th The 8 World Congress on Controversies in Ophthalmology (COPHy) Anterior Segment ● Glaucoma ● Retina Madrid, Spain, March 30 - April 1, 2017 www.comtecmed.com/cophy COMBINED TREATMENT WITH PHOTODYNAMIC THERAPY AND INTRAVITREAL ANTI-VGEF INYECTION FOR CIRCUMSCRIBED CHOROIDAL HEMANGIOMA: LONG-TERM (THREE YEARS) RESULTS 2 1 1 1 B. Domínguez García , A. José Gómez Escobar , M. Jesús Díaz Granda , F. Espejo Arjona , 1 I. Relimpio López 1 Ophthalmology, Hospital Virgen Macarena, Spain 2 Ophthalmology, Hospital Juan Ramón Jiménez, Spain Purpose: To evaluate the long-term efficacy of verteporfin photodynamic therapy (PDT) combined with intravitreal anti-VGEF injections (Bevacizumab) as the primary treatment for symtomatic choroidal hemangioma (CCH). Methods: Interventional case series. Ten subjects with CCH and evidence of exudative macular edema changes on optical coherence tomography (OCT). Five minutes after intravenously Verteporfin infusion, a 689 nm laser was applied with a intensity of 600 mW/cm2, light dose of 50 J/cm2 for 83 seconds. For two patients we used a intensity of 600 mW/cm2, light dose of 100 J/cm2 for 166 seconds. Retreatment were performed in case of persistent exudation found on OCT. Results: One patient received 1 PDT sessión, Four patients received 2 PDT session at 50J/cm2. Theree eyes treated with 50J/cm2 received 3 PDT session. One patient required 4 PDTs and another patient required 5 PDTs. After a follow up of three years, BCVA improved by 3 lines in 6 eyes, OCT showed the complete resolution of macular exudation in this casses and all tumors responded with a reduction in size (ultrasound). In 4 eyes, visual acuity did not increase and macular exudation on OCT was persistent. Conclusion: The theree-year results of combining PDT with anti-VGEF injections in treating symptomatic CCH support that this treatment is effective in terms of resolution of exudative subretinal fluid and recovery of VA in 60% of our casses, who needed 2.5 PDTs medium. In the other patients we must consider another modalities of treatment. Case selection and prognostic factors need to be defined so we could foresee the response to the treatment and consider another therapeutic strategy. Financial Disclosure: No
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