SUPPLEMENTARY APPENDIX
Supplementary Table 1. OCT Qualitative and Quantitative Analyses of Dissected Stent Edges
N (analyzed stent edge)
Plaque Characteristics
Stent-landing region
“Normal” vessel
Presence of atherosclerotic plaque
- Circumferential distribution
- Eccentric distribution
Plaque type
- Fibrotic
- Fibro-calcific
- Lipid-rich
Calcium quantification
- Angle, degrees
- Calcium-to-lumen distance, mm
Lipid-rich plaque quantification
- FC surface area, mm2
- Average FC thickness, µm
- Minimum FC Thickness, µm
- TCFA
Quantitative Measurements
Stent Border (inside the stent)
Stent area, mm2
Stent eccentricity index
5-mm Stent Edge (outside the stent)
Lumen area, mm2
MLA, mm2
Lumen eccentricity index
Post-PCI diameter stenosis, %
Post-PCI area stenosis, %
Vascular Stretching
Peri-Stent Region
- SD/LD
- SA/LA
5-mm Stent Edge
- SD/Mean LD
- SA/Mean LA
Distal Edge
72
Proximal Edge
34
P Value
4 (5.6)
68 (94.4)
18 (26.5)
50 (73.5)
1 (2.9)
33 (97.1)
18 (54.5)
15 (45.5)
0.578
0.578
0.023
0.038
32/68 (47.1)
24/68 (35.3)
12/68 (17.6)
4/33 (12.1)
17/33 (51.5)
12/33 (36.4)
0.022
0.209
0.100
106.30 ± 67.25
0.08 ± 0.08
153.25 ± 85.53
0.05 ± 0.06
0.112
0.180
0.41 ± 0.17
149.67 ± 42.34
70.97 ± 45.41
7/12 (58.3)
0.46 ± 0.17
148.99 ± 46.32
60.83 ± 30.90
7/12 (58.3)
0.080
0.387
0.044
1.000
5.91 ± 2.15
0.10 ± 0.08
7.84 ± 3.45
0.14 ± 0.09
0.013
0.042
4.90 ± 2.26
3.97 ± 2.12
0.21 ± 0.06
19.83 ± 8.80
20.94 ± 11.33
7.70 ± 4.36
6.42 ± 4.21
0.23 ± 0.09
20.44 ± 9.17
18.87 ± 12.51
0.003
0.009
0.166
0.814
0.458
1.02 ± 0.06
1.05 ± 0.14
1.00 ± 0.09
1.06 ± 0.43
0.104
0.860
1.13 ± 0.11
1.27 ± 0.25
1.04 ± 0.13
1.07 ± 0.24
0.005
0.006
Data presented as mean ± SD or number (percentage). FC: fibrous cap; LA: lumen area; LD: lumen
diameter; MLA: minimum lumen area; PCI: percutaneous coronary intervention; SA: stent area; SD: stent
diameter; TCFA: thin cap fibroatheroma
Supplementary Table 2. OCT Qualitative and Morphometric Analysis of Edge Dissections Identified
Both by OCT and Angiography Versus OCT Alone
N (dissected edges)
Dissection Longitudinal Length, mm
OCT + Angiography
OCT Alone
17
89
3.43 ± 2.08
1.77 ± 1.35
Dissection Appearance on OCT
Flap
P Value
0.005
0.373
17 (100)
85 (95.5)
1 (5.8)
12 (13.5)
Number of Flaps per Dissection
1.82 ± 0.64
1.38 ± 0.77
0.018
Number of Cavities per Dissection
0.05 ± 0.24
0.13 ± 0.34
0.281
Maximum Flap Depth, mm
0.94 ± 0.48
0.55 ± 0.34
0.006
Maximum Flap Opening, mm
0.62 ± 0.26
0.34 ± 0.33
0.001
Maximum Flap Length, mm
1.61 ± 0.59
0.99 ± 0.64
0.001
Maximum Flap Area, mm2
0.72 ± 0.53
0.33 ± 0.32
0.008
Maximum Cavity Depth, mm
0.45 ± 0.0
0.46 ± 0.26
0.967
Maximum Cavity Opening, mm
0.47 ± 0.0
0.65 ± 0.27
0.519
Maximum Cavity Area, mm2
0.14 ± 0.0
0.21 ± 0.17
0.712
5 (29.4)
5 (5.6)
0.002
Hematoma Longitudinal Length
2.92 ± 2.24
0.90 ± 0.20
0.114
Maximum Hematoma Area, mm2
0.98 ± 0.61
0.85 ± 0.65
0.746
4 (23.5)
0 (0.0)
<0.0001
Cavity
Intramural Hematoma
Intraluminal Thrombus
Depth of Vessel Injury
<0.0001
Intimal
0 (0.0)
50 (56.2)
Medial
12 (70.6)
39 (43.8)
Adventitial
5 (29.4)
0 (0.0)
Data presented as mean ± SD or number (percentage)
Supplementary Table 3. OCT Qualitative and Morphometric Characteristics of Individual NonTreated Dissections in Patients with MACE
Patients
1
2
3
4
4
Dist. Edge
Prox. Edge
5
6
Dissection Longitudinal Length, mm
0.4
0.6
1.0
2.2
1.2
1.0
1.0
Dissection Appearance on OCT
Flap
Flap
Flap
Flap
Flap
Flap
Flap/Cavity
Number of Flaps per Dissection
1
1
1
2
1
1
1
Number of Cavities per Dissection
0
0
0
0
0
0
1
Maximum Flap Depth, mm
0.45
0.23
0.42
0.69
0.55
0.49
0.21
Maximum Flap Opening, mm
0.24
0.12
0.31
0.15
0.35
0.23
0.12
Maximum Flap Length, mm
1.21
0.38
0.75
1.35
1.28
1.34
0.26
0.21
0.05
0.14
0.52
0.41
0.32
0.03
Maximum Cavity Depth, mm
…
…
…
…
…
…
0.55
Maximum Cavity Opening, mm
…
…
…
…
…
…
0.97
…
…
…
…
…
…
0.3
Intramural Hematoma
No
No
No
No
No
No
No
Intraluminal Thrombus
No
No
No
No
No
No
No
Depth of Vessel Injury
Intimal
Intimal
Intimal
Medial
Medial
Medial
Intimal
No
No
No
No
No
No
No
Maximum Flap Area, mm
2
Maximum Cavity Area, mm
2
Dissection Seen by Angiography
Supplementary Table 4. OCT Qualitative and Morphometric Analysis of Non-Treated Dissections
in Patients With and Without MACE
Edge Dissections Left Untreated
P Value
Overall
No MACE
MACE
82
75
7
1.75 ± 1.54
1.81 ± 1.59
1.12 ± 0.59
0.26
Flap
78 (95.1)
71 (94.6)
7 (100)
0.53
Cavity
12 (14.6)
11 (14.6)
1 (14.3)
0.97
Number of Flaps per Dissection
1.34 ± 0.74
1.36 ± 0.76
1.14 ± 0.37
0.46
Number of Cavities per Dissection
0.14 ± 0.35
1.14 ± .035
1.14 ± 0.37
0.97
Maximum Flap Depth, mm
0.52 ± 0.32
0.52 ± 0.34
0.43 ± 0.17
0.47
Maximum Flap Opening, mm
0.32 ± 0.32
0.33 ± 0.34
0.21 ± 0.09
0.35
Maximum Flap Length, mm
0.92 ± 0.60
0.92 ± 0.62
0.93 ± 0.47
0.95
Maximum Flap Area, mm2
0.29 ± 0.30
0.29 ± 0.31
0.24 ± 0.18
0.64
Maximum Cavity Depth, mm
0.43 ± 0.24
0.42 ± 0.25
0.55 ± 0
0.65
Maximum Cavity Opening, mm
0.62 ± 0.26
0.59 ± 0.25
0.97 ± 0
0.17
Maximum Cavity Area, mm2
0.18 ± 0.15
0.89 ± 0.62
1.10 ± 0
0.45
7 (8.5)
7 (9.3)
0 (0)
0.39
1.98 ± 2.00
1.98 ± 2.00
0
N/A
0.79 ± 0.56
0.79 ± 0.56
0
N/A
1 (1.2)
1 (1.3)
0
0.75
Intimal
47 (57.3)
43 (57.4)
4 (57.2)
0.99
Medial
34 (41.5)
31 (41.3)
3 (42.8)
0.93
1 (1.2)
1 (1.3)
0 (0)
0.75
N (dissected edges left untreated)
Dissection Longitudinal Length, mm
Dissection Appearance on OCT
Intramural Hematoma
Hematoma Longitudinal Length
Maximum Hematoma Area, mm
Intraluminal Thrombus
2
Depth of Vessel Injury
Adventitial
Data presented as mean ± SD or number (percentage). P value is for comparison between OCT-detected
dissection with and without MACE