois, 1995
University of Illinois Senate, 1995-1999.
Search Committee for Head of Microbiology and Immunology, University of Illinois at Chicago, 1996.
Medical Center Strategic Planning Committee, University of Illinois at Chicago, 1996.
College of Medicine, New Research Building Planning Committee, University of Illinois at Chicago, 1996.
Research Resources Center Management Committee, University of Illinois at Chicago, 1996.
Faculty Senate, University of Illinois at Chicago, 1996-1998
Medical Curriculum Committee, M3, University of Illinois College of Medicine, 1996
M.D./Ph.D. Advisory Executive Committee, 1996-present
Chair, Search Committee for Head of Psychiatry, University of Illinois College of Medicine, 1997
Executive Head of Department of Pharmacology (University of Illinois at Chicago, Champaign-Urbana,
Rockford, and Peoria campuses) 1995-2001
Member, University of Illinois College of Medicine Executive Committee (Chicago rep) 1997-2001
University of Illinois, College of Medicine, Chicago Executive Committee, 1997-2003
10
President’s Retreat on Research, December, 1998
Search Committee for Director of MRI Center, 1999
Member, Dean’s Five-Year Review Committee, University of Illinois College of Medicine (1998-1999)
Research Building Planning Committee and Committee for Selection of Architects, New Medical Research
Building (appointed by Dean) 1998-2001
Technology Commercialization Task Force (Appointed by Vice Chancellor of Research) 1999
Institutional Review Board (IRB) Prioritization Committee for College of Medicine, 1999
Chair, Merger Committee for Departments of Biochemistry and Molecular Biology and Molecular Genetics,
1999-2000
Intellectual Property Committee, University of Illinois, 2000-2001
Chair, Search for Head of Department of Biochemistry and Molecular Genetics, 2000-2002
Member of University of Illinois campus-wide Committee to Review Institutional Programs in Genomics
and Bioinformatics, 2000-2001
Advisory Board for Ph.D. Program in Bioinformatics, Dept of Biomedical Engineerng. 2001
College of Medicine Committee on Faculty Awards, 2001-present
Graduate College Executive Committee, 2001-2003
Task Force on Animal Research Facilities, 2001
Search Committee for Faculty Recruitment in Departments of Ophthalmology and Neurology, 2000-2001
Member, Research Committee of Department of Medicine, 2002
Search Committee for Chief of Div. of Respiratory and Critical Care Medicine, Dept of Medicine, College
of Medicine, 2002-2003
University of Illinois Intellectual Property Committee, 2003-2006
Space Planning Committee for new Biomedical Research Building, 2004-2005
Search Committee for Head of Department of Dermatology, College of Medicine, 2004
Search Committee for Head of Department of Opthalamology, College of Medicine, 2004-2005
Search Committee for Chief of Div. of Hematology and Oncology, Dept of Medicine, College of Medicine,
2004-2005
Distinguished Professor Selection Panel 2004, 2005
Search Committee, Director of Cancer Center 2006
Co-Chair, Search Committee, Head of Anesthesiology 2006
Member, Dept. of Opthalamolgy Eye Transplant Consortium (NEI application)
Search Committee, Cardiology Division Chief, Dept. of Medicine 2006-2007
Principal Investigator in Stem Cell and Regenerative Research Program 2005-2008
College of Medicine 125th Anniversary Organizing Committee, 2007
GENERAL LECTURES AND REPORTS RELATED TO DEVELOPMENT OF RESEARCH AND
TEACHING PROGRAMS
11
Presentation to Department of Anesthesiology, The Albany Medical Center. "Development of Research
Programs in Anesthesia" delivered at The University Club, Albany, N.Y. 1982.
"Structuring Basic Sciences in Medical School" Report written for The Ministries of Labour and Health, The
Government of Pakistan Sept. l984.
Development of Biotechnology in the Capital District: "Value of Monoclonal Antibodies in Therapeutics"
Lecture delivered to Capital District Science and Technology Council at Albany International Corp.
(at request of Richard Gaintner, M.D. President, Albany Medical Center) May, 1987.
"Development of Academic Research Interactions with the Pharmaceutical Industry" (Report written for
Roger Bone M.D., Dean of Rush Medical College, Chicago, IL, l991).
"How's and Why's of Gene Therapy" Bishop Anderson Institute, Chicago, IL, 1994
Workshop on Recruitment and Faculty Development for New Administrators, The University of Illinois,
November 1997.
Status of Molecular Pharmacology Research: presentation to Special Assistant to President of University of
Illinois, May, 2000.
Status of Department of Pharmacology, report delivered to department heads, University of Illinois College
of Medicine, 2006
Lecture “Hope and Illusions of Stem Cell Therapeutics”, University of Illinois Translational Research
Center Lecture, 2007
VISITING PROFESSORSHIPS, INVITED SEMINARS, AND SYMPOSIA PRESENTATIONS
(Since 1980)
Department of Physiology, Jefferson Medical College, Philadelphia, l980.
Department of Cardiology, The Hospital for Sick Children, University of Toronto, 1980.
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, l980.
Department of Physiology, University of Toronto, Canada, 1980.
New York Academy of Sciences Symposium on "Lung Microvascular Injury" (meeting co-chair with
N.C. Staub), New York City, l981.
American Thoracic Society (Eastern) Hanover, N.H. Symposium Speaker, 1981.
International Symposium on Blood Vessels, Kuwait, l982.
Department of Physiology, Georgetown University, Washington, D.C., l982.
NIH Workshop Symposium on Arachidonate Acid Metabolites and Pulmonary Circulation, Washington
(Consensus Conference), 1982.
Merck-Frosst Canada, Montreal, 1982.
Department of Medicine, Pulmonary Division, University of California School of Medicine, San Diego,
1983.
Department of Physiology, University of South Alabama, Mobile, l983.
St. Mary's Hospital Research Seminar, San Francisco, l983.
Pulmonary Insufficiency Symposium, 9th International Congress of Thrombosis and Hemostasis,
Stockholm, 1983.
Pulmonary Fluid Balance Symposium, International Congress of Physiology, Sydney, Australia, 1983.
Upjohn Laboratories, Kalamazoo, Michigan, 1983.
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Prostaglandins and Lung Fluid Balance Symposium, American Physiological Society (Symposium
Chairman and Speaker) Honolulu, l983.
Departments of Surgery and Anesthesiology, University of Toronto, l983.
American Heart Association Meetings, Invited Speaker, Anaheim, CA, 1983.
Department of Medicine, Critical Care Symposium, Wayne State University, Detroit (Symposium
Speaker), l983.
Department of Medicine (Pulmonary Division), University of Rochester School of Medicine, N.Y.,
1983.
Continuing Medical Education Course, The Albany Medical College, St. Maarten, l984.
European Society of Hematology, Berne, Switzerland (Symposium Speaker), 1984.
Ibuprofen and Lung Injury Conference, Clearwater, Florida (Co-Chairman of Consensus Conference),
l984.
Department of Physiology, McGill University Faculty of Medicine and Meakins-Christie Labs,
Montreal, l984.
American Heart Association, Cardiopulmonary Council, Acute Lung Injury Symposium, Dallas
(Symposium Speaker), 1984.
Department of Physiology, Ohio State University Medical School, Columbus, Ohio, l984.
Trudeau Society of New York, West Point, N.Y. (Plenary Speaker), 1985.
Department of Medicine, St. Louis University of Medicine, St. Louis, Missouri, l985.
Department of Physiology, Hahnemann Medical College, Philadelphia, PA, l985.
Department of Anesthesiology, University of Texas, School of Medicine, Houston, TX, 1985.
Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, l985.
Leukotrienes in Cardiovascular and Pulmonary Function, Philadelphia Physiology Society (Symposium
Speaker), 1985.
Workshop on "Oxygen Radicals and Tissue Injury", Florence, Italy, l985.
Satellite Symposium on "Thrombin", 10th International Congress of Thrombosis and Hemostasis, San
Diego, CA, (Symposium Speaker), 1985.
New York Academy of Sciences Symposium "Bioregulatory Functions of Thrombin" New York, l986.
Departments of Physiology and Medicine, University of Kentucky School of Medicine, Lexington, 1986.
Vienna Shock Forum, Vienna, Austria "Fibrin-Neutrophil Interactions", 1986.
Department of Physiology, Loyola University School of Medicine-Chicago "Mediators of Lung Vascular
Injury", 1986.
Department of Physiology, Chicago Medical School, North Chicago,"Mediators and Mechanisms of
Pulmonary Edema", 1986.
Acute Lung Injury Symposium, Upjohn, San Diego, Conference Summary, l986.
Department of Medicine, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada,
"Endothelial-Neutrophil Interactions: Role in Vascular Injury", l986.
Department of Physiology, Thomas Jefferson School of Medicine, Philadelphia, PA, "Determinants of
Endothelial Permeability", 1986.
Grover Pulmonary Circulation Symposium. Deckers, Colorado, "Role of Thrombin in Lung Injury",
1986.
University of Pennsylvania "Modulation of Endothelial Permeability", 1987.
NIH Conference on Pulmonary Hypertension, Philadelphia "Reperfusion Lung Injury", 1987.
Department of Physiology, Tulane University, New Orleans "Neutrophil-Endothelial Interactions", 1987.
ASPET Meeting, Honolulu, "Non-Steroidal Anti-Inflammatory Agents and Lung Vascular Injury", 1987.
Cetus Corp., Emeryville, California, "Endothelial Barrier Function", l987.
Department of Pharmacology, New York Medical College, "Regulation of Endothelial Permeability",
l987.
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Critical Care Medicine Symposium, Erasmus University, Rotterdam, Holland, "Mechanisms of
Pulmonary Edema" (Symposium Speaker), 1987.
Department of Medicine, Duke University Medical Center, Durham, North Carolina "Mediators of Lung
Vascular Injury", 1988.
Burroughs-Wellcome Co., Research Triangle Park, North Carolina, "Modulation of Endothelial
Permeability" 1988.
Department of Physiology, State University of New York, Buffalo, New York, "Lung Vascular
Permeability", 1988.
Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania, "Regulation of
Endothelial Cell Permeability", 1988.
Department of Physiology, New York Medical College, Valhalla, New York, "Endothelial Barrier
Function", l988.
Second Vienna Shock Forum, Ludwig Boltzmann Institut fur Experimentelle Traumatogie, Vienna,
Austria, "Neutrophil Sequestration and Mediators of Endothelial Injury", 1988.
12th Annual Conference of Shock, Florida, Symposium Speaker "Protective Effect of TNF in Vascular
Injury" (Symposium Speaker), 1989 (June).
Berlex Laboratories (Boehringer-Mannheim), Cedar Knolls, New Jersey, "Release of Endothelin in
Circulation", 1989 (January).
Department of Medicine, Case-Western Reserve University, "Neutrophil-Mediated Endothelial Injury",
Cleveland, Ohio, 1989 (February).
Zambon Group Satellite Symposium on "Present Concepts of ARDS" in conjunction with 24th Annual
Meeting of S.E.P.C.R. Lausanne, Switzerland, 1989 (June).
The Aga Khan University School of Medicine, Karachi, Pakistan, "The Vascular Barrier and Endothelial
Transport", l989 (July).
Merck Laboratories, Rahway, New Jersey "Neutrophil-Mediated Increases in Vascular Permeability",
1989 (May).
Wadsworth Laboratories, New York State Department of Health, Albany, N.Y., "Vascular Barrier
Function",1989 (April).
All-India Institute of Medical Sciences, New Delhi, "Mechanisms of Endothelial Injury", l989 (July).
Royal College of Physicians (London) "Role of Platelets in Pulmonary Embolism", l989 (October).
American Thoracic Society Meeting (Eastern Section), Atlantic City, Plenary Speaker "New Findings in
Pathogenesis of Acute Lung Injury", 1989 (October).
World Congress of Pulmonary and Critical Care Medicine, Bombay, India. Plenary Lecture on
"Mechanisms of Lung Vascular Injury", 1989 (November).
Rush Medical College, Department of Medicine. Chicago "Role of Neutrophil Interactions in
Endothelial Injury", 1990 (January).
Yale University School of Medicine, Department of Medicine, New Haven. "Molecular Mechanisms of
Neutrophil- Endothelial Interactions", 1990 (January).
Department of Physiology, University of Tennessee, Memphis, "Role of Neutrophil-Endothelial
Interactions in Lung Vascular Injury", 1990 (March).
Gordon Research Conference on "Physical and Chemical Aspects of Water, Solute, and Cell Exchange
in the Microvasculature". Title: "Regulation of Endothelial Barrier Function by Second
Messengers", 1990 (June).
Wiggers-Bernard Conference, Vienna, Austria, Invited Address: "Role of Granulocyte Adhesion
Molecules in Organ Injury", 1990 (May).
Fifth European Congress of Intensive Care. Invited Address: "Role of Lipid Mediators in Tissue
Injury", Amsterdam, Holland. 1990 (June).
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Georgetown University Medical School, Washington, D.C.: "Role of Neutrophil-Endothelial
Interactions in the Inflammatory Response", 1990 (June).
Medical College of South Carolina: "Role of PMN-Endothelial Interactions in the Inflammatory
Response", Charleston, SC. 1990 (June).
State University of New York at Brooklyn Medical School: "Molecular Mechanisms of NeutrophilEndothelial Interaction: Role in Endothelial Injury". 1990 (July).
NIH Consensus Conference "Neuropeptides in Lungs". Bethesda, MD. 1990 (September).
Surgery Grand Rounds, "Molecular Mechanisms of ARDS", Albany Medical Center, Albany, NY, 1991
(March).
University of Miami School of Medicine, "Role of Endothelial Adhesion Molecules in Inflammation",
Miami, l991 (May).
Second International Conference on Shock, "Role of Endothelial and Leukocyte Adhesion Molecules in
Vascular Injury", Vienna, Austria, l991 (June).
Hoffman-LaRoche, "Neutrophil-Mediated Lung Injury", Nutley, NJ, 1991 (August).
European Workshop on Inflammation, "Vascular Endothelium in Inflammation", Frankfurt, Germany,
1991 (October).
Seventh International Symposium on Cardiopulmonary Emergencies, Plenary Lecture, Erasmus
University, Rotterdam Netherlands, 1991 (November).
Corvas, "Molecular Mechanisms of Endothelial Injury", La Jolla, CA, l992 (March).
NIH Workshop on Sickle Cell Disease, "Mechanisms of Lung Microvascular Injury", Bethesda, MD,
l992 (April).
Case-Western Reserve School of Medicine, Department of Physiology, Cleveland, OH: "NeutrophilEndothelial Interactions", 1992 (June).
FASEB Summer Conference on Bioregulatory Functions of Thrombin "Thrombin's Role in
Inflammation and Endothelial Dysfunction", Saxton River, Vermont, 1992 (August).
IBC Symposium, Royal College of Physicians, London, England, "Influence of Platelets on Endothelial
Cell Function", 1992 (June).
Columbia University College of Physicians and Surgeons, Department of Medicine, "Leukocyte
Adhesion Mechanisms in Inflammation", l992 (September).
Chicago Lung Conference on Pulmonary Vascular Disease, "Intimal Surface Molecules: Coagulation
and Cell Adhesion", 1992 (October).
Karolinska Institute "Vascular Endothelium in Inflammation", Stockholm, 1992 (December).
University of Linkoping "Molecular Basis of Vascular Endothelial Injury" Linkoping, Sweden, 1992
(December).
American Thoracic Society Symposium, "Mechanisms of Acute and Chronic Pulmonary Vascular
Disease", San Francisco, l993 (May).
Critical Care Society Symposium, "Pulmonary Intravascular Coagulation and Vascular Endothelial
Injury", New York, NY 1993 (June).
Gordon Conference on Vascular Endothelial Barrier "Oxidant Activation of Second Messengers", New
Hampshire, l993 (June).
University of Illinois, Dept. of Pharmacology, "Regulation of Endothelial Barrier Function", Chicago, IL
1993 (December).
Northwestern University, Department of Biomedical Engineering, "Endothelial Barrier Function",
Evanston, IL 1994 (January).
Michael Reese Hospital, "Endothelial Barrier Function and its Regulation", Chicago, IL 1994 (March).
University of Health Sciences/Chicago Medical School, "Molecular Basis of Induction of ICAM-1", N.
Chicago, IL 1994 (April).
FASEB Symposium "Second Messenger Regulation of Endothelial Barrier" Anaheim, CA 1994 (April).
15
Loyola University School of Medicine, "Molecular Basis of Leukocyte-Endothelial Interactions",
Maywood,
IL 1994 (May).
International Society of Heart Research, "Modulation of Endothelial Permeability by Oxidative Stress"
Copenhagen, Denmark, 1994 (June).
Pulmonary Circulation Foundation Symposium (Grover Conference), "Neutrophil Adherence to
Endothelium and Oxidant Lung Injury", Deckers, Colorado, 1994 (October).
University of Illinois College of Medicine (Cardiovascular Sciences Group), "Gene Regulation of
ICAM-1", Chicago, IL, 1994 (November).
Northwestern University Medical School (Pulmonary Division) "Neutrophil-Endothelial Cell Adhesion
and Migration Responses", Chicago, IL 1995 (March).
The Lankenau Medical Research Center, Philadelphia, PA, Invited Address: "Protein Kinase-C
Regulation of Endothelial Barrier Function", 1995 (March).
University of Sherbrooke, Workshop "Physiology and Pathophysiology of Vascular Endothelium", title
of presentation "Paracellular Transport in Endothelia". Sherbrooke, Quebec, Canada 1995 (May).
Red Cell Inc. “Role of Cytokines in Inflammation-Mediated Vascular Injury”, San Francisco, CA 1995
(Dec.)
University of Louisville, Department of Physiology, “Regulation of the Endothelial Barrier”, Louisville,
KY, 1996 (January)
Japanese Thoracic Society, “Lung Endothelium and ARDS”, Japan 1996 (April)
Jichi Medical College, Visiting Professor, Utsinomiya, Japan 1996 (April)
American Thoracic Society, “Oxidant-Induced ICAM-1 Expression”, New Orleans, 1996 (May)
Johns Hopkins, Div. of Cardiology, “Oxidant Signaling of the Endothelial Adhesion Molecule ICAM1”, Baltimore, 1996 (May).
VI International Congress of Microcirculation “Second Messenger Regulation of Endothelial
Permeability”, Munich, 1996 (August)
Eisai Research Laboratories, University College, London “Albumin Transport Mechanisms in
Endothelial Cells”, London, U.K. 1997 (January)
University of Chicago, Dept. Radiation and Cellular Oncology, “Transport Mechanisms in the
Endothelial Cell”, 1997 (Feb)
FASEB Symposium “Thrombin and Vascular Medicine”; Invited Lecturer “Thrombin-Induced Loss of
Endothelial Integrity,” Saxtons River, Vermont, 1997 (August)
University of Chicago, Department of Medicine, “Molecular and Cellular Pathophysiology of
Endothelial Barrier Function”, 1998 (March)
University of Indiana, School of Medicine, “Endothelial Permeability Mechanisms”, 1998 (May)
FASEB Summer Research Conference Circulation and Signaling Invited Speaker “Genetic Approaches
to Studying Endothelial Permeability”, Oregon, 1998 (August)
University of Illinois College of Medicine (Section of Digestive and Liver Diseases) “Endothelial
Transport Pathways and Regulation of Endothelial Barrier, Chicago, IL 1999 (March)
Department of Cell Biology, Cleveland Clinic Foundation, “Regulation of Vascular Endothelial
Permeability” 1999 (June)
FASEB Summer Conference “Thrombin and Vascular Medicine”, Saxtons River, Vermont, “Cell
Interactions” Speaker and Discussant, 1999 (June)
Vienna Shock Conference “Signaling Pathways Regulating Endothelial Barrier Function” 1999
(Nov)
EB 2000 Symposium, Co-Chair and Speaker, “Mechanisms Regulating Endothelial Cell Barrier
Function”, San Diego, 2000 (April)
Endothelial Cell Phenotypes, NIH Conference, “Barrier Properties of Microvascular Endothelium:
Receptor-Mediated Transcytosis”, Bethesda MD 2000 (June)
16
Pfizer, Sandwich, UK “Neutrophil Inhibitory Factor and β2 Integrin Blockade” 2000 (July)
University of Vienna, Institute of Anatomy, “Vesicle Trafficking in Endothelial Cells” 2000
(October)
University of Illinois, College of Pharmacy, “Cell Biology and Molecular Pharmacology of Microvessel
Endothelial Barrier: Novel Drug Delivery Approaches” 2000 (October)
University of Toronto, Dept. of Physiology, “Vesicle Trafficking and Transcytosis and the Regulation of
Endothelial Permeability” 2000 (November)
FASEB Conference “Thrombin and Vascular Medicine” in Montana; presentation “Role of VECadherin/Catenin Complex in the Mechanism of Increased Endothelial Permeability”. 2001
(June)
SUNY Upstate Medical Center, “Neutrophil Trafficking and Host-Defense in Genetically Modified
Mice” 2001 (June)
Johns Hopkins University School of Medicine, "Proteases and Protease-Activated Receptors in Lung
Disease" 2001 (June)
University of Vienna, Symposium “Exocytosis and Endocytosis in Vascular Biology and Vascular
Pathology" 2001 (September)
University of Pittsburg School of Medicine, “Regulation of Endothelial Permeability” Departments of
Medicine and Pharmacology, December, 2001
University of Pennsylvania School of Medicine, “Signaling Mechanisms of Endothelial Barrier
Function” Institute of Environmental Medicine, January 2002
Texas A&M University School of Medicine, Department of Physiology and Biophysics, “Mechanisms of
Endothelial Injury” January 2002
Grover Conference on Vascular Signaling, “Signaling Mechanisms Regulating Caveolae Fission and
Endothelial Transport”, Colorado, September, 2002
Brigham and Women’s Hospital, Dept of Pathology, “Regulation of Endothelial Barrier Function”,
Boston, November, 2002
Northwestern University School of Medicine, Department of Pharmacology, March 2003
Long Island Jewish Hospital/Albert Einstein College of Medicine, June 2003
50th Annual Meeting Japanese Anesthesiology Society, Yokohama, Plenary Address, May 30 2003
University of Alabama Conference on Vascular Biology, October 8, 2003
University of Southern California School of Medicine, Dept. of Medicine, October 2003
Society of Free Radical Biology and Medicine, Plenary Speaker, “Vascular Redox Signaling and
Oxidative Stress,” Seattle,WA November, 2003
Vanderbilt University Dept. of Pharmacology School of Medicine, Nashville, April 2004
University of Chicago, Dept. of Neurobiology, Physiology, and Pharmacology, March 2004
Loyola University School of Medicine, Department of Pharmacology, Maywood, IL April 2004
American Transplant Congress, “TLRs and Vascular Inflammation”, Boston, MA May 2004
Gordon Conference, Discussion Leader, “Endothelial Cell Phenotypes in Health and Disease, New
Hampshire, August 2004
Grover Conference “Pulmonary Circulation: Genetic and Environmental Determinants of the Pulmonary
Endothelial Cell Function,” Colorado, September, 2004
37th Annual Society for Leukocyte Biology Meeting, “Cellular Mechanisms of Inflammation”, Toronto,
October 2004
University of Nebraska, Dept. of Physiology, Omaha, Sept 2004
University of Rochester, Depts. of Pediatrics and Medicine, Rochester, NY, November 2004
Argonne National Labs, Dept. of Cell Biology, Argonne, IL, December 2004
International Union of Physiological Sciences, Symposium Speaker, San Diego CA, April 2005
17
Graduate Program in Lung Biology, "Molecular Biology and Medicine of the Lung", Geissen, Germany
(invited speaker), August, 2005
Invited Symposium Speaker “Oxidant Signaling” American Heart Association Meeting 2005, Dallas
Medical College of Wisconsin, Department of Pharmacology, Milwaukee, WI, 2005
University of Texas Health Sciences Center, Tyler 2006
Medical College of Georgia, Vascular Biology Center, Augusta, 2006
University of South Alabama, Department of Pharmacology, Mobile, 2006
EB2006 Speaker at Symposium “Regulation of Endothelial Permeability”, San Francisco, 2006
American Thoracic Society “Role of TrpC Channels in Endothelial Permeability Regulation” San Diego,
2006
Gordon Conference “Endothelial Cell Heterogenity”, Maine, August, 2006
Grover Conference “Rho GTPases and the Pulmonary Circulation” Colorado, September, 2006
PHYSIOCON, University of Delhi and V. Patel Chest Institute, Transplantation of Endothelial
Progenitor Cells (EPCs): a First Aid Kit for Vascular Repair, Delhi, India, Feb., 2007
Northwestern University, Dept of Medicine (Cardiology), Endothelial Progenitor Cells in the Treatment
of Lung Vascular Injury, Chicago, March, 2007
EB2007 Symposium, “Interrelations between Transcellular Ion Transport Function and Paracellular
Tight Junctional Properties in Lung Epithelial and Endothelial Barriers”, Washington DC, April,
2007
American Thoracic Society Research Achievement Award Lecture, ATS Meeting, May 2007, San
Francisco
FASEB Summer Conference 2007, Symposium Speaker “Lysophospholipid Mediators in Health and
Disease”, June, 2007, Tuscon, AZ
Symposium Speaker, “REGULATION OF TRANSPORT PHENOMENA IN BIOLOGICAL SYSTEMS”, Antalya,
Turkey, Sept. 2007
University of Tennessee School of Medicine, Department of Pharmacology, Ocotober, 2007
McLaughlin Symposium 2007 “The Microcirculation in Acute Viral and Bacterial Infections”.
University of Texas at Galveston. October, 2007
St. Louis University School of Medicine, Department of Biochemistry, March 2008
EB2008 Symposium Invited Speaker “Regulation of eNOS-derived NO Production” 2008, San Diego
2nd International Congress on Cell Membranes and Oxidative Stress: Focus on Calcium Signaling
and TRP Channels, Isparta, Turkey, June 2008
Excellence Cluster Cardio-Pulmonary System Meeting, “Role of reactive oxygen species (or NADPH
Oxidase) in endothelial cell permeability control”, Bad Neuheim, Germany, June 2008
Grover Conference “Receptors, Channels, and Transporters and their role in the Development of
Pulmonary Vascular Disease”, lecture title: “TRP Channels in Lung Endothelial Barrier
Function”, Deckers Colorado, 2008
Cape Cod Vascular Biology Signaling Conference. Lecture title: “Vascular biology phenotype in the
eNOS/cav-1 knockout mouse”. September, 2008
The Beijing Joint Conference of Physiological Sciences, Invited Lecture ”Calcium Signaling in
Endothelial Cells”, Oct 19-22, 2008.
Beijing University, Institute of Molecular Medicine, “Endothelial Signaling via Caveolae”, Oct 21, 2008
EB 2009 Symposium Speaker, “Pulmonary Vascular Regeneration”, New Orleans, LA , April, 2009.
Northwestern University School of Medicine, Division of Allergy, Dept of Medicine, “Control of
Neutrophil Motility and Mechansims of Lung Inflammation”, Chicago, IL, April 2009
Beth Israel Hospital, Boston, Dept of Medicine, Visiting Professor, June 2009
American Thoracic Society 2009 Workshop “Stem Cells and Lung Biology Workshop” Invited Speaker,
May 2009 San Deigo
18
Vermont Stem Cell Conference, Invited Speaker “Mechanisms of Differentiation of Human Embryonic
Stem Cells to Endothelial Cells”, Burlington, VT, July, 2009
Australian Vascular Biology Society, Canberra, Plenary Leacure. September, 2009
University of Virginia, Cardiovascular Center, September, October 2009
Department of Cell Biology, SUNY Downstate, Brooklyn, NY 2010
Gordon Conference, Biology of Nox’s, Les Diaberets, Switzerland, 2010
EB 2010, Invited Speaker, Endothelial Permeabality Regulation Symposium, New Orleans 2010
American Thoracic Society Meeting, Invited Speaker “The Endothelium in ARDS”, San Diego 2010
16th International Vascular Biology Meeting, Invited Symposium Speaker, “Vascular Integrity”, Los
Angeles, 2010
CURRENT RESEARCH AND TRAINING SUPPORT (as Principal Investigator or Program
Director)
“Mechanisms of Thrombin-Induced Increase in Pulmonary Vascular Permeability” (RO1 HL-45638 for
yr 09-12), Principal Investigator Malik, 2000-2009 ($1,125,000 Total Direct)
NRSA Postoctoral Pulmonary Training Program (“Lung Biology and Pathobiology”) (T32 HL 07829 (yr
06-11), Program Director A. B. Malik, 1995-2005; yr 11-16 2005-2010 ($2,800,000 Total
Direct).
Program Project P01 HL60678 “Signaling of Endothelial Permeability and Lung Vascular Injury” (yr 0610) Principal Investigator Malik, 2005-2010 (Total Direct Cost $7,244,208).
NRSA Pharmacological Sciences Training Grant T32 GM73088 “Pharmacological Sciences Training
Program”; (yr 01-05) Program Director A. B. Malik 2005-2010 (Total Direct Costs $1,024,000)
Program Project P01 HL077806 “Mechanisms of PMN-Mediated Lung Inflammation and Injury”
(yr 01-5) Principal Investigator, Malik, 2005-2010 (Total Direct Costs $5,892,000)
“ENDOTHELIAL PROGENITOR CELL TREATMENT OF LUNG VASCULAR INJURY” NIH
5R01HL090152 grant P.I. Malik 2007-2012 (Total amount $2,500,000)
ORGANIZATION OF CONFERENCES AND SYMPOSIA (as Chair or Primary Organizer)
“Lung Microvascular Injury”, International Conference sponsored by The New York Academy of
Sciences, May, 1981.
“Prostaglandins, Leukotrienes, and Lung Fluid Balance”, The American Physiological Society
Symposium August, 1983.
“Ibuprofen and Lung Injury”, Symposium sponsored by The Upjohn Co., January, 1984.
19
“Pulmonary Embolic Disease", American Thoracic Society Symposium, May, 1985.
"Endothelial Transport”, Federation of American Societies of Experimental Biology
Symposium, April, 1986.
“Mechanisms and Modulation of Lung Vascular Injury”, American Society of Pharmacology and
Experimental Therapeutics Symposium, Honolulu, HA, August, 1987.
“High Altitude Physiology and Pathophysiology: Consequences of Hypoxia”, Continuing Medical Education
Symposium, The Albany Medical College, January, 1988.
“Endothelial Barrier Function”, Cell Physiology Section of American Physiological Society, FASEB,
Symposium, Anaheim, CA., March, 1989.
Co-Chair of Symposium on “Pathogenesis of Lung Disease in Sickle Cell Hemoglobinopathies”. National
Heart, Lung, Blood Institute. April, 1992.
“Control of Pulmonary Vasculature by Endothelial-Dependent Mechanisms”. Co-Chairperson. American
Thoracic Society Symposium, Miami, FL., May, 1992.
4th Vienna Shock Forum, Co-organizer, June, 1993.
“In Vivo Cell Biology” Symposium, Division of Lung Disease, NHLBI Workshop Bethesda, MD, June, 1993.
Postgraduate Symposium, American Heart Association Meeting, Atlanta, GA., “The Endothelium as an
Inflammatory Organ”, 1993.
Chair, Consensus Conference on “Endothelial Cell: Recent Developments”, Division of Lung Disease, NHLB1,
March, 1995.
Chicago Signal Transduction Symposium, Organizing Committee, Chicago, IL, May 1995-2000
Midwest ASPET Symposium, “Recent Advances in Endothelial Biology,” Chicago, IL, June 1995.
Midwest ASPET Symposium, Chicago, IL, June 1996 and May 1997 (Organizing Committee) .
EB 2000, Molecular Mechanisms Regulating Endothelial Barrier Function in Pulmonary Microvessels. San Diego,
CA, April 2000.
EB 2001, “G-Protein Regulation of Endothelial Function”, Orlando, April 2001.
EB 2002, “Protein Transport Across Lung Air-Blood Barrier” New Orleans, April 2002.
Organizing Committee, Grover Conference on the Pulmonary Circulation” 2002, 2004, 2006, 2008, Deckers,
Colorado.
EB 2003 Symposium “Caveolae and Endothelial Function”, American Physiological Society, April 2003
20
EB 2004 Symposium “Integrated Control of Lung Fluid Balance” American Physiological Society, April 2004
American Heart Association 2007 Symposium “Stem Cells, Pulmonary Vascular Diseases, and Therapeutics”
Orlando
American Thoracic Society 2008 Symposium “Stem Cell Mediated Lung Therapy” Toronto, Canada
EB 2009 Symposium “Lung Injury and Treatment with Stem Cells”, American Physiological Society, April,
2009
WORK RELATED TO THERAPEUTICS DEVELOPMENT AND PATENTS
Consensus Conference on Therapeutic Use of Ibuprofen In Acute Lung Injury, Jan, 1983, St. Petersburg, FL (CoChairman with M. Gee, Ph.D.) Upjohn Co.
Treatment of Endotoxic Shock with Monoclonal Antibody (IB4) Against Neutrophil Adhesion Complex (in
conjunction with Sam Wright, Ph.D., Rockefeller University and Jeffrey Cooper, M.D., Albany Medical
Center/Merck, Sharp and Dohme, Rahway, N.J.
Endothelin-1 Receptor Antagonists with Anti-Hypertensive Effects with Dr. Thomas Andersen, Dept. of
Biochemistry, Albany Medical College, Albany, NY.
PATENT: Transcytosis Vehicles and Enhancers for Drug Delivery (Awarded US patent# 6204054)
PATENT: Silencing of TGFβ Receptor Type II Expression by siRNA (Awarded US patent# 20060229266)
PATENT: Peptide Carrier for Drug Delivery (Awarded US patent# 20070077239)
POST-DOCTORAL FELLOWS and CURRENT POSITIONS
(completing training with Dr. Malik)
Bing C. Lee, M.D. (1977-1979). Chief, Surgical Intensive Care Unit, East Orange, VA Medical Center,and
Professor of Surgery, College of Medicine and Dentistry of New Jersey, Newark, N.J.
Hoyt van der Zee, M.D. (1976-1978). Professor of Anesthesiology, The Albany Medical Center, Albany, N.Y.
Tawfic Hakim, Ph.D. (1979-1981). Associate Professor, Department of Physiology and Director of Surgical
Research, SUNY. Upstate Medical School, Syracuse, N.Y.
Philip S. Barie, M.D. (1980-1982). Professor of Surgery, Cornell University Medical College. Director, Surgical
Intensive Care Unit, The New York Hospital.
21
Jeffrey A. Cooper, M.D. (1983-1985). Professor of Radiology (Chief of Nuclear Medicine) and
Professor of Pediatrics, Albany Medical College, Albany, N.Y.
Joe G. N. Garcia, M.D. (1984-1985). Professor and Chairman of Medicine, University of Chicago School of
Medicine, Chicago, IL.
Arnold Johnson, Ph.D. (1982-1984). Career Scientist, Albany Veteran's Hospital and Associate
Professor of Physiology and Cell Biology, Albany Medical College, Albany, N.Y.
David F. Kern, Ph.D. (1982-1985). Associate Professor of Physiology, East Tennessee School of
Medicine, Johnston City, TN.
Fred L. Minnear, Ph.D. (1979-1982). Professor of Physiology and Assoc. Dean of Graduate College, West
Virginia University Health Science Center, Morgantown, WV,
Maria V. Tahamont, Ph.D. (1980-1982). Associate Professor of Biological Sciences, Rowan College of New
Jersey
Marc B. Perlman, M.D. (1984-1986). Professor, Pediatrics (Clinical-track) University of Massachusetts School
of Medicine, and Neonatologist Berkshire Medical Center, Pittsfield, MN
Kenneth L. Burhop, Ph.D. (1984-1986). Vice President, Drug Delivery Development, Baxter Labs. Corporate
Research, Round Lake, IL.
William Selig, Ph.D. (1984-1986). Senior Director of Preclinical Development, Magen Biosciences, Groveland,
MA
Jonathan Shepard, Ph.D. (1985-1987). Dept of Rehabilitation Medicine, University of Nebraska, Omaha.
Carol Burgess, M.D. (1986-1987). Professor in Medicine (Clinical), Albany Medical Center, Albany, N.Y.
Michael Powers, Ph.D. (1987-1988). Research Scientist, Affymax Research Institute, Santa Clara, CA
Michael Horgan, M.D. (1986-1988). Professor of Pediatrics (Head of Neonatal Division), Albany Medical
College, Albany, N.Y.
Brian McCandless, M.D. (1987-1989). Associate Professor of Nuclear Medicine (Radiology). Albany Medical
College, Albany, N.Y.
22
Joseph Lynch, M.D. (1987-1989). Chief of Pulmonary Division, Columbia County Hospital, Hudson, N.Y.
Christopher Horvath, D.V.M. (1987-1989). Staff, New England Primate Center, Harvard Medical School,
Boston, MA.
Marilyn Fisher, M.D. (1989-1991). Associate Professor, Department of Pediatrics, Albany Medical Center,
Albany, NY. Gerard Palace, Ph.D. (1989-1991). Scientist, GelTex, Waltham, MA.
Lester Gibbs, Ph.D. (1989-1991). Senior Investigator, Smith-Kline and Beecham, Philadelphia, PA.
Hazel Lum, Ph.D. (1988-1992). Professor, Dept. of Pharmacology, Rush Presbryterian Medical Center, Chicago,
IL
Catherine Partridge, Ph.D. (1989-1992). Assistant Professor, Department of Biochemistry, Albany Medical
College, Albany, N.Y.
Harold Magazine, Ph.D. (1990-1992). Associate Professor, Department of Biology, Queen's College, CUNY,
Flushing, N.Y.
Joaquim Pinheiro, M.D. (1988-1992). Associate Professor, Department of Pediatrics, The Albany Medical
Center, Albany, N.Y.
Judy Aschner, M.D. (1988-1992). Professor, Department of Pediatrics, Head of Neonatology, Vanderbilt
University School of Medicine, Nashville, TN
Robert Kaslovsky, M.D. (1989-1992). Associate Professor, Department of Pediatrics, The Albany Medical
Center, Albany, N.Y.
Chinnaswamy Tiruppathi, Ph.D. (1991-1993). Associate Professor of Pharmacology, University of Illinois,
Chicago, IL.
Renli Qiao, M.D., Ph.D. (1992-1994). Associate Professor, Department of Medicine, University of Southern
California, Los Angeles.
Elizabeth Everitt, Ph.D. (1993-1995). Principal Scientist, Abbott Research Laboratories, North Chicago, IL.
Joseph Barnard, Ph.D.. (1993-1995). Assistant Professor (Research), Johns Hopkins, Department of
23
Medicine, Baltimore, MD.
Amlan Raychaudhury, Ph.D. (1993-1995). Instructor in Pharmacology, Rush Presbyterian St Luke’s Medical
Center, Chicago, IL
David Beno, Ph.D. (1995-1996). Assistant Professor of Pediatrics, Rush-Presbyterian St. Luke’s Medical Center,
Chicago, IL.
Philip Sass Ph.D. (1996-1998) Senior Scientist, Magainin Labs., Philadelphia, PA.
Karen Buchkovich, Ph.D (1996-1998) Senior Scientist Cephalon, Inc., Philadelphia, PA.
Walter Niles, Ph.D. (1995-1998) Current Position: Principal Investigator, Aurora Biosciences Corporation, San
Diego, CA
Shu-Fang Liu, M.D., Ph.D., (1995-1999) Assistant Professor, Department of Medicine, Albert EinsteinCollege of
Medicine, Bronx, NY.
Richard Minshall, Ph.D., (1998-2000) Associate Professor, Departments of Anesthesiology and Pharmacology,
University of Illinois, Chicago, IL.
Arshad Rahman, Ph.D., (1994-1999) Associate Professor, Department of Pediatrics, University of Rochester,
Rochester, NY.
Ning Xu, M.D., (1999-2001) Clinical Trials Director, PAREXEL International, Beijing, PRC
Dolly Metha, Ph.D., (1999-2003) Associate Professor, Department of Pharmacology, University of Illinois
College of Medicine, Chicago.
Jie Fan, M.D., (2000-2003) Associate Professor, Department of Surgery, University of Pittsburgh.
Panos Kouklis, Ph.D., (1998-2003) Assistant Professor of Cell Biology, University of Ionnina, Greece.
Qinghui Liu, Ph. D., (2000-2003) Research Assistant Professor, Dept of Cell Biology, University of Michigan.
Evan Ong, M.D., (2001-2003) Assistant Professor Dept. of Surgery, University of Arizona, Tuscon
Sean Garrean, M.D., Surgical Resident, University of Illinois, Chicago, IL
24
Cordus Easington, M.D., (2002-2003) Resident, Dept of Medicine, Northwestern/Evanston Medical Center,
Chicago.
Janie Orrington-Myers, D.O., (2002-2004) Surgery Resident, Olympic Heights Hospital, Chicago
Scott Allen, Ph.D., (2002-2004) Assistant Professor, University of Tampa, Tampa, FL
Jian Fu Ph.D. (2003-2005) Assistant Professor, University of Texas Health Sciences Center, Tyler, TX
Kamran Javaid M.D. (2001-2005) Medicine Resident, University of Chicago
Sophie Toya, M.D. (2004-2005) Maternity leave ; returned 2008-present
Nikos Maniatis, M.D. (2004-2006) Assistant Professor, Department of Medicine (Pulmonary Division),
University of Athens, Greece
You-Yang Zhao Ph.D. (2004-2007) Assistant Professor, Department of Pharmacology, University of Illinois,
Chicago
Sanda Predescu Ph.D. (2001-2006) Assistant Professor, Rush Medical College, Chicago, IL
Ram Ramchandan Ph.D. (2005-2008) Res. Assistant Professor, Department of Pediatics, UIC
Thomas Trianatafillou (2005-2008) Research Assistant Professor, Resident Geriatric Medicine, UIC
Liquan Cai (2007-2008) Research Assistant Professor, Assistant Professor, Univ. Pittsburgh
25
Ph.D. STUDENTS (completing training with Dr. Malik) and CURRENT POSITIONS:
Arnold Johnson, Ph.D. (1979-1982). Career Investigator, Albany Veteran's Hospital and Professor of Medicine
and Physiology and Cell Biology, The Albany Medical College, Albany, NY.
Thomas Noonan, Ph.D. (1982-1986). Senior Scientist, Boehringer-Ingelheim, Fairfield, CT.
Siu K. Lo, Ph.D. (1983-1987). Patent Attorney, Kenyon and Kenyon, New York, NY.
Rene Gzabo-Garcia, M.D. (1982-1987) (Former Fulbright Fellow in Malik Lab). Professor of Physiology,
University of Santo Domingo, Dominican Republic.
Ming Ge, M.D. (1988-1991) Entrepreneur, Irvine, CA.
Weihong Yan, Ph.D. (1992-1997) Director, Bioinformatics Lab, UCLA
Chad Ellis, Ph.D. (1993-1998) Staff NIH, National Cancer Institute, Rockville, MD.
John Kefer, Ph.D. (1995-1999) Medical Resident, Cleveland Clinic
Andrea True, Ph.D. (1995-1999) Scientist, Trimeris, Durham, NC
Michael Holinstat, Ph.D. (1999-2004) Assistant Professor of Biochemisty, Thomas Jeffereson Medical
School,Philadelphia, PA.b (co-mentor with Dr. Dolly Mehta)
Maria Konstantoulaki, Ph.D. (1999-2004) Post-Doctoral Fellow, Dept of Cell Biology, University College,
London
Ayesha Shajahan, Ph.D. (2000-2004) Post-Doctoral Fellow, Lombardi Cancer Center, Georgetown University,
Washington DC (co-mentor with Dr. Richard Minshall)
David Jho M.D./Ph.D (2001-2004) Resident in Surgery, Massachchusett General Hospital/Harvard Medical
School, Boston, MA
Michael Broman M.D/Ph.D. (2001-2006), Resident in Medicine (Medical Scientist Training Program),
University of Chicago, Chicago, IL
Irene Klein M.D./Ph.D. Resident in Medicine, Mayo Clinic, Jacksonville, FL
Randal Frey, Ph.D. Research Assistant Professor, Division of Pulmonary Medicine, UIC Medical Center
Gias Ahmmed, M.D., Ph.D.Instuctor, Department of Emerency Medicine, University of Chicago
Yidan Zhao MD, Ph.D. Research Assistant Professor, Dept of Pharmacology, University of Illinois
Kamran Mirza, M.D. Ph.D. Resident in Pathology, University of Chicago
Takeshi Kawamura MD, Assistant Professor of Anesthesiology, University of Tokyo
Xiao Su, Res. Assistant Professor of Medicine, UCSF
CURRENT POST-DOCTORAL FELLOWS, RES. FACULTY, and Ph.D. STUDENTS:
Kurt Bachmaier M.D.
Claudie Hecquet, Ph.D.
Anke Di, M.D.
Yuru Liu
Sophie Toya
2003
2006
2006
2006
2007
26
Ignatius Gomes
Alex Garcia
Emily Vandenbroucke
Yulia Komarova
Rizwan Siddiqui
Rajasingh Johnson
Tracey Dugan
Zhenjia Wang
2009
2008
2006
2006
2008
2009
2009
2007
MASTER'S STUDENTS, CENTER OF BIOMEDICAL ENGINEERING RENSSELAER POLYTECHNIC
INSTITUTE (Completing M. Sci. (Eng) with Dr. Malik):
Scott J. Solano, M. Eng
Carole A. Heath, M. Eng
Mark D. Kramer, M. Eng
1983
1984
1984
SABBATICAL or GUEST WORKERS IN DR. MALIK's LABORATORY
Khatim Mustapha, M.D., Ph.D., Professor of Medicine and Physiology, Kuwait University Faculty of Medicine,
Kuwait (1984-1985).
Yoshiki Ishii, M.D., Associate Professor, Jichi Medical School, Tochigi-Ken, Japan (1990-1991)
S. Sugama, M.D., Assistant Professor, Jichi Medical School, Tochigi-Ken, Japan (1991-1992)
Shoji Ohno M.D., Assistant Professor, Jichi Medical School, Tochigi-Ken, Japan (1993-1994)
Magnus Bergenfeldt, M.D., Associate Professor, Malmö University, Malmö, Sweden (1995-1996)
Masashi Bando, M.D. Assistant Professor, Jichi Medical School, Tochigi-Ken, Japan (1995-1996)
Asun Romero, Ph.D. Dept. of Pharmacology, University of Barcelona, Spain, 2000
Jun Shimizu, M.D. Department of Anesthesiology, Nippon Medical School, Tokyo, 2003-2005
Kayo Shimizu, M.D. Department of Surgery, Nippon Medical School, Tokyo, 2003-2006
Hiroshi Ohkawara, MD, First Department of Internal Medicine, Fukushima Medical University, Fukushima,,
Japan. 2006-2008
Geerten von Nieuw Amerogen Ph.D., Department of Physiology, University of Amsterdam, Holland. 2008
27
PUBLICATIONS
A. Peer-Reviewed Research Publications
1. Thippegowda PB, Singh V, Sundivakkam PC, Xue J, Malik AB, Tiruppathi C. Ca2+ influx via TRPC
channels induces NF-κB -dependent A20 expression to prevent thrombin-induced apoptosis in endothelial
cells. Am J Physiol Cell Physiol. 2010 in press
2. Su X, Matthay MA, Malik AB. Requisite role of the cholinergic α7 nicotinic acetylcholine receptor pathway
in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol. 184:401-10, 2010.
3. Wang Z, Tiruppathi C, Minshall RD, Malik AB. Size and dynamics of caveolae studied using nanoparticles
in living endothelial cells. Amer. Chem. Soc. Nano. 22:4110-6, 2010.
4. Zhao YD, Ohkawara H, Vogel SM, Malik AB, Zhao YY. Bone marrow-derived progenitor cells prevent
thrombin-induced increase in lung vascular permeability. Am J Physiol Lung Cell Mol Physiol. 298:L36-44.
2010.
5. Wary KK, Vogel SM, Garrean S, Zhao YD, Malik AB. Requirement of α41beta and α51 integrin
expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury
and edema in mice. Stem Cells. 27:3112-20, 2009.
6. Hu G, Malik AB, Minshall RD. Toll-like receptor 4 mediates neutrophil sequestration and lung injury
induced by endotoxin and hyperinflation. Crit Care Med. 38:194-201, 2010.
7. Qian F, Deng J, Cheng N, Welch EJ, Zhang Y, Malik AB, Flavell RA, Dong C, Ye RD. A non-redundant
role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 28:2896907, 2009.
8. Zhao YD, Ohkawara H, Rehman J, Wary KK, Vogel SM, Minshall RD, Zhao YY, Malik AB. Bone marrow
progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1
and Cdc42 signaling. Circ. Res. 105:696-704, 2009.
9. Gorovoy M, Han J, Pan H, Welch E, Neamu R, Jia Z, Predescu D, Vogel S, Minshall RD, Ye RD, Malik AB,
Voyno-Yasenetskaya T. LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in
mouse lungs. Circ. Res.105:549-56, 2009.
10. Klein IK, Predescu DN, Sharma T, Knezevic I, Malik AB, Predescu S. Intersectin-2L regulates caveola
endocytosis secondary to Cdc42-mediated actin polymerization. J Biol Chem. 284:25953-61, 2009.
11. Zhang G, Han J, Welch EJ, Ye RD, Voyno-Yasenetskaya TA, Malik AB, Du X, Li Z. Lipopolysaccharide
stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent
protein kinase pathway. J Immunol. 182:7997-8004, 2009
12. Zhao YY, Y.D. Zhao, M.K. Mirza, J.H. Huang, H-H. S.K. Potula, S.M. Vogel, V. Brovkovych, J. X.-J.Yuan,
J Wharton, and A. B. Malik. Persistent eNOS activation secondary to caveolin-1 deficiency induces
pulmonary hypertension in mice and humans through protein kinase G nitration. J. Clin. Invest. 119:2009-18,
2009.
28
13. Xue J, P., B. Thippegowda, G. Hu, K. Bachmaier K, J. W. Christman, A. B. Malik, C. Tiruppathi. NF-κB
regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic
NF-κB site in the ICAM-1 gene. Physiol. Genomics 10;38: 42-53, 2009
14. Knezevic II, S. S. A. Predescu, R. F. Neamu, M. S. Gorovoy, N. M. Knezevic, C. Easington C, A. B. Malik
D. N. Predescu. Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional
disassembly and increase in vascular permeability. J. Biol. Chem. 284:5381-94, 2009.
15. Sundivakkam PC, A.M. Kwiatek, T. T. Sharma, R. D. Minshall, A. B. Malik AB, C. Tiruppathi. Caveolin-1
scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in
endothelial cells. Am J Physiol Cell Physiol. 296:C403-13, 2009.
16. Bair, A. M., P. B. Thippegowda, M. Freichel, N. Cheng, R. Ye, S. M. Vogel, Y. Yu, V. Flockerzi, A. B. Malik
and C. Tiruppathi. Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-κB activation in
endothelial cells through AMP-activated PKCδ. J. Biol. Chem. 284:563-74, 2009.
17. Tauseef, M., V. Kini, N. Knezevic, M. Brannen, R. Ramachandran, H. Fryst, J. Saba, S. M. Vogel, A. B. Malik
and D. Mehta. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through
sphingosine-1-phosphate receptor in endothelial cells. Circ. Res. 103:1164-72, 2008
18. Xu, J., X-P Gao, R. Ramchandran, Y-Y Zhao, S. M. Vogel, and A. B. Malik. Non-muscle MLCK mediates
neutrophil transmigration in sepsis-induced lung inflammation by the activation of 2 integrins. Nature
Immunology. 9: 880-886, 2008.
19. Hu, G., S. M. Vogel, R. Neamu, D. E. Scwartz, A. B. Malik, and R. M. Minshall. ICAM-1 dependent neutrophil
adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability. Circ. Res.
102:e120-31, 2008.
20. Ramachandran, R., D. Metha, S. M. Vogel, M. K. Mirza, P. Kouklis and A. B. Malik. Critical role of Cdc42 in
mediating endothelial barrier protection in vivo. Am. J. Physiol. Lung Cell Mol. Physiol. 295:L363-9, 2008.
21. Tiruppathi C., J. Shimizu, K. Miyawaki-Shimizu, S. M. Vogel, A. M. Bair, R. D. Minshall, D. Predescu and A.
B. Malik. Role of NF-κB-dependent caveolin-1 expression on mechanism of increased endothelial
permeability induced by LPS. J. Biol. Chem. 283: 4210-18, 2008.
22. Brovkovych, V., X-P Gao, E. Ong, S. Brovkovych, M. L. Brennan, X. Su, S. L. Hazen, A. B. Malik and R. A.
Skidgel. Augmented iNOS expression and increased NO production reduce sepsis-induced lung injury and
mortality in myeloperoxidase-null mice. Am. J. Physiol. Lung Cell Mol. Physiol. 295: L96-103, 2008.
23. Maniatis N. A., V. Shirin, D. E. Schraufnagel, S. Okada, S. M. Vogel, A. B. Malik and R. D. Minshall. Increase
pulmonary vascular resistance and defective pulmonary artery filling in caveolin1-/- mice. Am. J. Physiol.
Lung Cell Mol. Physiol. 294: L865-73, 2008.
24. Hecquet, C. M., G. U. Ahmmed, S. M. Vogel, and A. B. Malik. Role of TrpM2 channels in mediating H2O2induced Ca2+ entry and endothelial hyper-permeability. Circ. Res. 102: 347-55, 2008.
29
25. Hu, G., R. D. Ye, M. C. Dinauer, A. B. Malik, and R. D. Minshall. Neutrophil caveolin-1 contributes to the
mechanism of lung inflammation and injury. Am. J. Physiol. Lung Cell Mol. Physiol. 294: L178-86, 2008.
26. Knezevic N, A. Roy, B. Timblin, M. Konstantoulaki, T. Sharma, A.B. Malik, and D. Mehta. GDI-1
phosphorylation switch at serine 96 induced RhoA activation and increase in endothelial permeability. Mol.
Cell. Biol. 27:6323-6333, 2007.
27. Azim A. C. , H. Cao, X. Gao, M. Joo, A. B. Malik, R. B Breeman, R. T. Sadikot, G.Y. Park and J. W. Christman.
Regulation of cyclooxygenase 2 expression by small GTPase Rac2 in bone marrow macrophages. Am. J.
Physiol. Lung Cell Mol. Physiol. 293:L668-73, 2007
28. Gorovoy, M., R. Neamu, J. Niu, S. Vogel, D. Predescu, J. Miyoshi, Y. Takai Y, V. Kini, D. Mehta, A. B. Malik
and T. Voyno-Yasenetskaya. RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates
endothelial barrier function in mouse lungs. Circ Res. 101:50-58, 2007.
29. Bachmaier, K., S. Toya, T. Triantafillou, S. Garrean, G.Y. Park, R.S. Frey, S. M. Vogel, R. Minshall, J. W.
Christman, C. Tiruppathi and A. B. Malik. E3 ubiquitin ligase Cbl-b regulates the acute inflammatory
response underlying lung injury. Nature Medicine 13:920-926, 2007.
30. Predescu, S., D. Predescu and A. B. Malik. Intersectin-1s regulates the mitochondrial pro-apoptotic pathway in
endothelial cells. J. Biol. Chem. 282:17166-17178, 2007.
31. Mclaughlin, J. N., M. Patterson and A. B. Malik. Protease activated receptor-3 (PAR-3) regulates PAR-1
signaling. Proc Nat’l Acad. Sci. 104: 5662-7, 2007.
32. Ramakrishna S., I. M. Kim, V. Petrovic, D. Malin, I.C. Wang, T.V. Kalin, L. Meliton, Y. Y Zhao, T. Ackerson,
Y. Qin, A. B. Malik, R. H. Costa, and V. V. Kalinichenko. Myocardium defects and ventricular hypoplasia in
mice homozygous null for the Forkhead Box m1 transcription factor. Dev. Dyn. 236:1000-1013, 2007.
33. Singh I., N. Knezevic, G. U. Ahmmed, V. Kini, A. B. Malik and D. Mehta. Gαq -TRPC6-mediated Ca2+ entry
induces RhoA activation and resultant endothelial cell shape change in response to thrombin. J Biol. Chem.
282:7833-43, 2007.
34. Gao, X.P., X. Zhu, J. Fu, Q. Liu, R.S. Frey and A.B. Malik. Blockade of class IA phosphoinositide 3-kinase in
neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation. J Biol. Chem.
282:6116-25, 2007.
35. Siddiqui S Z. K. Siddiqui, S. Uddin, R. D. Minshall and A. B. Malik. p38 MAPK activation coupled to
endocytosis is a determinant of endothelial monolayer integrity. Am. J. Physiol. Lung Cell Mol. Physiol. 292:
L114-124, 2007
36. Maniatis N. A., V. Brovkovych, S. E, Allen, T. A. John, A. N. Shajahan, C. Tiruppathi, S. M. Vogel, R. A.
Skidgel, A. B. Malik and R. D. Minshall. Novel mechanism of endothelial nitric oxide synthase activation
mediated by caveolae internalization in endothelial cells. Circ. Res. 99: 870-877, 2006.
30
37. Zhao Y-Y, Gao X-P, Zhao Y-D, Mirza M.K, Frey R.S, Kalinichenko V.V, Costa R.H, and A.B. Malik.
Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following vascular injury induced by
lioppolysaccharide. J. Clin. Invest. 116:2333-43, 2006.
38. Garrean, S., X-P., Gao, V. Brovkovych, Y.Y. Yang, S.M. Vogel, and A. B. Malik. Caveolin-1 regulates NF-κB
activation and lung inflammatory response to sepsis induced by LPS. J. Immunology. 177:4853-60, 2006.
39. Kwiatek A.M., Minshall, R.D., Cool, D.R., Skidgel R.A., and A.B. Malik. Caveolin-1 regulates store-operated
Ca2+ influx by binding of its scaffolding domain to TRPC1 in endothelial cells. Mol. Pharmacol. 70:1174-83.
2006.
40. Orrington-Myers J, Gao X-P, Kouklis P, Broman M, Rahman A, Vogel S, and A.B. Malik. Regulation of lung
neutrophil recruitment by VE-cadherin. Am. J. Physiol. Lung Cell Mol. Physiol. 291: L764-71, 2006
41. Vogel S, Orrington-Myers J, Broman M, and A.B. Malik . De novo ICAM-1 synthesis in the mouse lung: model
of assessment of protein expression in lungs. Am. J. Physiol. Lung Cell Mol. Physiol. 291:L496-501, 2006.
42. Paria BC, Bair AM, Xue J, Yu Y, and A.B. Malik. Ca2+ influx-induced by PAR-1 activates a feed-forward
mechanism of TRPC1 expression via NF-κB activation in endothelial cells. J. Biol. Chem. 281: 20715-20727,
2006.
43. Frey RS, Gao X-P, Javaid K, Siddiqui SS, Rahman A, and A.B. Malik. Phosphatidylinositol 3-kinase gamma
signaling through PKCζ induces NADPH oxidase-mediated oxidant generation and NF-κB activation in
endothelial cells. J. Biol. Chem. 281:16128-16138, 2006.
44. Holinstat M, N. Knezevic, M. Broman, A. M. Samarel, A. B. Malik, and D. Mehta. Suppression of RhoA activity
by focal adhesion kinase-induced activation of p190RhoGAP: Role in regulation of endothelial permeability.
J. Biol. Chem. 281:2296-2305, 2006
45. Broman MT, P. Kouklis, X-P Gao, R. Ramchandran, R. F. Neamu, R. D. Minshall RD, and A. B. Malik. Cdc42
regulates adherens junction stability and endothelial permeability by inducing α-catenin interaction with the
vascular endothelial cadherin complex. Circ. Res. 98:73-80, 2006.
46. Miyawaki-Shimizu K, D. Predescu, J. Shimizu, M. Broman, S. Predescu, and A. B.
Malik.
siRNA-induced caveolin-1 knock-down in mice increases lung vascular permeability via the junctional
pathway. Am. J. Physiol. Lung Cell Mol. Physiol. 290:L405-413, 2006.
47. Predescu, S., D. N. Predescu, K. Shimizu, I. K. Klein, and A. B. Malik. Cholesterol-dependent syntaxin-4 and
SNAP-23 clustering regulates caveolae fusion with the endothelial plasma membrane. J. Biol. Chem. 280:
37130-8, 2005.
48. Ong ES, X-P. Gao, D. Predescu and A. B. Malik. Phosphatidylinositol 3-kinase γ regulation of neutrophil
sequestration in lung interstitium and its role in tissue injury. Am. J. Physiol. Lung Cell Mol. Physiol.
289:L1094-103, 2005.
31
49. Jho D., D. Mehta, G. Ahmmed, X.P.Gao, C. Tiruppathi, M. Broman and A. B. Malik. Angiopoietin-1 opposes
VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2+ influx. Circ. Res.
96:1282-1290, 2005.
50. Mehta D., M. Konstantoulaki, G.U. Ahmmed, and A.B. Malik. Sphingosine-1-phosphate-induced mobilization of
intracellular Ca2+ mediates Rac activation and adherens junction assembly in endothelial cells. J. Biol. Chem.
280:17320-17328, 2005.
51. Andreeva A.V., M.A. Kutuzov, R. Vaiskunaite, J. Profirovic, T.E. Meigs, S. Predescu, A. B. Malik and T.
Voyno-Yasenetskaya. Gα12 interaction with αSNAP induces VE-cadherin localization at endothelial junctions
and regulates barrier function. J. Biol. Chem. 280:30376-83, 2005.
52. Fu J., A. P. Naren, X-P, Gao, G. Ahmmed and A. B. Malik. PKCα phosphorylation of syntaxin 4 and Munc18c
regulates exocytosis of Weibel-Palade bodies in endothelial cells. Signaling cell surface P-selectin expression.
J. Biol. Chem. 280:3178-3184, 2005.
53. Zhou X., X.P. Gao, J. Fan, Q. Liu, K.N. Anwar, R.S. Frey, and A.B. Malik. Toll-like receptor 4 (TLR4) induces
the expression of CD11b/CD18 integrin in neutrophils. Am. J. Physiol. Lung Cell Mol. Physiol. 288:L655662, 2005.
54. Gao X-P., Q. Liu, M. Broman, R. Frey, and A.B. Malik. Inactivation of CD11b in a mouse transgenic model
protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol. Genomics 21: 230-242,
2005.
55. Predescu D., S. Predescu, J.Shimizu, K. Miyawaki-Shimizu, and A.B Malik. Constitutive eNOS-derived nitric
oxide is a determinant of endothelial junctional integrity. Am. J. Physiol. Lung Cell Mol. Physiol. 289:L371381, 2005.
56. Lin P, X-P., Gao, A.B. Malik, and R.D. Ye. Lysophosphatidylcholine modulates neutrophil activation through
elevation of cAMP. J. Immunol. 174:2981-2989, 2005.
57. Wang Y., R. J. Keogh, C.A. Mitchell, R.S. Frey, K. Javaid, A.B. Malik, S. Schurmans, S. Tridandapani, and C.
B. Marsh. SHIP2 is recruited to the cell membrane upon M-CSF stimulation and regulates M- CSF-induced
signaling. J. Immunol. 173: 6820-6830, 2004.
58. Anwar K.N., F. Fazal, A. B. Malik, A. Rahman A. RhoA/ROCK pathway signals thrombin-induced ICAM-1
expression in endothelial cells via activation of IKKβ and phosphorylation of RelA/p65. J. Immunol. 173:
6965-6972, 2004.
59. Shajahan A.N., C. Tiruppathi, A. V. Smrcka, A. B. Malik and R. D. Minshall. Gβ activation of Src induces
caveolae-mediated endocytosis in endothelial cells. J. Biol. Chem. 279: 48055-48062, 2004.
60. Paria B.C., S. M.Vogel, G.U. Ahmmed, S. Alamgir, J. Shroff J, A. B. Malik and C Tiruppathi. Tumor necrosis
factor-α-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am. J.
Physiol. Cell Mol. Physiol. 287: L1303-L1313, 2004.
32
61. Ahmmed G.U., D. Mehta, S. Vogel, M. Holinstat, B.C. Paria, C Tiruppathi, and A.B. Malik. Protein kinase Cα
phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J. Biol. Chem.
279:20941-10949, 2004.
62. Nakamura, H., S. S. Siddiqui, X. Shen, A. B. Malik, J. S. Pulido, N. M. Kumar and B. Yue. RNA interference
targeting of transforming growth factor-β receptor surpresses ocular inflammation and fibrosis. Molecular
Vision 10:703-11, 2004.
63. Tiruppathi, C, T. Naqvi, Y Wu, S.M. Vogel, R.D. Minshall, and A.B. Malik. Albumin mediates the transcytosis
of myeloperoxidase by means of caveolae in endothelial cells. Proc. Natl. Acad. Sci. 101:7699-7704, 2004.
64. Rahman, A, K.N. Anwar, M. Ninhajuddin, K.M. Bijli, K. Javaid, A.L. True, and A.B. Malik. cAMP targeting of
p38 MAP kinase inhibits thrombin-induced NF-κB activation and ICAM-1 expression in endothelial cells. Am.
J. Physiol Cell Mol. Physiol 287: L1017-L1024, 2004.
65. Shajahan A.N., B.K. Timblin, R. Sandoval, C. Tiruppathi, A.B. Malik and R.D. Minshall. Role of Src-induced
dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. J. Biol. Chem. 279:2039220400, 2004.
66. Siddiqui S.S., Z.K. Siddiqui, and A.B. Malik. Albumin endocytosis by endothelial cells induces activation of
TGF-β receptor-II signaling. Am. J. Physiol. Lung Cell Mol. Physiol. 286:L1016-L1026, 2004.
67. Kouklis P, M. Konstantoulaki, S. Vogel, M. Broman and A. B. Malik. Cdc42 regulates the restoration of
endothelial barrier function. Circ. Res. 94:159-66, 2004.
68. Fan, J. R. Frey and A.B. Malik. TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil
NADPH oxidase: mechanism of stable ICAM-1 expression and augmented neutrophil migration. J. Clin.
Invest., 112:1234-43, 2003.
69. Predescu, S., D. Predescu, B. K. Timblin, and A. B Malik Expression, subcellular localization, and function of
intersectin in endothelial cells. Mol. Biol. Cell. 14: 4997-5010, 2003.
70. Paria, B.C., A.B. Malik, A.M. Kwiatek, A. Rahman, M.J. May, S. Ghosh, and C. Tiruppathi. TNFα induces NFκB-dependent TRPC1 expression in endothelial cells. J. Biol. Chem., 278:37195-203, 2003.
71. Mehta, D., G.U. Ahmmed, B. Paria, M. Holinstat, T. Voyno-Yasenetskaya, C. Tiruppathi, R.D. Minshall, and
A.B. Malik. RhoA interaction with inositol 1,4,5-triphosphate receptor and transient receptor potential
channel-1 regulates Ca2+ entry. Role of signaling increased endothelial permeability. J. Biol. Chem.,
278:33492-500, 2003.
72. Ong, E., X.P. Gao, N. Xu, D. Predescu, A. Rahman, M.T. Broman, D.H. Jho, and A.B. Malik. E. coli pneumonia
induces CD18-independent airway neutrophil transalveolar migration in the absence of increased lung vascular
permeability. Amer. J. Physiol. Lung Cell Mol. Physiol., 285:L879-88, 2003.
33
73. Li, Z., G. Zhang, G.C. Le Breton, X. Gao, A.B. Malik, and X. Du. Two waves of platelet secretion induced by
thromboxane A2 receptor, and a critical role for phosphoinosidtide 3-kinase. J. Biol. Chem., 278:30725-31,
2003.
74. Javaid, K., A. Rahman, K.N. Anwar, R.S. Frey, R.D. Minshall, and A.B. Malik. Tumor necrosis factor-α induces
early-onset endothelial adhesivity by protein kinase Cζ-dependent activation of intercellular adhesion
molecule-1. Circ. Res. 92: 1089-1097, 2003.
75. Holinstat, M., D. Mehta, T. Kozasa, R.D. Minshall, and A.B. Malik. Protein kinase Cα-induced p115 RhoGEF
phosphorylation signals endothelial cytoskeletal rearrangement. J. Biol. Chem.. 278: 28793-98, 2003.
76. Konstanoukalis, M. Kouklis, P. and A.B. Malik. Protein kinase C modifications of VE-cadherin, p120, and βcatenin contribute to endothelial barrier dysfunction induced by thrombin. Amer. J. Physiol. Lung Cell Molec.
Physiol. 285: L434-L442, 2003.
77. Kouklis, P., M. Konstanoukalis, and A.B. Malik. VE-cadherin induced Cdc42 signaling regulates formation of
membrane protrusions in endothelial cells. J. Biol. Chem 278: 16230-16236, 2003.
78. Jie Fan and A. B. Malik. Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil
migration by modulating cell surface expression of chemokine receptors. Nature Medicine 9:315-321, 2003.
79. John T.A., S.M. Vogel, C. Tiruppathi, A. B. Malik, and R. D. Minshall. Quantitative analysis of albumin uptake
and transport in the rat microvessel endothelial monolayer. Amer. J. Physiol., Lung Cell. Mol. Physiol.
284:L187-196, 2003.
80. Predescu, D., S. Predescu and A. B. Malik. Transport of nitrated albumin across continuous vascular
endothelium. Proc. Nat’l Acad. Sci 99:13932-13937, 2002.
81. Skidgel, R. A., X-P., Gao, V. Brovkovych, A. Rahman, D. Jho, S. Predescu, T. J. Standiford, and A. B. Malik
Nitric oxide stimulates macrophage inflammatory protein-2 (MIP-2) expression in sepsis. J. Immunol.
169:2093-2101, 2002.
82. Rahman, A., A. L. True, K. N. Anwar, R. D. Ye, T. Voyno-Yasenetskaya and A.B. Malik. Gαq and Gαi regulate
PAR-1 signaling of thrombin-induced NF-κB activation and ICAM-1 transcription in endothelial cells Circ.
Res. 91:398-405, 2002.
83. Vanhauwe, J.F., T.O. Thomas, R.D. Minshall, C. Tiruppathi, A. Li, A. Gilchrist, A.B. Malik, and H. E. Hamm
Thrombin receptors activate Go proteins in endothelial cells to regulate intracellular calcium and cell shape
changes. J. Biol.Chem. 277: 34143-34149, 2002.
84. Tiruppathi, C., S. M. Vogel, M. Freichel, B. C. Paria, D. Mehta and A. B. Malik Impairment of store- operated
Ca2+ entry in TrpC4-/- mice interferes with thrombin-induced increase in lung microvascular permeability
Circ. Res. 9:70-76, 2002.
85. Frey, R.S., A. Rahman, J. C. Kefer, R. D. Minshall, and A. B. Malik PKCζ regulates TNFα-induced activation of
NADPH oxidase in endothelial cells. Circ. Res. 90:1012-1019, 2002.
34
86. Gao, X., T. J. Standiford, A. Rahman, M. Newstead, S. M. Holland, M. C. Dinauer, Q. Liu, and A.B. Malik.
Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by
gram negative sepsis: Studies in p47phox-/- and gp91phox-/- mice. J. Immunol. 168:3974-82, 2002.
87. Uddin S, A. Sassano A, D. K. Deb, A. Verma, B. Majchrzak, A. Rahman, A. B. Malik, E. N. Fish. L.C. Platanias
Protein kinase Cδ is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J
Biol. Chem. 277:14408-16, 2002.
88. Mehta, D., C. Tiruppath, R. Sandoval, R.D. Minshall, and A.B. Malik. Modulatory role of focal adhesion kinase
in regulating human pulmonary arterial endothelial barrier function. J. Physiol. 539:779-789, 2002.
89. Fan, Jie, R. S. Frey, A. Rahman, and A. B. Malik. Role of NADPH oxidase in the mechanism of TNFα-induced
NF-κB activation and ICAM-1 expression in endothelial cells. J. Biol. Chem. 277:3404-3411, 2002.
90. Ning X., X.Gao, R. D. Minshall, A. Rahman, and A. B. Malik. Reversal of sepsis-induced PMN uptake and lung
vascular injury by conditional expression of NIF. Amer. J. Physiol. 28:L796-802, 2002.
91. Gao, X., N. Xu, M. Sekosan, D. Mehta, A. Rahman, and A. B. Malik. Differential role of CD18 integrins in
mediating lung neutrophil sequestration and increased microvascular permeability induced by E. coli in mice
J.Immunology 167 2895-2901, 2001.
92. Rahman, A., A. N. Anwar, S. Uddin, Ning. Xu, R. D. Ye, L. C. Planatis, and A. B. Malik. Protein kinase Cδ
(PKCδ and p38 MAP kinase regulate thrombin-induced NF-κB activation and ICAM-1 gene transcription in
endothelial cells. Mol. Cell. Biol. 21 5554-5565, 2001.
93. Vogel, S. M. R. D. Minshall, M. Pilipovic, C. Tiruppathi, and A. B. Malik Albumin uptake and transport in
pulmonary endothelial cells in vivo induced by albumin-binding protein (gp60). Amer. J. Physiol. 281:
L1512-1522, 2001.
94. Tiruppathi , C., T. Naqvi, R. Sandoval, D. Mehta, and A. B. Malik. Synergistic effects of tumor necrosis factor-α
and thrombin in increasing endothelial permeability. Amer. J. Physiol. 281:L958-968, 2001.
95. Mehta, D., A. Rahman, A. Jalali and A. B. Malik. PKCα signals Rho activation through Rho-GDI
phosphorylation and regulates thrombin-induced endothelial cell barrier function. J. Biol. Chem 276: 2261422620, 2001.
96. Yang, M., H. Sang, A. Rahman, D. Wu, A. B. Malik, and R. D. Ye. Role of Gα16 in activation of NF-κB via
phospholipase Cβ and protein kinase C. J. Immunology 166:6885-6892, 2001.
97. Sandoval, R., A.B. Malik, R. D. Minshall, P. Kouklis, CA Ellis, and C. Tiruppathi. Ca2+ signalling and PKCα
activate increased endothelial permeability by disassembly of VE-cadherin junctions. J. Physiol. (London)
533: 547-559, 2001.
98. John T.A., S.M. Vogel, C. Tiruppathi, W.D. Niles, R.C. Minshall, and A.B. Malik. Active transalveolar albumin
transport in the rat lung. J. Physiol. (London) 533:433-445, 2001.
35
99. John, T.A., S.M. Vogel, M. Sekosan, and A.B. Malik. Reversible temperature-sensitive alterations in lung fluid
balance. Shock 16:294-297, 2001.
100. Vogel, S.M., W.D. Niles, R.D. Minshall, C. Tiruppathi, C.R. Easington, S.M. Hollenberg, J.E. Parrillo, and A.B.
Malik. Evidence of transcellular permeability pathway in microvessels. Microvasc. Res. 61:87-101, 2001.
101. Sandoval, R., A.B. Malik, T. Naqvi, D. Mehta, and C. Tiruppathi. Requirement for Ca2+ signaling in the
mechanism of thrombin-induced increase in endothelial permeability. Amer. J. Physiol. 280:L239-L24, 2001.
102. Kefer, J.C., A. Rahman, and A.B. Malik. Decrease in intracellular oxidant buffering capacity impairs TNFαinduced NF-κB DNA binding activity and ICAM-1 transcription in endothelial cells. Shock 15: 11-15, 2001.
103. Gao, X., S. M. Vogel, N. Xu, R. D. Ye, P. Andrade-Gordon, C. Tiruppathi, and A. B. Malik. Abrogation of
thrombin-induced increase in endothelial permeability in Proteinase Activated Receptor-1 (PAR-1-/-) knockout
mice. Physiological Genomics 4: 137-145, 2000.
104. Minshall, R.D., W.D. Niles, C. Tiruppathi, S.M. Vogel, A. Gilchrist, H.E. Hamm, and A.B. Malik. Endothelial
cell surface gp60 activates vesicle formation via Gi-coupled Src kinase signaling pathway. J. Cell Biol.
150:1057-1070, 2000.
105. True, A.L., A. Rahman, K.N. Anwar, and A.B. Malik. Activation of NF-κB induced by H2O2 and TNFα and its
effects on ICAM-1 expression in endothelial cells. Amer. J. Physiol. 279: L302-311, 2000.
106. Gao, X., P. Kouklis, N. Xu, R.D. Minshall, R. Sandoval, S.M. Vogel, and A.B. Malik. Reversibility of increased
microvessel permeability in response to VE-cadherin disassembly. Amer. J. Physiol., 279: L1218-L1225,
2000.
107. Xu, N., A. Rahman, R.D Minshall, C. Tiruppathi, and A.B. Malik. β2 integrin blockade driven by E-selectin
promoter prevents neutrophil sequestration and lung injury in mice. Circulation Research 87:254-260, 2000.
108. Rahman, A, K.N. Anwar, and A.B. Malik. Protein kinase Cζ mediates TNFα-induced ICAM-1 gene transcription
in endothelial cells. Amer. J. Physiol., 279: C906-C914, 2000.
109. Ali, M.Y, A., Z.K. Siddiqui, A.B. Malik, and S.S. Siddiqui. A novel C-terminal kinesin subfamily may be
involved in chromosomal movement in Caenorhabditis elegans. FEBS Lett 470: 70-76, 2000.
110. Tiruppathi, C., W. Yan, R. Sandoval, T. Naqvi, AN, Pronin, J. M, Benovic and A.B. Malik. G-protein-coupled
receptor kinase-5 regulates thrombin-activated signaling in endothelial cells. Proc. Natl. Acad. Sci. 97: 74407445, 2000.
111. Srinivasan, H.B., S.M. Vogel, D. Vidyasagar, and A.B. Malik. Protective effect of lung inflation in reperfusioninduced lung microvascular injury. Amer. J. Physiol., 278:H951-H957, 2000.
112. Lo, S.K., A. Rahman, N. Xu, M.Y. Zhou, P. Nagpala, H.A. Jaffe, and A.B. Malik. Neutrophil Inhibitory Factor
abrogates neutrophil adhesion by blockade of CD11a and CD11b β2 integrins. Molecular Pharmacol., 56:926932, 1999.
36
113. Ellis, C.A., A.B. Malik, A. Gilchrist, H. Hamm, R. Sandoval, T. Voyno-Yasenetskaya, and C. Tiruppathi.
Thrombin induces PAR-1 gene expression in endothelial cells via activation of Gi-linked Ras/MAPK pathway.
J. Biol. Chem., 274:13718-13727, 1999.
114. Liu, S.F., X. Ye., and A.B. Malik. Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents in vivo
expression of pro-inflammatory genes. Circulation, 100:1330-1337, 1999.
115. Liu, S.F, X. Ye, and A.B. Malik. Pyrrolidine dithiocarbamate prevents I-κB degradation and reduces
microvascular injury induced by lipopolysaccharide in multiple organs. Molecular Pharmacol., 5:658-667,
1999.
116. Rahman, A., K.N. Anwar, A.L. True, and A.B. Malik. Thrombin-induced p65 homodimer binding to downstream
NF-κB site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J. Immunol.
162:5466-5476, 1999.
117. Rahman, A., M. Bando, J. Kefer, K.N. Anwar, and A.B. Malik. Protein kinase C-activated oxidant generation in
endothelial cells signals intercellular adhesion molecule-1 gene transcription. Molecular Pharmacol., 55:575583, 1999.
118. Niles, W.D. and AB Malik: Endocytosis and exocytosis events regulate vesicle traffic in endothelial cells. J.
Membrane Biol. 167: 85-101, 1999.
119. Ellis, C. A., C. Tiruppathi, R. Sandoval, W.D. Niles, and A.B. Malik. Time course of recovery of endothelial cell
surface thrombin receptor (PAR-1) expression. Amer. J. Physiol. 276: C38-C45, 1999.
120. Yan, W., C. Tiruppathi, H. Lum, R. Qiao, and A.B. Malik. Protein kinase Cβ1 regulates heterologous
desensitization of thrombin receptor (PAR-1) in endothelial cells. Amer. J. Physiol. 274: C387-C395, 1998.
121. Rahman, A., J. Kefer, M. Bando, W.D. Niles, and A.B. Malik. E-selectin expression in human endothelial cells
by TNFα-induced oxidant generation and NF-κB activation. Amer. J. Physiol. 275: L533-L544, 1998.
122. Lu, Y-T., S.F. Liu, J.M. Mitchell, A.B. Malik, P.G. Hellewell, and T.W. Evans. The role of endogenous nitric
oxide in modulating ischemia-reperfusion injury in the isolated, blood perfused rat lung. Amer. Rev. Resp.
Crit. Care Med. 157: 273-279, 1998.
123. Vuong, P.T., A.B. Malik, P. G. Nagpala, and H. Lum. Protein kinase Cβ modulates thrombin-induced Ca2+
signaling and permeability increase. J. Cell. Physiol. 175: 379-387, 1998.
124. Zhou, M-Y., S.K. Lo, M. Bergenfeldt, C. Tiruppathi, H.A. Jaffe, and A.B. Malik. In vivo expression of
neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltraiton
and injury by a β2 integrin-dependent mechanism. J. Clin. Invest. 101: 2427-2437, 1998.
125. Aschner, J.L., H. Lum, P.W. Fletcher, and A.B. Malik. Bradykinin- and thrombin-induced increases in
endothelial permeability occur independently of phospholipase C but require protein kinase C activation. J.
Cellular Physiol. 173:387-396, 1997.
37
126. Tiruppathi, C., W. Song, M. Bergenfeldt, and AB Malik. Gp60 activation mediates albumin transcytosis in
endothelial cell by tyrosine kinase-dependent pathway. J. Biol. Chem. 272: 25968-25975, 1997.
127. Jaffe, H.A., P.G. Nagpala, J.C. Yu, Z. Gao, and A.B. Malik. Transfer and expression of Neutrophil Inhibitory
Factor gene in endothelial and epithelial cells prevents neutrophil adhesion. Chest 111: 94S-95S, 1997.
128. Aschner, J.L., H. Lum, P.W. Fletcher, and A.B. Malik. Transmembrane signalling and bradykinin-induced
increased endothelial permeability. J. Cellular Physiol. 173: 387-396, 1997.
129. Nguyen, L.T., H. Lum, C. Tiruppathi, and A.B. Malik. Site-specific thrombin receptor antibodies inhibit
thrombin-induced increases in [Ca2+]i and endothelial permeability. Amer. J. Physiol. 273: C1756-C1763,
1997.
130. Liu, S.F, X Ye, and A.B. Malik: In vivo inhibition of NF-κB activation prevents inducible nitric oxide synthase
expression and systemic hypotension in a rat model of septic shock. J. Immunol. 159: 3976-3983, 1997.
131. Ohno, S. and A.B. Malik. Polymorphonuclear leuckocyte (PMN) inhibitory factor prevents PMN-dependent
endothelial cell injury by an anti-adhesive mechanism. J. Cellular Physiol. 171:212-216, 1997
132. RayChaudhury, A., H. Frischer, and A.B. Malik. Inhibition of endothelial cell proliferation and bFGF-induced
phenotypic modulation by nitric oxide. J. Cellular Biochem. 63:125-134, 1996.
133. Siflinger-Birnholm, A., H. Lum, P.J. Del Vecchio, and A.B. Malik. Involvement of Ca2+ in the H2O2-induced
increase in endothelial permeability. Amer. J. Physiol. L973-l978, 1996.
134. Everitt, E.A., A. Malik and B. Hendey. Fibronectin enhances the migration rate of human neutrophils in vitro.
J. Leukocyte Biol. 60:199-206, 1996.
135. Barnard, J.W., M.G. Biro, S.K. Lo, S. Ohno, M. Moyle, H.R. Soule, and A.B. Malik. Neutrophil Inhibitory
Factor (CD11b/CD18 antagonist) prevents neutrophil-dependent lung injury. J. Immunology 155:4876-4881,
1996.
136. Yan, W., C. Tiruppathi, H. Lum, R. Qiao, and A.B. Malik. TNFα decreases the expression of proteolyticallyactivated thrombin receptor in endothelial cells. J. Cellular Physiol. 166: 561-567, 1996.
137. Nagpala, P.G., Vuong, P.T., Malik, A.B, and H. Lum. PKCβ1 overexpression augments phorbol ester-induced
increase in endothelial permeability. J. Cellular Physiol. 166:249-255, 1996.
138. Tiruppathi, C., A.Finnegan, and A.B. Malik. Isolation and characterization of a cell surface albumin binding
protein from vascular endothelial cells. Proc. Natl. Acad. Sci. (USA). 93: 250-254, 1996.
139. Roebuck, K., A. Rahman, V. Lakshminarayanan, K. Janakidevi and A.B. Malik. H2 O2 and tumor necrosis
factor-α activate intercellular adhesion molecule-1 (ICAM-1) gene transcription through distinct cis-regulatory
elements within the ICAM-1 promoter. J. Biol. Chem. 270:18966-18974, 1995.
140. Janakidevi, J., C.Tiruppathi, P.J. Del Vecchio, H.I. Magazine, J.M.B. Pinheiro, and A.B. Malik. Growth
characteristics of pulmonary artery smooth muscle cells from Fawn-Hooded rats: A model of pulmonary
hypertension. Amer. J. Physiol. 12: L465-L470, 1995.
38
141. Kaslovsky, R.A., K. Parker, A. Siflinger-Birnboim, and A.B. Malik. Increased endothelial permeability after
neutrophil activation occurs by a diffusion-dependent mechanism. Microvasc. Res. 49:227-232, 1995.
142. Qiao, R., W. Yan, H. Lum, C. Tiruppathi, and A.B. Malik. Arg-Gly-Asp peptide increases endothelial hydraulic
conductivity: Comparison with thrombin response. Amer. J. Physiol. 269:C110-C117, 1995.
143. Qiao, R., H.S. Wang, W. Yan, L.E. Odekon, P.J. Del Vecchio, T.J. Smith and A.B. Malik. Extracellular matrix
hyaluronan is a determinant of the endothelial barrier. Amer. J. Physiol. 269:C103-C109, 1995.
144. Magazine, H.E. A.B. Malik, C.A. Bruner, D. Shi, and T.T. Andersen. Vascular contractile potency of
endothelin-1 is increased in the presence of macrophages/monocytes. Amer. J. Physiol. 266:H1620-H1625,
1994.
145. Goligorsky, M.S., J. Simone, H. Magazine, T.T. Andersen, A.B. Malik, and W.F. Bahou. Termination of
endothelin signaling: Role of nitric oxide. J. Cellular Physiol. 158:485-494, 1994.
146. Lum, H., T.T. Andersen, J.W. Fenton II, and A.B. Malik. Thrombin receptor activation peptide induces
pulmonary vasoconstriction. Amer. J. Physiol. 35:C448-C454, 1994.
147. McCandless, B.K., R.P. Kaufman, Jr., J.A. Cooper, P.H. Neumann, and A.B. Malik. Lung neutrophil uptake
after endotoxin in rabbits is mediated by CD18-integrin dependent- and- independent mechanisms. Amer. J.
Physiol. 266:H1451-H1456, 1994.
148. Schnitzer, J.E., A. Siflinger-Birnboim, P.J. Del Vecchio, and A.B. Malik. Segmental differentiation of
permeability, protein, glycosylation, and morphology of cultured bovine pulmonary vascular endothelium.
Biochem. Biophy. Res. Com. 199:11-19, 1994.
149. Lum, H., L. Gibbs, L. Lai, and A.B. Malik. CD18 integrin-dependent endothial injury: Effects of opsonized
zymosan and phorbol ester activation. J. Leukocyte Biol. 55:58-63, 1994.
150. Lo, S.K., M.B. Bevilacqua, and A.B. Malik. E-selectin ligands mediate tumor necrosis factor-induced
neutrophil sequestration and edema in guinea pig lungs. Circ. Res. 75:995-960, 1994.
151. Siflinger-Birnboim, A., D.C. Bode and A.B. Malik. Adenosine 3'5'-cyclic monophosphate attenuates neutrophilmediated increase in endothelial permeability. Amer. J. Physiol. 264:H370-H375, 1993.
152. Siflinger-Birnboim, A., and A.B. Malik. Neutrophil adhesion to endothelial cells impairs the effects of catalase
and glutathione in preventing endothelial injury. J. Cellular Physiol. 155:234-239, 1993.
153. Palace, G.P., P.J. Del Vecchio, M.J. Horgan, and A.B. Malik. Release of tumor necrosis factor following
pulmonary artery occlusion and reperfusion. Amer. Rev. Resp. Dis. 147:143-147, 1993.
154. Horgan, M.J., G.P. Palace, J.E. Everitt and A.B. Malik. TNFα release in endotoxemia mediates neutrophildependent pulmonary edema. Amer. J. Physiol. 264:H1161-H1165, 1993.
155. Kaslovsky, R.A., L. Lai, K. Parker, and A.B. Malik. Mediation of endothelial injury following neutrophil
adherence to extracellular matrix. Amer. J. Physiol. 264:L401-L405, 1993.
39
156. Pinheiro, J.M.B. and A.B. Malik. Endothelin-1-induced mechanisms of pulmonary vasodilation in neonatal pigs.
J. Physiol. (London) 469:739-752, 1993.
157. Lum, H., T.T. Andersen, A. Siflinger-Birnboim, J.W. Fenton II, and A.B. Malik. Thrombin receptor peptide
inhibits thrombin-induced increase in endothelial permeability by receptor desensitization. J. Cell Biol.
120:1491-1499, 1993.
158. Pinheiro, J.M.B., T.T. Anderson, and A.B. Malik. Receptor mechanism of thrombin-mediated pulmonary
vasodilation in neonates. Amer. J. Physiol. 265: L355-L359, 1993.
159. Ishii, Y., Y. Wang, P.J. Del Vecchio, S.M. Goyert, and A.B. Malik. Lipopolysaccharide binding protein and
CD14 interaction induces TNFα generation and neutrophil sequestration in lungs following intratracheal
endotoxin. Circ. Res. 73:15-23, l993.
160. Qiao, R., A. Siflinger-Birnboim, H. Lum, C. Tiruppathi, and A.B. Malik. Albumin and Ricinus communis
agglutinin decrease endothelial permeability via interactions with the matrix. Amer. J. Physiol. 265:C439C446, l993.
161. Partridge, C.A., J.J. Jeffrey, and A.B. Malik. A 96 kD gelatinase induced by tumor necrosis factor α (TNFα)
promotes increased microvascular endothelial permeability. Amer. J. Physiol. 265:L438-L447, l993.
162. Lo, S.K., K. Janakidevi, L. Lai, and A.B. Malik. Hydrogen peroxide-induced increase in endothelial
adhesiveness is dependent on ICAM-1 activation. Amer. J. Physiol. 264:L406-L412, l993.
163. Abraham, W.M., A. Ahmed, A. Cortes, M.J. Spinella, A.B. Malik, and T.T. Andersen. A specific endothelin-1
antagonist blocks inhaled endothelin-1-induced bronchoconstriction in sheep. J. Appl. Physiol. 74:2537-2542,
1993.
164. Del Vecchio, P.J., A. Siflinger-Birnboim, P.N. Belloni, L.A. Holleran, H. Lum, and A.B. Malik. Culture and
characterization of pulmonary microvascular endothelial cells. In Vitro Cell Dev. Biol. 28:711-715, l992.
165. Sugama, Y. and A.B. Malik. Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity
and neutrophil adhesion by P-selectin dependent mechanism. Circ. Res. 71:1015-1019, 1992.
166. Palace, G.P., M.J. Horgan, and A.B. Malik. Generation of 5-lipoxygenase metabolites following pulmonary
reperfusion in isolated lungs. Prostaglandins 43:339-349, 1992.
167. Lum, H., D.A. Barr, J.R. Shaffer, R.J. Gordon, A.M. Ezrin, and A.B. Malik. Reoxygenation of endothelial cells
increases permeability by oxidant-dependent mechanisms. Circ. Res. 70:991-998, 1992.
168. Lo, S.K., P.J. Del Vecchio, H. Lum, and A.B. Malik. Fibrin contact increases endothelial permeability to
albumin. J. Cellular Physiol. 151:63-70, 1992.
169. Ryan, T.J., L. Lai, and A.B. Malik. Plasmin generation induces neutrophil aggregation: dependence on catalytic
and lysine-binding sites. J. Cellular Physiol. 151:255-261, 1992.
40
170. Ishii, Y., C.A. Partridge, P.J. Del Vecchio, and A.B. Malik. Tumor necrosis factor-α-mediated decrease in
glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2. J. Clin. Invest. 89:794815, 1992.
171. Ge, M., G. Tang, T.J. Ryan, and A.B. Malik. Fibrinogen degradation product fragment D induces endothelial
detachment by activation of cell-mediated fibrinolysis. J. Clin. Invest. 90:2508-2516, 1992.
172. Magazine, H.I., A.B. Malik, C.A. Bruner, and T.T. Andersen. Acetylated endothelin-1 is a constrictor in guinea
pig lung vasculature but not in isolated vascular strips. J. Expt. Pharmacol. Therapeutics. 260:632-636, 1992.
173. Tiruppathi, C., A.B. Malik, C.R. Keese, P.J. Del Vecchio, and I. Giaever. Electrical method for detection of
endothelial cell shape change in real time: Assessment of endothelial barrier function. Proc. Natl. Acad. Sci.
(USA) 89:7919-7923, 1992.
174. Partridge, C.A., F.A. Blumenstock, and A.B. Malik. Pulmonary microvascular endothelial cells constitutively
release xanthine oxidase. Arch. Biochem. Biophys. 294:184-187, 1992.
175. Kaufman, R.P., B.K. McCandless, and A.B. Malik. Neutrophil (PMN) CD18 integrin mediates endotoxininduced intrarenal PMN sequestration. Surg. Forum 43:732-734, 1992.
176. Lum, H., J.L. Aschner, P.G. Phillips, P.W. Fletcher, and A.B. Malik. Time course of thrombin-induced increase
in endothelial permeability: relationship to Ca2+i and inositol polyphosphates. Amer. J. Physiol. 263:L219L225, 1992.
177. Siflinger-Birnboim, A., M.S. Goligorsky, P.J. Del Vecchio, and A.B. Malik. Activation of protein kinase C
contributes to hydrogen peroxide-induced increase in endothelial permeability. Lab. Invest. 67:24-30, 1992.
178. Paty, P.K., P.F. Sherman, J.M. Shepard, A.B. Malik, and J.E. Kaplan. The role of adenosine in platelet-mediated
reduction in pulmonary vascular permeability. Amer. J. Physiol. 262:H771-H777, 1992.
179. Pinheiro, J.M.B. and A.B. Malik. K+ATP-channel activation causes marked vasodilation in the hypertensive
neonatal pig lung. Amer. J. Physiol. 262:H1532-1536, 1992.
180. Tiruppathi, C., H. Lum, T.T. Andersen, J.W. Fenton II, and A.B. Malik. The thrombin receptor 14-amino acid
peptide binds to endothelial cells and stimulates calcium transients. Amer. J. Physiol. 263:L595-L601, 1992.
181. Partridge, C.A., C.J. Horvath, P.J. Del Vecchio, P.G. Phillips and A.B. Malik. Influence of extracellular matrix
in tumor necrosis factor-induced increase in endothelial permeability. Amer. J. Physiol. 263:L627-L633, 1992.
182. Ishii, Y., S.K. Lo, and A.B. Malik. Neutrophil adhesion to TNFα-activated endothelial cells potentiates
leukotriene B4 production. J. Cellular Physiol. 153:187-195, 1992.
183. Lo, S.K., J.E. Everitt, J. Gu, and A.B. Malik. TNFα mediates pulmonary edema by ICAM-1 and CD18dependent mechanisms. J. Clin. Invest. 89:981-1005, 1992.
184. Janakidevi, K., M.A. Fisher, P.J. Del Vecchio, C. Tiruppathi, J. Figge, and A.B. Malik. Endothelin-1 stimulates
DNA synthesis and proliferation of pulmonary artery smooth muscle cells. Amer. J. Physiol. 263:C1295C1301, 1992.
41
185. Sugama, Y., C. Tiruppathi, K. Janakidevi, T.T. Andersen, J.W. Fenton II, and A.B. Malik. Thrombin-induced
expression of endothelial P-selectin and intercellular adhesion molecule-1: Mechanism for prolonging
neutrophil adhesion. J. Cell Biol. 119:935-944, 1992.
186. Magazine, H.I., T.T. Andersen, M.S. Goligorsky, and A.B. Malik. Evaluation of endothelin receptor populations
using endothelin-1 biotinylated at lysine-9 sidechain. Biochem. Biophys. Res. Com. 181:1245-1250, 1991.
187. Horvath, C.J., J.E. Kaplan, and A.B. Malik. Role of PAF in mediating TNFα-induced pulmonary
vasoconstriction and plasma-lymph transport. Amer. Rev. Resp. Dis. 144:1337-1341, 1991.
188. Lum, H., A. Siflinger-Birnboim, F.A. Blumenstock and A.B. Malik. Serum albumin decreases transendothelial
permeability to macromolecules. Microvasc. Res. 42:91-102, 1991.
189. Siflinger-Birnboim, A., J. Schnitzer, H. Lum, F.A. Blumenstock, C-P.J. Shen, P.J. Del Vecchio, and A.B. Malik.
Lectin binding to gp60 decreases albumin binding and transport in pulmonary artery endothelial monolayers.
J. Cellular Physiol. 149:575-584, 1991.
190. Gu, J., J.M.B. Pinheiro, M. D'Andrea, S. Muralidharan, and A.B. Malik. Detection of endothelin-like
immunoreactivity in epithelium and fibroblasts of the human umbilical cord. Tissue and Cell 23:437-444,
1991.
191. Fisher, M.A., P.J. Del Vecchio, G.P. Palace, E.M. Denholm, L. Lai and A.B. Malik. Thrombin-mediated release
of lipids from pulmonary artery endothelial cells promotes neutrophil adherence. Circ. Res. 68:930-939, 1991.
192. Ge, M., T.J. Ryan, H. Lum, and A.B. Malik. Fibrinogen degradation product fragment D increases endothelial
monolayer permeability. Amer. J. Physiol. 261:L283-L289, 1991.
193. Kaslovsky, R.A., L. Gibbs, and A.B. Malik. Neutrophils from chronic granulatomous disease fail to increase
endothelial permeability. Amer. J. Physiol. 261:H1226-H1230, 1991.
194. Horgan, M.J., M. Ge, J. Gu, R. Rothlein, and A.B. Malik. Role of ICAM-1 in neutrophil-mediated lung vascular
injury following reperfusion. Amer. J. Physiol. 261:H1578-H1584, 1991.
195. Spinella, M.J., A.B. Malik, J. Everitt, and T.T. Andersen. Design and synthesis of a specific endothelin-1
antagonists: effects on pulmonary vasoconstriction. Proc. Natl. Acad. Sci. 88:7443-7446, 1991.
196. Mullins, R.J., M.V. Tahamont, D.R. Bell and A.B. Malik. Effect of saline resuscitation from endotoxin shock
on lung transvascular fluid and protein exchange. Amer. J. Physiol. 260:H1415-H1423, 1991.
197. Horgan, M.J., J.M.B. Pinheiro, and A.B. Malik.
vasoconstriction. Circ. Res. 69:157-164, 1991.
Mechanisms of endothelin-1-induced pulmonary
198. McCandless, B.K., M.R. Powers, J.A. Cooper, and A.B. Malik. Effect of albumin on hydraulic conductivity of
pulmonary artery endothelial monolayers. Amer. J. Physiol. 260:L571-L576, 1991.
199. Gibbs, L.S., L. Lai, and A.B. Malik. Tumor necrosis factor enhances the neutrophil-dependent increase in
endothelial permeability. J. Cellular Physiol. 145:496-500, 1990.
42
200. Kaslovsky, R.A., H. Lum, N. Gilboa, B.K. McCandless, S.D. Wright, and A.B. Malik. Pulmonary edema
induced by phagocytosing neutrophils: Protective effect of monoclonal antibody against phagocyte CD18
integrin. Circ. Res. 67:795-802, 1990.
201. Lynch, J.J., T.J. Ferro, F.A. Blumenstock, A.M. Brockenauer and A.B. Malik. Increased endothelial albumin
permeability mediated by protein kinase C activation. J. Clin. Invest. 85:1991-1998, 1990.
202. Burgess, C.A., B.K. McCandless, J.A. Cooper, and A.B. Malik. Leukotriene B4 increases pulmonary
transvascular fluid filtration by a neutrophil independent mechanism. J. Appl. Physiol. 68:1260-1264, 1990.
203. Aschner, J.L., J.M. Lennon, J.W. Fenton II, M. Aschner, and A.B. Malik. Enzymatic activity is necessary for
thrombin-mediated increase in endothelial permeability. Amer. J. Physiol. 259:L270-L275, 1990.
204. Lo, S-K., R.R. Garcia-Szabo, and A.B. Malik. Leukocyte repletion reverses protective effect of neutropenia in
thrombin-induced increase in lung vascular permeability. Amer. J. Physiol. 259:H149-H155, 1990.
205. Horgan, M.J., S.D. Wright, and A.B. Malik. Antibody against leukocyte integrin (CD18) prevents reperfusioninduced lung vascular injury. Amer. J. Physiol. 259:L315-L319, 1990.
206. Daudi, I., T.M. Saba, M. Lewis, E. Lewis, F.A. Blumenstock, P. Gudewicz, A.B. Malik and J.W. Fenton.
Fibronectin fragments in lung lymph after thrombin-induced lung vascular injury. Lab. Invest. 61:539-547,
1989.
207. Moon, D.G., M.J. Horgan, T.T. Andersen, S.R. Krystek, Jr., J.W. Fenton II and A.B. Malik. Endothelin-like
pulmonary vasoconstrictor peptide released by α-thrombin. Proc. Natl. Acad. Sci. (USA) 86:9529-9533, 1989.
208. Phillips, P.G., H. Lum, A.B. Malik and M-F. Tsan. Phallacidin prevents the thrombin-induced increase in
endothelial permeability to albumin. Amer. J. Physiol. 257:C562-C567, 1989.
209. Garcia, R.R., J.W. Fenton II, S.K. Lo, M. Hussain, and A.B. Malik. Increased transvascular protein transport in
lungs induced by non-thrombogenic γ-thrombin. Amer. J. Physiol. 256:H1690-H1696, 1989.
210. Shepard, J.M., D. Moon, P.F. Sherman, L.K. Weston, P.J. Del Vecchio, F.L. Minnear, A.B. Malik and J.E.
Kaplan. Platelets decrease albumin permeability of pulmonary artery endothelial monolayers. Microvasc. Res.
37:256-266, 1989.
211. Perlman, M.B., A. Johnson, W. Jubiz, and A.B. Malik. Lipoxygenase products induce neutrophil activation and
increased endothelial permeability after pulmonary microembolism. Circ. Res. 64:62-73, 1989.
212. Powers, M.R., F.A. Blumenstock, J.A. Cooper and A.B. Malik. Role of arginyl sites in albumin-induced
reduction of endothelial conductivity. J. Cellular Physiol. 141:558-564, 1989.
213. Horgan, M.J., H. Lum and A.B. Malik. Pulmonary edema following pulmonary artery occlusion and
reperfusion. Amer. Rev. Resp. Dis. 5:1421-1428, 1989.
214. Lo, S.K., T.J. Ryan, N. Gilboa, L. Lai, and A.B. Malik. Plasmin induces neutrophil adherence to endothelium:
Role of catalytic and lysine-binding sites. J. Clin. Invest. 84:886-891, 1989.
43
215. Lum, H., P.J. Del Vecchio, A.S. Schneider, and A.B. Malik. Calcium dependence of the thrombin-induced
increase in endothelial albumin permeability. J. Appl. Physiol. 66:1471-1476, 1989.
216. Ferro, T.J., J.J. Lynch and A.B. Malik. Macrophages activated by fibrin microembolism increase albumin
permeability across pulmonary artery endothelium. Amer. Rev. Resp. Dis. 139:940-945, 1989.
217. Cooper, J.A. and A.B. Malik. Pulmonary transvascular flux of transferrin. J. Appl. Physiol. 67:1850-1854,
1989.
218. Ferro, T.J., A. Johnson, J. Everitt, and A.B. Malik. Recombinant interleukin-2 causes pulmonary edema and
vasoconstriction independent of circulating lymphocytes. J. Immunology 142:1916-1921, 1989.
219. Lo, S.K., L. Lai, J.A. Cooper, and A.B. Malik. Thrombin-induced generation of neutrophil-activating factors in
blood. Amer. J. Pathol. 130:22-32, 1988.
220. McCandless, B.K., J.E. Kaplan, J.A. Cooper and A.B. Malik. Determinants of platelet kinetics: Effects of
pulmonary microembolism. J. Appl. Physiol. 65:1716-1722, 1988.
221. Horvath, C.J., T.J. Ferro, G. Jesmok and A.B. Malik. Recombinant tumor necrosis factor increases pulmonary
vascular permeability independent of neutrophils. Proc. Natl. Acad. Sciences (USA) 85:9219-9223, 1988.
222. Garcia-Szabo, R., A. Johnson and A.B. Malik. Thromboxane increases pulmonary vascular resistance and
transvascular fluid and protein exchange after pulmonary microembolism. Prostaglandins 35:707-721, 1988.
223. Siflinger-Birnboim, A., J.A. Cooper, P.J. Del Vecchio, and A.B. Malik. Selectivity of the endothelial
monolayer: Effects of increased permeability. Microvasc. Res. 36:216-227, 1988.
224. Lo, S.K., K.E. Burhop, J.E. Kaplan, and A.B. Malik. Role of platelets in maintenance of pulmonary vascular
permeability to protein. Amer. J. Physiol. 254:H763-H771, 1988.
225. Hakim, T.S., and A.B. Malik. Hypoxic vasoconstriction in blood- and plasma-perfused lungs. Resp. Physiol.
72:109-122, 1988.
226. Burhop, K.E., W.M. Selig, and A.B. Malik. Monohydroxyeicosatraenoic acids induce pulmonary
vasoconstriction and edema. Circ. Res. 62:687-698, 1988.
227. Phillips, P., P.J. Higgins, A.B. Malik and M.F. Tsan. Effect of hyperoxia on the cytoarchitecture of cultured
endothelial cells. Amer. J. Pathol. 132:47-60, 1988.
228. Garcia, J.G.N., M.B. Perlman, T.J. Ferro, A. Johnson, William Jubiz and A.B. Malik. Inflammatory events after
fibrin microembolization. Amer. Rev. Resp. Dis. 137:630-635, 1988.
229. Chan, K., R. Bizios, and A.B. Malik. Enhancement of thrombin-induced chemiluminescence of neutrophils by
opsonized zymosan. Tissue and Cell 20:13-17, 1988.
230. Bizios, R., L.C. Lai, J.A. Cooper, P.J. Del Vecchio, and A.B. Malik. Thrombin-induced adherence of
neutrophils
to cultured endothelial monolayers: Increased endothelial adhesivity. J. Cellular Physiol.
134:275-280, 1988.
44
231. Selig, W.M., K.E. Burhop, J.G.N. Garcia and A.B. Malik. Substance P-induced pulmonary vasoreactivity in the
guinea pig lung: Mechanisms of the response. Circ. Res. 62:196-203, 1988.
232. Noonan, T.C., W.M. Selig, K.E. Burhop, C.A. Burgess, and A.B. Malik. Pulmonary microvascular response to
LTB4: Effects of perfusate composition. J. Appl. Physiol. 64:1989-1996, 1988
233. Cooper, J.A., S.K. Lo, and A.B. Malik. Fibrin is a determinant of pulmonary neutrophil sequestration. Circ.
Res. 63:735-741, 1988.
234. Burhop, K.E., W.M. Selig, D.A. Beeler, and A.B. Malik. Effect of heparin on increased pulmonary
microvascular permeability after bone marrow embolism. Amer. Rev. Resp. Dis. 136:134-141, 1987.
235. Siflinger-Birnboim, A., P.J. Del Vecchio, J.A. Cooper, F.A. Blumenstock, J. Shepard, and A.B. Malik.
Molecular sieving characteristics of the cultured endothelial monolayer. J. Cellular Physiol. 132:111-117,
1987.
236. Cooper, J.A., H. van der Zee, B.R. Line, and A.B. Malik. Relationship of positive end-expiratory pressure, lung
volume, and pulmonary epithelial clearance of 99mTc-DTPA. J. Appl. Physiol. 63:1586-1590, 1987.
237. Selig, W.M., K.E. Burhop, and A.B. Malik. Role of lipids in bone marrow-induced pulmonary edema. J. Appl.
Physiol. 62:1068-1075, 1987.
238. Bizios, R., L. Lai, J.W. Fenton II and A.B. Malik. Thrombin-induced thromboxane generation by neutrophils
and lymphocytes: Dependence on enzymic site. J. Cellular Physiol. 132:359-362, 1987.
239. Minnear, F.L., D. Martin, L. Hill, A.E. Taylor and A.B. Malik. Pulmonary vascular permeability and
morphologic changes induced by intravascular coagulation in lungs. Amer. J. Physiol. 253:H634-H644, 1987.
240. Cooper, J.A., P.J. Del Vecchio, F.L. Minnear, K.E. Burhop, W.M. Selig, J.G.N. Garcia, and A.B. Malik.
Measurement of albumin permeability across endothelial monolayers in vitro. J. Appl. Physiol. 62:10761083, 1987.
241. Shepard, J.M., S.K. Goderie, A.B. Malik, and H.K. Kimelberg. Effects of alterations in endothelial cell volume
on albumin permeability. J. Cellular Physiol. 133:389-394, 1987.
242. Perlman, M.B., A. Johnson and A.B. Malik. Ibuprofen prevents thrombin-induced lung vascular injury:
Mechanism of action. Amer. J. Physiol. 252:H605-H614, 1987.
243. Horgan, M.J., J.W. Fenton II and A.B. Malik. α-thrombin-induced pulmonary vasoconstriction. J. Appl.
Physiol. 63:1993-2000, 1987.
244. Johnson, A., S.K. Lo, F.B. Blumenstock and A.B. Malik. CVF-induced decomplementation: Effect on lung
transvascular protein flux after thrombin. J. Appl. Physiol. 62:863-869, 1987.
245. Noonan, T.C. and A.B. Malik. Pulmonary vascular response to leukotriene D4 in awake sheep: the role of
thromboxane. J. Appl. Physiol. 60:765-769, 1986.
45
246. Garcia, J.G.N., A. Siflinger-Birnboim, R. Bizios, P.J. Del Vecchio, J.W. Fenton II and A.B. Malik. Thrombininduced increase in albumin permeability across the endothelium. J. Cellular Physiol. 128:96-104, 1986.
247. van der Zee, H., J.A. Cooper, T.S. Hakim and A.B. Malik. Alterations in pulmonary fluid balance induced by
positive end-expiratory pressure. Respir. Physiol. 64:125-133, 1986.
248. Heath, C.A., L. Lai, R. Bizios and A.B. Malik. Pulmonary hemodynamic effects of anti-leukocyte serum
induced leukopenia. J. Leukocyte Biol. 39:385-397, 1986.
249. Perlman, M.B., S.K. Lo and A.B. Malik. Effects of prostacyclin on pulmonary transvascular fluid and protein
exchange after thrombin in awake sheep. J. Appl. Physiol. 60:546-553, 1986.
250. Lai, L. and A.B. Malik. Effect of tranexamic acid on neutrophil superoxide anion generation induced phorbol
myristate acetate. Thromb. Res. 41:269-247, 1986.
251. Selig, W.M., T.C. Noonan, D.F. Kern and A.B. Malik. Pulmonary microvascular responses to arachidonic acid
in the isolated perfused guinea pig lung. J. Appl. Physiol. 60:1972-1979, 1986.
252. Garcia, J.G.N., M. Perlman, P. Garcia, A. Malik and B. Keogh. Effects of BAL fluid on neutrophil function in
rheumatoid arthritis. Chest 89:151S-153S, 1986.
253. Noonan, T.C., W.M. Selig, D.F. Kern, and A.B. Malik. Mechanism of peptidoleukotriene-induced increases in
pulmonary transvascular fluid filtration. J. Appl. Physiol. 61:1928-1934, 1986.
254. Kern, D.F., K. Saldeen, T. Saldeen and A.B. Malik. Pulmonary vascular effects of a fibrin(ogen)-derived
vasoactive peptides. Thromb. Res. 42:783-788, 1986.
255. Mustafa, K.Y, W.M. Selig, K.E. Burhop, F.L. Minnear, and A.B. Malik. Hyperthermia-induced pulmonary
edema. J. Appl. Physiol. 60:1980-1985, 1986.
256. Siflinger-Birnboim, A., P.J. Del Vecchio, J.A. Cooper and A.B. Malik. Transendothelial albumin flux: Evidence
against asymmetric transport. J. Appl. Physiol. 61:2035-2039, 1986.
257. Cooper, J.A., P.J. Feustel, B.R. Line and A.B. Malik. Pulmonary epithelial clearance of 99MTc-DTPA after
thrombin-induced pulmonary microembolism. Am. Rev. Respir. Dis. 134:734-738, 1986.
258. Burhop, K.E., H. van der Zee, R. Bizios, J.E. Kaplan and A.B. Malik. Pulmonary vascular response to plateletactivating factor in awake sheep and the role of cyclooxygenase metabolites. Amer. Rev. Respir. Dis.
134:548-554, 1986.
259. Bizios, R., L. Lai, J.W. Fenton II and A.B. Malik. Thrombin-induced chemotaxis and aggregation of
neutrophils. J. Cellular Physiol. 128:485-490, 1986.
260. Cerda, J., R.E. Urizar, R. Conran, F.A. Blumenstock, J.E. Kaplan, A.B. Malik, and R. Simon. Disseminated
intravascular coagulation (DIC) induced by liquoid (polyanetholsulfonate) in the rat. V. Effects on circulating
fibronectin. Br. J. Expt. Path. 67:623-628, 1986.
46
261. Minnear, F.L., A. Johnson and A.B. Malik. β-adrenergic modulation of pulmonary transvascular fluid and
protein exchange. J. Appl. Physiol. 60:266-274, 1986.
262. Johnson, A., M.B. Perlman, F.A. Blumenstock and A.B. Malik. Superoxide dismutase prevents thrombininduced increase in lung vascular permeability: Role of superoxide anion in alterations in lung fluid balance.
Circ. Res. 59:405-415, 1986.
263. Garcia-Szabo, R.R., A. Johnson, and A.B. Malik. Leukocytes are required for the trypsin-induced increase in
lung vascular permeability. Amer. J. Pathol. 124:377-383, 1986.
264. Burhop, K.E., J.G.N. Garcia, W.M. Selig, S.K. Lo, H. van der Zee, J.E. Kaplan, and A.B. Malik. Platelet
activating factor increases lung vascular permeability to protein. J. Appl. Physiol. 61:2210-2217, 1986.
265. Johnson, A., J.A. Cooper, and A.B. Malik. Effect of complement activation with Cobra Venom Factor on
pulmonary vascular permeability. J. Appl. Physiol. 61:2202-2209, 1986.
266. Bizios, R., L. Lai, J.W. Fenton, S. Sonder and A.B. Malik. Thrombin-induced aggregation of lymphocytes:
nonenzymic induction by an hirudin-blocked thrombin exosite. Thromb. Res. 38:425-431, 1985.
267. Johnson, A. and A.B. Malik. Pulmonary transvascular fluid and protein exchange after thromboembolization:
Effects of cyclooxygenase inhibitors. Amer. Rev. Resp. Dis. 132:70-76, 1985.
268. Noonan, T., D.F. Kern and A.B. Malik. Pulmonary microcirculatory responses to leukotrienes B4, C4, and D4 in
sheep. Prostaglandins 30:419-439, 1985.
269. Lo, S.K., M. Perlman, G.D. Niehaus and A.B. Malik. Thrombin-induced alterations in lung fluid balance in
awake sheep. J. Appl. Physiol. 58:1421-1427, 1985.
270. van der Zee, H., R. Bizios and A.B. Malik. High frequency ventilation: Lack of effect of lung lymph dynamics
and prostaglandins. Respir. Physiol. 61:31-42, 1985.
271. Kern, D.F. and A.B. Malik. Microvascular albumin permeability in the isolated-perfused lung: Effects of EDTA.
J. Appl. Physiol. 58:372-375, 1985.
272. Cooper, J.A., R. Bizios and A.B. Malik. Pulmonary neutrophil kinetics in sheep: Effects of altered
hemodynamics. J. Appl. Physiol. 59:796-801, 1985.
273. Johnson, A., R. Garcia-Szabo, J.E. Kaplan and A.B. Malik. Fibrin degradation products increase lung
transvascular fluid filtration after thrombin-induced pulmonary microembolism. Thromb. Res. 37:543-554,
1985.
274. Garcia-Szabo, R., D.F. Kern and A.B. Malik. Pulmonary vascular response to thrombin: Effects of thromboxane
synthetase inhibition with OKY-046 and OKY-1581. Prostaglandins 28:851-866, 1984.
275. Cooper, J.A., S.J. Solano, R. Bizios, J.E. Kaplan and A.B. Malik. Pulmonary neutrophil kinetics after thrombininduced intravascular coagulation. J. Appl. Physiol. 57:826-832, 1984.
47
276. Garcia-Szabo, R.R., D.F. Kern, R. Bizios, J.W. Fenton II, F.L. Minnear, S.K. Lo and A.B. Malik. Comparison
of α- and γ-thrombin on lung fluid balance in anesthetized sheep. J. Appl. Physiol. 57:1375-1383, 1984.
277. Johnson, A., F.A. Blumenstock, M. Hussain and A.B. Malik. Differential effects of complement activation
induced by Cobra Venom Factor (CVF) on pulmonary transvascular fluid and protein exchange. Amer. J.
Pathol. 114:410-417, 1984.
278. Garcia-Szabo, R.R. and A.B. Malik. Pancreatitis-induced increase in lung vascular permeability: protective
effect of trasylol. Amer. Rev. Resp. Dis. 129:580-583, 1984.
279. Neumann, P.H., C.M. Kivlen, A. Johnson, F.L. Minnear and A.B. Malik. Effect of alveolar hypoxia on regional
pulmonary perfusion. J. Appl. Physiol. 56:338-342, 1984.
280. van der Zee, H., P.H. Neumann, F.L. Minnear and A.B. Malik. Effects of transient intracranial hypertension on
lung fluid and protein exchange. J. Appl. Physiol. 54:178-184, 1983.
281. van der Zee, H. and A.B. Malik. Relationship of pulmonary edema after hemorrhagic shock to intravascular
coagulation. Circ. Shock 10:91-100, 1983.
282. Minnear, F.L., P.S. Barie and A.B. Malik. Effects of transient increases in pulmonary vascular pressures on lung
fluid balance. J. Appl. Physiol. 55:983-989, 1983.
283. Tahamont, M.V. and A.B. Malik. Granulocytes mediate lung vascular injury after thrombin. J. Appl. Physiol.
54:1489-1495, 1983.
284. Johnson, A., F.A. Blumenstock, and A.B. Malik. Effect of complement depletion on lung fluid balance after
thrombin. J. Appl. Physiol. 55:1480-1485, 1983.
285. Bizios, R., F.L. Minnear, H. van der Zee and A.B. Malik. Effects of cyclooxygenase and lipoxygenase
inhibition on lung fluid balance after thrombin. J. Appl. Physiol. 55:462-471, 1983.
286. Minnear, F.L., C.M. Kivlen and A.B. Malik. Lack of increase in lung vascular permeability in sheep with
bradykinin. J. Appl. Physiol. 55:1079-1084, 1983.
287. Garcia-Szabo, R.R., M.B. Peterson, W.D. Watkins, R. Bizios, D.L. Kong and A.B. Malik. Thromboxane
generation after thrombin: Protective effect of thromboxane synthetase inhibition on lung fluid balance. Circ.
Res. 53:214-222, 1983.
288. Garcia-Szabo, R.R., F.L. Minnear, R. Bizios, A. Johnson and A.B. Malik. Role of thromboxane in the
pulmonary vascular response to pulmonary microembolization. Chest 83S:76S-78S, 1983.
289. Malik, A.B., A. Johnson, M.V. Tahamont, H. van der Zee and F.A. Blumenstock. Role of blood components in
mediating lung vascular injury after vascular thrombosis. Chest 83S:21S-24S, 1983.
290. Johnson, A., M.V. Tahamont and A.B. Malik. Thrombin-induced lung vascular injury: Role of fibrin and
fibrinolysis. Amer. Rev. Resp. Dis. 128:38-44, 1983.
48
291. Kivlen, C.M., A. Johnson, T. Pittman, A.E. Guile and A.B. Malik. Effect of converting enzyme inhibition on
pulmonary edema after microembolization. J. Appl. Physiol. 53:1546-1550, 1982.
292. Barie, P.S., M.V. Tahamont, F.A. Blumenstock and A.B. Malik. Prevention of pulmonary vascular injury after
acute pancreatitis by neutrophil depletion. Amer. Rev. Resp. Dis. 126:904-908, 1982.
293. Popp, A.J., D.J. Shah, R.A. Berman, W.H. Paloski, J.C. Newell, J.A. Cooper, M.E. Gottlieb, R.S. Bourke and
A.B. Malik. Delayed pulmonary dysfunction in head-injured patients. J. Neurosurgery 57:784-790, 1982.
294. Johnson, A., Kaplan, J.E., M.V. Tahamont and A.B. Malik. Lung fluid balance after pulmonary embolization:
Effects of thrombin versus fibrin aggregates. J. Appl. Physiol. 52:1565-1570, 1982.
295. Barie, P.S. and A.B. Malik. The role of intravascular coagulation and granulocytes in the lung vascular injury
after injection of bone marrow in sheep. Circ. Res. 50:830-838, 1982.
296. Malik, A.B., M.V. Tahamont, F.L. Minnear, A. Johnson and J.E. Kaplan. Lung fluid and protein exchange after
pulmonary vascular thrombosis: role of formed elements. Chest 815:54S-57S, 1982.
297. Tahamont, M.V., P.S. Barie, F.A. Blumenstock, M.H. Hussain and A.B. Malik. Increased lung vascular
permeability after pancreatitis and trypsin infusion. Amer. J. Pathol. 109:15-26, 1982.
298. Malik, A.B., R.J. Mullins, P.S. Barie, D.R. Bell and B.C. Lee. Thoracic duct lymph flow after pancreatitis: role
in circulatory collapse. Adv. in Shock Res. 8:81-90, 1982.
299. Malik, A. B. Effect of defibrinogenation on lung fluid and protein exchange after embolization. J. Appl.
Physiol. 53:895-900, 1982.
300. Barie, P.S. and A.B. Malik. Effect of pulmonary artery occlusion on lung fluid and protein exchange. J. Appl.
Physiol. 53:543-548, 1982.
301. Johnson, A. and A.B. Malik. Pulmonary edema after embolization: Protective effect of granulocytopenia. J.
Appl. Physiol. 52:155-161, 1982.
302. Minnear, F.L., D.L. Moon, J.E. Kaplan and A.B. Malik. Effect of ADP-induced platelet aggregation on lung
fluid balance in sheep. Amer. J. Physiol. 11:H645-H651, 1982.
303. Minnear, F.L., P.S. Barie and A.B. Malik. Effects of norepinephrine and epinephrine on lung fluid balance in
sheep. J. Appl. Physiol. 50:1353-1357, 1981.
304. Barie, P.S., F.L. Minnear and A.B. Malik. Increased pulmonary vascular permeability after bone marrow
injection in sheep. Amer. Rev. Resp. Dis. 123:648-653, 1981.
305. Minnear, F.L., P.S. Barie and A.B. Malik. Lung fluid and protein exchange in the acute sheep preparation. J.
Appl. Physiol. 50:1358-1361, 1981.
306. Johnson, A. and A.B. Malik. Effects of different-sized microemboli on lung fluid and protein exchange. J.
Appl. Physiol. 57:461-464, 1981.
49
307. Auen, E.F., A.B. Malik, L.R. Nelson, V. Foster, C. Kivlen and R.S. Bourke. Regional cerebral blood flow after
brain injury: response to hypoxia. J. Cerebral Blood Flow and Metab. 1:526-527, 1981.
308. Lee, B.C. and A.B. Malik. Mechanisms of pulmonary edema after acute pancreatitis. Amer. Rev. Resp. Dis.
123:618-621, 1981.
309. Barie, P.S., T.S. Hakim and A.B. Malik. Effects of pulmonary artery occlusion on extravascular fluid
accumulation. J. Appl. Physiol. 50:102-106, 1981.
310. Hakim, T.S., F.L. Minnear, H. van der Zee and A.B. Malik. Adrenoceptor control of lung fluid balance. J. Appl.
Physiol. 51:68-72, 1981.
311. Zwolak, R.M., A.B. Malik, E.S. Morrison and R.F. Scott. Regional coronary perfusion and bioenergetics in
experimental atherosclerosis. Amer. J. Pathol. 99:143-155, 1980.
312. van der Zee, H., A.B. Malik, B.C. Lee and T.S. Hakim. Increased lung vascular permeability during intracranial
hypertension: role of sympathetic mechanisms. J. Appl. Physiol. 48:273-280, 1980.
313. Malik, A.B., H. van der Zee and B.C. Lee. Inhibition of microembolization-induced pulmonary edema by
heparin in rats. Thromb. Res. 18:139-147, 1980.
314. Johnson, A. and A.B. Malik. Effect of defibrinogenation on extravascular lung water content after embolization.
J. Appl. Physiol. 49:841-845, 1980.
315. Malik, A.B. and S.E. Tracy. Bronchovascular adjustments after pulmonary microembolization. J. Appl. Physiol.
49:476-481, 1980.
316. Malik, A.B. and H. van der Zee. Regional pulmonary perfusion during edema. J. Appl. Physiol. 49:834-840,
1980.
317. Johnson, A. and A.B. Malik. Effect of granulocytopenia on lung extravascular fluid accumulation after
microembolism. Amer. Rev. Resp. Dis. 122:561-566, 1980.
318. Barie, P.S., F.L. Minnear, A.B. Malik and S.R. Powers, Jr. Fat embolism induced pulmonary edema in sheep.
Prevention by fibrinogen depletion. Surg. Forum 31:21-24, 1980.
319. Hakim, T.S., H. van der Zee and A.B. Malik. Effect of sympathetic nerve stimulation on pulmonary
transvascular fluid and protein exchange. J. Appl. Physiol. 47:1025-1030, 1979.
320. Lee, B.C., H. van der Zee and A.B. Malik. Pathogenesis of pulmonary edema in experimental acute pancreatitis.
Surg. Forum 30:420-422, 1979.
321. Johnson, A. and A.B. Malik. Effect of heparin on pulmonary edema after microembolization in rats. Thromb.
Res. 16:329-333, 1979.
322. Malik, A.B., B.C. Lee and H. van der Zee. Pulmonary transvascular fluid dynamics in sheep during hemorrhage.
Lymphology 12:149-158, 1979.
50
323. Malik, A.B., B.C. Lee, H. van der Zee and A. Johnson. The role of fibrin in the genesis of pulmonary edema
after embolization in dogs. Circ. Res. 45:120-125, 1979.
324. Lee, B.C., H. van der Zee and A.B. Malik. Site of pulmonary edema after regional pulmonary embolization. J.
Appl. Physiol. 47:556-560, 1979.
325. Malik, A.B. and H. van der Zee. Lung vascular permeability following progressive pulmonary
microembolization. J. Appl. Physiol. 45:590-597, 1978.
326. Abe, T., A.B. Malik, H. O'Kane and A.S. Geha. The effects of induced high cholesterol state upon normal and
hypertrophied rabbit heart. Jap. Circ. J. 42:1025-1031, 1978.
327. Malik, A.B. and H. van der Zee. Mechanism of pulmonary edema induced by microembolization. Circ. Res.
42:72-79, 1978.
328. Malik, A.B., D.J. Loegering, J. Kaplan and T.M. Saba. Cardiac output and its distribution following traumatic
shock. Circ. Shock 5:73-84, 1978.
329. Malik, A.B. Role of metabolic acidosis in the pulmonary vascular response to hemorrhage and shock. J.
Trauma 18:108-114, 1978.
330. Malik, A.B. and A.S. Geha. Coronary flow, cardiac function and myocardial O2 consumption in ventricular
hypertrophy induced by volume and pressure overloading. Cardiovasc. Res. 11:310-316, 1977.
331. Malik, A.B., J.A. Krasney and G.J. Royce. Respiratory influence on the total and regional cerebral blood flow
responses to intracranial hypertension in anesthetized dogs. Stroke 8:243-249, 1977.
332. Van Heuven, W.A.J., A.B. Malik, C.A. Schaffer, D. Cohen and M. Mehu. Retinal blood flow derived from dye
dilution curves. Arch. Ophthalmol. 95:297-301, 1977.
333. Zwolak, R.M., A.B. Malik, E.S. Morrison and R.F. Scott. Regional coronary vascular reserve in experimental
atherosclerosis. Circulation 46:111-137, 1977.
334. Malik, A.B. and H. van der Zee. Thrombin-induced pulmonary insufficiency. Thromb. Res. 11:497-502, 1977.
335. Malik, A.B. Coronary vascular adjustments in physical training. Cardiovasc. Med. 2:1137-1142, 1977.
336. Malik, A.B. and H. van der Zee. Time course of pulmonary vascular response to microembolization. J. Appl.
Physiol. 43:51-58, 1977.
337. Malik, A.B. Pulmonary vascular response to increase in intracranial pressure: role of sympathetic mechanisms.
J. Appl. Physiol. 42:335-343, 1977.
338. Malik, A.B. and J.C. Newell. Pulmonary perfusion and gas exchange in hemorrhage and shock. J. Appl.
Physiol. 42:279-286, 1977.
339. Malik, A.B., I.H. Chaudry, T. Abe and A.S. Geha. Effects of atherosclerosis on the hypertrophied rabbit heart.
Exp. Mol. Pathol. 25:293-300, 1976.
51
340. Malik, A.B. and B.S.L. Kidd. Pulmonary arterial wedge and left atrial pressures and the site of hypoxic
pulmonary vasoconstriction. Respiration 33:123-132, 1976.
341. Malik, A.B., J. Kaplan and T.M. Saba. Reference sample method for cardiac output and regional blood flow
determinations in the rat. J. Appl. Physiol. 40:472-475, 1976.
342. Malik, A.B. and J. Newmark. Adrenergic mechanisms and the pulmonary vascular response to respiratory
acidosis. Respiration 33:179-187, 1976.
343. Malik, A.B., W.A.J. van Heuven and L.F. Satler. Effects of isoproterenol and norepinephrine on regional ocular
blood flows. Invest. Ophthal. 16:492-495, 1976.
344. Malik, A.B. and A.S. Geha. Role of adrenergic mechanisms in the development of cardiac hypertrophy. Proc.
Soc. Exp. Biol. Med. 150:796-800, 1975.
345. Malik, A.B., J. Shapiro, J. Yankics, A. Rojales and A.S. Geha. A simplified method for producing rapid
ventricular hypertrophy in rats. Cardiovasc. Res. 8:801-805, 1974.
346. Malik, A.B. and A.S. Geha. Myocardial function and perfusion in cardiac hypertrophy induced by pressure and
volume overloading. Surg. Forum 26:246-247, 1974.
347. Malik, A.B., A.E. Baue, A.S. Geha and I.H. Chaudry. Distribution of high-energy phosphates in the heart. Proc.
Soc. Exp. Biol. Med. 145:1382-1385, 1974.
348. Malik, A.B., H. O'Kane and A.S. Geha. Cardiac performance in ventricular hypertrophy induced by pressure and
volume overloading. J. Appl. Physiol. 37:867-874, 1974.
349. Malik, A.B. and B.S.L. Kidd. The independent effects of changes in H+ and CO2 concentrations on pulmonary
hemodynamics. Can. J. Physiol. Pharmacol. 51:139-147, 1973.
350. Malik, A.B. and B.S.L. Kidd. Time course of pulmonary vascular response to hypoxia. Amer. J. Physiol.
224:1-6, 1973.
351. Malik, A.B. and B.S.L. Kidd. Independent effects of changes in H+ and CO2 concentrations on hypoxic
pulmonary vasoconstriction. J. Appl. Physiol. 34:318-323, 1973.
352. Malik, A.B., T. Abe, H. O'Kane and A.S. Geha. Cardiac function, coronary flow, and oxygen consumption in
stable left ventricular hypertrophy. Amer. J. Physiol. 225:186-191, 1973.
353. Geha, A.S., A.B. Malik, T. Abe and H. O'Kane. Response of the hypertrophied heart to stress. Surgery 74:276283, 1973.
354. O'Kane, H., A.S. Geha, R.E. Kleiger, T. Abe, M.T. Salaymeh and A.B. Malik. Stable left ventricular
hypertrophy in the dog; experimental production, time course and natural history. J. Thoracic Cardiovasc.
Surg. 65:264-271, 1973.
355. Abe, T., A.B. Malik, H. O'Kane and A.S. Geha. Effects of isoproterenol and l-norepinephrine on function,
coronary flow, and oxygen consumption of the intact left ventricle. Surgery 74:562-569, 1973.
52
356. Geha, A.S., T. Abe, I.H. Chaudry, A.B. Malik, H. O'Kane and A.E. Baue. Metabolism of high energy phosphate
compounds in stable hypertrophied myocardium. European Surg. Res. 5:14-15, 1973.
357. Malik, A.B. and B.S.L. Kidd. Adrenergic blockade and the pulmonary vascular response to hypoxia. Respir.
Physiol. 19:96-106, 1973.
53
B. Review Articles, Book Chapters, and Dissertations (*denotes peer-review)
1.
*Di A, Malik AB. TRP channels and the control of vascular function. Curr Opin Pharmacol. 2010 in press
2.
*Frey RS, Ushio-Fukai M, Malik AB. NADPH oxidase-dependent signaling in endothelial cells: role in
physiology and pathophysiology. Antioxid Redox Signal. 11:791-8, 2009.
3.
*Hecquet, C., and A. B. Malik. TRPM2 as an oxidant sensor in endothelial cells. Thrombosis and Haemostasis.
10:619-25, 2009
4.
Ushio-Fukai, M., R. S. Frey, T. Fukai, and A. B. Malik. Reactive oxygen species and endothelial permeability.
In Free Radical Effects on Membranes, Current Topics on Membranes, Vol 61, ed S. Matalon and R. P. Patel.
Elsevier. pp 148-177, 2008
5.
*Komarova, Y and A. Malik. FGF signaling preserves the integrity of endothelial adherens junctions.
Developemental Cell 15:335-6, 2008.
6.
*Vandenbroucke, E., D. Mehta, R. D. Minshall, and A.B. Malik. Regulation of endothelial junctional
permeability. Annal N. Y. Acad. Sci. 1123:134-45, 2008.
7.
*Komarova, Y. A., D. Mehta, and A. B. Malik. Dual regulation of endothelial junctional permeability. Science
STKE. 2007 Nov 13; 2007(412).
8.
*Predescu, S., D. Predescu and A. B. Malik. Molecular determinants of endothelial transcytosis and their role in
endothelial permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 293:L823-842, 2007.
9.
*Van Driessche, W., J. L. Kreindler, A. B. Malik, S. Margulies, S. A. Lewis, K. J. Kim. Interrelations/crosstalk
between transcellular transport function and paracellular tight junctional properties in lung epithelial and
endothelial barriers. Am. J. Physiol. Lung Cell. Mol. Physiol. 293:L520-L244, 2007.
10.
*Broman, M. B., D. Mehta and A. B. Malik. Cdc42 regulates the restoration of adherens junctions and
endothelial permeability. Trends in Cardiovascular Medicine. 17:151-156, 2007.
11.
Minshall, R.D. and A.B. Malik. Paracellular and transcellular control of endothelial permeability. In: The
Vascular Endothelium, Edited by S. Mondada and E.A. Higgs. Handbook Exp Pharmacol. (176 Pt 1):107-44,
2006.
12.
*Liu, SF, and A.B. Malik. NK-κB activation as a pathological mechanism of septic shock and inflammation.
Am. J. Physiol: Lung Cell Mol. Physiol. 290:L622-L645, 2006.
*Tiruppathi, C., G. U. Ahmmed, S. M. Vogel and A. B. Malik. Ca2+ signaling, Trp channels, and endothelial
permeability. Microcirculation 13:693-708, 2006.
*D. Metha and A. B. Malik. Signaling mechanisms regulating endothelial permeability. Physiological Reviews
86:279-367, 2006.
13.
14.
54
15.
Broman, M.T. and A.B. Malik. Cellular and molecular biology for intensivists: A primer. Endothelial Cells.
Crit. Care Med., 33:S517-9, 2005.
16.
Garcia, J. G. N. and A. B. Malik. Pulmonary circulation and regulation of fluid balance. In Textbook of
Respiratory Medicine, 3rd Edition, Edited by J.F. Murray and J.A. Nadel. W.B. Saunders, Philadelphia, pg. 119154, 2005.
17.
*Ahmmed G. U. and A. B. Malik. Functional role of TRPC channels in the regulation of endothelial
permeability. Pflugers Arch. 451:131-42, 2005.
18.
Minshall, R.D. and A.B. Malik. Paracellular and transcellular control of endothelial permeability. In: The
Vascular Endothelium, Edited by S. Mondada and E.A. Higgs. Handbook Exp Pharmacol. (176 Pt 1):107-44,
2006.
19.
*Predescu, D., S.M. Vogel and A. B. Malik. Functional and morphological studies of protein transcytosis in
continuous endothelia. Am. J. Physiol Lung Cell Mol Physiol. 287: L895-901, 2004.
20.
*Mehta D., Bhattacharya, J., Matthay M.A., and Malik A.B. Integrated control of lung fluid balance. Am. J.
Physiol. Cell Mol. Physiol. 287: L1081-L1090, 2004.
Frey, R.S. and A.B. Malik. Oxidant signaling in lung cells. Am. J. Physiol Lung Cell Mol Physiol. 286:L1-L3,
2004.
21.
22.
*Minshall, R.D., Sessa, W.C., Stan, R.V., Anderson, RGW, and A. B. Malik. Caveolin regulation of endothelial
function. Am. J. Physiol., Lung Cell. Mol. Physiol., 285:L1179-L1183, 2003.
23.
Mehta, D. R.D. Minshall, and A. B. Malik. Regulation of endothelial permeability: Contributions of paracellular
and transcellular pathways. Proceedings of American Heart Association Conference of Pro-inflammatory
Signaling Mechanisms. Editor J. Bhattacharya, Humana Press, 2005
24.
*Tiruppathi, C., R. D. Minshall., B. C. Paria., S. M. Vogel, and A. B. Malik. Role of Ca 2+ signaling in the
regulation of endothelial permeability. Vascular Pharmacology (Invited Review) 39: 173-185, 2002.
25.
*Kim, K. J. and A. B. Malik. Protein transport across lung epithelial barrier. Amer. J Physiol: Lung Cell Mol
Physiol. 284:L247-L259, 2003
26.
*Minshall, R.D., C. Tiruppathi, S. M. Vogel, and A. B. Malik. Vesicle formation and trafficking in endothelial
cells and regulation of endothelial barrier function. Histochemistry and Cell Biology 117: 105-112, 2002.
27.
*Vogel, S.M. and A.B. Malik. Albumin transcytosis in mesothelium:further evidence of a transcellular pathway
in polarized cells. Amer. J. Physiol. (Editorial Focus) 282: L1-L2. 2002.
28.
*Jie Fan, R. D. Ye and A. B. Malik. Transcriptional mechanisms of acute lung injury. Amer. J Physiol: Lung
Cell Mol Physiol. 281: L1037-1050, 2001.
29.
*Stevens, T., J. G. Garcia, D. M. Shasby, J. Bhattacharya, and A.B. Malik. Mechanisms regulating endothelial
cell barrier function. Amer. J. Physiol. 279: L419-L422, 2000.
55
30.
Malik, A.B., S.M. Vogel, R.D. Minshall, and C. Tiruppathi. Pulmonary circulation and regulation of fluid
balance. In Textbook of Respiratory Medicine, 3rd Edition, Edited by J.F. Murray and J.A. Nadel. W.B.
Saunders, Philadelphia, pg. 119-154, 2000.
31.
Lum, H. and A.B. Malik. Mechanisms of increased endothelial permeability. Can. J. Physiol. Pharmacol. 74:
787-800, 1996.
32.
Rahman, A, K.A. Roebuck and A.B. Malik. Transcriptional regulation of endothelial adhesion moleculed gene
expression by oxidants and cytokines. In: Nitric Oxide and Radicals in Pulmonary Vasculature. Proceedings of
the VII Grover Conference. Weir, E.K, Archer, S.L. and Reeves, J.T., Editors. Futura Publishing Co., NY. 6385, 1996.
33.
*Siflinger-Birnboim, A. and A.B. Malik. Regulation of endothelial permeability by second messengers. Soc.
Crit. Care Med. 4:87-98, 1996
34.
*Malik, A.B. and S.K. Lo. Vascular endothelial adhesion molecules and tissue inflammation. Pharmacological
Reviews. 213-229, 1996.
35.
Dull, R.O., H.A. Jaffe, M. Ge, T.J. Ryan and A.B. Malik. Pulmonary vascular endothelium and coagulation. The
Lung: Scientific Foundations. 2nd Edition, Edited by: R. Crystal, E. Weibel and J. West. Lippincott Williams &
Wilkins, New York, N.Y. chapter 44, pp 653-662, 1997
36.
Malik, A.B. The Society Pages: Research-in-Progress at Member Institutions of Central Society for Clinical
Research. J. Lab. and Clin. Med. 123:5-12, 1994.
37.
Crapo, J., A.B. Malik, B. Mossman, and D.B. Gail. In vivo cell biology. Amer. J. Respir. Crit. Care Med.
150:282-286, 1994.
38.
Malik, A.B., and P.J. Feustel. Pulmonary circulation and lung fluid and solute exchange. Textbook of
Respiratory Medicine. 2nd Edited by J.F. Murray and J.A. Nadel. W.B. Saunders, Philadelphia, pp. 139-171,
1994.
39.
Barnard, J.W. and A.B. Malik. Control of endothelial permeability in: Proceedings of XV International Society
for Heart Research. S. Harinso and K. Kjildsen, eds. Monduzzi Editore Bolgna, pp. 109-115, 1994.
40.
*Lum, H. and A.B. Malik. Regulation of vascular endothelial barrier function. Amer. J. Physiol. 267: L223L241, 1994.
41.
Weil, J.V., O. Castro, A.B. Malik, G. Rodgers, D.R. Bonds, and T.P. Jacobs. Pathogenesis of lung diseases in
sickle hemoglobinopathies. Amer. Rev. Resp. Dis. 148:249-256, l993.
42.
Malik, A.B., Endothelial cell interactions and integrins. In: New Horizons: Sepsis: Cellular and Physiologic
Mechanisms. Edited by E. Abraham. Society of Critical Care Medicine, Anaheim, CA. 1:37-51, 1993.
43.
Fenton, J.W. II, F. Ni, J.I. Witting, D.V. Brezniak, T.T. Andersen, and A.B. Malik. The rational design of
thrombin-directed anti-thrombotics in: The Design of Synthetic Inhibitors of Thrombin. G. Claeson, M.I. Scully,
V.V. Kakkar, eds., Plenum Press, New York, pp. 1-13, 1993.
56
44.
Malik, A.B. Cellular mechanisms of leukocyte adhesion. In: Pathophysiology of Shock, Sepsis and Organ
Failure. Springer-Verlag, Berlin. Edited by G. Schlag, pp. 61-78, 1993.
45.
Malik, A.B. and A. Siflinger-Birnboim. Vascular endothelial barrier function and its regulation. In: Biological
Barriers to Protein Delivery. Edited by K.L. Audus and T. Raub, Plenum Publishing Corp., New York, pp. 231268, 1993.
46.
Malik, A.B. and J.W. Fenton II. Thrombin-mediated increase in vascular endothelial permeability. Sem. Throm.
Hemostasis. 18:193-199, 1992.
47.
Garcia, J.G.N., J.L. Aschner, and A.B. Malik. Regulation of thrombin-induced endothelial barrier dysfunction
and prostaglandin synthesis. Thrombin: Structure and Function. Edited by L.J. Berliner, Plenum Publishing
Corp., New York pp. 397-430, 1992
48.
Magazine, H.I., A.B. Malik, C.A. Bruner, M.S. Goligorsky, and T.T. Andersen. Site specific biotinylation of
endothelin-1 potential use for characterization of endothelin receptor populations. In: Peptides: Chemistry,
Structure, and Biology. Edited by J.E. Rivier and G.R. Marshall. Proceedings of the 12th American Peptide
Symposium, Escom pp 427-428, 1992.
49.
Malik, A.B. Vascular endothelium in inflammation. Advances in Rheumatology and Inflammation. Edited by
R. Müller-Peddinghaus, Karger, Basel, Switzerland Vol. 2, pp. 83-106, 1992.
50.
Ge, M., T.J. Ryan, and A.B. Malik. Pulmonary endothelium and coagulation. In: The Lung: Scientific
Foundations. Edited by R.G. Crystal, J.B. West, P.J. Barnes, N.S. Cherniack, and E.R. Weibel, Raven Press,
New York, pp. 329-336, 1991.
51.
Malik, A.B. Molecular mechanisms of neutrophil-mediated pulmonary microvascular injury. In: The Pulmonary
Circulation and Acute Lung Injury. Futura Press, Mount Kisco, NY. Edited by S.I. Said. pp 333-540, 1991.
52.
Kaplan, E. and A.B. Malik. The contribution of platelets to pulmonary embolism. In: The Platelet in Health and
Disease. Edited by C.P. Page, Blackwell Scientific Publications, Oxford, pp 210-227, 1991.
53.
Malik, A.B. Molecular mechanisms of neutrophil-mediated pulmonary vascular injury: Role of adhesion
proteins. In: Shock, Sepsis and Organ Failure: 2nd Wiggers Symposium. Edited by G. Schlag, H. Redl, J.H.
Siegel and D.L. Traber, Springer-Verlag, Berlin, pp. 323-347, 1991.
54.
Fisher, M.A. and A.B. Malik. Interactions between neutrophils and endothelial cells mediate lung vascular
injury. Applied Cardiopulmonary Physiol. 4:175-189, 1991.
55.
Malik, A.B. Mediators of lung vascular injury. European Resp. J. 3(Suppl 11):499S-506S, 1990.
56.
Malik, A.B. Mechanisms of lung vascular injury and edema induced by pulmonary microembolism. Med. Princ.
and Pract. 2:1-9, 1990.
57.
Moon, D.G., M.J. Horgan, T.T. Andersen, S.R. Krystek, Jr., J.W. Fenton II, and A.B. Malik. Thrombin-induced
release of endothelin-like vasoconstrictive peptides from the pulmonary circulation. In: Endothelium-Derived
Contracting Factors (Editors: G.M. Rubanyi and P.M. Vanhoutte) Basel, Karger, pp 149-154, 1990.
57
58.
Malik, A.B. and A. Johnson. Role of humoral mediators in the pulmonary vascular response. In: Pulmonary
Vascular Physiology and Pathophysiology. Edited by E.K. Weir and J.T. Reeves. (Lung Biology in Health and
Disease series Exec. Ed. C. Lenfant). Marcel Dekker, Inc., New York 38:445-468, 1989.
59.
Del Vecchio, P.J. and A.B. Malik. Thrombin-induced neutrophil adhesion. In: Second Vienna Shock Forum.
Edited by G. Schlag and H. Redl, Alan R. Liss, Inc., New York. 308:101-112, 1989.
60.
*Malik, A.B., J.J. Lynch and J.A. Cooper. Endothelial barrier function. J. Invest. Dermatal. 93(Suppl):625-675,
1989.
61.
*Ferro, T.J., and A.B. Malik. Mechanisms of lung vascular injury and edema after pulmonary microembolism. J.
Crit. Care 4:118-126, 1989.
62.
*Malik, A.B. and C.J. Burgess. Mediators of lung vascular injury and edema after thrombin. Applied
Cardiopulmonary Pathophysiology. 2:5-11, 1988.
63.
*Malik, A.B., M.R. Powers, H. Lum, J.M. Shepard and Alma Siflinger-Birnboim. Endothelial monolayer
permeability. Applied Cardiopulmonary Pathophysiology. 2:131-140, 1988.
64.
Garcia, J.G.N., W. Jubiz and A.B. Malik. Leukotrienes and the pulmonary microcirculation. State-of-the-Art
Review. Amer. Rev. Resp. Dis. 136:161-169, 1987.
65.
Malik, A.B. Role of fibrin-neutrophil interactions in lung vascular injury. In: First Vienna Shock Forum. Edited
by G. Schlag and H. Redl, Alan R. Liss, Inc., New York pp 32-24, 1987.
66.
*Malik, A.B., and M. Horgan. Mechanisms of thrombin-induced lung vascular injury and edema. Amer. Rev.
Resp. Dis. 136:467-470, 1987.
67.
*Del Vecchio, P.J., A. Siflinger-Birnboim, J.M. Shepard, and A.B. Malik. Endothelial monolayer permeability to
macromolecules. Fed. Proc. 46:2511-2515,1987.
68.
Kaplan, J.E., and A.B. Malik. Thrombin-induced intravascular coagulation: Role in vascular injury. Sem.
Thromb. Hemost. 13:398-415, 1987.
69.
Malik, A.B. Neutrophil-dependent and -independent increases in endothelial permeability. In: Oxygen FreeRadical in Shock, edit. by G.P. Novelli, Karger Basel, pp 83-86, 1986.
70.
*Malik, A.B. Thrombin-induced endothelial injury. Sem. Thromb. Haemostasis 12:184-196, 1986.
71.
*Malik, A.B., S.K. Lo, and R. Bizios. Thrombin-induced alterations in endothelial permeability. Ann. N.Y.
Acad. Sci. 485:293-309, 1986.
72.
Malik, A.B., J.W. Fenton, A. Johnson, J. Cooper, R. Bizios and F.L. Minnear. Thrombin-induced pulmonary
microembolism: mechanisms of lung vascular injury. Chapter in "Acute Pulmonary Insufficiency. The Role of
Haemostatic, Fibrinolytic and Related Mechanisms." T. Saldeen (editor), Walter de Gruyter & Co., Berlin, pp.
33-61, 1985.
58
73.
*Malik, A.B., M. Perlman, J. Cooper, T. Noonan and R. Bizios. Pulmonary microvascular effects of arachidonic
acid metabolites and their role in lung vascular injury. Fed. Proc. 44:36-42, 1985.
74.
*Malik, A.B. Mechanisms of neurogenic pulmonary edema. Circulation Res. 57:1-20, 1985.
75.
Malik, A.B. Mediators of pulmonary vascular injury and edema after thrombin. In: The Pulmonary Circulation
and Acute Lung Injury. Edited by S.I. Said. Futura Publishing Co., Mount Kisko, N.Y. 1985, pp. 429-454.
76.
*Malik, A.B., W.M. Selig and K.E. Burhop. Cellular and humoral mediators of pulmonary edema. Lung
163:193-219, 1985.
77.
Malik, A.B., T.C. Noonan, W.M. Selig and J.G.N. Garcia. Effects of exogenous leukotrienes on the pulmonary
circulation. In: Leukotrienes in Cardiovascular and Pulmonary Function (Progress in Clinical and Biological
Research, Vol. 199). Edited by A.M. Lefer and M.L. Gee. Alan Liss, Inc., New York, pp. 221-235, 1985.
78.
Malik, A.B., J.G. Garcia, S.K. Lo, J.A. Cooper, M.B. Perlman and A. Johnson. Mechanisms of lung vascular
injury after thrombin. In: Acute Lung Injury: Pathogenesis of Adult Respiratory Distress Syndrome. H. Kazemi,
A. Hyman and P. Kadowitz (editors), P.S.G. Publishing Co., Littleton, MA, pp. 145-165, 1985.
79.
*Malik, A.B. and S.K. Lo. Thrombin-endothelial interactions: role in lung vascular injury. Molecular Aspects of
Medicine (edited by B. Fanburg). 8:515-554, 1985.
80.
Johnson, A., F.A. Blumenstock and A.B. Malik. Role of oxygen radicals in pulmonary vascular injury. In:
Oxygen Radicals in Chemistry and Biology, edited by W. Bors, M. Saran and D. Tait. Walter de Gruyter & Co.,
Berlin, New York, pp. 931-938, 1984.
81.
Malik, A.B. The role of fibrin-leukocyte interactions in the pathogenesis of shock lung. Thrombose und
hamostaseforschung E.A. Beck (editor). F.K. Schatter Verlag (New York) pp. 273-286, 1984.
82.
*Malik, A.B. and A. Johnson. Interactions between formed elements and the pulmonary endothelium. General
Pharmacol. 14:197-200, 1983.
83.
*Malik, A.B., F.L. Minnear and A.J. Popp. Catecholamine-induced pulmonary edema. General Pharmacol.
14:55-60, 1983.
84.
*Malik, A.B. (Review Article). Pulmonary edema after pancreatitis: role of humoral factors. Circ. Shock 10:7180, 1983.
85.
*Malik, A.B. Edema polmonare da pancretite: ruolo dei fattori umorali. Selezione Bibliografica Richter 1-9,
1983. (Italian translation of above paper).
86.
*Malik, A.B. Pulmonary microembolism. Physiological Reviews 63:1114-1207, 1983.
87.
*Malik, A.B. Mechanisms of lung vascular injury after intravascular coagulation. Ann. New York Acad. Sci.
384:213-234, 1982.
88.
*Barie, P.S. and A.B. Malik. Metabolic factors as mediators of lung vascular injury. Ann. New York Acad. Sci.
384:344-355, 1982.
59
89.
Malik, A.B. and N.C. Staub (editors). Mechanisms of Pulmonary Microvascular Injury. Annals of New York
Academy of Sciences, New York, 1982.
90.
Barie, P.S., M.V. Tahamont, F.A. Blumenstock and A.B. Malik. The role of neutrophils in the pathogenesis of
pulmonary vascular permeability after acute pancreatitis. Curr. Surg. 39:411-413, 1982.
91.
Nelson, L.R., E.L. Auen, R.S. Bourke, K.D. Barron, A.B. Malik et al. A comparison of animal head injury
models developed for treatment modality evaluation. In: Head Injury: Basic and Clinical Aspects: Seminars in
Neurological Surgery, edited by R.G. Grossman and P.L. Gildenberg. Raven Press, pp. 117-127, 1982.
92.
*Minnear, F.L. and A.B. Malik. Mechanisms of neurogenic pulmonary edema. Ann. New York Acad. Sci.
384:169-190, 1982.
93.
Carr, F.K., R.D. Goldfarb, D.J. Loegering and A.B. Malik. The effects of indomethacin on cardiovascular
adjustments during experimental myocardial ischemia. Advances in Shock Research, Volume I, Alan R. Liss,
New York, pp. 251-260, 1979.
94.
Malik, A.B., S.E. Tracy, T.S. Hakim and B.C. Lee. Bronchovascular alterations after embolism. Microvasc. Res.
12 (Pt. 2):590-591, 1979.
95.
Malik, A.B., D.J. Loegering, J.E. Kaplan and T.M. Saba. Regional blood flow following traumatic shock. In:
Microcirculation, Plenum Press, New York (Edited by J. Grayson and W. Zingg) 2:164-166, 1976.
96.
Malik, A.B. Studies on the pulmonary circulation. Ph.D. Thesis, University of Toronto, National Library of
Canada, Ottawa, Canada, 1971.
97.
Malik, A.B. Hypoxic pulmonary vasoconstriction. M.Sc. Thesis, University of Toronto, 1969.
60