Supplementary Fig. S1: A. Confirmation of EAC in post-treatment animals B.
Potential response to AUY-922. Abnormal patterns of keratinization in distal
areas of the esophagus where EAC normally develops. Observed only in
treatment animals.
Supplementary Fig. S2: A. Decrease in tumor volume as measured by MRI pre
and post-treatment in 3 individual animals. Animal 3 tumor volume was below
MRI detection levels but tumor was confirmed by endoscopic visualization pretreatment. B. Corresponding decrease in Hsp90b gene expression upon AUY922
treatment.