PROBIO-K
Complex Powder
Maintain kidney function for CKD
Copyright © New Bellus Inc. All rights reserved.
Chronic Kidney Disease
Chronic kidney disease (CKD) is a progressive loss in kidney function over time that
can lead to kidney failure, also called end-stage renal disease, ESRD, which requires
dialysis or a kidney transplant to maintain life. Another consequence of CKD is that it
increases the risk of cardiovascular disease.
Chronic kidney disease
ESRD
Treatment
Proper Diet or Medication
ESRD
Dialysis Treatment
Kidney Transplant
There is no cure for chronic kidney disease, although treatment
can slow or halt the progression of the disease. In the recent
years, developing a simple and convenient adjuvant therapy with
low risk of side effect has been concerned.
PROBIO-K complex powder can help CKD patients to
maintain kidney function and reduce the risk of
cardiovascular disease
Feature
 The best three strains providing the best healing efficacy.
 Conduct stability assessment to ensure the quality of strains.
All probiotic strains are correct strains by using TAF-certified DAN sequencing method, and
are checked using API50 and PFGE strains as QC to avoid contamination and mutations.
 Has been proved to survive in gastric acid and bile salts
environment to reach and colonize in the intestine for proper
function.
Applied patented 5-layer micro-encapsulation protection.
Part I
Feature
 Complete safety assessment to ensure product cause no harm
to human body.
Evaluated by a clinical study. Probiotic strains tested for antibiotic resistance.
 Clinically proved to maintain kidney function for chronic kidney
disease patients.
 Reduce the risk of cardiovascular disease.
 Improve the quality of life for chronic kidney disease patients.
Part II
Exclusive Selected Strains
Lactobacillus
salivarius LS159
Lactococcus lactis
subsp. lactis LL358
Lactobacillus
pentosus LPE588
The best combination of strains to help
with treatment of chronic kidney disease
Clinically Proven
Lactococcus lactis
subsp. lactis LL358
Maintain Kidney Function
PROBIO-BAC® PROBIO-K was proved to maintain kidney function for
chronic kidney disease. Clinic trial indicated that taking PROBIO-K
complex powder would lower blood urea nitrogen level and uric acid.
Blood urea nitrogen (mg/dL)
7.6
(mg/dL)
Uric
尿酸acid
(mg/dL)
7.4
7.2
7
6.8
6.6
6.4
6.2
Before taking
PROBIO-K
Taking
PROBIO-K
for 12 weeks
6
0週taking
Before
PROBIO-K
12週
Taking
PROBIO-K
for 12 weeks
Note: As kidney function gets worse, the kidney cannot remove blood urea nitrogen and uric acid from blood normally.
Fig. The effect of BUN and uric acid change of the third & forth stage CDK patients.
Lower Blood Glucose Levels
Blood glucose (mg/dL)
PROBIO-BAC® PROBIO-K was clinically proved to lower blood glucose
levels with 65% of subjects. High blood glucose levels would increase
kidney burden, but PROBIO-K was proved to enhance kidney protection.
Before taking
PROBIO-K
Taking
PROBIO-K
for 12 weeks
Fig. The effect of blood glucose levels of the third & forth stage CDK patients.
Lower Triglyceride Levels
PROBIO-BAC® PROBIO-K was clinically proved to lower triglyceride
levels with 63% of subjects, reducing the risk of cardiovascular disease.
189
Triglyceride(mg/dL)
三酸甘油酯(mg/dL)
188
187
186
185
184
183
182
181
180
Before
0週taking
PROBIO-K
Taking
12週
PROBIO-K
for 12 weeks
Fig. The effect of triglyceride levels of the third & forth stage CDK patients.
Reduce Renal Toxicity
PROBIO-BAC® PROBIO-K was clinically proved to lower Indoxyl
Sulfate(IS). Indoxyl Sulfate is regarded as a marker of renal dysfunction,
also has a substantial role in the progression of CKD.
Toxicity
The percentage of
having improvement
IS
40.91%
Fig. The percentage of lowering IS levels of the third & forth stage CDK patients.
Improve the Quality of Life
PROBIO-BAC® PROBIO-K could help CDK patients to improve symptoms
of fatigue, cramp, sleeping difficulty, constipation, dizziness and itchy skin.
Symptom
The percentage of
having improvement
Fatigue
52.17%
Cramp
47.83%
Sleeping difficulty
39.13%
Constipation
34.78%
Dizziness
30.43%
Itchy skin
30.43%
Fig. The improvement of symptoms of the third & forth stage CDK patients.
Patented Technology
Patented 5-layer micro-encapsulation protection
(Patented No. M479761)
Durable protection
Lactic acid bacteria
Heat-resistant
Acid-resistant
Bile salt-resistant
Lysozyme-resistant,
Strong Colonization
Proved to survive in gastric acid and bile salts environment to reach and colonize in the intestine.
Certification
ISO22000
Patented No. M479761
HACCP
HALAL
GMP
ISO17025
Suitable For
 Keep a healthy kidney function
 Renal disease patient
Suggested Use
0.1~0.5 g/day (1.0~5.0╳1010CFU/day)
Supporting Document
 SPEC
 COA
 MSDS
 HALAL Certification
 DNA Verification
 Marketing Proposal