Arterial Paclitaxel Distribution and Deposition
by Christopher J. Creel, Mark A. Lovich, and Elazer R. Edelman
Circulation Research
Volume 86(8):879-884
April 28, 2000
Copyright © American Heart Association, Inc. All rights reserved.
Equilibrium distribution of paclitaxel reveals partitioning above and beyond perfusate
concentration and a spatial gradient of drug across the arterial wall.
Christopher J. Creel et al. Circ Res. 2000;86:879-884
Copyright © American Heart Association, Inc. All rights reserved.
Tissue concentration normalized by the endovascularly (A) or perivascularly (B) applied
concentration as a function of time in the presence of a physiological transmural hydrostatic
pressure gradient of 90 mm Hg (average±SE, n=3).
Christopher J. Creel et al. Circ Res. 2000;86:879-884
Copyright © American Heart Association, Inc. All rights reserved.
Total arterial deposition as a function of time in the presence of a physiological transmural
hydrostatic pressure gradient of 90 mm Hg (average±SE, n=3).
Christopher J. Creel et al. Circ Res. 2000;86:879-884
Copyright © American Heart Association, Inc. All rights reserved.
Comparison of paclitaxel and heparin average arterial tissue concentrations at 1 hour with
delivery from the endovascular and perivascular aspects (average±SE, n=3).
Christopher J. Creel et al. Circ Res. 2000;86:879-884
Copyright © American Heart Association, Inc. All rights reserved.