SINO-DANISH BREAST CANCER RESEARCH CENTRE
Full list of peer reviewed publications for 2012, 2011, 2010, and 2009
Publications marked ‘1’: at least two Danish partners
Publications marked ‘2’: Danish/Chinese partner(s)/co-authorship
Peer reviewed publications 2012
No. Year
1
Author, Title, Place of publication, page number(s)
1
or
2
2
2012 N.H. Staunstrup, J. Madsen, M.D.N.L. Primo, J. Li, Y. Liu, P. Kragh, R. Li,
M. Schmidt, S. Purup, F. Dagnæs-Hansen, L. Svensson, T.K. Petersen, H.
Callesen, L. Bolund & J.G. Mikkelsen.
Development of transgenic cloned pig models of skin inflammation by DNA
transposon-directed ectopic expression of human β1 and α2 integrin.
PLoS One 7, 5 (2012) 1-18
PR/
2
2012 P. Zhang, Y. Zhang, H. Dou, J. Yin, Y. Chen, X. Pang, G. Vajta, L. Bolund,
Y. Du & R.Z. Ma.
Handmade cloned transgenic piglets expressing the nematode fat-1 gene
Cellular Reprogramming 14, 3 (2012) 258-266.
PR/
CO
2
3
2012 Y. Hou, L. Song, P. Zhu, B. Zhang, Y. Tao, X. Xu, F. Li, K. Wu, J. Liang, D.
Shao, H. Wu, X. Ye, C. Ye, R. Wu, M. Jian, Y. Chen, W. Xie, R. Zhang, L.
Chen, X. Liu, X. Yao, H. Zheng, C. Yu, Q. Li, Z. Gong, M. Mao, X. Yang, L.
Yang, J. Li, W. Wang, Z. Lu, N. Gu, L. Goodman, L. Bolund, K. Kristiansen,
J. Wang, H. Yang, Y. Li, X. Zhang & J. Wang
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative
myeloproliferative neoplasm.
Cell 148, 5 (2012) 873-885.
PR/
CO
2
4
2012 X. Xu, Y. Hou, X. Yin, L. Bao, A. Tang, L. Song, F. Li, S. Tsang, K. Wu, H.
Wu, W. He, L. Zeng, M. Xing, R. Wu, H. Jiang, X. Liu, D. Cao, G. Guo, X.
Hu, Y. Gui, Z. Li, W. Xie, X. Sun, M. Shi, Z. Cai, B. Wang, M. Zhong, J. Li,
Z. Lu, N. Gu, X. Zhang, L. Goodman, L. Bolund, J. Wang, H. Yang, K.
Kristiansen, M. Dean, Y. Li & J. Wang
Single-cell exome sequencing reveals single-nucleotide mutation
characteristics of a kidney tumor.
Cell 148, 5 (2012) 886-895.
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2
5
2012 J. Li, K. Wang, F. Gao, T.D. Jensen, S.T. Li, P.M. Deangelis, S. Kølvraa, C.
Proby, O. Forslund, L. Bolund & O.P.F. Clausen.
Array comparative genomic hybridization of keratoacanthomas and
squamous cell carcinomas: Different patterns of genetic aberrations
suggest two distinct entities.
Journal of Investigative Dermatology 132, 8 (2012) 2060-2066.
PR/
CO
2
6
2012 Y. Luo, L. Lin, L. Bolund, T.G. Jensen & C.B. Sørensen
PR/
2
1
CO
Genetically modified pigs for biomedical research.
Journal of Inherited Metabolic Disease 35, 4 (2012) 695-713.
CO
7
2012 Y. Luo, E. Kofod-Olsen, R. Christensen, C.B. Sørensen & L. Bolund.
Targeted Genome Editing by Recombinant Adeno-Associated Virus (rAAV)
Vectors for Generating Genetically Modified Pigs.
Journal of Genetics and Genomics 39, 6 (2012) 269-274.
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2
8
2012 C.B. Søresen, Y. Luo & L. Bolund
Recombinant AAV-mediated homologous recombination in nuclear donor
cells for SCNT cloning in pigs.
Transgenic Research 21, 4 (2012) 904-905.
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2
9
2012 J.F. Bentzon, C.B. Sørensen, R.H. Al-Mashhadi, P.M. Kragh, L.B. Nielsen,
J. Li, L. Lin, Y. Liu, B. Moldt, M. Schmidt, T. Thim, G. Vajta, S. Purup, L.
Bolund, H. Callesen, J.G. Mikkelsen & E. Falk.
Hypercholesterolemic minipigs created by liver-specific expression of a
PCSK9 gain-of-function mutant.
Transgenic Research 21, 4 (2012) 910-911.
311
2012 Y. Luo, L. Bolund & C.B. Sørensen.
Pig gene knockout by rAAV-mediated homologous recombination:
comparison of BRCA1 gene knockout efficiency in Yucatan and Göttingen
fibroblasts with slightly different target sequences.
Transgenic Res. 21(2012) 671-676, doi: 10.1007/s11248-011-9563-1.
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2
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2
2012 M.A.M. Groenen, A.L. Archibald, H. Uenishi, C.K. Tuggle, Y. Takeuchi, M.F.
Rothschild, C. Rogel-Gaillard, C. Park, D. Milan, H-J. Megens, S. Li, D.M.
Larkin, H. Kim, L.A.F. Frantz, M. Caccamo, H. Ahn, B.L. Aken,
A. Anselmo, C. Anthon, L. Auvil, B. Badaoui, C.W. Beattie, C. Bendixen,
D. Berman, F. Blecha, J. Blomberg, L. Bolund, M. Bosse, S. Botti, B. Zhan,
M. Bystrom, B. Capitanu, D. Carvalho-Silva, P. Chardon, C. Chen, R.
Cheng, S-H. Choi, W. Chow, R.C. Clark, C. Clee, R.P.M.A. Crooijmans,
H.D. Dawson, P. Dehais, F. De Sapio, B. Dibbits, N. Drou, Z-Q. Du, K.
Eversole, J. Fadista, S. Fairley, T. Faraut, G.J. Faulkner, K.E. Fowler, M.
Fredholm, E. Fritz, J.G.R. Gilbert, E. Giuffra, J. Gorodkin, D.K. Griffin,J.L.
Harrow, A. Hayward, K. Howe, Z-L Hu, S.J. Humphray, T. Hunt,H.
Hornshøj, J-T. Jeon, P. Jern, M. Jones, J. Jurka, H. Kanamori,
R. Kapetanovic, J. Kim, J-H. Kim, K-W. Kim, T-H. Kim, G. Larson, K. Lee,
K-T. Lee, R. Leggett, H.A. Lewin, Y. Li, W. Liu, J.E. Loveland, Y. Lu,
J.K. Lunney, J. Ma, O. Madsen, K. Mann, L. Matthews, S. McLaren,
T. Morozumi, M.P. Murtaugh, J. Narayan, D.T. Nguyen, P. Ni, S-J. Oh,
S. Onteru, F. Panitz, E-W. Park, H-S. Park, G. Pascal, Y. Paudel, M. PerezEnciso, R. Ramirez-Gonzalez, J.M. Reecy, S. Rodriguez-Zas, G.A.
Rohrer,L. Rund, Y. Sang, K. Schachtschneider, J.G. Schraiber, J. Schwartz,
L. Scobie, C. Scott, S. Searle, B. Servin, B.R. Southey, G. Sperber, P.
Stadler, J.V. Sweedler, H. Tafer, B. Thomsen, R. Wali, J. Wang, J. Wang,
S. White, X. Xu, M. Yerle, G. Zhang, J. Zhang, J. Zhang, S. Zhao, J.
Rogers,C. Churcher & L.B. Schook.
Analyses of pig genomes provide insight into porcine demography and
evolution.
Nature 491, 7424, (2012) 393-398.
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2
10
11
2
12
2012 J. Blechingberg, Y. Luo, L. Bolund, C.K. Damgaard & A.L.Nielsen
Gene Expression Responses to FUS, EWS, and TAF15 Reduction and
Stress Granule Sequestration Analyses Identifies FET-Protein NonRedundant Functions.
PLoS One 7, 9 (2012) e46251.
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13
2012 L. Andreasen, L. Bolund, I. Niemann, E.S. Hansen & L. Sunde.
Mosaic moles and non-familial biparental moles are not caused by
mutations in NLRP7, NLRP2 or C6orf221.
Molecular Human Reproduction 18, 12 (2012) 593-8.
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14
2012 J. Li, X. Lin, N. Brünner, H. Yang & L. Bolund
Novel Methods in the Study of the Breast Cancer Genome:
Towards a Better Understanding of the Disease of Breast Cancer
Journal of Cancer Therapy 3 (2012) 797-809.
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2
15
2012 Y. Li, X. Xu, L. Song, Y. Hou, Z. Li, S. Tsang, F. Li, K. McGee, K. Wu,
H. Wu, X. Ye, G. Li, L. Wang, B. Zhang, J. Liang, W. Xie, R. Wu, H. Jiang,
X. Liu, C.Yu, H. Zheng, M. Jian, L. Nie, L. Wan, M. Shi, X. Sun, A. Tang, G.
Guo, Y. Gui, Z. Cai, J. Li, W. Wang, Z. Lu, X. Zhang, L. Bolund,
K. Kristiansen, J. Wang, H. Yang, M. Dean & J.Wang
Single-cell sequencing analysis characterizes common and cell-lineagespecific mutations in a muscle-invasive bladder cancer.
GigaScience 1, 12 (2012) doi:10.1186/2047-217X-1-12.
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2
16
2012 X. Fang, Y. Mu, Z. Huang, Y. Li, L. Han, Y. Zhang, Y. Feng, Y. Chen,
X. Jiang, W. Zhao, X. Sun, Z. Xiong, L. Yang, H. Liu, D. Fan, L. Mao,
L. Ren, C. Liu, J. Wang, K. Li, G. Wang, S. Yang, L. Lai, G. Zhang, Y. Li,
J. Wang, L. Bolund, H. Yang, J. Wang, S. Feng, S. Li & Y. Du.
The sequence and analysis of a Chinese pig genome.
GigaScience 1, 16 (2012) doi:10.1186/2047-217X-1-16
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2
17
2012 Gromova I, Gromov P, Kroman N, Wielenga VT, Simon R, Sauter G,
Moreira JM.
Immunoexpression analysis and prognostic value of BLCAP in breast
cancer.
PLoS One. 2012;7(9):e45967. doi: 10.1371/journal.pone.0045967. Epub
2012 Sep 25
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18
2012 Jespersen H, JH Andersen, HJ Ditzel, and Mouritsen.
Lipids, curvature stress, and the action of lipid prodrugs:
Free fatty acids and lysolipid enhancement of drug transport across
liposomal membranes.
Biochimie. 94:2-10, 2012.
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19
2012 Gravgaard KH, M Lyng, A-V Laenkholm, R Søkilde, BS Nielsen, T Litman,
HJ Ditzel.
The miRNA-200 family and miRNA-9 exhibit differential expression in
primary vs. corresponding metastatic tissue in breast cancer.
Breast Cancer Res Treat, Epub 2012 Feb.
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3
2
1
20
2012 Regan M, B Leyland-Jones, M Bouzyk, Biasi, B Thuerlimann, M Lyng, HJ
Ditzel, P Neven, M Debled, R Maibach, K Price, R Gelber, A Coates, A
Goldhirsch, J Rae, G Viale.
CYP2D6 and response to tamoxifen for endocrine-responsive early breast
cancer: the BIG 1-98 trial.
J Natl Cancer Inst. 104:441-451, 2012.
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21
2012 Lund RR, MG Terp, A-V Laenkholm, ON Jensen, R Leth-Larsen, HJ Ditzel.
Quantitative proteomics of primary tumors with varying metastatic
capabilities using stable isotope-labeled proteins of multiple histogenic
origins.
Proteomics, 12:2139-2148, 2012.
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22
2012 Lyng M, A-V Laenkholm, R Søkilde, KH Gravgaard, T Litman, HJ Ditzel.
Global microRNA expression profiling of high-risk ER+ breast cancers from
patients receiving adjuvant Tamoxifen mono-therapy: a DBCG study.
PLoS One, 2012;7(5):e36170.
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23
2012 Leth-Larsen R, MG Terp, AG Christensen, D Elias, T Kühlwein, ON Jensen,
OW Petersen, HJ Ditzel.
Functional heterogeneity within the CD44 high human breast cancer stem
cell-like compartment reveals a gene signature predictive of distant
metastasis.
Mol Med. 18: 1109-1121, 2012.
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24
2012 Terp MG, RR Lund, ON Jensen, R Leth-Larsen, HJ Ditzel.
Identification of markers associated with highly aggressive metastatic
phenotypes using quantitative comparative proteomics.
Cancer Genomics & Proteomics, 9:265-273, 2012.
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25
2012 Gjerstorff MF, HI Rösner, CB Pedersen, KB Greve, S. Schmidt, D Elias,
Wilson KL, J Mollenhauer, H Besir, FM Poulsen, NE Møllegaard, HJ Ditzel.
GAGE Cancer-germline antigens are recruited to the nuclear envelope by
germ cell-less (GCL). PLoS One, 2012;7(9):e45819.
doi: 10.1371/journal.pone.0045819. Epub 2012 Sep 20.
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2012 Alvheim, A.R., Malde, M.K., Osei-Hyiaman, D., Lin, Y.H., Pawlosky, R.,
Madsen, L., Kristiansen, K., Frøyland, L. & Hibbeln, J.R (2012).
Dietary linoleic acid elevates endogenous 2-1 AG and anandamide inducing
obesity.
Obesity 20, 1984-94. doi: 10.1038/oby.2012.38
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27
2012 Petersen, R.K., Larsen, S.B.; Jensen, D.M., Christensen, J., Olsen, A., Loft,
S., Nellemann, C., Overvad, K., Kristiansen, K., Anne Tjønneland, A. &
Vogel, U. (2012).
PPARgamma-PGC-1alpha activity is determinant of alcohol related breast
cancer.
Cancer Lett. 315, 59-68.
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28
2012 Hallenborg, P., Feddersen, S. Francoz, S., Murano, I., Sundekilde, U.,
Petersen, R.K., Olson, M.V., Lozano, G., Cinti, S. Madsen, L., Marine, J.-C.
& Kristiansen, K.
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4
Mdm2 controls CREB-dependent transactivation and initiation of adipocyte
differentiation.
Cell Death and Differentiation, 19, (2012) 1381-1389.
29
2012 Jia, B., Madsen, L., Petersen, R.K., Techer, N., Kopperud, R., Døskeland,
S.O., Ailhaud, G., Wang, J., Amri, E.-Z. & Kristiansen, K. (2012).
Activation of Protein Kinase A and Exchange Protein Directly Activated by
cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem
Cells.
PLoS One, 7, e34114.
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2
30
2012 Qin, H., Lillefosse, H.H., Fjære, E., Myrmel, L.S., Midtbø, L.M., Jarlsby,
R.H., Ma, T., Jia, B., Petersen, R.K., Sonne, S.B., Chwalibog, A., Frøyland,
L., Liaset, B., Kristiansen, K. & Madsen, L. (2012).
High glycemic index carbohydrates abrogate the anti-obesity effect of fish
oil in mice.
Am. J. Physiol. Endocrin. Metab., 302, E1097-1112.
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2
31
2012 Schrader E, Wein S, Kristiansen K, Christensen LP, Rimbach G, Wolffram
S. (2012).
Plant Extracts of Winter Savory, Purple Coneflower, Buckwheat and Black
Elder Activate PPAR-γ in COS-1 Cells but do not Lower Blood Glucose in
Db/db Mice In vivo.
Plant Foods Hum Nutr. 67, 377-83. doi: 10.1007/s11130-012-0322-0.
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32
2012 Chen, F., Zhang, W., Liang, Y., Huang, J., Li, K., Green, C.D., Liu, J.,
Zhang, G., Zhou, B., Yi, X., Wang, W., Liu, H., Xu, X., Shen, F., Qu, N.,
Wang, Y., Gao, G., San, A., Jiangbai, L., Sang, H., Fang, X., Kristiansen,
K., Yang, H,, Wang, J,, Han, J,D,, Wang, J, (2012).
Transcriptome and network changes in climbers at extreme altitudes.
PLoS One 7, e31645.
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33
2012 Madsen, L. & Kristiansen, K. (2012).
Of mice and men: Factors abrogating the antiobesity effect of omega-3 fatty
acids.
Adipocyte, 1, 1–4.
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34
2012 Weischenfeldt, J., Waage, J.E., Tian, G., Zhao, J., Damgaard, I., Jakobsen,
J.S., Kristiansen, K., Krogh, A., Wang, J. & Porse, B.T. (2012).
Mammalian tissues defective in nonsense-mediated mRNA decay display
highly aberrant splicing patterns.
Genome Biology, 13, R35.
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35
2012 Li, R., Fan, W., Huang, Q., Zhang, J., Zhou, Y., Hu, Y. Zi, S., Li, J., Ni, P.,
Zheng, H., Zhang, Y., Zhao, M., Hao, Q. McDermott, J., Samudrala, R.,
Kristiansen, K., Wong, G. K.-S. & Wang, J. (2012).
Improved gene annotation of the rice (Oryza sativa) genomes.
BMC Genomics, in press.
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36
2012 Qin, J., Li, Y., Zhang, F., Li, S., Zhu, J., Cai, Z., Zhang, W., Liang, S., Guan,
Y., Li, J., Peng, Y., Li, X., Chen, W., Gong, M., Yu, J., Zhang, Y., Zhang, D.,
Zhang, M., Liu, X., Hansen, T., Almeida, M., LeChatelier, E., Renault, P.,
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5
2
2
2
Pons, N., Batto, J.-M., Zhang, Z., Jie, Z., Li, S., Yang, H., Wang, J., Ehrlich,
S.D., Pedersen, O., Kristiansen, K. & Wang, J. (2012).
A Metagenome-Wide Association Study of gut microbiota identifies markers
associated with Type 2 Diabetes.
Nature 490, 55-60. doi:10.1038/nature11450.
37
2012 Xavier, C.P., Lima, C.F., Pedro, D.F., Wilson, J.M., Kristiansen, K. &
Pereira-Wilson, C. (2012).
Ursolic acid induces cell death and modulates autophagy through JNK
pathway in apoptosis-resistant colorectal cancer cells.
J. Nutr. Biochem. . Epub 2012 Jul 26. PMID: 22841540
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38
2012 Hildebrand, F., Ebersbach, T., Nielsen, H.B., Li, X., Sonne, S.B., Bertalan,
M., Dimitrov, P., Madsen, L., Qin, J., Wang, J., Raes, J., Kristiansen, K. &
Licht, T.R. (2012).
A comparative analysis of the intestinal metagenomes present in guinea
pigs (Cavia porcellus) and humans (Homo sapiens).
BMC Genomics 13, 514. DOI: 10.1186/1471-2164-13-514.
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2
39
2012 Pernille B Hertel, Dongsheng Tu, Bent Ejlertsen, Maj-Britt Jensen, Eva
Balslev, Shan Jiang, Frances P O’Malley, Kathleen I Pritchard, Lois E
Shepherd, Annette Bartels, Nils Brünner, Torsten O Nielsen.
TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from
adjuvant anthracyclines in high risk breast cancer patients.
Breast Cancer Res and Treatment, 2012, 132: 225-234
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1
40
2012 Borst L, Wesolowska A, Joshi T, Borup R, Nielsen FC, Andersen MK,
Jonsson OG, Wehner PS, Wesenberg F, Frost BM, Gupta R, Schmiegelow
K.
Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive
childhood acute lymphoblastic
leukaemia.
Br J Haematol. 2012 May;157(4):476-82
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41
2012 Dalgaard MD, Weinhold N, Edsgärd D, Silver JD, Pers TH, Nielsen JE,
Jørgensen N, Juul A, Gerds TA, Giwercman A, Giwercman YL, CohnCedermark G, Virtanen HE,Toppari J, Daugaard G, Jensen TS, Brunak S,
Rajpert-De Meyts E, Skakkebæk NE, Leffers H, Gupta R.
A genome-wide association study of men with symptoms of testicular
dysgenesis syndrome and its network biology interpretation.
J Med Genet. 2012 Jan;49(1):58-65.
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42
2012 Stranzl T, Larsen MV, Lund O, Nielsen M, Brunak S.
The cancer exome generated by alternative mRNA splicing dilutes
predicted HLA class I epitope density.
PLoS One. 2012;7(9):e38670.
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43
2012 Jensen PB, Jensen LJ, Brunak S.
Mining electronic health records: towards better research applications and
clinical care.
Nat Rev Genet. 2012 May 2;13(6):395-405.
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6
Peer reviewed publications 2011
No.
1
Year
Author, Title, Place of publication, page number(s)
1
or
2
2011 Nielsen KV and Brünner N.Re: Topoisomerase II Alpha and responsiveness
of breast cancer to adjuvant chemotherapy
J Natl Cancer Inst. 2011 Feb 16;103(4):352-353.
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2
2011 Schmitt M, Harbeck N, Brünner N, Jänicke F, Meisner C, Mühlenweg B,
Jansen H, Dorn J, Nitz U, Kantelhardt EJ, Thomssen C. Cancer therapy
trials employing level-of-evidence-1 disease forecast cancer biomarkers
uPA and its inhibitor PAI-1.
Expert Rev Mol Diagn. 2011 Jul;11(6):617-34.
PR/
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3
2011 Anne-Sofie Schrohl, Hans Christian Pedersen, Susie Steen Jensen, Signe
Lykke Nielsen and Nils Brünner. Human epidermal growth factor receptor-2
(HER-2) immunohistochemistry: Specificity of clinically approved antibodies.
J Histopathology, 2011, 59(5):975-83.
PR/
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4
2011 Tvedskov TF, Bartels A, Jensen MB, Paaschburg B, Kroman N, Balslev E,
Brünner N. Evaluating TIMP-1, Ki67, and HER2 as markers for non-sentinel
node metastases in breast cancer patients with micrometastases to the
sentinel node. APMIS. 2011 Dec;119(12):844-52.
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5
2011 Holten-Andersen L, Thaysen-Andersen M, Jensen SB, Buchwald C, Højrup
P, Offenberg H, Nielsen HJ, Brünner N, Nauntofte B, Reibel J. Salivary
tissue inhibitor of metalloproteinases-1 localization and glycosylation profile
analysis. APMIS. 2011 Nov;119(11):741-9.
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6
2011 Maria Grazia Daidone, Nadia Harbeck, John A. Foekens, Fred C.G.J.
Sweep4 John Martens, Nils Brünner, Christoph Thomssen, Jacqueline A.
Hall, Roberto Salgado, Anneke Geurts-Moespot, M. Joe Duffy, Manfred
Schmitt. Identification, Validation and Clinical Implementation of Tumorassociated Biomarkers: Translational Strategies of the EORTCPathoBiology Group. Eur J Cancer. 2011
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7
2011 Obad S, Dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C,
Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D,
Hannon GJ, Kauppinen S.
Silencing of microRNA families by seed-targeting tiny LNAs
Nat Genet. 2011 43(4):371-8.
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8
2011 Eskildsen T, Taipaleenmäki H, Stenvang J, Abdallah BM, Ditzel N, Nossent
AY, Bak M, Kauppinen S, Kassem M.
MicroRNA-138 regulates osteogenic differentiation of human mesenchymal
stem cells in vivo
Proc Natl Acad Sci U S A. 2011 108(15):6139-44.
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9
2011 Lundberg M, Thorsen SB, Assarsson E, Villablanca A, Tran B, Gee N,
Knowles M, Nielsen BS, Gonzalez Couto E, Martin R, Nilsson O, Fermer C,
Schlingemann J, Christensen IJ, Nielsen HJ, Ekstrom B, Andersson C,
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7
Gustafsson M, Brunner N, Stenvang J, Fredriksson S.
Multiplexed homogeneous proximity ligation assays for high throughput
protein biomarker research in serological material.
Mol Cell Proteomics. 2011 10(4):M110.004978
10
2011 Petersen, R.K., Christensen, K.B., Assimopoulou, A.N., Fretté, X.,
Papageorgiou, V.P., Kristiansen, K. & Kouskoumvekaki, I. (2011)
Pharmacophore-driven identification of PPARγ agonists from natural
sources. J. Comput. Aided Mol. 25, 107-16.
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11
2011 Kiilerich, P., Pedersen, S.H., Kristiansen, K. & Madsen, S.S. (2011).
Corticosteroid regulation of Na(+),K(+)-ATPase alpha1-isoform expression
in Atlantic salmon gill during smolt development. Gen. Comp. Endocrinol.
170, 283–289.
PR/
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12
2011 Staunstrup, N.H., Sharma, N., Bak, R.O., Svensson, L., Petersen, T.K.,
Aarenstrup, L., Kristiansen, K., Bolund, L. & Mikkelsen, J.G. (2011). A
Sleeping Beauty DNA transposon-based genetic sensor for functional
screening of vitamin D3 analogues. BMC Biotechnology, 11, 33.
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13
2011 Hakim-Weber. R., Krogsdam, A.M., Jorgensen, C., Fischer, M., Prokesch,
A., Bogner-Strauss, J.G., Bornstein, S.R., Hansen, J.B., Madsen, L.,
Kristiansen, K., Trajanoski, Z., & Hackl, H. (2011). Transcriptional regulatory
program in wild-type and retinoblastoma gene-deficient mouse embryonic
fibroblasts during adipocyte differentiation. BMC Res. Notes 4, 157-169.
PR/
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14
2011 Du Z.-Y., Ma, T., Lock, E.-J., Kristiansen, K., Frøyland, L. & Madsen, L.
(2011). Depot-dependent effects of adipose tissue explants on co-cultured
hepatocytes. PLoS One, 6, e20917.
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15
2011 Arumugam, M,, Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende,
D.R., Fernandes, G.R., Tap, J., Bruls, T., Batto, J.M., Bertalan, M., Borruel,
N., Casellas, F. , Fernandez, L., Gautier, L., Hansen, T., Hattori, M.,
Hayashi, T., Kleerebezem, M., Kurokawa, K., Leclerc, M., Levenez, F.,
Manichanh, C., Nielsen, H.B., Nielsen, T., Pons, N., Poulain, J., Qin, J.,
Sicheritz-Ponten, T., Tims, S., Torrents, D., Ugarte, E., Zoetendal, E.G.,
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Petersen TN, Brunak S, von Heijne G, Nielsen H.
Nat Methods. 2011 Sep 29;8(10):785-6. doi: 10.1038/nmeth.1701.
PR/
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64
2011
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65
2011 Li Q, Eklund AC, Birkbak NJ, Desmedt C, Haibe-Kains B, Sotiriou C,
Symmans WF, Pusztai L, Brunak S, Richardson AL, Szallasi Z. Consistent
metagenes from cancer expression profiles yield agent specific predictors of
chemotherapy response.BMC Bioinformatics. 2011, Jul 28;12:310.
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66
2011 Christiansen P, Bjerre K, Ejlertsen B, Jensen MB, Rasmussen BB,
Lænkholm AV, Kroman N, Ewertz M, Offersen B, Toftdahl DB, Møller S,
Mouridsen HT; Danish Breast Cancer Cooperative Group.
Mortality rates among early-stage hormone receptor-positive breast cancer
patients: a population-based cohort study in Denmark. J Natl Cancer Inst.
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Wang K, Wernersson R, Brunak S.
The strength of intron donor splice sites in human genes displays a
bell-shaped pattern. Bioinformatics. 2011 Nov 15;27(22):3079-84. Epub
2011 Oct 12.
15
2011 Sep 21;103(18):1363-72. Epub 2011 Aug 31. PMID:21881042
67
2011 Di Leo A, Desmedt C, Bartlett JM, Piette F, Ejlertsen B, Pritchard KI,
Larsimont D, Poole C, Isola J, Earl H, Mouridsen H, O'Malley FP, Cardoso
F, Tanner M, Munro A, Twelves CJ, Sotiriou C, Shepherd L, Cameron D,
Piccart MJ, Buyse M; HER2/TOP2A Meta-analysis Study Group.
HER2 and TOP2A as predictive markers for anthracycline-containing
chemotherapy regimens as adjuvant treatment of breast cancer: a metaanalysis of individual patient data. Lancet Oncol. 2011 Nov;12(12):1134-42.
Epub 2011 Sep 12.PMID:21917518.
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68
2011 Colleoni M, Giobbie-Hurder A, Regan MM, Thürlimann B, Mouridsen H,
Mauriac L, Forbes JF, Paridaens R, Láng I, Smith I, Chirgwin J, Pienkowski
T, Wardley A, Price KN, Gelber RD, Coates AS, Goldhirsch A.
Analyses adjusting for selective crossover show improved overall survival
with adjuvant letrozole compared with tamoxifen in the BIG 1-98 study.
J Clin Oncol. 2011 Mar 20;29(9):1117-24. Epub 2011 Feb
14.PMID:21321298.
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69
2011 Edlund P, Ahlgren J, Bjerre K, Andersson M, Bergh J, Mouridsen H, Holmberg SB, Bengtsson NO, Jakobsen E, Møller S, Lindman H, Blomqvist
C.Dose-tailoring of FEC adjuvant chemotherapy based on leukopenia is
feasible and well tolerated. Toxicity and dose intensity in the Scandinavian
Breast Group phase 3 adjuvant Trial SBG 2000-1.
Acta Oncol. 2011 Apr;50(3):329-37. Epub 2011 Feb 8. PMID:21299448
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Peer reviewed publications 2010
No.
Year
1
2010 Ejlertsen B, Jensen MB, Nielsen KV, Balslev E, Rasmussen BB Willemoe
GL, Hertel PB, Knoop AS, Mouridsen HT, Brünner N., HER2, TOP2A, and
TIMP-1and responsiveness to adjuvant anthracycline-containing
chemotherapy in high-risk breast cancer patients, J. Clin Oncol,
2010,20:984-90.
PR/
CO
2
2010 Nielsen HJ, Christensen IJ, Brünner N.
A novel prognostic index in colorectal cancer defined by serum
carcinoembryonic antigen and plasma tissue inhibitor of metalloproteinases1. Scand J Gastroenterol., 2010;45(2):200-7.
PR/
CO
3
2010 Joergensen MT, Brünner N, De Muckadell OB.,
Comparison of circulating MMP-9, TIMP-1 and CA19-9 in the detection of
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CO
Author, Title, Place of publication, page number(s)
16
1
or
2
1
pancreatic cancer, Anticancer Res., 2010, 30(2):587-92.
4
2010 Steffensen KD, Waldstrøm M, Christensen RK, Bartels A, Brünner N,
Jakobsen A., Lack of relationship between TIMP-1 tumour cell
immunoreactivity, treatment efficacy and prognosis in patients with
advanced epithelial ovarian cancer, BMC Cancer., 2010, 7;10:185.
PR/
CO
5
2010 Birgisson H, Nielsen HJ, Christensen IJ, Glimelius B, Brünner N.,
Preoperative plasma TIMP-1 is an independent prognostic indicator in
patient with primary colorectal cancer: A prospective validation study,
Eur J Cancer., 2010, 46:3323-3331
PR/
CO
6
2010 Mechetner E, Brünner N, Parker RJ.,In vitro drug responses in primary and
metastatic colorectal cancers, Scand J Gastroenterol., 2010, 46:70-78.
PR/
CO
7
2010 Napieralski R, Brünner N, Mengele K, Schmitt M. Emerging biomarkers in
breast cancer care,Biomark Med., 2010, 4:505-22.
PR/
CO
8
2010 Jensen SA, Vainer B, Bartels A, Brünner N, Sørensen JB., Expression of
matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of
metalloproteinases 1 (TIMP-1) by colorectal cancer cells and adjacent
stroma cells-associations with histopathology and patients outcome,
Eur J Cancer, 2010, 46:3233-3242.
PR/
CO
9
2010 Kolenda J, Jensen SS, Aaberg-Jessen C, Christensen K, Andersen C,
Brünner N, Kristensen BW., Effects of hypoxia on expression of a panel of
stem cell and chemoresistance markers in glioblastoma-derived spheroids,
J Neurooncol, 2010.
PR/
CO
10
2010 Svendsen MN, Brünner N, Christensen IJ, Ytting H, Bentsen C, Lomholt AF,
Nielsen HJ., Biological variations in plasma VEGF and VEGFR-1 may
compromise their biomarker value in colorectal cancer,
Scan J Clin Lab Invest, 2010; 70:503-511
PR/
CO
11
2010 Mengele K, Napieralski R, Magdolen V, Reuning U, Gkazepis A, Sweep F,
Brünner N, Foekens J, Harbeck N, Schmitt M.,Characterization of the levelof-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI1, Expert Rev Mol Diagn, 2010,10:947-962
PR/
CO
12
2010 Schmitt M, Mengele K, Napieralski R, Magdolen V, Reuning U, Gkazepis A,
Sweep F, Brünner N, Foekens J, Harbeck N, Clinical utility of level-ofevidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1,
Expert Rev Mol Diagn, 2010, 10:1051-1067
PR/
CO
13
2010 Aldulaymi B, Byström P, Berglund A, Christensen IJ, Brünner N, Nielsen HJ,
Glimelius B., High plasma TIMP-1 and serum CEA levels during
combination chemotherapy for metastatic colorectal cancer are significantly
associated with poor outcome,Oncology, 2010, 9:144-149
PR/
CO
14
2010 Jian Li, Kai Wang, Thomas Dyrso Jensen, Lars Bolund, Carsten Wiuf,
Tumor heterogeneity in three types of cancer: breast, colon, and skin, 2010,
BMC Research Note, 3:321.
PR/
CO
17
15
2010 Thomas D. Jensen, Jian Li, Kai Wang, Jan Lindebjerg, Steen Kølvraa, Lars
Bolund, Anders Jakobsen, Gert B. Petersen, Shengting Li, Dorthe G.
Crüger, Identification of chromosome aberrations in sporadic microsatellite
stable and instable colorectal cancers using array-based comparative
genomic hybridization, Cancer Genetics and Cytogenetics, 2010
PR/
CO
16
2010 Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N,
Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung
NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW,
Winer EP, Garber JE. Efficacy of Neoadjuvant Cisplatin in Triple-Negative
Breast Cancer, Journal of Clinical Oncology, 2010, Mar 1;28(7):1145-53.
Epub 2010 Jan 25.
PR/
CO
17
2010 Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Li Y, Desmedt C, Sotiriou C,
Szallasi Z, Iglehart JD, Richardson AL, Wang ZC., Amplification of
LAPTM4B and YWHAZ contributes to chemotherapy resistance and
recurrence of breast cancer, Nat Medicine, 2010, Feb;16(2):214-8. Epub
2010 Jan 24.
PR/
CO
18
2010 Juul N, Szallasi Z, Eklund AC, Li Q, Burrell RA, Gerlinger M, Valero V,
Andreopoulou E, Esteva FJ, Symmans WF, Desmedt C, Haibe-Kains B,
Sotiriou C, Pusztai L, Swanton C., Assessment of an RNA interference
screen-derived mitotic and ceramide pathway metagene as a predictor of
response to neoadjuvant paclitaxel for primary triple-negative breast cancer:
a retrospective analysis of five clinical trials, Lancet Oncol., 2010,
Apr;11(4):358-65. Epub Feb 26.
PR/
CO
19
2010 Burrell RA, Juul N, Johnston SR, Reis-Filho JS, Szallasi Z, Swanton C.,
Targeting chromosomal instability and tumour heterogeneity in HER2positive breast cancer, J Cell Biochem., 2010, Nov 1;111(4):782-90.
PR/
CO
20
2010 Swanton C, Larkin JM, Gerlinger M, Eklund AC, Howell M, Stamp G,
Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L,
Beuselinck B, Oudard S, Hoffmann J, Gyorffy B, Torrance CJ, Boehme KA,
Volkmer H, Toschi L, Nicke B, Beck M, Szallasi Z, Predictive biomarker
discovery through the parallel integration of clinical trial and functional
genomics datasets, Genome Med., 2010, Aug 11;2(8):53.
PR/
CO
21
2010 Li Q, Eklund AC, Juul N, Haibe-Kains B, Workman CT, Richardson AL,
Szallasi Z, Swanton C., Minimising immunohistochemical false negative ER
classification using a complementary 23 gene expression signature of ER
status, PLoS One., 2010, Dec 1;5(12):e15031.
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CO
22
2010 Madsen, L. & Kristiansen, K., The importance of dietary modulation of cAMP
and insulin signaling in adipose tissue and the development of obesity, Ann.
N.Y. Acad. Sci. 2010, 1-14.
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23
2010 Li, R., Li, Y., Zheng, H., Luo, R., Zhu, H., Li, Q., Qian, W., Ren, Y., Tian, G.,
Li, J., Zhou, G., Zhu, X., Wu, H., Qin, J., Jin, X., Li, D., Cao, H., Hu, X.,
Blanche, H., Cann. H., Zhang, X., Li, S., Bolund, L., Kristiansen, K., Yang,
H., Wang, J. & Wang, J., Building the sequence map of the human
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18
2
pangenome, Nature Biotechnol., 2010, 28, 57-63.
24
2010 Hao, Q., Hansen, J. B. Petersen, R. K., Hallenborg, P., Jørgensen, C., Cinti,
S., Larsen, P. J., Steffensen, K. R., Wang, H., Collins, S., Wang, J,.
Gustafsson, J-Å., Madsen, L. & Kristiansen. K. (2010) Activation of the
PGC1α promoter by ADD1/SREBP1c in brown adipocytes, Biochim.
Biophys, Acta, 2010, 1801, 421–429.
25
2010 Li, R., Zhu, H., Ruan, J., Qian, W., Fang, X., Shi, Z., Li, Y., Li, S., Shan, G.,
Kristiansen, K., Li, S., Yang, H., Wang, J. & Wang, J., De novo assembly of
the human genomes with massively parallel short read sequencing,
Genome Res., 2010, 20, 265-272.
26
2010 Li, R., Fan, W., Tian, G., Zhu, H., He, L., Cai, J., Huang, Q., Cai, Q., Li. B.,
Bai, Y., Zhang, Z., Zhang, Y., Wang, W., Li, J., Wei, F., Li, H., Jian, M., Li,
J., Zhang, Z., Nielsen, R., Li, D., Gu, W., Yang, Z., Xuan, Z., Ryder, O.A.,
Leung, F.C., Zhou, Y., Cao, J., Sun, X., Fu, Y., Fang, X., Guo, X., Wang, B.,
Hou, R., Shen, F., Mu, B., Ni, P., Lin, R., Qian, W., Wang, G., Yu, C., Nie,
W., Wang, J., Wu, Z., Liang, H., Min, J., Wu, Q., Cheng, S., Ruan, J., Wang,
M., Shi, Z., Wen, M., Liu, B., Ren, X., Zheng, H., Dong, D., Cook, K., Shan,
G., Zhang, H., Kosiol, C., Xie, X., Lu, Z., Zheng, H., Li, Y., Steiner, C.C.,
Lam, T.T., Lin, S., Zhang, Q., Li, G., Tian, J., Gong, T., Liu, H., Zhang, D.,
Fang, L., Ye, C., Zhang, J., Hu, W., Xu, A., Ren, Y., Zhang, G., Bruford,
M.W., Li, Q., Ma, L., Guo, Y., An, N., Hu, Y., Zheng, Y., Shi, Y., Li, Z., Liu,
Q., Chen, Y., Zhao, J., Qu, N., Zhao, S., Tian, F., Wang, X., Wang, H., Xu,
L., Liu, X., Vinar, T., Wang, Y., Lam, T.W., Yiu, S.M., Liu, S., Zhang, H., Li,
D., Huang, Y., Wang, X., Yang, G., Jiang, Z., Wang, J., Qin, N., Li, L., Li, J.,
Bolund, L., Kristiansen, K., Wong, G.K., Olson, M., Zhang, X., Li, S., Yang,
H., Wang, J. & Wang, J., The complete genome sequence of the giant
panda, Nature, 2010, 463, 311-317.
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2
27
2010 Ruzzin, J., Petersen, R. K., Meugnier, E., Madsen, L., Lock, E.-J., Lillefosse,
H., Ma, T., Pesenti, S., Sonne, S. B., Marstrand, T. T., Du, Z.-Y., Chavey,
C., Fajas, L., Lundebye, A.-K., Brand, C. L., Vidal, H., Kristiansen, K. &
Frøyland, L., Persistent Organic Pollutant Exposure Leads to Insulin
Resistance Syndrome, EHP, 2010, 118, 465-471.
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2
28
2010 Du, Z.-Y., Ma, T., Winterthun, S., Kristiansen, K., Frøyland, L. & Madsen, L.,
Carnitine modulates metabolic competition between eicosapentaenoic acid
and arachidonic acid regulating prostaglandin E2 synthesis in rat
hepatocyte-Kupffer cells, Biochim. Biophys. Acta, 2010, 1801,526–536.
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2
29
2010 Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J.S., Albrechtsen, A.,
Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M.,
Nielsen, K., Gilbert, M.T., Wang, Y., Raghavan, M., Campos, P.F., Kamp,
H.M., Wilson, A.S., Gledhill, A., Tridico, S., Bunce, M., Lorenzen, E.D.,
Binladen, J., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M.,
Orlando, L., Kristiansen, K., Bak, M., Tommerup, N., Bendixen, C., Pierre,
T.L., Grønnow, B., Meldgaard, M., Andreasen, C., Fedorova, S.A., Osipova,
L.P., Higham, T.F., Ramsey, C.B., Hansen, T.V., Nielsen, F.C., Crawford,
M.H., Brunak, S., Sicheritz-Pontén. T., Villems, R., Nielsen, R., Krogh, A.,
Wang, J. & Willerslev, E., The Diploid Genome of an Ancient Palaeo-
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2
19
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2
Eskimo. Nature, 2010, 463,757-762.
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2010 Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C.,
Nielsen, T., Pons, N., Levenez, F., Yamada, T., Mende, D.R., Li, J., Xu, J.,
Li, S., Li, D., Cao, J., Wang, B., Liang, H., Zheng, H., Xie, Y., Tap, J.,
Lepage, P., Bertalan, M., Batto, J.M., Hansen, T., Le Paslier, D., Linneberg,
A., Nielsen, H.B., Pelletier, E., Renault, P., Sicheritz-Ponten, T., Turner, K.,
Zhu, H., Yu, C., Li, S., Jian, M., Zhou, Y., Li, Y., Zhang, X., Li, S., Qin, N.,
Yang, H., Wang, J., Brunak, S., Doré, J., Guarner, F., Kristiansen, K.,
Pedersen, O., Parkhill, J., Weissenbach, J., MetaHIT Consortium, Bork, P.,
Ehrlich, S.D. & Wang, J., A human gut microbial gene catalog established
by deep metagenomic sequencing, Nature, 2010, 464, 59-65.
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2
31
2010 Zhang, G., Guo, G., Hu, X., Zhang, Y., Li, Q., Li, R., Zhuang, R., Lu, Z., He,
Z., Fang, X., Chen, L., Tian, W., Tao, Y., Kristiansen, K., Zhang, X., Li, S.,
Yang, H., Wang, J. & Wang, J., Deep RNA sequencing at single base-pair
resolution reveals high complexity of the rice transcriptome, Genome Res.,
2010, 20, 646-654.
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2
32
2010 Christensen, K.B., Petersen, R.K., Kristiansen, K. & Christensen, L.P.,
Identification of bioactive compounds from flowers of black elder (Sambucus
nigra L.) that activate the human peroxisome proliferator-activated receptor
(PPAR) gamma, Phytother Res. Suppl., 2010, 2, 129-132.
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33
2010 Kiec-Wilk, B., Grzybowska-Galuszka, J., Polus, A., Pryjma, J., Knapp A. &
Kristiansen, K., The MAPK-dependent regulation of the Jagged/Notch gene
expression by VEGF, bFGF or PPAR gamma mediated angiogenesis in
HUVEC., J Physiol Pharmacol., 2010, 61, 217-25.
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34
2010 Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K.,
Giacobino, J.P., De Matteis, R. & Cinti, S., The emergence of cold-induced
brown adipocytes in mouse white fat depots is predominantly determined by
white to brown adipocyte transdifferentiation, Am. J. Physiol. Endocrinol.
Metabolism, 2010 298, E1244-E1253.
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35
2010 Xiang, H., Zhu, J., Chen, Q., Dai, F., Li, X., Li, M., Zhang, H., Zhang, G., Li,
D., Dong, Y., Zhao, L., Lin, Y., Cheng, D., Yu, J., Sun, J., Zhou, X., Ma, K.,
He, Y., Zhao, Y., Guo, S., Ye, M., Guo, G., Li, Y., Li, R., Zhang, X., Ma, L.,
Kristiansen, K., Guo, Q., Jiang, J., Beck, S., Xia, Q., Wang, W. & Wang, J.,
Single base-resolution methylomes of the silkworm reveals a sparse
epigenomic map., Nature Biotechnol., 2010, 28, 516-520.
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36
2010 Hallenborg, P., Jørgensen, C., Petersen, R.K., Feddersen, S., Araujo, P.,
Markt, P., Langer, T., Furstenberger, G., Krieg, P., Madsen, L. &
Kristiansen, K., Epidermis-type lipoxygenase 3 regulates adipocyte
differentiation and PPARγ activity, Mol. Cell. Biol., 2010, 30, 4077-4091.
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37
2010 Wein, S., Behm, N., Petersen, R.K., Tereszczuk, J., Kristiansen, K. & and
Wolffram, W., Quercetin enhances adiponectin secretion by a PPAR-γ
independent mechanism, Eur. J. Pharm. Sci., 2010, 41,16-22.
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38
2010 Madsen, L., Pedersen, L.M., Haldis Lillefosse, H.H., Fjære, E., Bronstad, I.,
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20
2
2
Hao, Q., Petersen, R.K., Hallenborg, P., Ma, T., De Matteis, R., Araujo, P.,
Mercader, J., Bonet, M.L.; Hansen, J.B., Cannon, B., Nedergaard, J., Wang,
J., Cinti, S., Voshol, P., Døskeland, S.O. & Kristiansen, K.,UCP1 induction
during recruitment of brown adipocytes in white adipose tissue is dependent
on cyclooxygenase activity, PLoS ONE, 2010, 5, e11391, 2010, 1-13.
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39
2010 Zhang, H., Schulz, T.J., Espinoza, D.O., Huang, T.L. Emanuelli, B.,
Kristiansen, K. & and Yu-Hua Tseng Y.-H.,Crosstalk between Insulin and
BMP Signaling Systems in Brown Adipogenesis, Mol. Cell. Biol., 2010, 30,
4224–4233.
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2010 Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H.,
Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T., Grarup, N., Guo,
Y., Hellman, I., Jin, X., Li, Q,, Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H.,
Wu, R., Yu, C., Zheng, H., Astrup, A., Bolund, L., Holmkvist. J., Jørgensen,
T., Kristiansen. K., Schmitz. O., Schwartz, T.W., Zhang, X., Li, R., Yang, H.,
Wang, J., Hansen, T., Pedersen, O., Nielsen, R. & Wang, J., Resequencing
of 200 human exomes identifies an excess of low-frequency nonsynonymous coding variantsm, Nat. Genet., 2010, 42, 969-972.
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2010 Li, Y., Zhu, J., Tian, G., Li, N,, Li. Q,, Ye, M., Zheng, H,, Yu, J., Wu, H., Sun,
J., Zhang, H., Chen, Q., Luo, R., Chen, M., He, Y., Jin, X., Zhang, Q., Yu,
C., Zhou, G., Sun, J., Huang, Y., Zheng, H., Cao, H., Zhou, X., Guo, S., Hu,
X., Li, X., Kristiansen, K., Bolund, L., Xu, J., Wang, W., Yang, H., Wang, J.,
Li, R., Beck, S., Wang, J., & Zhang, X., The DNA methylome of human
peripheral blood mononuclear cells, PLoS Biology, 2010, 9, e1000533.
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2
42
2010 Christiansen, E., Due-Hansen, M.E., Urban, C, Merten, N., Pfleiderer, M.,
Karlsen, K.K., Rasmussen, S.S., Steensgaard, M., Hamacher, A., Schmidt,
J., Drewke C., Petersen, R.K., Kristiansen, K., Ullrich, S., Kostenis; E.,
Kassack, M.U. & Trond Ulven, T., Structure-Activity Study of paraSubstituted Dihydrocinnamic Acids: Discovery of the Potent and Selective
FFA1 (GPR40) Receptor Agonist TUG-469, ACS Med. Chem. Lett., 2010, 1,
345-349.
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43
2010 Yi, X., Liang, Y., Huerta-Sanchez, .E, Jin, X., Cuo, Z.X., Pool, J.E., Xu, X,,
Jiang, H., Vinckenbosch, N., Korneliussen, T.S,, Zheng, H., Liu, T., He, W.,
Li, K., Luo, R., Nie, X., Wu, H., Zhao, M., Cao, H., Zou, J., Shan, Y., Li, S.,
Yang, Q., Asan, Ni P., Tian, G., Xu, J., Liu, X., Jiang, T., Wu, R., Zhou, G.,
Tang, M., Qin, J., Wang, T., Feng, S., Li, G., Huasang, Luosang, J., Wang,
W., Chen, F., Wang, Y., Zheng, X,, Li, Z., Bianba, Z., Yang, G., Wang, X.,
Tang, S., Gao, G., Chen, Y., Luo, Z., Gusang, L., Cao, Z., Zhang, Q.,
Ouyang, W., Ren, X., Liang, H., Zheng, H., Huang, Y., Li, J., Bolund, L.,
Kristiansen, K., Li, Y., Zhang, Y., Zhang, X., Li, R., Li, S., Yang, H., Nielsen,
R., Wang, J., & Wang, J., Sequencing of 50 human exomes reveals
adaptation to high altitude, Science, 2010, 329, 75-78.
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44
2010 Christensen, K.B., Jørgensen, M., Kotowska, D., R.K. Petersen R.K.,
Kristiansen, K. & L.P. Christensen, L.P. (2010). Activation of the nuclear
receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.), J.
Ethnopharmacol., 2010, 132, 127-133.
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45
2010 Dusko Ehrlich S; MetaHIT consortium, Metagenomics of the intestinal
microbiota: potential applications, Gastroenterol. Clin. Biol., 2010, 34, S2328.
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50
2010 Hansen TV, Steffensen AY, Jonson L, Andersen MK, Ejlertsen B, Nielsen
FC. The silent mutation nucleotide 744 G --> A, Lys172Lys, in exon 6 of
BRCA2 results in exon skipping, Breast Cancer Res Treat, 2010,
Feb,119(3), 547-550.
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51
2010 Nielsen KV, Müller S, Møller S, Schønau A, Balslev E, Knoop AS, Ejlertsen
B.Nielsen KV, Muller S, Moller S, et al., Aberrations of ERBB2 and TOP2A
genes in breast cancer, Mol Oncol, 2010, Apr,4(2), 161-168
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52
2010 Ejlertsen B, Mouridsen HT, Jensen MB, Andersen J, Andersson M, Kamby
C, Knoop AS; Danish Breast Cancer Cooperative Group. Ejlertsen B,
Mouridsen HT, Jensen MB, et al. Cyclophosphamide, methotrexate, and
fluorouracil; oral cyclophosphamide; levamisole; or no adjuvant therapy for
patients with high-risk, Premenopausal breast cancer, Cancer, 2010, May
1,116(9), 2081-2089.
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53
2010 Hansen TV, Jønson L, Albrechtsen A, Steffensen AY, Bergsten E, Myrhøj T,
Ejlertsen B, Nielsen FC., Identification of a novel BRCA1 nucleotide
4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A
(p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for
genetic screening of Greenlandic Inuit families with high risk for breast
and/or ovarian cancer. Breast Cancer Res Treat, 2010, Nov,124(1), 259264.
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54
2010 Steffensen AY, Jonson L, Ejlertsen B, Gerdes AM, Nielsen FC, Hansen TV.
Identification of a Danish breast/ovarian cancer family double heterozygote
for BRCA1 and BRCA2 mutations. Fam Cancer, 2010, Sep,9(3), 283-287.
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55
2010 Gunnarsdóttir KA, Jensen MB, Zahrieh D, Gelber RD, Knoop A, Bonetti M,
Mouridsen H, Ejlertsen B. CEF is superior to CMF for tumours with TOP2A
aberrations: a Subpopulation Treatment Effect Pattern Plot (STEPP)
analysis on Danish Breast Cancer Cooperative Group Study 89D. Breast
Cancer Res Treat, 2010, Aug,123(1), 163-169.
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56
2010 Nielsen KV, Ejlertsen B, Müller S, Møller S, Rasmussen BB, Balslev E,
Lænkholm AV, Christiansen P, Mouridsen HT. Amplification of ESR1 may
predict resistance to adjuvant tamoxifen in postmenopausal patients with
hormone receptor positive breast cancer. Breast Cancer Res Treat, 2010,
Jun 17.
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CO
57
2010 Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T,
Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, Cao J,
Wang B, Liang H, Zheng H, Xie Y, Tap J, Lepage P, Bertalan M, Batto JM,
Hansen T, Le Paslier D, Linneberg A, Nielsen HB, Pelletier E, Renault P,
Sicheritz-Ponten T, Turner K, Zhu H, Yu C, Li S, Jian M, Zhou Y, Li Y,
Zhang X, Li S, Qin N, Yang H, Wang J, Brunak S, Doré J, Guarner F,
Kristiansen K, Pedersen O, Parkhill J, Weissenbach J; MetaHIT Consortium,
Bork P, Ehrlich SD, Wang J., A human gut microbial gene catalogue
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2
established by metagenomic sequencing, Nature, 2010, 646, 59-65.
58
2010 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ,
Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M., Quantitative
phosphoproteomics reveals widespread full phosphorylation site occupancy
during mitosis, Science Signal., 2010, 3, ra3.
PR/
CO
59
2010 Brorsson C, Hansen NT, Bergholdt R, Brunak S, Pociot F, The Type 1
Diabetes - HLA Susceptibility Interactome - Identification of HLA GenotypeSpecific Disease Genes for Type 1 Diabetes, PLoS One, 2010, 5, e9576.
PR/
CO
60
2010 Gauthier NP, Jensen LJ, Wernersson R, Brunak S, Jensen TS,
Cyclebase.org: version 2.0, an updated comprehensive, multi-species
repository of cell cycle experiments and derived analysis results, Nucleic
Acids Res, 2010, 38, D699-D702.
PR/
CO
61
2010 Kristensen DM, Nielsen JE, Kalisz M, Dalgaard MD, Audouze K, Larsen ME,
Jacobsen GK, Horn T, Brunak S, Skakkebaek NE, Leffers H, OCT4 and
downstream factors are expressed in human somatic urogenital epithelia
and in culture of epididymal spheres, Mol Hum Reprod, 2010, 16, 835-845.
PR/
CO
62
2010 Blicher T, Gupta R, Wesolowska A, Jensen LJ, Brunak S, Protein annotation
in the era of personal genomics. Curr Opin Struct Biol., 2010, 20, 335-341.
PR/
CO
63
2010 Audouze K, Juncker AS, Roque FJSSA, Krysiak-Baltyn K, Weinhold N,
Taboureau O, Jensen TS, Brunak S, Deciphering Diseases and Biological
Targets for Environmental Chemicals using Toxicogenomics Networks,
PLos Computational Biology, 2010, 6, e1000788.
PR/
CO
64
2010 Lage K, Mollgard K, Greenway S, Wakimoto H, Gorham JM, Workman CT,
Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM,
Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S,
Seidman CE, Seidman JG, Larsen LA, Dissecting spatio-temporal protein
networks driving human heart development and related disorders, Molecular
Systems Biology, 2010, 6, 381.
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65
2010 Taboureau O, Nielsen SK, Audouze K, Weinhold N, Edsgärd D, Roque FS,
Kouskoumvekaki I, Bora A, Curpan R, Jensen TS, Brunak S, Oprea TI.
ChemProt: a disease chemical biology database, Nucleic Acids Res, 2010
Oct 8.
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66
2010 Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, DesdoitsLethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S,
Skakkebæk NE, Nellemann C, Main KM, Jégou B, Leffers H. Intrauterine
exposure to mild analgesics is a risk factor for development of male
reproductive disorders in human and rat, Hum Reproduction, 2010 Nov 8.
PR/
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67
2010 Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C,
Frederiksen H, Brunak S, Skakkebaek NE, Jégou B, Hansen JB, Junker S,
Leffers H. Many Putative Endocrine Disruptors Inhibit Prostaglandin
Synthesis, Environ Health Perspect., 2010 Nov 16.
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2
1
68
2010 Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I,
Metspalu M, Metspalu E, Kivisild T, Gupta R, Bertalan M, Nielsen K,
Gilbert MTP, Wang Y, Raghavan M, Campos PF, Kamp HM, Wilson AS,
Gledhill A, Tridico S, Bunce M, Lorenzen ED, Binladen J, Guo X, Zhao J,
Zhang X, Zhang H, Li Z, Chen M, Orlando L, Kristiansen K, Bak M,
Tommerup N, Bendixen C, Pierre TL, Grønnow B, Meldgaard M,
Andreasen C, Fedorova SA, Osipova LP, Higham TFG, Ramsey CB,
Hansen TV, Nielsen FC, Crawford MH, Brunak S, Sicheritz-Ponten T,
Villems R, Nielsen R, Krogh A, Wang J, Willerslev E, Ancient Human
Genome Sequence of an Extinct Palaeo-Eskimo,
Nature, 2010, 11 Feb;463(7282):757-62.
PR/
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69
2010 Julenius K, Johansen M, Zhang Y, Brunak S, Gupta R, Prediction of
Glycosylation Sites in Proteins, Bioinformatics for Glycobiology and
Glycomics, 2010.
PR/
CO
70
2010 Hedegaard M, Krafft C, Ditzel HJ, Johansen LE, Hassing S, Popp J.,
Discriminating Isogenic Cancer Cells and Identifying Altered Unsaturated
Fatty Acid Content as Associated with Metastasis Status, Using K-Means
Clustering and Partial Least Squares-Discriminant Analysis of Raman Maps,
Anal Chem., 2010, 82:2797-2802.
PR/
CO
71
2010 Leth-Larsen R, Lund RR, Ditzel HJ., Plasma membrane proteomics and its
application in clinical cancer biomarker discovery, Mol Cell Proteomics,
2010, 9:1369-1382.
72
2010 Gjerstorff MF, Burns J, Ditzel HJ. Cancer-germline antigen vaccines and
epigenetic enhancers: Future strategies for cancer treatment. Expert Opin
Biol Ther, 2010,10:1061-1075.
PR/
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73
2010 Gjerstorff M.F., H. Besir, M. Larsen, H.J. Ditzel, Expression, purification and
characterization of the cancer-germline antigen GAGE12I: A candidate for
cancer immunotherapy, Protein Expr Purif. 2010, 73:217-22.
PR/
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74
2010 Rasmussen N., J.H. Andersen, H Jespersen, O. G. Mouritsen, H. J. Ditzel,
Effect of free fatty acids and lysolipids oncellular uptake of doxorubicin in
human breast cancer cell lines, Anti-Cancer Drugs, 2010, 21:674-7.
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2
1
Peer reviewed publications 2009
No.
Year
1
2009 Frederiksen C, Lomholt AF, Davis GJ, Dowell BL, Blankenstein MA,
Christensen IJ, Brünner N, Nielsen HJ. Changes in plasma TIMP-1 levels
after resection for primary colorectal cancer. Anticancer Res. 2009
Jan;29(1):75-81
Author, Title, Place of publication, page number(s)
24
1
or
2
PR/
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2
2009 Aaberg-Jessen C, Christensen K, Offenberg H, Bartels A, Dreehsen T,
Hansen S, Schrøder HD, Brünner N, Kristensen BW., Low expression of
tissue inhibitor of metalloproteinases-1 (TIMP-1) in glioblastoma predicts
longer patient survival. J Neurooncol.2009,1: 117-128
PR/
CO
3
2009 Schrohl A, Look MP, Meijer-van Gelder ME, Foekens JA, Brünner N: Tumor
tissue levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and
outcome following adjuvant chemotherapy in premenopausal lymph nodepositive breast cancer patients. BMC Cancer, 9(1): 322, 2009
PR/
CO
4
2009 Li, Jian ; Gao, Fei ; Li, Ning ; Li, Shengting ; Yin, Guangliang ; Tian, Geng ;
Jia, Shangang ; Wang, Kai ; Zhang, Xiuqing ; Yang, Huanming ; Nielsen,
Anders Lade ; Bolund, Lars. An improved method for genome wide DNA
methylation profiling correlated to transcription and genomic instability in two
breast cancer cell lines. / BMC Genomics. 2009 ; vol. 10, England. s. 223
PR/
CO
2
5
2009 Wang, Kai ; Li, Jian ; Li, Shengting ; Bolund, Lars ; Wiuf, Carsten.:
Estimation of tumor heterogeneity using CGH array data. In: BMC
Bioinformatics. 2009 ; vol. 10, nr. 1, Jan 9. p. 12
PR/
CO
2
6
2009 Duffy MJ, Napieralski R, Martens JW, Span PN, Spyratos F, Sweep FC,
Brünner N, Foekens JA, Schmitt M; on behalf of the EORTC PathoBiology
Group. Methylated genes as new cancer biomarkers. Eur J Cancer 2009, 3:
335-346
PR/
CO
7
2009 Gro Willemoe, Pernille Bræmer Hertel, Annette Bartels, Maj-Britt Jensen,
Eva Balslev, Henning Mouridsen , Bent Ejlertsen and Nils Brünner.
Lack of TIMP-1 tumor cell immunoreactivity predicts effect of adjuvant
antracycline based chemotherapy in patients (n=647) with primary breast
cancer. A Danish Breast Cancer Cooperative Group Study.
Eur J Cancer, 2009, 45: 2528-2536
PR/
CO
8
2009 Györffy B, Molnar B, Lage H, Szallasi Z, Eklund AC. Evaluation of
microarray preprocessing algorithms based on concordance with RT-PCR in
clinical samples. PLoS One. 2009 May 21;4(5):e5645
PR/
CO
9
2009 Lin, Lin ; Kragh, Peter M ; Purup, Stig ; Kuwayama, Masashige ; Du, Yutao ;
Zhang, Xiuqing ; Yang, Huanming ; Bolund, Lars ; Callesen, Henrik ; Vajta,
Gábor. I: Osmotic stress induced by sodium chloride, sucrose or trehalose
improves cryotolerance and developmental competence of porcine oocytes.
/ Reproduction, Fertility and Development. 2009 ; vol. 21, nr. 2, Australia. s.
338-44
PR/
CO
10
2009 Marie Klintman, Sidse Ørnbjerg Würtz, Ib Jarle Christensen, Pernille
Bræmer Hertel, Mårten Fernö, Martin Malmberg, Henning Mouridsen,
Frederik Cold, Anne-Sofie Schrohl, John A Foekens, Per Malmström, Nils
Brünner. Association between tumor tissue TIMP-1 levels and objective
response to first-line chemotherapy in metastatic breast cancer. Breast
Cancer Res and Treatment, 2009
PR/
CO
11
2009 Schrohl A-S, Look MP, Meier-van Gelder ME, Foekens JA and Brünner N.
PR/
25
1
1
Tumor tissue levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)and
outcome following adjuvant chemotherapy in premenopausal lymph nodepositive breast cancer patients: A retrospective study. BMC Cancer 2009, 9,
322
CO
12
2009 Schrötzlmair F, Kopitz C, Halbgewachs B, Lu F, Algül H, Brünner N,
Gänsbacjer B, Krüger A. Tissue Inhibitor of metalloproteases-1-induced
scattered liver metastasis is mediated by host-derived urokinase- type
plasminogen activator.,J Cell Mol Med 2009, 23
PR/
CO
13
2009 Li, J ; Villemoes, K ; Zhang, Y ; Du, Y ; Kragh, P M ; Purup, S ; Xue, Q ;
Pedersen, A M ; Jørgensen, Arne Lund ; Jakobsen, Jannik ; Bolund, L ;
Yang, H ; Vajta, G. I: Efficiency of two enucleation methods connected to
handmade cloning to produce transgenic porcine embryos Reproduction in
Domestic Animals. 2009 ; vol. 44, no. 1, Feb. Germany. p. 122-7
PR/
CO
14
2009 Lin, Lin ; Du, Yutao ; Liu, Ying ; Kragh, Peter M ; Li, Juan ; Purup, Stig ;
Kuwayama, Masashige ; Zhang, Xiuqing ; Yang, Huanming ; Bolund, Lars ;
Vajta, Gábor.: Elevated NaCl concentration improves cryotolerance and
developmental competence of porcine oocytes. In: Reproductive
BioMedicine Online. 2009; vol. 18, nr. 3, 2009-Mar. England. s. 360-6
PR/
CO
15
2009 Egerod FL, Brünner N, Svendsen JE, Oleksiewicz MB.PARalpha and
PPARgamma are co-expressed, functional and show positive interactions in
the rat urinary bladder urothelium. J Appl Toxicol 2009, 37: 948-958
PR/
CO
16
2009 Hans J. Nielsen, Ib J. Christensen, Nils Brünner. A novel prognostic index in
colorectal cancer defined by serum CEA and plasma TIMP- 1,Scandinavian
J Gastroenterology 2009, 45: 200-207
PR/
CO
17
2009 Li, Jian ; Wang, Kai ; Li, Shengting ; Timmermans-Wielenga, Vera ; Rank,
Fritz ; Wiuf, Carsten ; Zhang, Xiuqing ; Yang, Huanming ; Bolund, Lars. DNA
copy number aberrations in breast cancer by array comparative genomic
hybridization. / In: Genomics Proteomics & Bioinformatics. 2009 ; vol. 7, no.
1-2, 2009-Jun. China. p. 13-24
PR/
CO
18
2009 Ditzel H.J. Affinity isolation of antigen-specific circulating B cells for
generation of phage display-derived human monoclonal antibodies.
Methods Mol Biol. 562:37-43, 2009
PR
19
2009 Rasmussen N., H. J. Ditzel. Identification of the specificity of isolated phage PR
display single chain antibodies using yeast two-hybrid screens. Methods Mol
Biol. 562:165-176, 2009
20
2009 Sunde, Lone; Bisgaard, Marie Luis; Soll-Johanning, Helle; Jacobsen, Niels
Otto; Bolund, Lars; Skouv, Jan; Lynge, Elsebeth. / Familial colorectal
cancer, can it be identified by microsatellite instability and chromosomal
instability? - A case-control study. In: Cancer Biomarkers. 2009 ; vol. 5, no.
4, Netherlands. p. 197-205
PR/
CO
21
2009 Gjerstorff M.F., J.S. Burns, O. Nielsen, M. Kassem, and H. J. Ditzel.
Epigenetic modulation of cancer-germline antigen gene expression in
PR
26
2
2
tumorigenic human mesenchymal stem cells: implications for cancer
therapy. Am. J. Pathol. 175:314-323, 2009
22
2009 Leth-Larsen R., R. Lund, H.V. Hansen, A. V. Lænkholm, O.N. Jensen, D.
Tarin, and H.J. Ditzel Metastasis-related plasma membrane proteins of
human breast cancer cells identified bycomparative quantitative mass
spectrometry. Mol Cell Proteomics, 8:1436-1449, 20
PR
23
2009 Lund R., R. Leth-Larsen, O.N. Jensen and H.J. Ditzel. Efficient isolation and
quantitative proteomic analysis of cancer cell plasma membrane proteins for
identification of metastasis-associated cell surface markers. J. Proteome
Res., 8:3078-3090, 2009
2009 Goldhirsch A, Ingle JN, Gelber RD, Coates AS, Thürlimann B, Senn HJ;
Panel members.Thresholds for therapies: highlights of the St Gallen
International Expert Consensus on the primary therapy of early breast
cancer 2009.Ann Oncol. 2009 Aug.;20(8):1319-29.
PR
25
2009 Giobbie-Hurder A, Price KN, Gelber RD; International Breast Cancer Study
Group; Design, conduct, and analyses of Breast International Group (BIG)
1-98: a randomized, double-blind, phase-III study comparing letrozole and
tamoxifen as adjuvant endocrine therapy for postmenopausal women with
receptor-positive, early breast cancer.BIG 1-98 Collaborative Group., Clin
Trials. 2009 Jun;6(3):272-87.
PR/
CO
26
2009 Kragh, Peter M ; Nielsen, Anders Lade ; Li, Juan ; Du, Yutao ; Lin, Lin ;
Schmidt, Mette ; Bøgh, Ingrid Brück ; Holm, Ida E ; Jakobsen, Jannik E ;
Johansen, Marianne G ; Purup, Stig ; Bolund, Lars ; Vajta, Gábor ;
Jørgensen, Arne Lund: Hemizygous minipigs produced by random gene
insertion and handmade cloning express the Alzheimer's disease-causing
dominant mutation APPsw. In: Transgenic Research. 2009 ; vol. 18, no. 4,
2009-Aug. Netherlands. p. 545-58
PR/
CO
27
2009 Rasmussen N., H. J. Ditzel. Scanning the cell surface proteome of cancer
cells and identification of metastasis-associated proteins using a subtractive
immunization strategy. J Proteome Res. 8:5048-5059, 2009
PR
28
2009 Schaller M, Bigler C, Danner D, Ditzel HJ, Trendelenburg M. Autoantibodies
against C1q in systemic lupus erythematosus are antigen-driven. J
Immunol. 183:8225-8231, 2009
PR/
CO
29
2009 Harboe TL, Eiberg H, Kern P, Ejlertsen B, Nedergaard L, TimmermansWielenga V et al. A high frequent BRCA1 founder mutation identified in the
Greenlandic population Fam Cancer 2009;8(4):413-9.
PR
30
2009 Henriksen KL, Rasmussen BB, Lykkesfeldt AE, Moller S, Ejlertsen B,
Mouridsen HT. An ER activity profile including ER, PR, Bcl-2 and IGF-IR
may have potential as selection criterion for letrozole or tamoxifen treatment
of patients with advanced breast cancer. Acta Oncol 2009;48(4):522-31
PR/
CO
31
2009 Hansen TO, Jonson L, Albrechtsen A, Andersen MK, Ejlertsen B, Nielsen
24FC. Large BRCA1 and BRCA2 genomic rearrangements in Danish high
PR/
CO
24
27
PR/
CO
ris25k breast-ovarian cancer families. Breast Cancer Res Treat
200926;115(2):315-23
32
2009 Hansen TV, Ejlertsen B, Albrechtsen A, Bergsten E, Bjerregaard P, Hansen
Tet al. A common Greenlandic Inuit BRCA1 RING domain founder mutation.
Breast Cancer Res Treat 2009;115(1):69-76.
PR/
CO
33
2009 Mouridsen H, Giobbie-Hurder A, Goldhirsch A, Thürlimann B, Paridaens R,
Smith I, Mauriac L, Forbes JF, Price KN, Regan MM, Gelber RD, Coates
AS. Letrozole therapy alone or in sequence with tamoxifen in women with
breast cancer.BIG 1-98 Collaborative Group, N Engl J Med. 2009 Aug
20;361(8):766-76
PR/
CO
34
2009 Lykkesfeldt AE, Henriksen KL, Rasmussen BB, Sasano H, Evans DB,
Moller S et al. In situ aromatase expression in primary tumor is associated
with estrogen receptor expression but is not predictive of response to
endocrine therapy in advanced breast cancer. BMC Cancer 2009;9:185
PR/
CO
35
2009 Rabaglio M, Sun Z, Price KN, Castiglione-Gertsch M, Hawle H, Thürlimann
B, Mouridsen H, Campone M, Forbes JF, Paridaens RJ, Colleoni M,
Pienkowski T, Nogaret JM, Láng I, Smith I, Gelber RD, Goldhirsch A,
Coates AS; Bone fractures among postmenopausal patients with endocrineresponsive early breast cancer treated with 5 years of letrozole or tamoxifen
in the BIG 1-98 trial. BIG 1-98 Collaborative and International Breast Cancer
Study Groups. Ann Oncol. 2009 Sep;20(9):1489-98.
PR/
CO
36
2009 Egerod FL. Svendsen JE ; Hinley J, Southgate J, Bartels A ; Brünner N,
Oleksiewicz M; PPARα and PPARγ coactivation rapidly induces Egr-1 in
the nuclei of the dorsal and ventral urinary bladder and kidney pelvis
urothelium of rats. / B. I: Toxicologic Pathology. 2009 ; vol. 37, no. 7, 2009.
United States. s. 947-58
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CO
37
2009 Ejlertsen B, Jensen MB, Rank F, Rasmussen BB, Christiansen P, Kroman N
et al. Population-based study of peritumoral lymphovascular invasion and
outcome among patients with operable breast cancer. J Natl Cancer Inst
2009;101(10):729-35
PR/
CO
38
2009 Liaset, B., Madsen, L. Hao, Q., Criales, G., Mellgren, G., Marschall, H.U.,
Espe, M., Frøyland, L. & Kristiansen, K. (2009). Fish protein hydrolysate
elevates plasma bile acids and reduces visceral adipose tissue mass in rats.
Biochim. Biophys. Acta. 2009;1791, 254-262.
PR/
CO
39
2009 Christensen, K.B., Minet, A., Svenstrup, H., Grevsen, K., Zhang, H., PR/
Schrader, E., Rimbach, G., Wein, S., Wolffram, S., Kristiansen K & CO
Christensen LP (2009). Identification of plant extracts with potential
antidiabetic properties: effect on human peroxisome proliferator-activated
receptor (PPAR), adipocyte differentiation and insulin-stimulated glucose
uptake. Phytother Res. 2009 [Epub ahead of print].
40
2009 Hallenborg, P., Feddersen, S., Madsen, L. & Kristiansen, K. (2009).The
Tumor Suppressors pRB and p53 as Regulators of Adipocyte Differentiation
28
PR
and Function. Expert Opin. Ther.Targets 2009:13, 1-12
41
2009 Mercader, J., Ribot, J., Murano, I., Cinti, S., Madsen, L., Kristiansen, K.,
Bonet, M. L. & Palou. (2009). Haploinsufficiency of the retinoblastoma
protein gene reduces diet-induced obesity, insulin resistance and
hepatostatosis in mice. Am. J. Physiol. Endocrin. Metab., 2009:297, E18493.
PR/
CO
42
2009 Christensen, K.B., Petersen, R.K., Kristiansen, K. & Christensen, L.P.
(2009). Activation of PPARγ by Metabolites from the Flowers of Purple
Coneflower (Echinacea purpurea). J. Nat. Prod. 2009 [Epub ahead of print]
PR
43
2009 Schierup, Mikkel Heide ; Mailund, Thomas ; Li, Heng ; Wang, Jun ;
Tjønneland, Anne ; Vogel, Ulla ; Bolund, Lars ; Nexø, Bjørn Andersen.
Haplotype frequencies in a sub-region of chromosome 19q13.3, related to
risk and prognosis of cancer, differ dramatically between ethnic groups. In:
BMC Medical Genetics. 2009 ; vol. 10
PR/
CO
44
2009 Elabd, C., Chiellini, C., Carmona, M., Cochet, O., Petersen, R.K., Pénicaud,
L., Kristiansen, K., Boulióumié, A., Casteilla, L., Dani, C., Ailhaud, G. &
Amri, E.-Z. (2009). Human adipose-derived stem cells differentiate into
functional brown adipocytes. Stem Cells 2009:27, 2753-2760
PR/
CO
45
2009 Li, R., Li, Y., Fang, X., Yang, H, Wang, J., Kristiansen, K. & Wang, J. (2009).
SNP detection for massively parallel whole-genome resequencing. Genome
Res. 2009:19, 1124-1132
PR/
CO
2
46
2009 Li, R., Yu, C., Li, Y., Lam, T.W., Yiu, S.M., Kristiansen, K. & Wang, J.
(2009). SOAP2: an improved ultrafast tool for short read alignment.
Bioinformatics 2009:25, 1966-1967.
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CO
2
47
2009 Li, R., Zhu, H., Ruan, J , Kristiansen, K. J. Wang. (2009). De novo
assembly of the human genomes with massively parallel short read
sequencing. Genome Res. 2009:20, ePub ahead of print
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2
48
2009 Li, R., Fan, W., Tian, G. Kristiansen, K., Wang, J. (2009). The complete
genome sequence of the giant panda. Nature, 2009.
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CO
2
49
2009 Ruzzin, J., Petersen, R. K., Meugnier, E., Madsen, L., Lock, E.-J., Lillefosse,
H., Ma, T., Pesenti, S., Sonne, S. B., Marstrand, T. T., Du, Z.-Y., Chavey,
C., Fajas, L., Lundebye, A.-K., Brand, C. L., Vidal, H., Kristiansen, K. &
Frøyland, L. (2009). Persistent Organic Pollutant Exposure Leads to Insulin
Resistance Syndrome. EHP, 2009.
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CO
50
2009 Hao, Q., Hansen, J. B. Petersen, R. K., Hallenborg, P., Jørgensen, C., Cinti,
S., Larsen, P. J., Steffensen, K. R., Wang, H., Collins, S., Wang, J,.
Gustafsson, J-Å., Madsen, L. & Kristiansen. K. (2009) Activation of the
PGC1α promoter by ADD1/SREBP1c in brown adipocytes. Biochem.
Biophys. Acta, 2009.
PR/
CO
51
2009 Du, Z.-Y., Ma, T., Winterthun, S., Kristiansen, K., Frøyland, L. & Madsen, L.
(2009). Carnitine modulates metabolic competition between
PR/
CO
29
2
2
eicosapentaenoic acid and arachidonic acid regulating prostaglandin E2
synthesis in rat hepatocyte-Kupffer cells. Biochim. Biophys. Acta, 2009.
52
2009 Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li QY, Hardcastle T, Lee
A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG,
Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z,
Downward J., Chromosomal instability determines taxane response. PNAS
2009, 106 , 8671-8676
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53
2009 Eklund AC, Qiyuan L, Juul N, Richardson AL, Szallasi Z., Identification of
robust, clinically relevant phenotypes of breast cancer from genome scale
molecular profiling, Cancer Research 2009, 69, 167S-167S
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CO
54
2009 Lee AJX, East P, Pepper S, Nicke B, Szallasi Z, Eklund AC, Downward J,
Swanton C. Concordance of exon array and real-time PCR assessment of
gene expression following cancer cell cytotoxic drug exposure. Cell cycle
2009, 7, 3947-3948
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CO
55
2009 Banasik K, Holmkvist J, Andersen G, Unoki H, Jensen TS, Pisinger C,
Borch-Johnsen K, Brunak S, Maeda S, Hansen T, Pedersen O The type 2
diabetes-associated C-allele of rs2237895 KCNQ1 associates with reduced
insulin release following an oral glucose load. Diabetologia, 52, S137-S137,
2009.
PR/
CO
56
2009 Juncker AS, Larsen MV, Weinhold N, Nielsen M, Brunak S, Lund O,
Systematic Characterization of Cellular Localization and Expression Profiles
of Proteins Containing MHC Ligands. PLoS ONE 4, e7448, 2009.
PR/
CO
57
2009 Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L,
Harrison NJ, Schwager C, Abdollahi A, Huber PE, Brunak S, Gjerdrum LM,
Moore HD, Andrews PW, Skakkebaek NE, Meyts ERD, Leffers H, Analysis
of Gene Expression Profiles of Microdissected Cell Populations Indicates
that Testicular Carcinoma In situ Is an Arrested Gonocyte., Cancer
Research 69, 5241-5250, 2009.
PR/
CO
58
2009 Bergholdt R, Brorsson C, Lage K, Nielsen JH, Brunak S, Pociot F,
Expression profiling of human genetic and protein interaction networks in
type 1 diabetes, PLoS One 4, e6250, 2009.
PR/
CO
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2009 Pappalardo F, Halling-Brown MD, Rapin N, Zhang P, Alemani D, Emerson
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