26.01.2015
REQUEST 1: To summarize the suggestions, the reviewer examined closely the
references used and recommends that the author re-structure these so that
they are accurate and so that ideas that you are referring to from other
sources are receiving appropriate credit. Furthermore, please ensure that
you are assigning the correct references to the intended text. It is
important to note that the onus is on the author to ensure that the
references are matched appropriately to the text they are intending to cite. DONE
REQUEST 2: In addition, given the nature of the figures in your manuscript, we request
that you provide us with the original files from which these figures were
generated. Please bear with us as this is an important step for us to verify
the authenticity of the figures as your own so that we can maintain
transparency in our journal: DONE
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Figure 1. The mitochondrial respiratory chain
Generated from:
El-Khoury R, Kemppainen KK, Dufour E, Szibor M, Jacobs HT et al.. Engineering the
alternative oxidase gene to better understand and counteract mitochondrial defects: state
of the art and perspectives. British journal of pharmacology 2014; 171(8): 2243-2249.
Figure 1.
And
Bayir H, Kagan VE. Bench-to-bedside review: Mitochondrial injury, oxidative stress and
apoptosis – there is nothing more practical than a good theory. Critical Care 2008; 12(1):
206.
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Figure 2.The Polyol Pathway in Hyperglycemia.
Generated from:
Yadav UCS, Srivastava SK, Ramana KV. Understanding the Role of Aldose Reductase in
Ocular Inflammation. Curr Mol Med.2010; 10(6): 540-549.
Figure 2, or click this link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912437/figure/F2/
And
Chung SS, Ho EC, Lam KS, Chung SK. Contribution of polyol pathway to diabetes-induced
oxidative stress. Journal of the American Society of Nephrology 2003; 14(suppl 3): 233-236.
Figure 3. Hyperglycemia The Role of Protein Kinase C Activation in Diabetes Complications
Generated from:
Geraldes P, King GL. Activation of Protein Kinase C Isoforms & Its Impact on Diabetic
Complications. Circulation research 2010; 106(8): 1319-1331.
REQUEST 3: Finally, our journal has recently introduced a new policy for all articles
published in upcoming issues. We now require that each manuscript include a
senior researcher (an individual with formal training in research) who can
verify the article and appear as an author on the manuscript. We request
this as it provides an additional expert's perspective which is an integral
component for review articles. Having a senior author will add to the
visibility of your manuscript and increase the impact the article will
generate in the scientific field by further validating the study. As a
result, we strongly encourage you to include a senior researcher as an
author on your manuscript.
I contacted Dr. Marten Szibor from the Research Program of Molecular Neurology, University of Helsinki,
Biomedicum Helsinki 1, Haartmanninkatu 8, 00290, Finland to be the senior author. His research group
focuses on mitochondrial gene expression, including AOX expression, which is also discussed in my
review.
I am awaiting his response.
REQUEST 4: Include previous editions of your manuscript as attachments in an email so
that we may be able to verify the references and style of the manuscript
prior to proceeding with acceptance.