Table 2. Functional ROI resulting from the conjunction of activations in the Control, PD OFF, and PD ON groups 1.
Table S3. Functional ROI resulting from the conjunction of activations in the Control, PD OFF, and PD On
Groups 1.
Region
Frontal
Encoding Phase
BA
Y
Z
6,31
6,31
24
4,6
4,6
6,8,9
10
6,9,10,46
6,9
10
46,47
9
9,44,45,47
10
47
-8
9
2
-43
42
-28
-33
36
16
31
-42
-47
48
34
45
-7
-7
35
-7
-8
28
51
19
37
52
26
6
13
28
40
45
44
8
37
38
37
-6
37
41
-1
0
25
18
-7
1
24.1
27.6
14.0
17.5
15.9
29.8
2.1
17.7
11.3
1.5
3.0
2.9
5.8
1.1
.4
L Postcentral
R Postcentral
2,3
3,5
7
-23
-29
-18
-62
37
55
22
40
9.0
6.0
3.5
24.6
L Postcentral
R Postcentral
L Superior, precuneus
-45
33
56
-15
L Superior, precuneus
2,3
2,3
5
7
R Superior, precuneus
7
16
-62
41
29.7
R Superior, precuneus
7
L Inferior
40
37
32
36
15
19.0
1.2
17.3
13.4
40
40
23
-41
-68
-45
-54
L Inferior
R Inferior
B Posterior cingulate
-46
-43
48
1
R Inferior
B Posterior cingulate
40
29,30
23
L Superior
R Superior
22
22
-50
52
-24
-27
6
8
21.7
20.8
L Superior
R Superior
22
22
L Middle
39
21
-47
-54
-59
-9
13
-13
12.3
4.7
L Middle
21
39
L preSMA/SMA, cingulate
R preSMA/SMA, cingulate
B Anterior cingulate
L Precentral
R Precentral
L Superior/middle
(medial, lateral)
R Superior/middle
(medial, lateral)
L Inferior
R Inferior
ml
Region
Frontal
Decision Phase
BA
X
Parietal
X
Y
Z
ml
L Pre SMA/SMA, cingulate
R Pre SMA/SMA, cingulate
B Anterior cingulate
L Precentral
R Precentral
L Superior/middle
(medial, lateral)
R Superior/middle
(medial, lateral)
6,31
6,31
24,32
4,6
4,6
6,9,10
6,8
6,9,10,11
-8
8
1
-41
42
-35
-16
30
-5
-3
34
-8
-7
27
34
27
46
46
9
39
39
29
43
34
30.3
32.6
12.9
21.9
16.6
23.5
12.0
37.4
L Inferior
9,44,47
-44
19
7
11.4
R Inferior
9,45,47
45
20
8
12.6
-41
50
16
-23
-7
-39
28
8
-46
-26
-23
-48
-58
-58
-72
-59
-62
-41
44
37
65
50
33
35
49
33
37
17.1
9.5
.9
10.6
4.6
.5
7.8
6.8
23.5
47
3
1
-43
-55
-33
37
14
24
22.3
8.8
.5
-51
52
50
-54
-41
-24
-24
-58
-28
-67
7
7
22
-5
22
21.2
17.6
.9
11.0
4.3
Parietal
Temporal
Temporal
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R Middle
L Inferior, fusiform gyrus
21,39
37
20
37
37
20
51
-35
-57
-47
38
60
-45
-59
-15
-67
-59
-14
5
-12
-19
0
-12
-17
18.4
6.3
1.0
.6
7.2
.4
L parahippocampus.
36
-22
-39
-6
5.0
R parahippocampus
36
25
-36
-7
6.0
L Insula
R Insula
13
13
-39
40
-9
-8
10
9
12.6
12.0
17,18,19
17,18,19
-20
21
-80
-81
9
9
43.4
45.2
-13
14
-24
25
-20
21
9
1
1
-20
-20
-3
-4
-13
-16
20
-27
-18
8
8
5
5
15
16
0
-18
-5
5.9
5.9
7.1
6.7
4.5
3.5
.4
7.8
3.8
0
0
0
-19
21
-21
23
-70
-45
-63
-56
-58
-60
-59
-23
-13
-3
-16
-17
-34
-34
1.5
1.0
.5
24.9
23.0
20.8
19.3
652.9
R Inferior, fusiform gyrus
Occipital
L Occipital
R Occipital
L parahippocampus,
amygdala
R parahippocampus,
amygdala
L Insula
R Insula
13
13
53
-35
-54
-46
39
50
48
-28
-19
27
14
28
-39
40
-42
-66
-11
-67
-59
-8
-67
-19
-46
-33
-45
-5
-7
-7
3
-13
-21
0
-12
-26
0
-12
3
-12
3
-14
9
9
16.8
3.5
1.3
.5
5.5
.6
.6
1.8
.5
2.3
.5
.5
14.4
13.6
17,18,19
17,18,19
-20
21
-80
-80
5
7
28.9
38.4
-12
13
-23
24
-15
13
-18
-19
-2
-2
-4
2
8
8
3
5
13
15
6.3
6.2
9.8
7.8
6.4
5.1
0
1
-24
-17
-17
-5
7.4
4.3
0
1
0
-19
20
-22
22
-71
-45
-63
-57
-56
-63
-62
-23
-13
-3
-17
-16
-33
-33
1.5
1.0
.6
24.1
29.8
21.5
22.3
662.7
36
L Occipital
R Occipital
Subcortical
Cerebellum
B Vermis (a, p)
(a)
(a)
L Lobule 4-6
R Lobule 4-6
L Lobule 7-10
R Lobule 7-10
R Inferior, fusiform gyrus
21,39
37
20
37
37
20
37
36
Occipital
Subcortical
L Thalamus
R Thalamus
L Putamen, GP
R Putamen, GP
L Caudate (body, tail)
R Caudate (body, tail)
(head)
B Brainstem
B Midbrain
R Middle
L Inferior, fusiform gyrus
L Thalamus
R Thalamus
L Putamen, GP
R Putamen, GP
L Caudate (head, body, tail)
R Caudate (head, body,
tail)
B Brainstem
B Midbrain
Cerebellum
B Vermis (a, p)
(a)
(a)
L Lobule 4-6
R Lobule 4-6
L Lobule 7-10
R Lobule 7-10
Total Volume
Total Volume
fROIs are displayed in Figure 3.
1
Conjunction ROIs were constructed separately for activations during the encoding (left columns) and decision (right columns)
phases. Brodmann areas (BA) were defined by the Talairach and Tournoux (1988) atlas. Cerebellar lobules were defined by the
Schmahmann atlas (Schmahmann et al., 2000). Coordinates represent distance in mm from anterior commissure: x, right(+)/left (-);
y, anterior (+)/posterior (-); z, superior (+)/inferior (-). B = bilateral, L= left hemisphere; R = right hemisphere; GP = globus pallidus;
SMA = supplementary motor area; a = anterior cerebellar lobule; b = posterior cerebellar lobule.
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