PRALUENT® (alirocumab)
ICD-10 Pocket Guide
Your guide to ICD-10 coding for clinical
atherosclerotic cardiovascular disease (ASCVD)
INDICATION AND USAGE
PRALUENT (alirocumab) is a PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9)
inhibitor antibody indicated as adjunct to diet and maximally tolerated statin therapy
for the treatment of adults with heterozygous familial hypercholesterolemia or clinical
atherosclerotic cardiovascular disease, who require additional lowering of LDL-C.
The effect of PRALUENT on cardiovascular morbidity and mortality has not
been determined.
IMPORTANT SAFETY INFORMATION
PRALUENT is contraindicated in patients with a history of a serious
hypersensitivity reaction to PRALUENT. Reactions have included
hypersensitivity vasculitis and hypersensitivity reactions
requiring hospitalization.
Please click here for full Prescribing Information.
For additional support with
ICD-10 coding, call
1-844-PRALUENT (1-844-772-5836)
and select 1, or contact your
PRALUENT® (alirocumab)
field access specialist.
Table of Contents
ASCVD: Coronary Heart Disease
Arteriosclerotic Heart Disease
4
With Angina
4
Other5
Acute Coronary Syndromes
5
Myocardial Infarction
5
Acute, Active
5
History of Heart Attack (old)
5
Angina5
Coronary Revascularization
5
ASCVD: Cerebrovascular
Arteriosclerotic Cerebrovascular Disease
Ischemic Stroke
Transient Ischemic Attack (TIA)
History of Ischemic Stroke
With Residuals
Without Residuals
6
7
9
10
10
10
ASCVD: Peripheral Vascular
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
Peripheral Artery Revascularization
Please use as many clinical ASCVD codes as needed
to appropriately describe your patient’s condition.
Brought to you by Sanofi and Regeneron Pharmaceuticals, Inc.
Please click here for full Prescribing Information.
­2
3
11
19
Coronary Heart Disease
Arteriosclerotic Heart Disease (other)
Arteriosclerotic Heart Disease With Angina
I25.10 Atherosclerotic heart disease of native coronary artery without angina pectoris
I25.110 Atherosclerotic heart disease of native coronary artery with unstable angina pectoris
I25.111 Atherosclerotic heart disease of native coronary artery with angina pectoris with documented spasm
I25.118 Atherosclerotic heart disease of native coronary artery with other forms of angina pectoris
I25.119 Atherosclerotic heart disease of native coronary artery with unspecified angina pectoris
I25.710 Atherosclerosis of autologous vein coronary artery bypass graft(s) with unstable angina pectoris
I25.711 Atherosclerosis of autologous vein coronary artery bypass graft(s) with angina pectoris with documented spasm
I25.718 Atherosclerosis of autologous vein coronary artery bypass graft(s) with other forms of angina pectoris
I25.719 Atherosclerosis of autologous vein coronary artery bypass graft(s) with unspecified angina pectoris
I25.730 Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unstable angina pectoris
I25.731 Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with angina pectoris with documented spasm
I25.738 Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with other forms of angina pectoris
I25.739 Atherosclerosis of nonautologous biological coronary artery bypass graft(s) with unspecified angina pectoris
I25.720 Atherosclerosis of autologous artery coronary artery bypass graft(s) with unstable angina pectoris
I25.721 Atherosclerosis of autologous artery coronary artery bypass graft(s) with angina pectoris with documented spasm
I25.728 Atherosclerosis of autologous artery coronary artery bypass graft(s) with other forms of angina pectoris
I25.729 Atherosclerosis of autologous artery coronary artery bypass graft(s) with unspecified angina pectoris
I25.700 Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris
I25.701 Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris with documented spasm
I25.708 Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris
I25.709 Atherosclerosis of coronary artery bypass graft(s), unspecified, with unspecified angina pectoris
I25.790 Atherosclerosis of other coronary artery bypass graft(s) with unstable angina pectoris
I25.791 Atherosclerosis of other coronary artery bypass graft(s) with angina pectoris with documented spasm
I25.798 Atherosclerosis of other coronary artery bypass graft(s) with other forms of angina pectoris
I25.799 Atherosclerosis of other coronary artery bypass graft(s) with unspecified angina pectoris
I25.810 Atherosclerosis of coronary artery bypass graft(s) without angina pectoris
I25.750 Atherosclerosis of native coronary artery of transplanted heart with unstable angina
I25.751 Atherosclerosis of native coronary artery of transplanted heart with angina pectoris with documented spasm
I25.758 Atherosclerosis of native coronary artery of transplanted heart with other forms of angina pectoris
I25.759 Atherosclerosis of native coronary artery of transplanted heart with unspecified angina pectoris
I25.811 Atherosclerosis of native coronary artery of transplanted heart without angina pectoris
I25.760 Atherosclerosis of bypass graft of coronary artery of transplanted heart with unstable angina
I25.761 Atherosclerosis of bypass graft of coronary artery of transplanted heart with angina pectoris with documented spasm
I25.768 Atherosclerosis of bypass graft of coronary artery of transplanted heart with other forms of angina pectoris
I25.769 Atherosclerosis of bypass graft of coronary artery of transplanted heart with unspecified angina pectoris
I25.812 Atherosclerosis of bypass graft of coronary artery of transplanted heart without angina pectoris
I25.82
I25.83 I25.84 Chronic total occlusion of coronary artery
Coronary atherosclerosis due to lipid rich plaque
Coronary atherosclerosis due to calcified coronary artery lesion
Acute Coronary Syndromes
I24.1
I24.0 I24.8 I23.7 Dressler’s syndrome (postmyocardial infarction syndrome)
Acute coronary thrombosis not resulting in myocardial infarction
Other forms of acute ischemic heart disease (includes acute and subacute coronary insufficiency)
Postinfarction angina
Acute Myocardial Infarction (active)
I21.09
I21.01 I21.02 I22.0 I21.19 I22.1 I21.11 I21.29 I21.4 I22.2 I21.21 I22.8 I21.3 I22.9 ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wall
ST elevation (STEMI) myocardial infarction involving left main coronary artery
ST elevation (STEMI) myocardial infarction involving left anterior descending coronary artery
Subsequent ST elevation (STEMI) myocardial infarction of anterior wall
ST elevation (STEMI) myocardial infarction involving other coronary artery of inferior wall
Subsequent ST elevation (STEMI) myocardial infarction of inferior wall
ST elevation (STEMI) myocardial infarction involving right coronary artery
ST elevation (STEMI) myocardial infarction involving other sites
Non-ST elevation (NSTEMI) myocardial infarction
Subsequent non-ST elevation (NSTEMI) myocardial infarction
ST elevation (STEMI) myocardial infarction involving left circumflex coronary artery
Subsequent ST elevation (STEMI) myocardial infarction of other sites
ST elevation (STEMI) myocardial infarction of unspecified site
Subsequent ST elevation (STEMI) myocardial infarction of unspecified site
History of Heart Attack (old)
I25.2 Old myocardial infarction
Coronary Revascularization
Z95.1
Presence of aortocoronary bypass graft (assigned when the patient is status post CABG)
Z95.5 Presence of coronary angioplasty implant and graft (assigned when the patient is status post coronary artery angioplasty with stenting)
Z98.61 Coronary angioplasty status (assigned when the patient is status post coronary artery angioplasty without stenting)
IMPORTANT SAFETY INFORMATION
PRALUENT® (alirocumab) is contraindicated in patients with
a history of a serious hypersensitivity reaction to PRALUENT.
Reactions have included hypersensitivity vasculitis and
hypersensitivity reactions requiring hospitalization.
Please click here for full Prescribing Information.
­4
5
Cerebrovascular Conditions
Arteriosclerotic Cerebrovascular Disease
I65.1
I65.21
I65.22
I65.23
I65.29
I65.01
I65.02
I65.03
I65.09
I65.8
I65.9
I66.01
I66.02
I66.03
I66.09
I66.11
I66.12
I66.13
I66.19
I66.21
I66.22
I66.23
I66.29
I66.3
I66.8
I66.9
I67.2 I67.81 I67.82 Occlusion and stenosis of basilar artery (not resulting in cerebral infarction)
Occlusion and stenosis of right carotid artery (not resulting in cerebral infarction)
Occlusion and stenosis of left carotid artery (not resulting in cerebral infarction)
Occlusion and stenosis of bilateral carotid arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified carotid artery (not resulting in cerebral infarction)
Occlusion and stenosis of right vertebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of left vertebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of bilateral vertebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified vertebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of other precerebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified precerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of right middle cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of left middle cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of bilateral middle cerebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified middle cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of right anterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of left anterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of bilateral anterior cerebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified anterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of right posterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of left posterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of bilateral posterior cerebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified posterior cerebral artery (not resulting in cerebral infarction)
Occlusion and stenosis of cerebellar arteries (not resulting in cerebral infarction)
Occlusion and stenosis of other cerebral arteries (not resulting in cerebral infarction)
Occlusion and stenosis of unspecified cerebral artery (not resulting in cerebral infarction)
Cerebral atherosclerosis (not resulting in cerebral infarction)
Acute cerebrovascular insufficiency (not resulting in cerebral infarction)
Cerebral ischemia (not resulting in cerebral infarction)
Ischemic Stroke
I63.02
I63.12 I63.22
I63.031 I63.032 I63.039
I63.131 I63.132 I63.139 I63.231
I63.232
I63.239
I63.011 I63.012 I63.019 I63.111 I63.112 I63.119 I63.211
I63.212
I63.219
I63.09 I63.19 I63.29
I63.00 I63.10 I63.20
Cerebral infarction due to thrombosis of basilar artery
Cerebral infarction due to embolism of basilar artery
Cerebral infarction due to unspecified occlusion or stenosis of basilar arteries
Cerebral infarction due to thrombosis of right carotid artery
Cerebral infarction due to thrombosis of left carotid artery
Cerebral infarction due to thrombosis of unspecified carotid artery
Cerebral infarction due to embolism of right carotid artery
Cerebral infarction due to embolism of left carotid artery
Cerebral infarction due to embolism of unspecified carotid artery
Cerebral infarction due to unspecified occlusion or stenosis of right carotid arteries
Cerebral infarction due to unspecified occlusion or stenosis of left carotid arteries
Cerebral infarction due to unspecified occlusion or stenosis of unspecified carotid arteries
Cerebral infarction due to thrombosis of right vertebral artery
Cerebral infarction due to thrombosis of left vertebral artery
Cerebral infarction due to thrombosis of unspecified vertebral artery
Cerebral infarction due to embolism of right vertebral artery
Cerebral infarction due to embolism of left vertebral artery
Cerebral infarction due to embolism of unspecified vertebral artery
Cerebral infarction due to unspecified occlusion or stenosis of right vertebral arteries
Cerebral infarction due to unspecified occlusion or stenosis of left vertebral arteries
Cerebral infarction due to unspecified occlusion or stenosis of unspecified vertebral arteries
Cerebral infarction due to thrombosis of other precerebral artery
Cerebral infarction due to embolism of other precerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of other precerebral arteries
Cerebral infarction due to thrombosis of unspecified precerebral artery
Cerebral infarction due to embolism of unspecified precerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of unspecified precerebral arteries
IMPORTANT SAFETY INFORMATION
Hypersensitivity reactions (e.g., pruritus, rash, urticaria), including some serious
events (e.g., hypersensitivity vasculitis and hypersensitivity reactions requiring
hospitalization), have been reported with PRALUENT treatment. If signs or symptoms
of serious allergic reactions occur, discontinue treatment with PRALUENT, treat
according to the standard of care, and monitor until signs and symptoms resolve.
Please click here for full Prescribing Information.
­6
7
Ischemic Stroke (cont’d)
I63.30 I63.311 I63.312 I63.319 I63.321 I63.322 I63.329 I63.331 I63.332 I63.339 I63.341 I63.342 I63.349 I63.39 I63.6 I63.40 I63.411
I63.412 I63.419 I63.421 I63.422 I63.429
I63.431 I63.432 I63.439
I63.441 I63.442 I63.449 I63.49 Cerebral infarction due to thrombosis of unspecified cerebral artery
Cerebral infarction due to thrombosis of right middle cerebral artery
Cerebral infarction due to thrombosis of left middle cerebral artery
Cerebral infarction due to thrombosis of unspecified middle cerebral artery
Cerebral infarction due to thrombosis of right anterior cerebral artery
Cerebral infarction due to thrombosis of left anterior cerebral artery
Cerebral infarction due to thrombosis of unspecified anterior cerebral artery
Cerebral infarction due to thrombosis of right posterior cerebral artery
Cerebral infarction due to thrombosis of left posterior cerebral artery
Cerebral infarction due to thrombosis of unspecified posterior cerebral artery
Cerebral infarction due to thrombosis of right cerebellar artery
Cerebral infarction due to thrombosis of left cerebellar artery
Cerebral infarction due to thrombosis of unspecified cerebellar artery
Cerebral infarction due to thrombosis of other cerebral artery
Cerebral infarction due to cerebral venous thrombosis, nonpyogenic
Cerebral infarction due to embolism of unspecified cerebral artery
Cerebral infarction due to embolism of right middle cerebral artery
Cerebral infarction due to embolism of left middle cerebral artery
Cerebral infarction due to embolism of unspecified middle cerebral artery
Cerebral infarction due to embolism of right anterior cerebral artery
Cerebral infarction due to embolism of left anterior cerebral artery
Cerebral infarction due to embolism of unspecified anterior cerebral artery
Cerebral infarction due to embolism of right posterior cerebral artery
Cerebral infarction due to embolism of left posterior cerebral artery
Cerebral infarction due to embolism of unspecified posterior cerebral artery
Cerebral infarction due to embolism of right cerebellar artery
Cerebral infarction due to embolism of left cerebellar artery
Cerebral infarction due to embolism of unspecified cerebellar artery
Cerebral infarction due to embolism of other cerebral artery
I63.50
I63.511
I63.512
I63.519
I63.521
I63.522
I63.529
I63.531
I63.532
I63.539
I63.541
I63.542
I63.549
I63.59
I63.8 I63.9 Cerebral infarction due to unspecified occlusion or stenosis of unspecified cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of right middle cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of left middle cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of unspecified middle cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of right anterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of left anterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of unspecified anterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of right posterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of left posterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of unspecified posterior cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of right cerebellar artery
Cerebral infarction due to unspecified occlusion or stenosis of left cerebellar cerebral artery
Cerebral infarction due to unspecified occlusion or stenosis of unspecified cerebellar artery
Cerebral infarction due to unspecified occlusion or stenosis of other cerebral arteries
Other cerebral infarction
Cerebral infarction, unspecified
Transient Ischemic Attack (TIA)
G45.0
G45.1
G45.2
G45.8
G45.9
Vertebro-basilar artery syndrome
Carotid artery syndrome (hemispheric)
Multiple and bilateral precerebral artery syndromes
Other transient cerebral ischemic attacks and related syndromes
Transient cerebral ischemic attack, unspecified
IMPORTANT SAFETY INFORMATION
The most commonly occurring adverse reactions (≥5% of patients treated with
PRALUENT and occurring more frequently than with placebo) are nasopharyngitis,
injection site reactions, and influenza.
Please click here for full Prescribing Information.
­8
9
History of Ischemic Stroke With Residuals
I69.31 I69.320
I69.321
I69.322
I69.323
I69.328
I69.359
I69.351
I69.352
I69.353
I69.354
I69.339
I69.331
I69.332
I69.333
I69.334
I69.349
I69.341
I69.342
I69.343
I69.344
I69.369
I69.361
I69.362
I69.363
I69.364
I69.365
I69.398
I69.390
I69.391
I69.392
I69.393
I69.398
I69.30
Cognitive deficits following cerebral infarction
Aphasia following cerebral infarction
Dysphasia following cerebral infarction
Dysarthria following cerebral infarction
Fluency disorder following cerebral infarction
Other speech and language deficits following cerebral infarction
Hemiplegia and hemiparesis following cerebral infarction affecting unspecified side
Hemiplegia and hemiparesis following cerebral infarction affecting right dominant side
Hemiplegia and hemiparesis following cerebral infarction affecting left dominant side
Hemiplegia and hemiparesis following cerebral infarction affecting right non-dominant side
Hemiplegia and hemiparesis following cerebral infarction affecting left non-dominant side
Monoplegia of upper limb following cerebral infarction affecting unspecified side
Monoplegia of upper limb following cerebral infarction affecting right dominant side
Monoplegia of upper limb following cerebral infarction affecting left dominant side
Monoplegia of upper limb following cerebral infarction affecting right non-dominant side
Monoplegia of upper limb following cerebral infarction affecting left non-dominant side
Monoplegia of lower limb following cerebral infarction affecting unspecified side
Monoplegia of lower limb following cerebral infarction affecting right dominant side
Monoplegia of lower limb following cerebral infarction affecting left dominant side
Monoplegia of lower limb following cerebral infarction affecting right non-dominant side
Monoplegia of lower limb following cerebral infarction affecting left non-dominant side
Other paralytic syndrome following cerebral infarction affecting unspecified side
Other paralytic syndrome following cerebral infarction affecting right dominant side
Other paralytic syndrome following cerebral infarction affecting left dominant side
Other paralytic syndrome following cerebral infarction affecting right non-dominant side
Other paralytic syndrome following cerebral infarction affecting left non-dominant side
Other paralytic syndrome following cerebral infarction, bilateral
Other sequelae of cerebral infarction
Apraxia following cerebral infarction
Dysphagia following cerebral infarction
Facial weakness following cerebral infarction
Ataxia following cerebral infarction
Other sequelae of cerebral infarction
Unspecified sequelae of cerebral infarction
Peripheral Vascular Conditions
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
I70.0
I70.1 I70.201 I70.202 I70.203 I70.208 I70.209 I70.211 I70.212 I70.213 I70.218 I70.219 I70.221 I70.222 I70.223 I70.228 I70.229 Atherosclerosis of aorta
Atherosclerosis of renal artery
Unspecified atherosclerosis of native arteries of extremities, right leg
Unspecified atherosclerosis of native arteries of extremities, left leg
Unspecified atherosclerosis of native arteries of extremities, bilateral legs
Unspecified atherosclerosis of native arteries of extremities, other extremity
Unspecified atherosclerosis of native arteries of extremities, unspecified extremity
Atherosclerosis of native arteries of extremities with intermittent claudication, right leg
Atherosclerosis of native arteries of extremities with intermittent claudication, left leg
Atherosclerosis of native arteries of extremities with intermittent claudication, bilateral legs
Atherosclerosis of native arteries of extremities with intermittent claudication, other extremity
Atherosclerosis of native arteries of extremities with intermittent claudication, unspecified extremity
Atherosclerosis of native arteries of extremities with rest pain, right leg
Atherosclerosis of native arteries of extremities with rest pain, left leg
Atherosclerosis of native arteries of extremities with rest pain, bilateral legs
Atherosclerosis of native arteries of extremities with rest pain, other extremity
Atherosclerosis of native arteries of extremities with rest pain, unspecified extremity
IMPORTANT SAFETY INFORMATION
Local injection site reactions including erythema/redness, itching, swelling, and
pain/tenderness were reported more frequently in patients treated with PRALUENT
(7.2% versus 5.1% for PRALUENT and placebo, respectively). Few patients
discontinued treatment because of these reactions (0.2% versus 0.4% for PRALUENT
and placebo, respectively), but patients receiving PRALUENT had a greater number
of injection site reactions, had more reports of associated symptoms, and had
reactions of longer average duration than patients receiving placebo.
History of TIA or Stroke Without Residuals
Z86.73
Personal history of transient ischemic attack (TIA) and cerebral infarction without residual deficits
Please click here for full Prescribing Information.
­10
11
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
(cont’d)
I70.231 I70.232 I70.233 I70.234 I70.235 I70.238 I70.239 I70.241 I70.242 I70.243 I70.244 I70.245 I70.248 I70.249 I70.25 I70.261 I70.262 I70.263 I70.268 I70.269 I70.291 I70.292 I70.293 I70.298 I70.299 170.301
I70.302
I70.303
I70.308
I70.309
I70.311
I70.312
I70.313
I70.318
I70.319
Atherosclerosis of native arteries of right leg with ulceration of thigh
Atherosclerosis of native arteries of right leg with ulceration of calf
Atherosclerosis of native arteries of right leg with ulceration of ankle
Atherosclerosis of native arteries of right leg with ulceration of heel and midfoot
Atherosclerosis of native arteries of right leg with ulceration of other part of foot
Atherosclerosis of native arteries of right leg with ulceration of other part of lower right leg
Atherosclerosis of native arteries of right leg with ulceration of unspecified site
Atherosclerosis of native arteries of left leg with ulceration of thigh
Atherosclerosis of native arteries of left leg with ulceration of calf
Atherosclerosis of native arteries of left leg with ulceration of ankle
Atherosclerosis of native arteries of left leg with ulceration of heel and midfoot
Atherosclerosis of native arteries of left leg with ulceration of other part of foot
Atherosclerosis of native arteries of left leg with ulceration of other part of lower left leg
Atherosclerosis of native arteries of left leg with ulceration of unspecified site
Atherosclerosis of native arteries of other extremities with ulceration
Atherosclerosis of native arteries of extremities with gangrene, right leg
Atherosclerosis of native arteries of extremities with gangrene, left leg
Atherosclerosis of native arteries of extremities with gangrene, bilateral legs
Atherosclerosis of native arteries of extremities with gangrene, other extremity
Atherosclerosis of native arteries of extremities with gangrene, unspecified extremity
Other atherosclerosis of native arteries of extremities, right leg
Other atherosclerosis of native arteries of extremities, left leg
Other atherosclerosis of native arteries of extremities, bilateral legs
Other atherosclerosis of native arteries of extremities, other extremity
Other atherosclerosis of native arteries of extremities, unspecified extremity
Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, right leg
Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, left leg
Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, bilateral legs
Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, other extremity
Unspecified atherosclerosis of unspecified type of bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, right leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, left leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, other extremity
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
I70.321
I70.322
I70.323
I70.328
I70.329
I70.331
I70.332
I70.333
I70.334
I70.335
I70.338
I70.339
I70.341
I70.342
I70.343
I70.344
I70.345
I70.348
I70.349
I70.35
I70.361
I70.362
I70.363
I70.368
I70.369
I70.391
I70.392
I70.393
I70.398
I70.399
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, right leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, left leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, bilateral legs
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, other extremity
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with rest pain, unspecified extremity
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of thigh
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of calf
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of ankle
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of heel and midfoot
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of foot
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of other part of lower leg
Atherosclerosis of unspecified type of bypass graft(s) of the right leg with ulceration of unspecified site
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of thigh
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of calf
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of ankle
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of heel and midfoot
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of foot
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of other part of lower leg
Atherosclerosis of unspecified type of bypass graft(s) of the left leg with ulceration of unspecified site
Atherosclerosis, unspecified type of bypass graft of other extremity, with ulceration
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, right leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, left leg
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, bilateral legs
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, other extremity
Atherosclerosis of unspecified type of bypass graft(s) of the extremities with gangrene, unspecified extremity
Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, right leg
Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, left leg
Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, bilateral legs
Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, other extremity
Other atherosclerosis of unspecified type of bypass graft(s) of the extremities, unspecified extremity
IMPORTANT SAFETY INFORMATION
Neurocognitive events were reported in 0.8% of patients treated with PRALUENT
and 0.7% of patients treated with placebo. Confusion or memory impairment were
reported more frequently by those treated with PRALUENT (0.2% for each)
than in those treated with placebo (<0.1% for each).
Please click here for full Prescribing Information.
­12
13
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
(cont’d)
I70.601 I70.602
I70.603
I70.608
I70.609
I70.611
I70.612
I70.613
I70.618
I70.619
I70.621
I70.622
I70.623
I70.628
I70.629
I70.631
I70.632
I70.633
I70.634
I70.635
I70.638
I70.639
I70.641
I70.642
I70.643
I70.644
I70.645
I70.648
I70.649
I70.65
I70.661
I70.662
I70.663
I70.668
I70.669
Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg
Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg
Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs
Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity
Unspecified atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, right leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, left leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, bilateral legs
Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, other extremity
Atherosclerosis of nonbiological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, right leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, left leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, bilateral legs
Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, other extremity
Atherosclerosis of nonbiological bypass graft(s) of the extremities with rest pain, unspecified extremity
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of thigh
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of calf
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of ankle
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of heel and midfoot
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of foot
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of other part of lower leg
Atherosclerosis of nonbiological bypass graft(s) of the right leg with ulceration of unspecified site
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of thigh
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of calf
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of ankle
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of heel and midfoot
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of foot
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of other part of lower leg
Atherosclerosis of nonbiological bypass graft(s) of the left leg with ulceration of unspecified site
Atherosclerosis of nonbiological bypass graft(s) of other extremity with ulceration
Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, right leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, left leg
Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, bilateral legs
Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, other extremity
Atherosclerosis of nonbiological bypass graft(s) of the extremities with gangrene, unspecified extremity
I70.691
I70.692
I70.693
I70.698
I70.699
I70.701
I70.702
I70.703
I70.708
I70.709
I70.711
I70.712
I70.713
I70.718
I70.719
I70.721
I70.722
I70.723
I70.728
I70.729
I70.731
I70.732
I70.733
I70.734
I70.735
I70.738
I70.739
Other atherosclerosis of nonbiological bypass graft(s) of the extremities, right leg
Other atherosclerosis of nonbiological bypass graft(s) of the extremities, left leg
Other atherosclerosis of nonbiological bypass graft(s) of the extremities, bilateral legs
Other atherosclerosis of nonbiological bypass graft(s) of the extremities, other extremity
Other atherosclerosis of nonbiological bypass graft(s) of the extremities, unspecified extremity
Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, right leg
Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, left leg
Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs
Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, other extremity
Unspecified atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, right leg
Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, left leg
Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, bilateral legs
Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, other extremity
Atherosclerosis of other type of bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, right leg
Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, left leg
Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, bilateral legs
Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, other extremity
Atherosclerosis of other type of bypass graft(s) of the extremities with rest pain, unspecified extremity
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of thigh
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of calf
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of ankle
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of heel and midfoot
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of foot
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of other part of lower leg
Atherosclerosis of other type of bypass graft(s) of the right leg with ulceration of unspecified site
IMPORTANT SAFETY INFORMATION
Liver-related disorders (primarily related to abnormalities in liver enzymes) were
reported in 2.5% of patients treated with PRALUENT and 1.8% of patients treated
with placebo, leading to treatment discontinuation in 0.4% and 0.2% of patients,
respectively. Increases in serum transaminases to greater than 3 times the upper limit
of normal occurred in 1.7% of patients treated with PRALUENT and 1.4% of patients
treated with placebo.
Please click here for full Prescribing Information.
­14
15
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
(cont’d)
I70.741 I70.742
I70.743
I70.744
I70.745
I70.748
I70.749
I70.75
I70.761
I70.762
I70.763
I70.768
I70.769
I70.791
I70.792
I70.793
I70.798
I70.799
I70.401
I70.402
I70.403
I70.408
I70.409
I70.411
I70.412
I70.413
I70.418
I70.419
I70.421
I70.422
I70.423
I70.428
I70.429
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of thigh
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of calf
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of ankle
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of heel and midfoot
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of foot
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of other part of lower leg
Atherosclerosis of other type of bypass graft(s) of the left leg with ulceration of unspecified site
Atherosclerosis of other type of bypass graft(s) of other extremity with ulceration
Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, right leg
Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, left leg
Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, bilateral legs
Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, other extremity
Atherosclerosis of other type of bypass graft(s) of the extremities with gangrene, unspecified extremity
Other atherosclerosis of other type of bypass graft(s) of the extremities, right leg
Other atherosclerosis of other type of bypass graft(s) of the extremities, left leg
Other atherosclerosis of other type of bypass graft(s) of the extremities, bilateral legs
Other atherosclerosis of other type of bypass graft(s) of the extremities, other extremity
Other atherosclerosis of other type of bypass graft(s) of the extremities, unspecified extremity
Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, right leg
Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, left leg
Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, bilateral legs
Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, other extremity
Unspecified atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, right leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, left leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, bilateral legs
Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, other extremity
Atherosclerosis of autologous vein bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, right leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, left leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, bilateral legs
Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, other extremity
Atherosclerosis of autologous vein bypass graft(s) of the extremities with rest pain, unspecified extremity
I70.431
I70.432
I70.433
I70.434
I70.435
I70.438
I70.439
I70.441
I70.442
I70.443
I70.444
I70.445
I70.448
I70.449
I70.45
I70.461
I70.462
I70.463
I70.468
I70.469
I70.491
I70.492
I70.493
I70.498
I70.499
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of thigh
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of calf
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of ankle
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of heel and midfoot
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of foot
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of other part of lower leg
Atherosclerosis of autologous vein bypass graft(s) of the right leg with ulceration of unspecified site
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of thigh
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of calf
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of ankle
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of heel and midfoot
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of foot
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of other part of lower leg
Atherosclerosis of autologous vein bypass graft(s) of the left leg with ulceration of unspecified site
Atherosclerosis of autologous vein bypass graft(s) of other extremity with ulceration
Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, right leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, left leg
Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, bilateral legs
Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, other extremity
Atherosclerosis of autologous vein bypass graft(s) of the extremities with gangrene, unspecified extremity
Other atherosclerosis of autologous vein bypass graft(s) of the extremities, right leg
Other atherosclerosis of autologous vein bypass graft(s) of the extremities, left leg
Other atherosclerosis of autologous vein bypass graft(s) of the extremities, bilateral legs
Other atherosclerosis of autologous vein bypass graft(s) of the extremities, other extremity
Other atherosclerosis of autologous vein bypass graft(s) of the extremities, unspecified extremity
IMPORTANT SAFETY INFORMATION
The most common adverse reactions leading to treatment discontinuation in patients
treated with PRALUENT were allergic reactions (0.6% versus 0.2% for PRALUENT
and placebo, respectively) and elevated liver enzymes (0.3% versus <0.1%).
PRALUENT is a human monoclonal antibody. As with all therapeutic proteins, there
is a potential for immunogenicity with PRALUENT.
Please click here for full Prescribing Information.
­16
17
Atherosclerosis of Peripheral and Other Non-coronary, Non-cerebral Vessels
(cont’d)
I70.501 I70.502
I70.503
I70.508
I70.509
I70.511
I70.512
I70.513
I70.518
I70.519
I70.521
I70.522
I70.523
I70.528
I70.529
I70.531
I70.532
I70.533
I70.534
I70.535
I70.538
I70.539
I70.541
I70.542
I70.543
I70.544
I70.545
I70.548
I70.549
I70.55
I70.561
I70.562
I70.563
I70.568
I70.569
Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg
Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg
Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs
Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity
Unspecified atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, right leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, left leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, bilateral legs
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, other extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with intermittent claudication, unspecified extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, right leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, left leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, bilateral legs
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, other extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with rest pain, unspecified extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of thigh
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of calf
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of ankle
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of heel and midfoot
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of foot
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of other part of lower leg
Atherosclerosis of nonautologous biological bypass graft(s) of the right leg with ulceration of unspecified site
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of thigh
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of calf
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of ankle
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of heel and midfoot
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of foot
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of other part of lower leg
Atherosclerosis of nonautologous biological bypass graft(s) of the left leg with ulceration of unspecified site
Atherosclerosis of nonautologous biological bypass graft(s) of other extremity with ulceration
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, right leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, left leg
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, bilateral legs
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, other extremity
Atherosclerosis of nonautologous biological bypass graft(s) of the extremities with gangrene, unspecified extremity
I70.591
I70.592
I70.593
I70.598
I70.599
I70.8 I70.90
I70.91
I70.92 I73.9 Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, right leg
Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, left leg
Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, bilateral legs
Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, other extremity
Other atherosclerosis of nonautologous biological bypass graft(s) of the extremities, unspecified extremity
Atherosclerosis of other arteries
Unspecified atherosclerosis
Generalized atherosclerosis
Chronic total occlusion of artery of extremities
Peripheral vascular disease, unspecified (assigned for PVD and PAD)
Peripheral Artery Revascularization
Z95.820Peripheral vascular angioplasty status with implants and grafts (assigned when the patient is status post peripheral artery
angioplasty with stenting)
Z98.62 Peripheral vascular angioplasty status (assigned when the patient is status post peripheral artery angioplasty without stenting)
IMPORTANT SAFETY INFORMATION
PRALUENT® (alirocumab) is contraindicated in patients with a history of a serious
hypersensitivity reaction to PRALUENT. Reactions have included hypersensitivity
vasculitis and hypersensitivity reactions requiring hospitalization.
Please click here for full Prescribing Information.
­18
19
Frequently Used Codes For My Office
Notes
Use this section to keep track of the ICD-10 diagnosis codes that your office frequently
uses when prescribing PRALUENT® (alirocumab) or enrolling patients in MyPRALUENT™.
ICD-10 Diagnosis Code
Code Description
IMPORTANT SAFETY INFORMATION
Hypersensitivity reactions (e.g., pruritus, rash, urticaria), including some serious
events (e.g., hypersensitivity vasculitis and hypersensitivity reactions requiring
hospitalization), have been reported with PRALUENT treatment. If signs or symptoms
of serious allergic reactions occur, discontinue treatment with PRALUENT, treat
according to the standard of care, and monitor until signs and symptoms resolve.
Please click here for full Prescribing Information.
­20
21
Important Safety Information
PRALUENT® (alirocumab) is contraindicated in patients with a history of a serious
hypersensitivity reaction to PRALUENT. Reactions have included hypersensitivity
vasculitis and hypersensitivity reactions requiring hospitalization.
Hypersensitivity reactions (e.g., pruritus, rash, urticaria), including some serious
events (e.g., hypersensitivity vasculitis and hypersensitivity reactions requiring
hospitalization), have been reported with PRALUENT treatment. If signs or symptoms
of serious allergic reactions occur, discontinue treatment with PRALUENT, treat
according to the standard of care, and monitor until signs and symptoms resolve.
The most commonly occurring adverse reactions (≥5% of patients treated with
PRALUENT and occurring more frequently than with placebo) are nasopharyngitis,
injection site reactions, and influenza.
Local injection site reactions including erythema/redness, itching, swelling, and
pain/tenderness were reported more frequently in patients treated with PRALUENT
(7.2% versus 5.1% for PRALUENT and placebo, respectively). Few patients
discontinued treatment because of these reactions (0.2% versus 0.4% for PRALUENT
and placebo, respectively), but patients receiving PRALUENT had a greater number
of injection site reactions, had more reports of associated symptoms, and had
reactions of longer average duration than patients receiving placebo.
If you have questions about ICD-10 or
need more information, call a MyPRALUENT™ care
specialist at 1-844-PRALUENT (1-844-772-5836)
or contact your field access specialist.
Neurocognitive events were reported in 0.8% of patients treated with PRALUENT
and 0.7% of patients treated with placebo. Confusion or memory impairment were
reported more frequently by those treated with PRALUENT (0.2% for each) than in
those treated with placebo (<0.1% for each).
Liver-related disorders (primarily related to abnormalities in liver enzymes) were
reported in 2.5% of patients treated with PRALUENT and 1.8% of patients treated
with placebo, leading to treatment discontinuation in 0.4% and 0.2% of patients,
respectively. Increases in serum transaminases to greater than 3 times the upper limit
of normal occurred in 1.7% of patients treated with PRALUENT and 1.4% of patients
treated with placebo.
The most common adverse reactions leading to treatment discontinuation in patients
treated with PRALUENT were allergic reactions (0.6% versus 0.2% for PRALUENT
and placebo, respectively) and elevated liver enzymes (0.3% versus <0.1%).
PRALUENT is a human monoclonal antibody. As with all therapeutic proteins, there is
a potential for immunogenicity with PRALUENT.
Please click here for full Prescribing Information.
­22
23
Please click here for full Prescribing Information.
©2015, Sanofi and Regeneron Pharmaceuticals, Inc.
09/2015 US.ALI.15.09.056 PRA-0197