Discussion leader: Andreas Meyer 11:40 12:00 SPP1710: “Dynamics of Thiol-based Redox Switches in Cellular Physiology” GBM Study Group “Redox Biology” 12.15 Sunday, 21.09.2014 12:30 Roland Lill, Marburg Redox events in the biogenesis of iron-sulfur proteins Wilhelm Voth, Göttingen GET3 functions as ATP-independent chaperone under oxidative stress conditions Rudi Glockshuber, Zürich Reduction of ScoI and CoxB by the periplasmic thioredoxin TlpA 09:40 10.00 10:15 10:30 15.00-18.30: Young investigator meeting SPP 1710: “Team building”, meet at the “Brückenaffe, Alte Brücke” 19:00: Get-together Kulturbrauerei Heidelberg Session 2: Discovery of new thiol switches Discussion leader: Karl-Josef Dietz 10:45 Coffee break 14:20 11:15 Discussion: Redox in the future: What are tomorrow’s questions? 12:00 Poster session II. 15:00 Monday, 22.09.2014 09:00 Katja Becker and Hannes Herrmann Welcome Session 1: Defined thiol switches Discussion leader: Tobias Dick 09:10 09:50 10:10 10:30 10.50 Neil Bulleid, Glasgow Redox regulation and disulfide formation in the endoplasmic reticulum Leopold Flohé, Magdeburg Half a century with glutathione peroxidases Luise Krauth-Siegel, Heidelberg GPx-type enzymes protect trypanosomes from subcellular membrane damages Marcus Conrad, Munich The Cys/GSH/GPx4 axis in control of cell death and degenerative disease Ivan Bogeski, Homburg/Saar The interplay between ORAI channels and NADPH oxidase 2 15:20 15:35 15.50 16.05 Coffee break Nicolas Rouhier, Nancy Plant glutaredoxins: iron or redox players? Helmut Sies, Düsseldorf Metabolic H2O2 generation: role in redox signaling and oxidative stress Gaetano Calabrese, Kaiserslautern Redox regulation in the mitochondrial intermembrane space Martin Gruhlke, Aachen Unravelling the physiological effects of the redox-toxin allicin from garlic Peng Wang, Berlin Thiol-based redox control of tetrapyrrole biosynthesis in higher plants Eva-Maria Hanschmann, Greifswald Nrx interaction partners in cellular (de)differentiation Session 3: Engineered thiol switches Discussion leader: Blanche Schwappach 13.30 14.50 Martin Kerschensteiner, Munich In vivo analysis of mitochondrial redox signals in nervous system pathology Frank Böhmer, Jena Oxidation of protein tyrosine phosphatases in acute myeloid leukemia cells Marina Rubini, Konstanz Acceleration of protein folding by a single amino acid replacement in thioredoxin Franziska Mohring, Giessen Determination of the glutathione redox potential in subcellular compartments of Plasmodium falciparum Bruce Morgan, Heidelberg Investigating cellular H2O2 homeostasis with ultra-sensitive genetically-encoded probes Closing remarks 15:00 End of the symposium 13:50 14:05 14.20 16:30 19:00 Bus to Castle tour Dinner Haus Buhl Tuesday, 23.09.2014 14:35 Discussion leader: Sabine Zachgo 09:00 11:10 Poster session I. The dangerous life of periplasmic proteins, electrons to the rescue Lars Leichert, Bochum Functional metagenomics of the thioredoxin superfamily Isabel Aller, Bonn Characterization of the ER-oxidoreductases ERO1 and ERO2 from Arabidopsis thaliana Nora Gutsche, Osnabrück Interactions of ROXYs with TGA transcription factors during the evolution of land plants Andrea Viehauser, Bielefeld Cysteinyl residues in redox-related functions of cyclophilin Cyp20-3 Jean-François Collet, Brussels
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