From: Endothelium-independent Vasoconstricting and Vasodilating Actions of Halothane on Rat Mesenteric Resistance
Blood Vessels
Anesthes. 1995;82(1):221-235.
Figure Legend:
Figure 3. (A) Caffeine (25 mM)-induced vasoconstriction is blocked by halothane (HAL) in a concentration-dependent manner. The
vasoconstricting response to caffeine is shown before halothane (Carbon sub 1) and 5 min after initiating continuous halothane
(Carbon2) at each halothane concentration tested (0.17–4.66 mM). (B) The concentration-response relationship for the effect of
halothane on caffeine-induced constrictions is shown (closed triangle). The percent maximal response represents the magnitude of
the caffeine response during halothane divided by the control response ([Carbon28 Carbon sub 1] x100) at each halothane
concentration
(plus/minus
The fit ©
to2017
a HillAmerican
equationSociety
(solid line)
yielded an IC 50All
of 1.6
mM;
the cooperativity factor was
Date of download:
7/31/2017SEM, n = 4).
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of Anesthesiologists.
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reserved.
1.9. For comparison, the concentration-response data for the vasoconstricting effect of halothane are also shown (closed square).