Mitochondria and Neurodegeneration
Lecture/Seminar series SS2017
9:00-10:45 CECAD Research Center, Joseph-Stelzmann-Str. 26
April 12
11:00 Introduction (Thomas Langer)
CECAD Research Center, seminar room 1st floor
General reading:
Nunnari, J. and Suomalainen, A. (2012) Mitochondria: In Sickness and in Health. Cell
148, 1145-1159.
April 18
Mitochondrial biogenesis and processes (Thomas Langer)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Bohnert, M., Pfanner, N., and van der Laan, M. (2015) Mitochondrial machineries for
insertion of membrane proteins. Curr. Opin. Struct. Biol. 33, 92-102.
Harbauer, A.B., Zahedi, R.P., Sickmann, A., Pfanner, N., and Meisinger, C. (2014)
The protein import machinery of mitochondria – a regulatory hub in metabolism,
stress and disease. Cell Metabol. 19, 357-372.
Kamer, K.J. and Mootha, V.K. (2015) The molecular era of the mitochondrial calcium
uniporter. Nat. Rev. Mol. Cell Biol. 16, 545-553.
April 19
Mitochondria, oxidative stress and ROS production (Jan Riemer)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Murphy, M. (2009) How mitochondria produce reactive oxygen species. Biochem. J.
417, 1-13. doi: 10.1042/BJ20081386.
Yun, J., and Finkel, T. (2014) Mitohormesis. Cell Metab. pii: S1550-4131(14)00017-5.
Sena, L.A., and Chandel, N.S. (2012) Physiological roles of mitochondrial reactive
oxygen species. Mol Cell. 48, 158-167.
Finkel, T. (2011) Signal transduction by reactive oxygen species. J. Cell Biol. 194, 715.
Hekimi, S., Lapointe, J., and Wen, Y. (2011) Taking a “good” look at free radicals in
the aging process. Trends Cell Biol. 21, 569-76.
April 20
Nuclear regulation of mitochondrial biogenesis (Elena Rugarli)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Scarpulla, R.C. (2012) Nucleus-encoded regulators of mitochondrial function:
Integration of respiratory chain expression, nutrient sensing and metabolic stress.
Biochim. Biophys. Acta 1819, 1088-1097.
Lesnik, C., Golani-Armon, A., and Arava, Y. (2015) Localized translation near the
mitochondrial outer membrane: An update. RNA Biology 12, 801-809.
Quirós, P.M., Mottis, A., and Auwerx, J. (2016) Mitonuclear communication in
homeostasis and stress. Nat. Rev. Mol. Cell Biol. 17, 213-226.
April 21
mtDNA organization and mitochondrial gene expression
(Aleksandra Trifunovic)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Bratic, A., and Larsson, N.G. (2013) The role of mitochondria in aging. J. Clin. Invest.
123, 951-957.
Hällberg, B.M, and Larsson, N.G. (2014) Making proteins in the powerhouse. Cell
Metab. 20, 226-240.
Acin-Perez, R., and Enriquez, J.A. (2014) The function of respiratory supercomplexes: the plasticity model. Biochim. Biophys. Acta 1837, 444-450.
Falkenberg, M., Larsson, N.G., and Gustafsson, C.M. (2007) DNA replication and
transcription in mammalian mitochondria. Annu. Rev. Biochem. 76, 679-99. Review.
April 24
mtDNA genetics and diseases (Elena Rugarli)
CECAD Research Center, seminar room 0.039/0.040
Bibliography
DiMauro, S., Schon, E.A., Carelli, V., and Hirano, M. (2013) The clinical maze of
mitochondrial neurology. Nat. Rev. Neurol. 9, 429-444. doi:10.1038/nneurol.2013.126
Ross, J.M., Stewart, J.B., Hagström, E., Brené, S., Mourier, A., Coppotelli, G.,
Freyer, C., Lagouge, M., Hoffer, B.J., Olson, L., and Larsson, N.G. (2013) Germline
mitochondrial DNA mutations aggravate ageing and can impair brain development.
Nature 501, 412-415.
Hill, J.H., Chen, Z., and Xu, H. (2014) Selective propagation of functional
mitochondrial DNA during oogenesis restricts the transmission of a deleterious
mitochondrial variant. Nat. Genet. 46, 389-392.
April 25
Mitochondrial fission and fusion (Mafalda Escobar)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Friedman, J.R. and Nunnari, J. (2014) Mitochondrial form and function. Nature 505,
335-343.
Mishra, P., and Chan, D.C. (2014) Mitochondrial dynamics and inheritance during cell
division, development and disease. Nat. Rev. Mol. Cell Biol. 15, 634-646.
Westermann, B. (2010) Mitochondrial fusion and fission in cell life and death. Nat.
Rev. Mol. Cell Biol. 11, 872-884.
April 26
Mitochondrial quality control and disease I (Thomas Langer)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Pickrell, A.M., and Youle, R.J. (2015) The roles of PINK1, Parkin, and mitochondrial
figelity in Parkinson’s disease. Neuron 85, 257-273.
Rugarli, E.I., and Langer, T. (2012) Mitochondrial quality control: a matter of life and
death for neurons. EMBO J. 31, 1336-1349.
Haynes, C.M., Fiorese, C.J., and Lin, Y.F. (2013) Evaluating and responding to
mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond.
Trends Cell Biol. 23, 311-318.
Youle, R., Van der Bliek, A.M. (2012) Mitochondrial fission, fusion and stress.
Science 337, 1062-1065.
April 26
12:00 Seminar room, MPI Biology of Ageing
Seminar Nika Danial, Harvard Medical School
“Tba”
April 28
Mitochondrial quality control and disease II (Thomas Langer)
CECAD Research Center, seminar room 0.037/0.038
Bibliography
Exner, N., Lutz, A.K., Haass, C., and Winklhofer, K.F. (2012) Mitochondrial
dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological
consequences EMBO J. 31, 3038 – 3062.
Chen, H., and Chan, D.C. (2009) Mitochondrial dynamics- fusion, fission, movement,
and mitophagy- in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-R176.
May 2
Mitochondria in neuronal development, survival and synaptic
transmission (Matteo Bergami)
CECAD Research Center, lecture hall ground floor
Bibliography
Arimura, N., and Kaibuchi, K. (2007) Neuronal polarity: from extracellular signals to
intracellular mechanisms. Nat. Rev. Neurosci. 8, 194-205.
Sheng, Z.H. (2014) Mitochondrial trafficking and anchoring in neurons: New insight
and implication. J. Cell Biol. 204, 1087-1098.
Sheng and Cai. (2012) Mitochondrial transport in neurons: impact on synaptic
homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77-93.
May 5
Student seminar I
CECAD Research Center, seminar room 0.037/0.038
May 12
Student seminars II
CECAD Research Center, seminar room 0.037/0.038
May 19
Student seminars III
CECAD Research Center, seminar room 0.037/0.038
May 24
Student poster session (CECAD Research Center,
09:00 – 12:00, seminar room 1st floor
June 2
Written exam
CECAD Research Center, seminar room 1st floor, 10:00 – 12:00