Michaelis–Menten enzyme kinetics. The hyperbolic relationship between enzymatic reaction velocity and the drug substrate concentration is described by
Michaelis–Menten enzyme kinetics. The KM is the substrate concentration when the velocity of the reaction is at 0.5Vmax.
Source: Drug Elimination and Hepatic Clearance, Applied Biopharmaceutics & Pharmacokinetics, 7e
Citation: Shargel L, Yu AC. Applied Biopharmaceutics & Pharmacokinetics, 7e; 2016 Available at: http://mhmedical.com/ Accessed: July 31,
2017
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