Appendix 1 Studies to implement guidelines at hospitals Author Year Type Setting Target Comparison Anonymous[66] 1996 cba mixed 1 Number of patients 271 Intervention strategy treatment control group group ma re co mm ma re Post intervention % % treatment control 88 81 2 357 ma re ol mm or - 37 35 3 1 2 Hypertension treatment 1 Reduction of radiography ankle 1 injuries Measurement of occular 1 pressure Cervical smear done 2 Influenza vaccinations 1 Fecal occult blood testing 2 Recoding smoking status 3 Influenza vaccinations 1 Mammography 1 Treatment of depression 1 Reduction of x ray pelvimetry 1 10 preventive health measures 1 Influenza vaccinations 1 Stop smoking treatment 1 2 3 Urethral catheterisation 1 300 798 855 2157 2218 ma re co mm or ma me re fb or ma me re or ma me fb ol or ma me re - 84 49 55 7,20 76 71 51 51 4,70 99 361 re pm mm - 17,20 11,20 396 551 547 674 535 4612 175 249500 200 872 710 710 710 16959 re mm me re re pm mm or ma me fb me re mm fi ma re pm or ma me fb re me re ma me re fi ma me re pm ma me re ma me re fi pm re me mm fi me me ma me ma me ma me - 23,10 40 18 73 62 53 23 1,06 52 36 58 75 61 8,60 18,40 42 17 28 59 41 22 3,64 39 4 2 41 27 7,80 127 70 64 66 17852 17852 17852 17852 ma fb ma me re pm re pm ma me ma re or ma fb ma re ma rp or ma me me me - 76 58 36 24 10 13,30 20 18,90 51,60 25 25 25 21,10 21,10 21,10 21,10 Treatment of benign prostatic hyplasia History taken according to score form Urinalysis Prophylaxis for trombolism Anderson[29] 1994 rct in Aucott [38] Auleley[64] 1996 1997 rct rct out mixed Becker [55] 1989 rct out Belcher [58] 1990 rct out Brady [61] Burack [69] Callahan [52] Chassin[67] Cheney [39] Cohen [40] Cohen [41] 1988 1994 1994 1986 1987 1982 1987 rct rct rct rct rct rct rct out mixed out mixed out out out Danchaivijitr [34] Dranitsaris[33] Evans [70] 1992 rct in 1995 1996 rct rct in mixed Oncology, treatment Treatment of hypercholesterolaemie Fowkes [24] 1986 Cba in Reduction of preoperative chest X ray 1 1 2 3 1 2 3 4 1 Author Year Type Setting Target Comparison Girotti [35] Gonzalez [60] Hay[17] Headrick [57] 1990 1989 1997 1992 cba rct cct rct in out in out Herman [45] 1994 rct out Hopkins [62] 1980 cct mixed Lee [65] 1995 cct mixed Leviton[19] 1999 rct in Litzelman[42] Lomas[32] 1993 1991 rct rct out in MacCosbe[36] Marton[53] 1985 1985 rct rct in out McDonald[43] McDonald [51] Nattinger [48] 1984 1976 1989 rct rct cba out out out Antibiotic prescribing Preventive stool tests Guidelines on length of stay Compliance to cholesterol guidelines Pneumococcal vaccination Influenza vaccination Reduction of secondary operation Reducion of admission to coronary care unit Prescribing antenatal corticosteroids Diabetes referral to podiatrist Vaginal birth after previous cesarean section Antibiotic treatment Reduction of glucose test ordering Reduction of digoxin test ordering Reduction of digoxin test ordering Child care, recording history Diabetes self monitoring guidelines Diabetes guidelines on oral drugs Guidelines on preventive care Guidelines on test ordering Mammography Nilasena [49] Overhage [31] Overhage [18] Robie [47] Robinson [25] 1995 1996 1997 1988 1996 rct rct rct cba cba out in in out in Diabetes guidelines Preventive care actions Following corollary orders Preventive stool tests Trombolytic therapy Mayefski[46] Mazzuca[54] 1993 1990 rct cba out out 1 1 1 1 2 1 2 1 Number of patients 420 159 209 161 146 599 577 603 Intervention strategy treatment control group group re ma re re me re pm me me re me ma me pm rp ma me ma me pm ma me ma me - Post intervention % % treatment control 78 18 74 41 70 30 46,80 41,80 50,60 41,80 21,60 3,40 5,10 3,40 9 19 1 1921 re - 10 10 1 3149 ma 69,40 57,40 1 1 2 1 1 5407 2834 2499 339 246 ma me re fb or ol co re ma me ol fb co fb rp ma me fb re ma ma - 54 25,30 11,80 78 36 47 14,50 14,50 10 45 2 232 fb - 7 14 3 234 ma me - 9 14 1 1 1174 728 fb ma me re or ma me 73 14 60 6 2 3 1 1 1 2 1 1 1 1 1 96 96 12466 226 379 356 164 1622 2080 62 222 ma me re or ma me re re re fb re pm me re re ma re me re ma fb co ma me ma me me ma - 26 24 49 36,90 61,80 54,30 54,90 23 50,40 40 86 20 20 29 11,20 29,20 29,20 51 24 29 46 68 2 Author Year Type Setting Target Rogers [56] 1982 rct out Safran [59] Sommers [30] 1995 1984 rct rtc out in Soumerai [26] 1998 rct in Soumerai [28] 1993 rct in Struewing [37] 1991 cct out Szilagyi [68] 1996 rct mixed Thomas [44] Vissers [63] 1983 1996 rct rct out mixed Weingarten[20] 1994 cct in Weingarten [21] Weingarten [23] 1994 1996 cct cct in in Wirtschafter[27] 1986 rct in Zenni [50] 1996 rct out Hypertension, omitting potassium test Guideline on blood testing Management of anemia Treatment of myocardial infarction Guidelines on blood transfusion Cancer screening by sigmoidoscopy Cancer screening by rectal examination Guidelines on immunizations Guidelines on ambulatory care Guidelines on treatment behaviour Guidelines on congestive heart failure Guidelines on chest pain Guidelines on treatment of pneumonia Neonatal chest X rays Monitoring of infant blood pressure Guidelines on childhood development Comparison 2 3 4 1 Number of patients 200 173 188 479 Intervention strategy treatment control group group ma re fb ma re fb ma fb re - Post intervention % % treatment control 93 68 95 68 77 68 6,10 14,10 1 1 2 1 389 256 248 1117 re fb co fb ma me ol rp ma 89 26 51 80 74 35 35 78 1 786 ma me ou - 43 32 1 339 me re rp or - 4,70 3,20 2 339 me re rp or - 68,80 75,40 1 2 1 1 868 911 185 233 re re pm re ma re pm ma 68 60 50,25 49 65 62 37,30 30 1 90 re - 33 25 1 1 375 146 re re - 69 76 50 64 1 2 340 340 ma me ma me ma ma 49 2 40 7 1 140 re - 48 31 cba: controlled before and after study, rct: randomised controlled trial, cct: controlled clinical trial, Intervention or control strategies: ma: educational material, me: educational meeting, re: reminders, fb: feedback, ou: outreach visits, pm: patient mediated, ol: opinion leader, co: consensus meeting, rp: revision of professional roles, fi: financial, or: organisational. 3
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