SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 1.INTRODUCTION 1.1 History of Deer park Lush green forests and rolling hills make up the natural beauty of union terriory of Dadra & nagar havali, situated in the foothills of the sahyadri . DN&H is former portugues colony , which merged into india in 1960 after suffering colonial rule since 1771.The forest suffered great damage during this foreign rule and the wild animals formerly found in large number , were drastically reduced. However after liberation the forest deparment has taken up several projects to restore the nature beauty of the forest . The 92 sq km dadra & nagar havali wildlife sanctuary was notified in 2000 to ensure greater protection and intensive manage ment intervention to restore and maintain the wildlife habitat areas. Two zones in the wildlife sanctuary, satmalia and Luhari are been developed since 1986-87 to encourage Nature Education through Eco-tourism. Satmalia, opened to the public on 24/11/2004, is basically a natural forest and offers several learning and fun opportunities to the visitor. Fig.1.1.Grassland Satmalia is being managed as a mix of forest woodland and grassland. Habitat management interventions include plantations of local tree species, grass species for restocking of the natural floral composition of the area. Soil and water conservation measures are taken up to augment natural water supply of the natural streams and perennial water sources through the area. The area was also restocked with the fauna which was earliest found in the UT forests,but lost during portuguese period. 1.2 The Flora The forests are classified as 3B-C2 southern tropical moist (mixed)Deciduous as per the Champion & seth classification. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 1 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.1.2 Forest &Animals Major tree species are Teak, Khair, Mahua, Sadad, Biyo,Shisham and Haldu. The area supports more than 200 species of trees, innumerable species of shrubs, creepers, herbs and grasses; several of these having medicinal value. A walk along the Nature trails is a rewarding experience in terms of viewing the plants, flowers and photography. An internal fair weather motorable 3.5 km long route is also maintained. 1.3 The Fauna The forest is a home to large herbivores like sambar,chital, nilgai and the chausinga, Fig.1.3chausinga which is the UT state animal, in their natural habitat. The carnivores like the leopard, jungle cat, Jackal and Hyenas can be sighted at rare intervals. Several smaller animals like the wild boar, Mongoose, wild Hare etc. Can also be spotted. Reptilians like the tortoise, Saw-scaled viper, Russrll’s viper, Common Cobra, Python, Green vine snake and Rat snake can be seen. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 2 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.1.4 Kingfisher Over 110 bird species add color to the forest and these include the endangered Vultures and peacocks, Water birds, Raptores like kites and Eagles in addition to the common forest birds like Drongos, Parakeets, owls, Egrets, Bulbuls, Mynahs, Kingfishers and woodpeckers. Insects, Dragonflies, Damselflies and Over 50 species of Butterflies including plain Tiger, Common Mormon, common Emigrant, Tawny coaster, Rustic etc.Can also be seen here. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 3 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 2.SPECIES OF DEER 2.1 DEER FAMILY OF INDIA Deer are the most ancient of all the ruminants ( cud chewing animals) and are mostly found in the forests or in the open grasslands. Even though they are part of Boride still there are many distinctions which separate them from this class. Nearly all the deer species have large fissure below each eye and the gall bladder is absent in nearly all the deer’s. Unlike other ruminants (cud chewing animals) deer have solid horns and that is its most distinguishing factor. Deer antlers are mass of solid bone and are shed on regular intervals and regrow again. Whereas in all other boride’s the horns are permanent and are not shed. India has a distinction of having the largest number of deer species in the world. The species found in India varies in size as per the areas they live in. The horn or the antler is the most important and fascinating part of a deer. The process starts gradually and with each shedding it grows more and finally takes its shape. During the growing of the antlers a soft shining skin covers the antlers and is known as “velvet”. This skin is highly sensitive as it is fed by many blood vessels and can be injured easily. When the antlers grow to take their final shape a ring of bone forms on the base and cuts off the supply of blood to the velvet thus leading to its shedding. During this period many deer can be seen rubbing their antlers on the tree trunk to get rid of the velvet. Shedding of velvet is usually followed by the period of rutting and many stags are seen sparing with each other to get hold of hinds. These fights are mostly jostling with each other antlers interlocked and are rarely fatal. The shedding of antlers is mainly after the finish of the rutting season. One factor playing important role in the shedding of horns is the availability of good grass. For males good intake of food means good source of calcium which helps in the formation of bone (antlers) whereas for female this period acts as a good source of nutrients to nurse the youngones. The surroundings play very important role in the body development of deer species. Deer species of central India are known for their large size and big antlers. Whereas the species found in Eastern and Southern India have antlers smaller in size. The difference in habitat of swamp deer has led to the development of two sub species, hard ground and soft ground barasingha. The swamp deer and the sambar have large funnel shaped ears to catch maximum sound as both inhabit denser parts of the forests. Whereas the chital has short ears as it inhabits the fringes of the forest and open grasslands where catching sound is much easier. Deer have profound effect on their surroundings and every type of deer plays a very important role for Nature. They keep a control on the growth of grass and other tree types which are favoured by them. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 4 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Different species of Deer There are 45 species of deer. These species are: Chinese Water Deer, Bornean Yellow Muntjac, Black Muntjac, Fea's Muntjac, Gong Shan Muntjac, Indian Muntjac, Leaf Muntjac, Reeves' Muntjac, Truong Son Muntjac, Giant Muntjac, Tufted Deer, White-lipped or Thorold's Deer, Philippine or Visayan Spotted Deer, Barasingha, Red Deer, Thamin, Philippine Sambar or Philippine Brown Deer, Sika Deer, Sunda Sambar or Rusa Deer, Indian Sambar, Chital, Calamian Deer, Bawean Deer, Hog Deer, Pere David's Deer, Fallow Deer, Persian Fallow Deer, Roe Deer, Moose (Elk), Mule Deer, White-tailed Deer, Pampas Deer, Red Brocket, Merioa Brocket, Dwarf Brocket, Grey Brocket, Pygmy Brocket, Yucatan Brown Brocket, Little Red Brocket, Northern Pudu, Southern Pudu, Marsh Deer, Peruvian Guemal or North Andean Deer, Chilean Guemal or South Andean Deer & Caribou/Reindeer S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 5 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 2.2 Deer in satmaliya Fig.2.1 spotted deer SPOTTED DEER (Axis axis) Local Name:Chittal, Chitra pashu. Physical measurements: Height:65 to 90 cms. Horns:85 cms. Weight:69 to 90 kgs. Gestation:6 months,Litter size-one Life span:15 to 20 years. Breeding:Any time of the year. Description:chital is the most beautiful animal in the deer family. It looks extraordinary beautiful due to white dots on its golden coat. Male gets large antlers, which are branched, New antlers are velvety. Food:Grass, Leaves fruits. Tender shoots bark etc. Distribution:In forests of Gir, Dangs and vansda. Habitat: Deciduous forests. Behavior:Crepuscular this animal likes to graze at morning and at evening. Takes rest due daytime. It passes the night in a group in open ground area keeping vigil in all S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 6 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. directions. Gives alarm call like a shrill “Poohoo”. During rutting period male gives rutting call which is “Onhoo-Onhoo” Signs of presence: Hoof marks, alarm calls,rutting call, Sheded antlers. As the name suggest Chital has bright spots on its body. Out of the deer species Chital is the most beautiful of them. Its coat has shining rufous-fawn color with bright white spots all over the body and hardly changes color even in summers. In India Chital is very widely distributed from the base of Himalayas to the steaming forests of the south except in the north east. It inhabits the fringes of the forests and prefers to graze in the grasslands. Any place with good grazing ground and plentiful water will have the presence of Chital. Chital are always seen in herds numbering 20-30 and will have many stags. In many areas very big herds sometimes numbering hundreds have been seen together. They are known to raid the cultivation fields especially in areas which are adjacent to the forests and cause heavy damage to the crops. The best species of Chital can be found in the terai region in the foothills of Himalayas and in Madhya Pradesh. Fig.2.2Chital in group Out of all deer Chital are most sociable animal. They can be easily seen in the company of other deer species inhabiting the same forest. A very special relation ship worth mentioning is between langur monkeys and the Chital. Where ever langurs feed on the trees, chital can be seen feeding on the leaves and tender shoots which the monkeys drop on the ground. This relationship also acts as an advance warning system against the arrival of predators. On seeing a predator langurs give alarm call which makes the deer on the ground alert against the danger. The rutting season differs in Chital according to the areas they inhabit. In the northern areas of India they tend to breed in winters and in warmer areas of Madhya Pradesh they mate in summer months. The rutting call of an adult stag is a loud bellow and quite often fierce fight between two stags can be seen for possession of hinds. There are no territorial fights in Chital, the fights when happens are mainly for protecting the doe from other stags. As Chital are preyed by virtually all the predators they have a very prolific breeding cycle and give birth to young one every six month. In the wild a hind can be seen with two or sometimes three young fawns all of different ages. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 7 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.2.3 sambar SAMBAR (CERVUS UNICOLOUR) Local name: Sambar, sabar. Physical Measurements: Length: 150 to 200 cms. Height:135 cms. Weight:180 to 300 kgs. Antlers: 105 cms. Maturity:N.A. Gestation: 6 Months, Litter size one Life Span:N.A. Breeding:November, December. Description:Largest deer of the country. Male sambar can be identified by its dark brown body and long branched antlers. It has a long round ears. Female does not have antlers. Males have mane around neck and throat. Food: Grass- Leaves, Wild fruits. Distribution:In Gujrat , Shoolpaneswar sanctuary. Gir and Dangs Forests. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 8 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Habitat: Rocky and hilly area of dense and open deciduous forests. Behavior: Crepuscular to nocturnal, it takes rest during day time in Forest. It grazes from evening to early morning. Prefers wallowing in poop, makes loud “bhoonk” call when frightened, usually found in small groups in our area. Signs of presence:Shedded antlers, hairs in wallowing area, droppings. Sambhar is the largest of all deer species found in the Indian Sub-continent. It also has the finest pair of antlers sometimes reaching a length of around 40 inches. A full grown adult stag can reach a weight of 300 kg. It is mainly a forest dweller and prefers hills and denser parts of the forest. In India Sambhar is found from the lower ranges of Himalayas to the forests of south India, from the forests of Rajasthan to the forests of north east India. The color of the coat is mainly brown with greyish tinge. The coat is mainly shaggy and coarse and in summers the hair fall down. The older stags are very dark in color almost looking black. Sambhar prefers to live in the denser parts of the forest and likes to feed on leaves, wild fruits and grass. They are extremely shy of humans and usually feed during the later part of the evenings and in night. The sense of hearing is very acute in Sambhar and they are helped in this by their large funnel shaped ears. On seeing a predator a Sambhar gives a honking bark which is repeated as long the predator is seen. In spite of its size Sambhar are very nimble in moving through thick undergrowth without making much noise. They are also very good swimmers and can be seen in the waters especially in the lakes of Ranthambore. The shedding of antlers takes place mainly in March end till mid April.Sambhar s prefer to come to same tree again and again for rubbing off the velvet from the antlers. The antler size varies in between the Sambhar found in Madhya Pradesh and the ones found in the forests of North east India. Sambhar's have the largest and very well developed facial glands to attract the females by secreting scent and leaving the marks on the tree trunks. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 9 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.2.4 sambar The fight between two stags is mainly for protecting the territory and rarely for the females. The mating takes place mainly in November and December and the young ones are born on the onset of rains when the forest is dense and the grass is high. Males prefer to live alone and separate from hinds as soon as the mating is over. Sambhar's always move around in small herds with hinds and young stags normally seen together. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 10 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.2.5 blue bull BLUE BULL (Boselaphus tragocamelus) Local Name:Nilgai,Rose. Physical measurements:Length:215 cms Height: 130-140 cms. Weight:7 to 12 kgs. Maturity:Female 25 months, male 30-35 months. Gestation:9 months, Litter size:two. Life span:20 yrs. Breeding:not definite Discription:sexually dimorphic; horse like build; male has bluish black coat, two white spots on each side of cheek; lips, chin, ankle and under surface of tail, white; S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 11 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. black tuft of stiff hairs on throat; young and subadult males greyish –brownish; small cone like horns, female dark, brown pale rufous in colour. Habitat:grasslands, open countryside, open forests, scrub forests etc., Avoids dense forests and steep with terrain. Behavior: crepuscular, usually in small herd of 5-25. Makes a grunting sound when danger is sensed, reports to same spot for dropping known as “adkadi”. Can jump more than 2 meters. Signs of presence:hoof marks, “Akdi.” Fig.2.6 barking deer BARKING DEER (Munticacus muntjak) Local name: Bhekhar, bhenkadu, kakar. Physical measuremeants: Height: 50 to 75cms. Weight:23 kgs. Antler size :10 to 13 cms. Gestation: 6 Months. Litter size: two Life span :15 to 20 years. Breeding : Round the year winter is peak breeding season. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 12 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Description: Animal of deer fimaly , dark red or reddish brown in colour,males have small antlers which are bifurcated. Food: leaves ,grass,and fruits. Distribution: shoolpaneswar sanct uary and in the forest of panch mahals, dangs and vyara. Habitat :dense forest. Behavior:diurnal,the call resembles barking of dogs and hence the name; very shy, usually seen signly or in paris. Sings of presence: it make sound like sound of barking of dogs. It smells fear ,runs away with continuos barking , sheded out antlers ect. Fig.2.7chowsinga FOUR HORNED ANTELOPE (Tetraceros quadricornis) Local Name: Chowsinga, ghuntadu, ghutar, ghutari. Physical Measurements: Length: 80-115 cms. Height:60-65 cms. Weight: 15 to 20 kgs. Horns:Anterior 1-3 cms,posterior 8-12 cms. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 13 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Gestation: 8 to 8.5 months, litter size 1-2. Life span: 15 years Breeding: january, may. Meturity:20 months. Description: only antelope with two pairs of horns. Reddish brown from above; under parts, white; horns are not ringed; pair of glands in hindlegs. Female similar but do not have horns and is slightly shorter. Distribution:In gujarat , Gir and Girnar forest in saurashtra, sabarkantha, panchmahals, vadodara and south Gujarat. Habitat:Open to dense forests in hilly and undulating country. Behavior:crepuscular, usually solitary or in pairs, prefers areas not far from the waterhole, comes out in open areas for feeding but not too far from the edge of the forests.Quite shy, defecates at one place. Signs of presence:Small “Aakhali” a place for defecating. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 14 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 3 VETERINARY TREATMENT 3.1 Disease Fig.3.1 disease contening deer o Chronic wasting Disease in Deer. Fig.3.2 johne’s disease o This Deer has the wasted look that is a typical symptoms of Johne’s disease. Fig.3.3 hemorrhagic disease o Hemorrhagic disease in deer can be caused by either epizootic nemorr hagic. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 15 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Fig.3.4 ears disease o Deer ears before treatment. 3.2 medicines The treatment of deer is depend upon their health. If the animal feel not well they give special treatment of any disease. Like anti shock drug, anti septic drug, anti biotic, e.g. tetracycline. Hydrogen peroxide is use as disinfectant. Iodine, sprit is use for dressing. The Medicines are mostly use for treatment of Deer which is Fenbendazole Albendazole Praziquantel Fenbendazole : Formula : C15H13N3O2S methyl N-(6-phenylsulfanyl-1H-benzoimidazol2-yl)carbamate Fenbendazole Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including roundworms, hookworms, whipworms, the taenia species of tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to Deer sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 16 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Toxicity Despite being widely used as a dewormer in many species, toxicity has been reported. Birds (storks, pink pelicans, vultures, pigeons and doves) and reptiles (vipers, turtles and tortoises) have shown toxicity associated with bone marrow suppression, intestinal crypt cell necrosis and distal villi sloughing.] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents. Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally. Albendazol Methyl [6-(propylthio)-1H-ben Albendazole, marketed as Albania, Eskazole, Zentel and Andazol, is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Although this use is widespread in the United States, the U.S. Food and Drug Administration (FDA) has not approved albendazole for this indication. It is marketed by Amedra Pharmaceuticals. Albendazole was first discovered at the SmithKline Animal Health Laboratories in 1972. It is a broad spectrum anthelmintic, effective against: roundworms, tapeworms, and flukes of domestic animals and humans. Content Main uses It is effective first line of treatment against: Flatworms Flukes/trematodes Fasciolosis Tapeworm/cestodes Cysticercosis Echinococcosis[2] Nematodes Enterobiasis (pinworm infection) Trichuriasis (whipworm infection) Ascariasis Hookworm Cutaneous larva migrans (caused by Ancylostoma) Filariasis Mode of action As a vermicidal, albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 17 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies. Albendazole also has been shown to inhibit the enzyme fumarate reductase, which is helminth-specific. This action may be considered secondary to the effect on the microtubules due to the decreased absorption of glucose. This action occurs in the presence of reduced amounts of nicotinamide-adenine dinucleotide in reduced form (NADH), which is a coenzyme involved in many cellular oxidation-reduction reactions. Albendazole has larvicidal effects in necatoriasis and ovicidal effects in ascariasis, ancylostomiasis, and trichinosis. Dosage Albendazole is only given orally (PO). Hydatid disease (Echinococcosis) Patients 60 kg or greater: 400 mg twice daily, with meals. Patients less than 60 kg: 15 mg/kg/day given in divided doses twice daily with meals (maximum total daily dose 800 mg). Treatment interval: 28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles. Praziquantel (RS)-2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)one Praziquantel (Biltricide) is an anthelmintic effective against flatworms. Praziquantel is not licensed for use in humans in the UK; it is, however, available as a veterinary anthelmintic, and is available for use in humans on a named-patient basis. Contents Uses Flukes/trematodes Praziquantel is used against Schistosoma. As of 2005, praziquantel is the primary treatment for human schistosomiasis, for which it is usually effective in a single dose. Praziquantel is also used to treat liver flukes such as Clonorchis sine sis, and against fascioliasis. Praziquantel is also used to treat paragonimiasis.Tapeworms/cestodes Praziquantel is also used to treat cestode (tapeworm) infections, including: S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 18 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Echinococcosis Cysticercosis, though it has been judged less effective than albendazole in treatment of neurocysticercosis. Intestinal tapeworms. In veterinary medicine it is widely used against tapeworms, either alone or in combination with pyrantel pamoate Mode of action Although the mode of action is not exactly known at present, there is experimental evidence that praziquantel increases the permeability of the membranes of schist some cells towards calcium ions. The drug thereby induces contraction of the parasites, resulting in paralysis in the contracted state. The dying parasites are dislodged from their site of action in the host organism and may enter systemic circulation or may be destroyed by host immune reaction (phagocytosis). Additional mechanisms including focal disintegrations and disturbances of oviposition (lying of eggs) are seen in other types of sensitive parasites. Another hypothesis concerning the mechanism of action of praziquantel has been recently reported. The drug seems to interfere with adenosine uptake in cultured worms. This effect may have therapeutical relevance given that the schist some, as the Tania and the echinococcus (other praziquantel sensitive parasites), is unable to synthesize purines such as adenosine de novo. Bayer's Animal Health Division website states, "Praziquantel is active against custodies’ (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited. Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces." Side effects The majority of side effects develop due to the release of the contents of the parasites as they are killed and the consequent host immune reaction. The heavier the parasite burden, the heavier and more frequent the side effects normally are. Central nervous system: Frequently occurring side effects are dizziness, headache, and malaise. Drowsiness, somnolence, fatigue, and vertigo have also been seen. Almost all patients with cerebral cysticercosis experience CNS side effects related to the cell-death of the parasites (headache, worsening of pre-existing neurological problems, seizures, arachnoiditis, and meningism). These side effects may be life-threatening and can be reduced by coadministration of corticosteroids. It is strongly recommended that all patients with cerebral cysticercosis are hospitalized during treatment. GI Tract: Approximately 90% of all patients have abdominal pain or cramps with or without nausea and vomiting. Diarrhea may develop and may be severe with colic. Sweating, fever, and sometimes bloody stools may occur together with diarrhea. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 19 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. Liver: Asymptomatic and transient increases of liver enzymes (AST and ALT) are noted frequently (up to 27%). No case of symptomatic liver damage has ever been seen so far. Sensitivity reactions: Urticaria, rash, pruritus and eosinophilia in white blood cell counts Other locations/body as a whole: Lower back pain, myalgia, arthralgia, fever, sweating, various cardiac arrhythmias, and hypotension Drug interactions Antibiotics A study found that the antibiotic rifampicin decreases plasma concentrations of praziquantel. Antiepileptics Carbamazepine and phenytoin are reported to reduce the bioavailability of praziquantel. Antimalarials Chloroquine reduces the bioavailability of praziquantel. Antacids / histamine H2-antagonists At least 2 studies indicate the drug cimetidine heightens praziquantel bioavailability. Dosage For schistosomiasis, the dose is 20 milligrams/kilogram by mouth every 4–6 hours for one day. For tapeworms, the dose is 5–25 mg/kg by mouth once. For liver fluke, the dose is 25 mg/kg by mouth every 4–6 hours for one day. These dosages are for patients over 4 years old, and are to be taken with food or a few minutes before a meal. Brand names Biltricide (Bayer) 600 mg Tablets (for human use) Cesol (Merck) Tablets Cestoved (Vedco) both tablets and injectable for veterinary use Cysticide (Merck) Tablets S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 20 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 4. Organs use in medicine 4.1Deer Antlers and Chinese Medicine Fig.4.1 Deer juice Deer antlers are thought to "build up spiritual as well as physical powers." They are consumed in tonics and teas at the beginning of the winter to ward off flu and colds. The deer antlers are usually cut with blood imbedded in them. Sometimes the blood is squeezed out of the horn. One woman who was buying deer antlers at a pharmacy told the New York Times, "I need energy. I want to have a second baby, and I think this will help." Deer antler are often sliced paper thin and boiled with ginseng and herbs. The slices closer to the root are considered more valuable and better for health than those near the tip. Slices from short antler are said tp be better than those form long antlers, A 29-day treatment costs around $1,100. According to research by the New Zealand Game Industry—a source of deer antlers—antler velvet stimulates the immune system and white blood cell production. Their research showed that the upper sections of the antlers were more affective than those from the lower sections. Some Korean farmer farmers raise deer for their antlers. The meat is sold to venison-loving Germany. Imported deer antlers are purchased at a price $5 for 75 grams and sold for $9 on the wholesale market and $20 on the retail market. Koreans also fancy elk antlers. Moose antlers are considered low quality. In South Korea, tonics made with deer antlers and the parts of endangered animals are often consumed on special occasions, once or twice a year to boost energy. Deer sinew and tendons are regarded as cures for rheumatism. They comes in large and small portions. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 21 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 4.2 Deer Penis Fig.4.2 Deer Penis Dried deer penis is popular in traditional Chinese medicine, and sold in Chinese pharmacies, believing it has important therapeutic properties and effective for athletic injuries, and remedy for impotency or male virility. 4.3 Deer Antlers Fig.4.3 Deer Antlers Deer antlers are believed to build up physical and spiritual powers, if antlers are mixed in tonic or tea drinks and consumed and best remedy for colds and flu. As they cut the antlers, they squeezed the blood in it and mixed on herbal preparations. The antlers are sliced thinly and boiled with ginseng herbal plants and other herbs. They also believed if the slices are closer to the antler’s roots it is more effective for health than the antler’s tip. But the New Zealand Game and Industry research said the tip of antlers are more effective than of the lower part and stimulates the immune system and production of white blood cells. Deer Musk when rubbed in the “private parts”, can stimulate virility. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 22 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. 4.4 Deer Sinew and Tendons Fig.4.5 Deer Sinew(fresh) fig.4.6 Deer back sinew (dried) Fig.4.7 Deer tendons 4.5 Deer Antler Velvet Deer Antler Velvet has been prized in Chinese medicine for its use as a sexual stimulant, as well as a tonic. A 2000 year old silk scroll describes the use of deer antler as a remedy for over 50 illnesses. It is considered one of the strongest ‘yang’, or ‘male energy’ tonics. Yang energy is an important aspect of sexuality and libido in both men and women, as well as a primary indicator of overall health, strength and vitality. While deer antler velvet does not act as an immediate sexual stimulant it has been shown to have adaptogenic effects, enhancing overall strength and endurance, and decreasing muscle fatigue. 9 Deer Antlers are high in IGF-1 (insulin growth factor). 10 Maintenance of sufficient IGF-1 is linked to “anti-aging” factors in humans, including enhanced physical activity, muscle function, and testosterone and DHEA levels. 11 Deer Antler is high in amino acids, including arginine and the branched chain amino acids valine, leucine and isoleucine, needed for growth of muscle fibers. Scientific studies show that deer antler is useful for anemia, by increasing hemoglobin, as well as the number of red blood cells, 12 which supports energy and vitality. Deer antlers regenerate yearly 13, and undergo extremely active mitotic growth. One hypothesis of deer antler’s sexual enhancing effects, is that S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 23 SATMALIYA DEER PARK: THE ECOLOGICAL PROUD OF D.N. & H. these quickly regenerating cells may act in a similar manner to stem cells, and provide ‘young and rejuvenating’ cellular substance to the body. Measurement of the proliferating cell nuclear antigen (PCNA) found that the entire antler is in a state of growth and renewal, especially the keratinocytes that make up the basal cell layer of the epidermis that forms the deer antler velvet. 14 Deer antler velvet contains several components that support the growth of healthy joint tissue, including several glycosaminoglycans such as chondroitin sulfate, keratin sulfate, hyaluronic acid, and dermatan sulfate. 15 The dosage is 500mg-1000 mg/ day. The only known caution is the possibility of mild stomach upset with larger than usual doses of this supplement. 4 PRECOUTION The deer is very sensitive from T.B. disease Dry atmosphere without stress and good food is it’s first requirements. Does & Don’ts Precautions in the Park Do's Engage in Photography. Visit in small groups. Silence and discipline pays. Carry drinking water, binoculars and first aid medicines. Respect animal and their customs. Walk along the Nature trails. Don’ts Do not expect to see animals as a matter of routine, be patient. Do not enter the park without permission. Do not walk alone in the humpies. Do not take away anything away from the park. Do not wear colorful clothes and perfumes. Do not disturb or tease animals. Do not carry radio, tape recorder and other valuables. Do not throw litter around including food. Do not carry plastic Do not play Music /Car horns or shout. DO not disturb the animals Do not swim in unfair waters and don't carry cigarette and match boxes. Do not pluck flowers, leaves. Do not damage trees. S.S.R. COLLEGE OF PHARMACY,SILVASSA, 2011-12 Page 24
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