Title-affiliation !" # $ # % # & ! " # ! ! "# # # $ % ! " " " ") & "' ( "* !" # $$% % " " "' ! " + ,-./ 0 ") "* ! " + &0 / 1 2 3 4 ' 5# 6 4 + ! $ # " " &' ( $ # # ) " # 0 6 7 exp[ U / k BT ] B 7 1/ 2 exp[ ( T / T ) ] B 0 0 … we have to take into account the system characteristics … $ ! ! ! %&' + ! ( + ! ! ( ) ) ' * ! * 3 4 *5 ' ' 3 *5 Minor groove ~ 1.2 nm Major groove ~ 2.2 nm 0 - . -1. , / /2 (2) deoxyribose nucleic acid : 3 14 ;5 6 7 ! 8 % % ! & 9 )$ 3 4*5 3 *5 (3) deoxyribose nucleic acid 3 1=5 3 $=4 >5 < ! < ! ! 44 ) & ) : ! + & 3 14 ;5 < $4< 14 !# ) ! ! i(0) $1 ! 4< ? - Ai xi 8 *8 8 # * '-% ( -9 )8 *8 ) )-9-' 6 )-9-' 6 8 " - : @ ;0; <=< " " >"8 # * 8 " < " " " -?-@ " ( A-9 -*!B " B 9 -$* ( A* -B " >* ;.0 5# " ;. =,< C $ $# " ! + ! 1 4C 8 # ! ! ! A ! " D # 4 4 ! 4 ! + ? ! ) ) < % ! 4 4 8 ! ! * ?+ $ i) GMCM ii) Percolation B# * $# 6 $ 6 E B# $# 6 !! ! B B Wij0 equilibrium transition probability [ni0 (1 ni0 )]1/ 2 [n 0j (1 n 0j )]1/ 2 ( 5# 6 # # 66 ' # " + ,G " " & " &, + ,GH " " & &, F $ " 6 I- 6 $ D ( J-3-% Z ij " 5# " A-B- [( q 2 / k BT )(Wij0 )] (9 1 " "# " "# F D $ " -? -J * ;1 &, & ij 1/ 2 ) ji * ln h ln h 0 h 0 T T "# 2/3 ln l ln l 0 l 0 T T 1/ 2 % ' 4<4 A-9 !* T0h 4 " -8 4 4 $> &GG0 &,. &,;G 8.79 103 K rmh (227 K ) 11.4 A (~ 3 base pairs) rmh (342 K) 8.7 A (~ 2 base pairs) % : 4<4 A-9 T0h !* 4 " -8 4 4 $> &GG0 &,. &,;G 1.45 10 4 K rmh (178 K ) 18.8 A (~ 5 base pairs) rmh (306 K ) 13 A (~ 4 base pairs) 9 " " " " " K # 6 $ & K # 6 $ * "# L M T r K # 6 $ " " < & 0 < N -= 8 & N -< 9 ' 6 "@ " D N&-< N -& " " 9 6 D( $ (B >" '( # . / 0 "1 "4 3 . 2 3 5 % % % ' End. Thank you. # % # Bibliography – Sources Theory + Experiments Acrobat Document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ibliography –Sources ,-)-9-' 6 1- - ( .-C # <N (B " -9 & /( "# 1 ;;< =1 -1* ;10 <G0 Theory + Experiments S # S T $ # ## # "$ " A- -? " R D ( 9 -? - -@ ;;; <;G= Q-)-:# " V-B ( 9 -? - - &GG @D,G . ;-9- - ( 9 -? - -C ;.= &G=& W?- -B ( ?-O-O N -& ;., .== ( " 9 D 0- S ( 6 PP6 B Q-)-:# " V-B ( 9 -? - - &GG @D,G . &G-)-9-' 6 (B T "# > ;;< =1 # # " 9- - ( 9 -? -J >" T S6 $ # < T Some illustrations used in this talk were processed after copying from: 1. National Human Genome Research Institute (http://www.genome.gov/). All of the illustrations in the Talking Glossary of Genetics are freely available and may be used without special permission. 2. Wikipedia the free-content encyclopedia (http://en.wikipedia.org/).
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