Supplementary table 3: Comparison of the regulatory ratios (WT versus mutant) obtained by
overexpression of ScHAP4 or HpHAP4A in Sc∆hap4 mutant: genes encoding components of the
mitochondrial translation apparatus
Gene
MEF2
RPM2
TUF1
MSD1
MRPL6
MRPL19
MSR1
YMR31
MRPS5
MRP51
MRPL7
MRPL15
RML2
MEF1
ISM1
PET123
Fold
change
*∆hap4
4
3.84
2.22
2.17
1.96
Fold
change
ScHAP4
9.3
4.03
no
no
no
Fold
change
HAP4A
4.21
5.35
2.02
1.93
2.74
1.85
no
1.96
1.85
1.85
1.81
no
3
no
no
no
2.36
Mitochondrial ribosomal protein (small subunit)
Mitochondrial ribosomal protein MRPL7
Mitochondrial ribosomal protein MRPL15
Mitochondrial ribosomal protein L2
Mitochondrial elongation factor G-like protein
1.79
no
2.67
1.79
1.79
1.75
1.72
no
no
no
no
3.03
2.75
2.14
3.63
Mitochondrial isoleucyl-tRNA synthetase
1.72*
no
no
Mitochondrial ribosomal protein of small subunit
1.69
no
2.59
1.69
no
2.26
1.69
1.67
1.67
no
no
no
2.36
no
no
1.67*
no
no
1.64
1.64
1.61
1.61
1.62
no
no
no
no
no
2.59
no
1.9
2.68
no
1.56
no
no
1.56
1.56
1.56
1.53
1.51
1.51
1.51
no
no
1.97
no
no
no
no
3.93
2.29
2.9
1.99
2.82
2.08
3.24
Function
Mitochondrial elongation factor G-like protein
Subunit of mitochondrial RNase P
Mitochondrial translation elongation factor Tu
Mitochondrial aspartyl-tRNA synthetase
Mitochondrial ribosomal protein MRPL6
Mitochondrial ribosomal protein of the large
subunit
Arginyl-tRNA synthetase
Mitochondrial ribosomal protein
Probable mitochondrial ribosomal protein S5
MRF1
Mitochondrial polypeptide chain release factor
MRPL11
Mitochondrial ribosomal protein MRPL11
MST1
Mitochondrial threonine-tRNA synthetase
MSE1
Mitochondrial glutamyl-tRNA synthetase
coupling of mitochondrial translation and
SLS1
transcription
MRPS17
weak similarity to bacterial ribosomal protein S17
GRS2
strong similarity to glycyl-tRNA synthetases
MSM1
Mitochondrial methionyl-tRNA synthetase
NAM9
putative Mitochondrial S4 ribosomal protein
AIM10
similarity to E.coli prolyl-tRNA synthetase
Mitochondrial ribosomal protein homologous to E.
MRP4
coli S2
MRPL40
Mitochondrial ribosomal protein MRPL40
MRPL9
Mitochondrial ribosomal protein MRPL9
MRPL35
Mitochondrial ribosomal protein MRPL35
MRPL10
Mitochondrial ribosomal protein MRPL10
MRPL17
ribosomal protein of the large subunit (YmL30)
NAM2
Mitochondrial leucyl tRNA synthetase
YMR158W Weak similarity to E.coli ribosomal S8 protein
* see footnotes of Table S1
1