Target Heart Failure Populations for Newer Therapies
by Lynne Warner Stevenson, Gregory Couper, Barbara Natterson, Gregg Fonarow,
Michele A. Hamilton, Mary Woo, and Julie W. Creaser
Circulation
Volume 92(9):174-181
November 1, 1995
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows relationship of ejection fraction (EF) to 2-year actuarial survival without urgent
transplant (Urg Tx) in 500 patients presenting 1988 to 1993 with New York Heart Association
class III or IV symptoms.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows actuarial survival and survival without urgent transplantation (urg tx) for 404 patients
presenting 1988 to 1993 for transplant evaluation with ejection fraction ≤25% and New York Heart
Association class III (n=139) or IV (n=265) symptoms.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.
Bar graph shows size of patient population and frequency of 2-year end points of death and
urgent transplant (Urg tx) for all patients with ejection fraction ≤25% and New York Heart
Association class IV symptoms, then for population groups that would be formed by dividing at
the median values for cardiac index (CI), right atrial pressure (RAP), and pulmonary capillary
wedge pressure (PCW) measured at the time of initial presentation.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.
Bar graph shows size of patient population and frequency of 2-year end points of death and
urgent transplant (urg tx) for all patients with ejection fraction ≤25% and New York Heart
Association class IV symptoms and then for the population groups that would be formed by
dividing at the median values for cardiac index (CI), right atrial pressure (RAP), and pulmonary
capillary wedge pressure (PCW) measured after therapy tailored to reduce PCW and systemic
vascular resistance.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows actuarial survival (Act surv), sudden death–free survival, and survival without urgent
transplantation (Urg tx, urgent tx) over 2 years for 128 patients who presented for
transplantation and were selected only on the basis of left ventricular ejection fraction (LVEF)
≤25% and left ventricular end-diastolic dimension (LVD) of ≥80 mm.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.
Plot shows relationship of actuarial survival (Act Surv) without urgent transplantation (urg tx) to
ability to exercise and achieve peak oxygen (pkVO2) consumption over 10 mL/kg per minute at
the time of presentation.
Lynne Warner Stevenson et al. Circulation. 1995;92:174-181
Copyright © American Heart Association, Inc. All rights reserved.