Microprobe activities in Lund
An overview
Overview
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University of Lund/ LTH
Physics – applied Nuclear Physics
Micro beam, PIXE and singe cell facility
Additional /potential resources
The irradiation facility, Status, plans and future.
Human resources, PhD program
• Lund University (LU) (http://www.lu.se )
is a research intensive and comprehensive
university with eight faculties,
• about 41000 students, (City of Lund 100 000)
• 6500 employees,
• and 3000 PhD students (460 PhD exams/year)
• The turnover is about 5000 million SEK
The Physics Department
( http://fysik.lu.se/ )
300 researchers and
employees:
• Experimental High
Energy Physics
• Nuclear Physics,
• Synchrotron
Radiation Physics,
• Atomic Physics and
• Solid State Physics
The Nuclear Microprobe group (http://micro.pixe.lth.se/) is a
main research group within the Division of Nuclear Physics
(http://nuclearphysics.pixe.lth.se/) and has a long
and world class tradition in the field of Ion beam
analysis using MeV ions for quantitative multielement characterisation of microscopic
structures, e.g. PIXE.
• A second field of interest is
the controlled use of single
MeV ions to specifically
create localised damage
for special purposes;
localised low dose
irradiation of single living
cells and direct write µmscale proton lithography.
•The irradiation facility is based on a single-ended 3 MeV electrostatic
accelerator, high quality focusing lenses and similar equipment.
•A facility for studying extreme low-dose irradiation of living cells is under
development at the laboratory.
•It is based on the technique to extract single MeV ions from the
accelerator system, allowing studies on a cellular level of phenomena like
mutagenic effects, bystander effect, adaptive response.
•The group has a close cooperation with the Department of Radiation
Physics in Lund regarding cell biology, and is also a part of the Lund
University network Alliance for Biomedical Imaging and Bioengineering
with competence in mathematical modelling and advanced image analysis.
The sub-micron line
• Several years ago funding was given to
construct the sub-micron beam line.
• The Single cell irradiation activity started with the
CELLION project.
• Instrumentation was decided to be integrated in
the coming sub-micron beam line that was
already under construction: split quadrupole lens
configuration, a new flexible irradiation chamber,
new high vacuum beam lines, etc.
The Lund sub-micron beamline
(not to scale)
Irradiation
chamber
Beam
viewer
+ FC
QPlens 2
HVdeflector
”Electrostatic
chopper”
Aperture
2
Crossover
QPlens 1
Aperture
1
The irradiation
chamber is built
around a framework
with flexible sides.
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Obj.& det.
X_Y_Z
Backplane
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Obj.& det.
Sample holder
Microscope
and
TV
X_Y_Z
Backplane
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Microscope
and
TV
X_Y_Z
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Beam
Scanning
coils
Microscope
and
TV
X_Y_Z
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Microscope
and
TV
X_Y_Z
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Microscope
and
TV
X_Y_Z
High
vacuum
pump
The irradiation
chamber is built
around a framework
with flexible sides.
Microscope
and
TV
X_Y_Z
High
vacuum
pump
Single cell irradiation project
• Existing facilities
• CELLION
• Funding for equipment (30 k€,Crafoord)
• For the project, 80% goes into instrumentation development including cell design, 20 % into biological programme.
Focused, horizontal beam
200 nm Si3N4 exit window
Particle detection after the cells (PIN diode)
Investigating the possibilities to use thín DE
detectors as pre-cell detector
Swedish PhD studies/ CELLION E.S.R.
• Courses (50 credits = 75
CTS)
• Research training
• Publications
---------= 4 years
(+ 20% teaching)
= 5 years
•Research training
•Publications
----------------= 3 years
---------------+ 1 year paid by
Lund University
=> PhD
Web based protocol for PhD
studies
• Formalities (supervisor,
subject, resources,..)
• Year by year plan
• Courses
• Conferences
• Research training
• Publications
Micro beam group
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Natalia Arteaga (CELLION), PhD
Vaida Auzelyte (proton litography), PhD
Mikael Elfman (res. Eng.)
Per Kristianssson (prof)
Klas Malmqvist (prof)
Charlotta Nilsson, (master thesis done, CELLION,PhD in
Leipzig)
Christer Nilsson (res. techn)
Jan Pallon ( CELLION) (Ass. Prof.)
Marie Wegdén (BNCT, H_H scattering, tomography), PhD
Fredrik Andersson (master thesis done) Bordeaux
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Anna Mölder, master thesis