Networks Igor Segota Statistical physics presentation Introduction • Network / graph = set of nodes connected 1 by edges (lines) 2 • The edges can be either undirected 3 or directed (with arrows) 5 • Random network = have N nodes and M edges placed between random pairs 4 - simplest mathematical model 6 • The mathematical theory of networks originates from 1950’s [Erdos, Renyi] • In the last 20 years abundance of data about real networks: – Internet, citation networks, social networks – Biological networks, e.g. protein interaction networks, etc. Introduction • Network / graph = set of nodes connected 1 by edges (lines) 2 • The edges can be either undirected 3 or directed (with arrows) 5 • Random network = have N nodes and M edges placed between random pairs 4 - simplest mathematical model 6 • The mathematical theory of networks originates from 1950’s [Erdos, Renyi] • In the last 20 years abundance of data about real networks: – Internet, citation networks, social networks – Biological networks, e.g. protein interaction networks, etc. Statistical measures • How to systematically analyze a network? Define: • Degree: number of neighbors of each 3 node “i”: qi • Average degree: <q> [over all nodes] • Degree distribution – probability that a randomly chosen node has exactly q neighbors: P(q) 1 2 5 4 6 Is there a notion of “path” or “distance” on a network? • Path length, or node-to-node distance: How many links we need to pass through to travel between two nodes ? Characterizes the compactness of a network “Scale-free” networks • If we look at the real world networks, e.g.: a) WWW, b) movie actors, c,d) citation networks, phone calls, metabolic networks, etc.. • They aren’t random – the degree distribution follows a power law: P(q) = A q-γ with 2 ≤ γ ≤ 3 • They do not arise by chance! • Examples: – WWW, publications, citations • Can we get an intuitive feeling for the network shape, given some statistical measure? Network comparison NP-complete problems on networks NP-complete problem Problem such that no solution that scales as a polynomial with system size is known. Directed Hamiltonian Path problem – Find a sequence of one-way edges going through each 3 node only once. • DNA computation: 1 2 4 5 6 NP-complete problems on networks NP-complete problem Problem such that no solution that scales as a polynomial with system size is known. Directed Hamiltonian Path problem – Find a sequence of one-way edges going through each 3 node only once. • DNA computation: 1 = TATCGGATCGGTATATCCGA 1 2 4 5 6 2 = GCTATTCGAGCTTAAAGCTA … • What about the edges ? [Aldeman; 1994.] NP-complete problems on networks CATATAGGCT CGATAAGCGA TATCGGATCGGTATATCCGA GCTATTCGAGCTTAAAGCTA 1 2 • For each pair of nodes, construct a corresponding edge • Due to directionality of DNA, edge orientation is preserved and 1->2 is not equal to 2->1 • Idea: generate all possible combinations of all possible lengths then filter out the wrong ones NP-complete problems on networks Generate Keep 1… …6 12354546 12354546 1235456 1235456 1246 1246 Keep those containing all 1,2,3,4,5,6 Keep len=6 1 2 23 124546 124546 124546 4 3 5 31235 1231 123546 4546 123546 123546 123546 6 Emergent phenomena on networks • Critical phenomena: an abrupt emergence of a giant connected cluster [simulation] • Analogous to the effect in percolation theory (in fact it is exactly the same effect…) p=0.1 p=0.2 p=0.3 p=0.4 p=0.45 p=0.47 p=0.49 p=0.5 p=0.51 0.53 0.55 p=0.6 p=0.7 p=0.8 p=0.9 Network percolation experiments Living neural networks [Breskin et. al., 2006] • Nodes = cells, edges = cell extensions + transmitting molecules • Rat brain neurons grown in a dish, everyone gets connected • Put a chemical that reduces the probability of neuron firing (disables edge) [effectively adjusts the <q>]
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