NEURONAL MEMBRANE PATCHES WITH
STOCHASTIC HODGKIN–HUXLEY
CHANNELS
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Mahmut Ozer, MuhammetUzuntarla, Matjaž Perc,
Lyle J.Graham
* Zonguldak Karaelmas University, Turkey
* University of Maribor, Slovenia
* Laboratory of Neurophysics and Physiology, France
* Journal of Theoretical Biology, 2009
VC Lab, Dept. of Computer Science, NTHU, Taiwan
SPIKE LATENCY AND JITTER OF
OVERVIEW
Introduction
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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Stochastic Resonance
 Neuron
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Na, K
Model and Methods
Simulation data
 Real data
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Conclusion
 Reference
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INTRODUCTION
Stochastic Resonance
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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•http://www.umsl.edu/~neurodyn/assets/pdf/VisualSR.pdf
INTRODUCTION
Neuron
VC Lab, Dept. of Computer Science, NTHU, Taiwan

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•http://www.nia.nih.gov/NR/rdonlyres/4E12F6CF-2436-47DB-8CC5-607E82B2B8E4/2372/neurons_big1.jpg
•http://people.eku.edu/ritchisong/301images/Neuron_action_potential.jpg
INTRODUCTION
Neuron
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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•http://www.nia.nih.gov/NR/rdonlyres/4E12F6CF-2436-47DB-8CC5-607E82B2B8E4/2372/neurons_big1.jpg
•http://faculty.washington.edu/chudler/ap.html
INTRODUCTION
Na, K
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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•http://people.eku.edu/ritchisong/301images/potassiumchannel_ionflow.jpg
MODEL AND METHODS
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Hodgkin and Huxley model (H-H)
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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Noise
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MODEL AND METHODS
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Mean Latency(ML)
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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Standard Deviation of the Latencies
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RESULTS
Dependence of latency and jitter on channel noise
during spontaneous firing
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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RESULTS
Dependence of latency and jitter on channel noise
and input frequency
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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RESULTS
Dependence of latency and jitter on the initial
input phase
VC Lab, Dept. of Computer Science, NTHU, Taiwan
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CONCLUSION
VC Lab, Dept. of Computer Science, NTHU, Taiwan
NDD(noise delayed decay)
 Low-pass filter in subthreshold regions
 Channels may enhance the range of input
frequencies for effective detection of first spikes
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REFERENCE
VC Lab, Dept. of Computer Science, NTHU, Taiwan
http://people.eku.edu/ritchisong/301notes2.htm
 Daqing Guo, Chunguang Li, Stochastic and
coherence resonance in feed-forward-loop
neuronal network motifs, Physical Review E 79,
2009
 http://beaver.dlc.ncnu.edu.tw/projects/emag/show.
aspx?dataId=f594b906-2b27-11d4-b17f0050bae32d5f
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