Action Potential Duration Restitution and Alternans in
Rabbit Ventricular Myocytes
by Joshua I. Goldhaber, Lai-Hua Xie, Tan Duong, Christi Motter, Kien Khuu, and
James N. Weiss
Circulation Research
Volume 96(4):459-466
March 4, 2005
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. APD and Ca2+i restitution measured by the S1S2 pacing protocol.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Comparison of APD restitution and APD restitution slope during S1S2 pacing (A and
D), and dynamic pacing (B and E), in two representative myocytes.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. A, Maximum slope of APD restitution and range of DIs with slope >1 for the S1S2 and
dynamic pacing protocols, respectively.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Effect of eliminating SR Ca2+ release on APD restitution and APD restitution slope
during S1S2 pacing (A and B) and dynamic pacing (C and D), in two representative myocytes
studied in the perforated patch configuration.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Effects of TG/RY (open bars) on the maximum slope of APD restitution (left) and range
of DIs with slope >1 (right) for the S1S2 and dynamic (Dyn) pacing protocols, respectively.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 6. Effect of buffering Ca2+i with BAPTA-AM on APD restitution and APD restitution slope
during S1S2 pacing (A and B) and single beat dynamic pacing (C and D), in representative
myocytes studied using the perforated patch configuration.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.
Figure 7. A, Effects of BAPTA-AM (open bars) on the maximum slope of APD restitution (left) and
range of DI with slope >1 (right) for the S1S2 and single beat dynamic (Dyn) pacing protocols,
respectively.
Joshua I. Goldhaber et al. Circ Res. 2005;96:459-466
Copyright © American Heart Association, Inc. All rights reserved.