C - Assiut University

CURRICULUM VITAE
Name:
Ikramy Abdel Raheem Khalil Ibraheem
Date of Birth: 7/12/1974
Place of birth: Tahta, Sohag, Egypt
Marital Status: Married
Military Service:
Status: Completed
Starting Date: December, 1997
Completion Date: February, 1999
Institute: Heliopolis Military Hospital – Heliopolis – Cairo – Egypt
Office Mailing Address:
Pharmaceutics Department – Faculty of Pharmacy – Assiut University – Assiut – Egypt
Home Mailing Address:
Al Marwa Tower, F11, Apartment Number 6 – Algomhuriya Street – Assiut – Egypt
Tel:
Home: (+20) 88-9201288
Mobile: (+20) 11-7545120
Email: [email protected]
Current Appointment:
Lecturer of Pharmaceutics - Pharmaceutics Department – Faculty of Pharmacy – Assiut
University – Assiut – Egypt
Language Ability:
English (Excellent) – Japanese (Good)
Academic Degrees:
1. Master in Pharmaceutical Sciences
Date Obtained: 25/3/2003
Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery
Institute: Hokkaido University – Sapporo – Hokkaido – Japan
Title: Octaarginine and Stearylated Octaarginine for Gene Delivery
2. Doctor of Philosophy in Pharmaceutical Sciences
Date Obtained: 24/3/2006
Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery
Institute: Hokkaido University – Sapporo – Hokkaido – Japan
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Title: Improved Cellular Uptake and Controlled Intracellular Trafficking of Liposomes by
Modification with Octaarginine Peptide for Drug and Gene Delivery
Higher Education:
1. Bachelor of Pharmaceutical Sciences
Institute: Faculty of Pharmacy – Assiut University - Assiut – Egypt
Starting Date: September, 1992
Completion Date: June, 1997
Grade: Excellent with Degree of Honor
2. Master of Pharmaceutical Sciences
Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery
Institute: Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo –
Hokkaido - Japan
Starting Date: April, 2001
Completion Date: March, 2003
3. Doctor of Philosophy in Pharmaceutical Sciences
Field: Molecular Design of Pharmaceutics – Drug and Gene Delivery
Institute: Graduate School of Pharmaceutical Sciences - Hokkaido University – Sapporo –
Hokkaido - Japan
Starting Date: April, 2003
Completion Date: March, 2006
Previous Employment:
1. From September, 1997 To December, 1997
Position: Demonstrator – Teaching Assistant
Institute: Pharmaceutics Department - Faculty of Pharmacy – Assiut University – Assiut –
Egypt
2. From January, 1998 To February, 1999
Position: Pharmacist
Institute: Heliopolis Military Hospital – Heliopolis – Cairo – Egypt
3. From March, 1999 To October, 2000
Position: Demonstrator – Teaching Assistant
Institute: Pharmaceutics Department - Faculty of Pharmacy – Assiut University – Assiut –
Egypt
4. From October, 2000 To March, 2001
Position: Research Student
Institute: Laboratory of Molecular Design of Pharmaceutics - Graduate School of
Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido – Japan
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5. From April, 2003 To March, 2006
Position: Research and Teaching Assistant
Institute: Laboratory of Molecular Design of Pharmaceutics - Graduate School of
Pharmaceutical Sciences - Hokkaido University – Sapporo – Hokkaido – Japan
6. From June, 2006 Till Present
Position: Lecturer of Pharmaceutics
Institute: Pharmaceutics Department – Faculty of Pharmacy – Assiut University – Assiut –
Egypt
Postgraduate Study:
1. From April, 1999 To September, 1999
Pre-master courses at Faculty of Pharmacy – Assiut University – Assiut –Egypt
Courses included:
Instrumental analysis, physical chemistry, laboratory safety, and statistical analysis
2. From October, 2000 To January, 2001
Pre-master courses at Graduate School of Pharmaceutical Sciences - Hokkaido University –
Sapporo – Hokkaido - Japan
Courses included:
Molecular biology and advanced pharmaceutics
Scholarships Awarded:
1.
A scholarship from the Egyptian Government to obtain Doctoral Degree from Japan
(October 2000 to March 2006)
2. A post-doctor research fellow from the Japan Society for the Promotion of Science
(JSPS) (September 2007 to September 2009)
Major Publications:
1. Ayman El-Sayed, Tomoya Masuda, Ikramy A. Khalil, Hidetaka Akita, and Hideyoshi Harashima.
Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion
independent endosomal escape. Journal of Controlled Release, 138, 160-167 (September, 2009).
2. Tomoko Higashi, Ikramy A. Khalil, Kaustabh K. Maiti, Woo Sirl Lee, Hidetaka Akita, Hideyoshi
Harashima, and Sung-Kee Chung. Novel lipidated sorbitol-based molecular transporters for
non-viral gene delivery. Journal of Controlled Release, 136, 140-147 (June 2009).
3. Hidetaka Akita, Asako Kudo, Arisa Minoura, Masaya Yamaguti, Ikramy A. Khalil, Rumiko
Moriguchi, Tomoya Masuda, Radostin Danev, Kuniaki Nagayama, Kentaro Kogure, and
Hideyoshi Harashima. Multi-layered nanoparticles for penetrating the endosome and nuclear
membrane via a step-wise membrane fusion process. Biomaterials, 30, 2940-2949 (May 2009).
4. El-Sayed A, Khalil I.A., Kogure K, Futaki S, and Harashima H. Octaarginine- and octalysinemodified nanoparticles have different modes of endosomal escape. J Biol Chem. 283:2345061. (August 2008)
5. Khalil I.A., Kogure K, Futaki S, Hama S, Akita H, Ueno M, Kishida H, Kudoh M, Mishina Y,
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Kataoka K, Yamada M, and Harashima H. Octaarginine-modified multifunctional envelopetype nanoparticles for gene delivery. Gene Ther. 14:682-9 (April 2007)
6. Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, and Hideyoshi Harashima. Octaargininemodified liposomes: Enhanced cellular uptake and controlled intracellular trafficking.
International Journal of Pharmaceutics, 354, 39-48 (April 2008).
7. Tianzhi Yang, Alamdar Hussain, Shuhua Bai, Ikramy A. Khalil, Hideyoshi Harashima, and
Fakhrul Ahsan. Positively charged polyethylenimines enhance nasal absorption of the
negatively charged drug, low molecular weight heparin. Journal of Controlled Release, 115,
289-297 (October 2006)
8. Akitada Iwasa, Hidetaka Akita, Ikramy A. Khalil, Kentaro Kogure, Shiroh Futaki, and Hideyoshi
Harashima. Cellular uptake and subsequent intracellular trafficking of R8-liposomes
introduced at low temperature. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758,
713-720 (June 2006)
9. Khalil, I.A., Kogure, K., Akita, H. & Harashima, H. Uptake pathways and subsequent
intracellular trafficking in nonviral gene delivery. Pharmacol Rev 58, 32-45 (March, 2006).
10. Khalil, I.A., Kogure, K., Futaki, S. & Harashima, H. High density of octaarginine stimulates
macropinocytosis leading to efficient intracellular trafficking for gene expression. J Biol
Chem 281, 3544-3551 (March, 2006).
11. Akita, H., Khalil, I.A., Kogure, K. & Harashima, H. Pharmacokinetic considerations in
nonviral gene delivery. In: Non-viral gene delivery: Gene Design and Delivery, SpringerVerlag, Tokyo 2005. Pages 135-154.
12. Mudhakir, D., Akita, H., Khalil, I.A., Futaki, S. & Harashima, H. Pharmacokinetic analysis of
the tissue distribution of octaarginine modified liposomes in mice. Drug Metab
Pharmacokinet 20, 275-81 (2005).
13. Khalil, I.A., Futaki, S., Niwa, M., Baba, Y., Kaji, N., Kamiya, H. & Harashima, H. Mechanism
of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular
association by hydrophobic core formation. Gene Ther 11, 636-44 (April, 2004).
14. Akita, H., Ito, R., Khalil, I.A., Futaki, S. & Harashima, H. Quantitative three-dimensional
analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene
delivery system using confocal laser scanning microscopy. Mol Ther 9, 443-51 (April, 2004).
Scientific Awards:
1. Best poster for young researchers – 2nd place – From the 9TH Liposome Research Days
(LRD) 2004 – Taiwan – May, 2004.
2. Nagai Konishi Student Award – From Nagai Foundation – Tokyo – Japan – September,
2005
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