CURRICULUM VITAE
Name:
Miles Wilkinson
Title and Affiliation:
a. Primary appointment
Professor, Department of Reproductive Medicine
School of Medicine
University of California, San Diego
b. Joint appointment
Professor, Biomedical Sciences (BMS) graduate program
U.C.S.D.
Birthplace:
Edinburgh, Scotland
Citizenship:
United States/United Kingdom
Home Address:
13660 Mango Dr., Del Mar, CA 92014
Office Address:
Sanford Consortium for Regenerative Medicine (SCRM), 2880
Torrey Pines Scenic Dr. Room 4011. Mailing address: UCSD, 9500
Gilman Dr., MC-0695, La Jolla, CA 92093
E-mail:
[email protected]
Education:
1979 B.A., Magna cum laude, University of California, Santa Barbara, CA
1980 Molecular Genetics (1st-class honors degree), University of Edinburgh, Scotland
1984 Ph.D., Biological Science, University of Warwick, England
Postgraduate Training:
1984-1985
Postdoctoral Fellow, Scripps Clinic and Foundation, La Jolla, CA
1985-1987
Postdoctoral Fellow, University of California, San Diego, CA
Academic and Professional Appointments:
July 1987 - June 1993 Assistant Professor, Microbiology and Immunology Department and the
Vollum Institute, Oregon Health Sciences University, Portland, OR
July 1993 - June 1994
Associate Professor, Microbiology and Immunology Department and the
Vollum Institute, Oregon Health Sciences University, Portland, OR
July 1994 – Aug 2000
Associate Professor, Department of Immunology
U. T. M. D. Anderson Cancer Center, Houston, TX
Miles Wilkinson, Ph.D.
2
Sep 2000 – Aug 2006
Professor, Department of Immunology
U. T. M. D. Anderson Cancer Center, Houston, TX
Sep 2006 – June 2009
Professor, Department of Biochemistry & Molecular Biology
U. T. M. D. Anderson Cancer Center, Houston, TX
July 2009 – present
Professor, Department of Reproductive Medicine
University of California, San Diego
Committee Memberships:
a. National and International:
American Society of Andrology, council member (2010 – 2013)
Testis Workshop, San Antonio, TX, organizing committee (2013)
North Carolina Biotechnology Center Grant Review Committee (1999-2001)
Ad Hoc Grant Reviewer:
(1) National Institutes of Health (1991 – present). Full-time member of MGB study
(2007 – 2012). MGB chair Fall 2010 – Summer 2012. Recent ad hoc reviews:
Challenge grant reviews (ZRG1-BDA-A-52), P01 applications for NIHCD (03/07 and
04/08), MGA study section (02/06), special reviews (07/04 and 08/04), CDF-1 study
section (10/03), and REB study section (06/03).
(2) Veteran’s Administration (1993 – 2001)
(3) National Science Foundation (1993 – present)
(4) American Cancer Society (1995 – 1997)
(5) Welcome Trust (U.K.) (1998 – present)
(6) Medical Research Council (MRC) of Canada (1999)
(7) Israel Science Foundation (2000)
(8) Ministry of Education of Flanders (Belgium) (2003)
(9) Ohio Cancer Research Associates (2006)
(10) UCSD Pediatrics Department (2012)
External Promotion and Tenure Reviewer (Internal candidate reviews listed
separately):
Revised July 29, 2017
Miles Wilkinson, Ph.D.
Rebecca Prokipcake, University of Toronto, 1999
Ann-Bin Shyu, University of Texas, 2001
Maria Hatzoglou, Case Western Reserve University, 2003
Ya-Huan Lou, U.T. Houston Health Sciences Center, 2005
Melissa Moore, Howard Hughes Medical Institute, Brandeis, 2005
Ambro Van Hoof, U.T. Houston Health Sciences Center, 2008
Dawn Chandler, The Ohio State University, 2010
Prabhakara Reddi, University of Virginia, 2012
Manjeet Rao, University of Texas, San Antonio, 2012
James MacLean, University of Southern Illinois, 2012
Jon Oatley, Washington State University, 2013
Manjeet Rao, University of Texas, San Antonio (P&T, 2nd attempt), 2013
Prabhakara Reddi, University of Virginia (2nd attempt), 2013
Debra Silver, Duke University, 2014
Manjeet Rao, University of Texas, San Antonio (tenure only), 2014
b. Local and state: None
Consultantships: Reviewer, Biology Textbooks, Cracom Publishing Corp.
Journal Reviewer:
Editorial board:
Biology of Reproduction, board of reviewing editors (May 2009 – present)
Spermatogenesis, editorial board (January 2010 – present)
Ad hoc reviewer:
High-Impact: Cell (2004- ), Genes & Development (2002- ), Molecular Cell (2002- ), Nature
(2004- ), Nature Cell Biology (2003- ), Nature Genetics (2004- ), Nature Medicine (2005), Nature Reviews Genetics (2011- ), PLOS Biology (2007- ), Science (1998- ).
General Biology: EMBO J. (1998- ), EMBO Reports (2003- ), EMBO Mol Med (2011- ), FEBS
Letters (2008- ), J. Biological Chemistry (2003- ), J. Cell Biology (2010- ), Molecular
and Cellular Biology (1994- ), Nature Structural & Molecular Biology (1997- ), PLoS
One (2012- ), Proceedings National Academy of Sciences U.S.A. (2000- ).
Reproduction: Asian J. Andrology (2009- ), Biology of Reproduction (2005- ), Endocrinology
(2003- ), J. Andrology (1996- ), Molecular and Cellular Endocrinology (2007- ),
Molecular Endocrinology (2004- ), Reproduction (2005- ), Reproductive Biology &
Endocrinology (2011- ), Reproduction, Fertility, and Development (2006- ), Sexual
Development (2006- ), Spermatogenesis (2012- ).
Nucleic Acid / Genetics / Genomics: American Journal of Human Genetics (2007- ), Annals of
Human Genetics (2002- ), BMC Genomics (2007- ), BMC Genetics (2008- ), BMC
Revised July 29, 2017
3
Miles Wilkinson, Ph.D.
Evolutionary Biology (2009- ), Gene (2003- ), Genome Biology (2003- ), Genome
Research (2010- ), Genomics (1997- ), Human Molecular Genetics (1997- ), Human
Genomics (2005- ), Human Mutation (2010- ), Molecular Biology & Evolution (2003- ),
Mutation Research (1998- ), Nucleic Acids Research (2006- ), PLoS Genetics (2011- ),
RNA (1999- ), RNA Biology (2004- ).
Other: American Journal of Physiology (2006- ), Applied Bioinformatics (2002- ), Biochimie
(2012- ), Biochimica et Biophysica Acta (2004- ), Biochimie (2012- ), BioTechniques
(1992- ), Blood (2001- ), BMC Molecular Biology (2004- ), Cancer Research (2007- ),
Cell Research (2011- ), Chemistry and Biology (2008- ), Developmental Biology (2007), Developmental Dynamics (2007- ), Eukaryotic Cell (2005- ), Genesis (2006- ),
International J. Radiation Oncology, Biology, Physics (2000- ), Journal of Biotechnology
(2007- ), J. Clinical Investigation (2003- ), J. Experimental Medicine (2001- ), J.
Immunology (1999- ), J. Mol. Cell Biol. (2011- ), Mechanisms of Development (1996- ),
Mol. Biology of the Cell (2004- ), Molecular Biology & Evolution (2009- ), Molecular &
Cellular Biochemistry (2012- ), Molecular Genetics & Metabolism (2005- ), Molecular
Therapy (2005- ), Nature Protocols (2010- ), Neurogenetics (2006- ), Toxicological
Sciences (2014- ).
Awards and Fellowships:
1976 – 1979 University of California, Regents Scholarship
1979
American Heart Association Scholarship
1981 – 1984
U.K. Foreign Student Scholarship
1984 – 1987
NIH Training Grant Postdoctoral Fellow
1996 - 2000
Graduate School of Biological Science Dean’s Excellence Award
1999
Outstanding Original Research Award for the best paper published in Journal of
Andrology
2000
John P. McGovern Award for Outstanding Teaching (nominated)
2001
Amgen Award for Basic Science Research Presentation: “A T-Cell Receptor RNA
Surveillance Mechanism” (postdoctoral-trainee Jun Wang)
2002
Amgen Award for Basic Science Research Presentation: “A Novel RNA
Surveillance Mechanism: Nonsense Codon-Mediated Nuclear mRNA Retention”
(postdoctoral-trainee Jun Wang)
2003
M.D. Anderson Cancer Center Faculty Achievement Award in Basic Science
2003
Graduate School of Biological Science Dean’s Excellence Award
Revised July 29, 2017
4
Miles Wilkinson, Ph.D.
2003
Amgen Award for Basic Science Research Presentation: “The Expression Pattern
and Function of a New Homeobox Gene Cluster on the X Chromosome”
(postdoctoral-trainee James MacLean)
2004
Graduate School of Biological Science, Commendation for service to the graduate
school (e.g., teaching and student committees)
2006
Ruby E. Rutherford Distinguished Professorship (endowed chair)
2006
M.D. Anderson Research Trust Award (5-year award)
2007
M.D. Anderson Alumni and Faculty Association Award for Clinical/Translational
Research: “The NMD RNA Surveillance Pathway Degrades Aberrant E-Cadherin
Transcripts in Hereditary Diffuse Gastric Cancer” (predoctoral-trainee Rachid
Karam)
Societies:
5
American Association for the Advancement of Science (1987 - 2002)
The American Society for Microbiology (1994 - 2001; 2008 - 2009)
The RNA Society (1995 - 2010)
American Association of Immunologists (2000 - 2005)
Society for the Study of Reproduction (2001 - present)
American Society for Biochemistry & Molecular Biology (2006 - 2010)
American Society for Andrology (2007 – present)
Bibliography:
Refereed articles:
1.
Wilkinson, M.F. & Morris (1983) An Interferon with Novel Characteristics Produced by
Human Mononuclear Leukocytes. Biochem. Biophys. Res. Comm. 111:498-503.
2.
Siggens, K.W., Wilkinson, M., Boseley, P.G., Slocombe, P.M., Cowling, G., & Morris, A.G.
(1984) Differences in the Expression of the Human Interferon-Gamma Gene in Fresh
Lymphocytes and Cultured Lymphoblasts. Biochem. Biophys. Res. Comm. 119:157-162.
3.
Wilkinson, M.F. & Morris, A.G. (1984) Gamma-Interferon Induction in Human Lymphoblasts
compared with Fresh Mononuclear Leukocytes: Earlier Synthesis, Rapid Shutoff and
Enhancement of Yields with Metabolic Inhibitors. Immunology 52:175-179.
4.
Wilkinson, M.F. & Morris, A.G. (1984) The E-Receptor Regulates Interferon-Gamma
Production: Four Receptor Model for Human Lymphocyte activation. Eur. J. Immunol.
14:708-713.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
6
5.
Wilkinson, M.F. & Morris, A.G. (1984) Role of the E-Receptor in IFN-Gamma Expression:
Sheep Erythrocytes Augment Interferon-gamma Production by Human Lymphocytes. Cellular
Immunology 86:109-117.
6.
Croll, A.O., Wilkinson, M.F. & Morris, A.G. (1985) Interleukin-2 Receptor Blockade by anti-tac
Antibody Inhibits IFN-Gamma Induction. Cellular Immunol. 92:184-189.
7.
Wilkinson, M.F., Morris, A.G., Leung, H., Crane, J., & Meager, A. (1985) Interferon-Gamma
Produced by Mitogen Activated T-lymphocytes does not Directly Mediate Lymphoproliferation.
Eur. J. Immunol. 15:404-407.
8.
MacLeod, C.L., Minning, L., Terhorst, C., Gold, D. & Wilkinson, M.F. (1986) Trans-negative
Regulation of T-cell Antigen Receptor Complex mRNA in SL12 Somatic Cell Hybrids. Proc.
Natl. Acad. Sci. U.S.A. 83:6989-6993.
9.
Croll, A.D., Wilkinson, M.F. & Morris, A.G. (1986) Gamma-IFN Production by Human Low
Density Lymphocytes Induced by T-cell Mitogens. Immunology 58:641-646.
10.
Siegal, J., Turner, A., Klinman, D., Wilkinson, M.F., Steinberg, A., MacLeod, C., Paul, W.,
Davis, M. & Cohen, D. (1987) Sequence Analysis of an X-linked, Lymphocyte Regulated
Gene Family (XLR): Homologies with the Nuclear Structural Proteins, Lamins A and C. J.
Exp. Med. 166:1702-1715.
11.
Wilkinson, M.F. & MacLeod, C.L. (1988) Induction of T-cell Receptor-Alpha and -Beta mRNA
in SL12 Cells Can Occur by Transcriptional and Post-transcriptional Mechanisms. EMBO J.
7:101-109.
12.
Wilkinson, M.F. & MacLeod, C.L. (1988) Complex Regulation of the T-cell Receptor-Alpha
Gene: Three Different Modes of Triggering Induction. Eur. J. Immunol. 18:873-879.
13.
Wilkinson, M.F. (1988) RNA Isolation: a Mini-prep Method. Nucleic Acids. Res. 16:10933.
14.
Wilkinson, M.F. (1988) A Rapid and Convenient Method for Isolation of Nuclear, Cytoplasmic
and Total RNA. Nucleic Acids. Res. 16:10934.
15.
Wilkinson, M.F., Georgopoulos, K., Terhorst, C. & MacLeod, C.L. (1989) The CD3-Delta
Gene Encodes Multiple Transcripts Regulated by Transcriptional and Post-transcriptional
Mechanisms. Eur. J. Immunol. 19:2355-2360.
16.
Douglass, J., Osborne, P.B., Cai, Y-C., Wilkinson, M.F., Christie, M. J. & Adelman, J. P.
(1990) Characterization and Functional Expression of a Rat Genomic DNA Clone Encoding a
Lymphocyte Potassium Channel. J. Immunol. 144:4841-4850.
17.
MacLeod, C.L., Fong, A.M., Seal, B. M., Walls, L. & Wilkinson, M.F. (1990) Isolation of
Novel cDNA Clones from T-Lymphoma Cells: One Encodes a Putative Multiple Membrane
Spanning Protein. Cell Growth and Diff. 1:271-279.
18.
MacLeod, C.L, Finley, K., Kakuda, D., Kozak, C.A. & Wilkinson, M.F. (1990) Activated T
Cells Express a Novel Gene on Chromosome 8 that is Closely Related to the Murine
Ecotropic Retroviral Receptor. Mol. Cell. Biol. 10:3663-3674.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
7
19.
Wilkinson, M.F., Kleeman, J., Richards, J & MacLeod, C.L. (1990) A Novel Onco-Fetal Gene
Expressed in a Stage-Specific Manner in Murine Embryonic Development. Dev. Biol.
141:451-455.
20.
Wilkinson, M.F., Doskow, J. & Lindsey, S. (1991) RNA Blots: Staining Procedures and
Optimization of Conditions. Nucl. Acids Res., 19:679.
21.
Qian, L. & Wilkinson, M.F. (1991) DNA Fragment Purification: Removal of Agarose 10
Minutes after Electrophoresis. Biotechniques, 10:736-737.
22.
Wilkinson, M.F., Fong, A.M., Huyuh, H., Hays, E.F. & MacLeod, C.L. (1991) A Model System
for T-Lymphocyte Differentiation: Regulation of CD4 and CD8 Gene Expression in SL12.4 TLymphoma Cell Clones. Mol. Immunol. 28:57-68.
23.
Takashi, T., Gause, W.C., Wilkinson, M.F., MacLeod, C.L. & Steinberg, A.D. (1991) IL 1induced Maturation of Progenitor Thymocytes. Eur. J. Immunol. 21:1385-1390.
24.
Vainiene, M., Offner, H. Morrison, W.J., Wilkinson, M.F. & Vandenbark, A.A. 1991) Clonal
Diversity of Basic Protein Specific T cells in Lewis Rats Recovered from Experimental
Autoimmune Encephalomyelitis. J. Neuroimmunol. 33:207-216.
25.
Sasaki, A., Doskow, J., MacLeod, C.L., Rogers, M., Gudas, L. & Wilkinson, M.F. (1991) The
Oncofetal Gene Pem Encodes a Homeodomain and is Regulated in Embryonic and Premuscle Stem Cells. Mech. Develop. 34:155-164.
26.
Wilkinson, M.F., Doskow, J., von Borstel, II., R.C., Fong, A.M. & MacLeod, C.L. (1991) The
Expression of Several T Cell Specific and Novel Genes are Repressed by Trans-acting
Factors in Immature T Lymphoma Clones. J. Exp. Med., 174:269-280.
27.
Herrick, T., Qian, L. & Wilkinson, M.F. (1992) TCR-Alpha mRNA Accumulation Does Not
Dictate Cell Surface TCR/CD3 Expression. Mol. Immunol. 29:531-536.
28.
Qian, L., Vu, M., Carter, M. & Wilkinson, M.F. (1992) A Spliced Intron Accumulates as a
Lariat in the Nucleus of T Cells. Nucleic Acid. Res. 20:5345-5350.
29.
Doskow, J. & Wilkinson, M.F. (1992) CD3-Gamma, -Delta, -Epsilon, TCR-Alpha and -Beta
Transcripts are Independently Regulated During Thymocyte Ontogency and T Cell Activation.
Immunol. 77:465-468.
30.
Qian, L, Theodore, L., Carter, M., Vu, M., Sasaki, A. & Wilkinson, M.F. (1993) T cell
Receptor-beta mRNA Splicing: Regulation of Unusual Splicing Intermediates. Mol. Cell. Biol.
13:1686-1696.
31.
Qian, L., Carter, M., Vu, M.N. & Wilkinson, M.F. (1993) Regulation of T cell Receptor-beta
mRNA Splicing During Thymic Maturation in vivo and in an Inducible T-Lymphoma Cell Clone
in vitro. J. Immunol. 151: 6801-6814.
32.
Carter, M.S., Doskow, J., Morris, P., Li, S., Nhim, R.P., Sandstedt, S. & Wilkinson, M.F.
(1995) A Regulatory Mechanism that Detects Premature Nonsense Codons in T-cell Receptor
Transcripts in vivo is Reversed by Protein Synthesis Inhibitors in vivo. J. Biol. Chem.
270:28995-29003.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
8
33.
Maiti, S., Doskow, J., Li, S., Nhim, R.P., Lindsey, J.S. & Wilkinson, M.F. (1996) The Pem
Homeobox Gene: Androgen-Dependent and -Independent Promoters Tissue-Specific
Alternative RNA Splicing. J. Biol. Chem. 271:17536-17546.
34.
Maiti, S., Doskow, J., Sutton, K., Nhim, R.P., Lawlor, D., Levan, K., Lindsey, J.S. &
Wilkinson, M.F. (1996) The Pem Homeobox Gene: Rapid Evolution of the Homeodomain, X
Chromosomal Localization, and Expression in Reproductive Tissue. Genomics 34:304-316.
35.
Lindsey, J.S. & Wilkinson, M.F. (1996) An Androgen-Regulated Homeobox Gene Expressed
in Rat Testis and Epididymis. Biol. Reprod. 55:975-983.
36.
Lindsey, J.S. & Wilkinson, M.F. (1996) Pem: A Testosterone & LH Regulated Homeobox
Gene Expressed in Mouse Sertoli Cells and Epididymis. Develop. Biol. 179:471-484.
37.
Carter, M.S., Li, S. & Wilkinson, M.F. (1996) A Splicing-Dependent Regulatory Mechanism
that Detects Translation Signals. EMBO J. 15:5965-5975.
38.
Nhim, R.P., Lindsey, J.S. & Wilkinson, M.F. (1997) A Processed Homeobox Gene Expressed
in a Stage-, Tissue- and Region-Specific Manner in Epididymis. Gene 185:271-276.
39.
Li, S., Leonard, D. & Wilkinson, M.F. (1997) TCR Mini-gene mRNA Expression Regulated by
Nonsense Codons: A Nuclear-associated Translation-like Mechanism. J. Exp. Med. 185:985992.
40.
Li, S. & Wilkinson, M.F. (1997) Site-directed Mutagenesis: A Two-step Method Using the
Polymerase Chain Reaction and Dpn1. BioTechniques 23:588-590.
41.
Sutton, K. & Wilkinson, M.F. (1997) The Rapidly Evolving Pem Homeobox Gene and Agtr2,
Ant2, and Lamp2 are Closely Linked in the Proximal Region of the Mouse X Chromosome.
Genomics 45:447-450.
42.
Sutton, K. & Wilkinson, M.F. (1997) Rapid Evolution of a Homeodomain: Evidence for
Positive Selection. J. Mol. Evol. 45:579-588.
43.
Sutton, K.A., Maiti, S., Tribley, W.A., Lindsey, J.S., Meistrich, M.L., Bucana, C.D., Sanborn,
B.M., Joseph, D.R., Griswold, M.D., Cornwall, G.A. & Wilkinson, M.F. (1998) Androgen
Regulation of the Pem Homeodomain Gene in Mice and Rat Sertoli and Epididymal Cells. J.
Andrology 19:21-30.
44.
Li, S. & Wilkinson, M.F. (1998) Nonsense Surveillance in Lymphocytes? Immunity 8:135141.
45.
Sutton, K.A., Vu, M.N. & Wilkinson, M.F. (1998) Distal V-Beta Promoters Transcribe Novel Tcell Receptor-Beta Transcripts in Early Development. Immunology 93:213-220.
46.
Misteli, T., Cáceres, J.F., Clement, J.Q., Krainer, A.R., Wilkinson, M.F. & Spector, D.L
(1998) Serine Phosphorylation of SR Proteins is Required for their Recruitment to Sites of
Transcription In Vivo. J. Cell Biol. 143:297-307.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
9
47.
Clement, J.Q. Qian, L., Kaplinsky, N. & Wilkinson, M.F., (1999) The Stability and Fate of a
Spliced Intron from Vertebrate Cells. RNA 5:206-220.
48.
Clement, J.Q. & Wilkinson, M.F. (2000) Rapid Induction of Nuclear Transcripts and Inhibition
of Intron Decay in Response to the Polymerase II Inhibitor DRB. J. Mol. Biol. 299:1179-1191.
49.
Shyu, A.B. & Wilkinson, M.F. (2000) The Double Lives of Shuttling RNA-Binding Proteins.
Cell 102:135-138.
50.
Wang, J. & Wilkinson, M.F. (2000) Site-Directed Mutagenesis of Large (13-kb) Plasmids in a
Single-PCR Procedure. BioTechniques 29(5): 976-978.
51.
Maiti, S., Meistrich, M.L., Wilson, G., Shetty, G., Marcelli, M., McPhaul, M.J., Morris, P.L. &
Wilkinson, M.F. (2001) Irradiation Selectively Inhibits Expression from the AndrogenDependent Pem Homeobox Gene Promoter in Sertoli Cells. Endocrinology 142:1567-1577.
52.
Clement, J.Q., Maiti, S. & Wilkinson, M.F. (2001) Localization and Stability of Introns Spliced
In Vivo from the Pem Homeobox Gene. J. Biol. Chem. 276:16,919-16,930.
53.
Mühlemann, O., Mock-Casagrande, C.S., Wang, J., Li, S., Custódio, N., Carmo-Fonseca, M.,
Wilkinson, M.F. & Moore, M.J. (2001) Precursor RNAs Harboring Nonsense Codons
Accumulate Near the Site of Transcription. Mol. Cell. 8:33-43.
Commentaries on this paper:
 Brogna, S. (2001) Pre-mRNA Processing: Insights from Nonsense.
16:R838-841.
 Faculty of 1000 (“Must Read”)
Current Biology
54.
Wilkinson, M.F. & Shyu, A.B. (2001) Bifunctional Regulatory Proteins that Control Gene
Expression in both the Nucleus and the Cytoplasm. BioEssays 23:775-787.
55.
Wang, J. & Wilkinson, M.F. (2001) Deletion Mutagenesis of Large (12-kb) Plasmids by a
One-Step PCR Protocol. BioTechniques 31:722-724.
56.
Wang, J., Han, Y. & Wilkinson, M.F. (2001) An Active Immunization Approach to Generate
Protective Catalytic Antibodies. Biochemical Journal 360:151-157.
57.
Wang, J., Han, Y., Liang, S. & Wilkinson, M.F. (2002) Catalytic Antibody Therapy against the
Insecticide Carbaryl. Biochem. Biophys. Res. Comm. 291:605-610.
58.
Wang, J., Vock, V.M., Olivas, O.R. & Wilkinson, M.F. (2002) A quality-control pathway that
downregulates aberrant TCR transcripts by a mechanism requiring UPF2 and translation. J.
Biol. Chem. 277:18,489-18,493, 2002.
59.
Rao, M.K., Maiti, S., Ananthaswamy, H.N. & Wilkinson, M.F. (2002) A Highly Active
Homeobox Gene Promoter Regulated by Ets and Sp1 Family Members in Normal Granulosa
Cells and Diverse Tumor Cell Types. J. Biol. Chem. 277:26036-26045.
60.
Bühler M., Wilkinson, M.F. & Mühlemann, O. (2002) Intranuclear Degradation of Nonsense
Codon-Containing mRNA. EMBO Reports 3:646-651.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
10
61.
Wayne, C. & Wilkinson, M.F. (2002) Expression of the Pem Homeobox Gene in Sertoli Cells
Increases the Frequency of Adjacent Germ Cells with DNA-Strand Breaks. Endocrinology
143:4875-4885.
62.
Wayne, C.M., MacLean, J.A., Cornwall, G. & Wilkinson, M.F. (2002) Two Novel Human Xlinked Homeobox Genes, hPEPP1 and hPEPP2, Selectively Expressed in the Testis. Gene
301:1-11.
63.
Rao, M.K., Wayne, C.M. & Wilkinson, M.F. (2002) Pem Homeobox Gene Regulatory
Sequences that Direct Androgen-Dependent Developmentally Regulated Gene Expression in
Different Subregions of the Epididymis. J. Biol. Chem. 277:48771-48778.
64.
Wang, J., Gudikote, J.P., Olivas, O.R. & Wilkinson, M.F. (2002) Boundary-independent Polar
Nonsense-mediated Decay. EMBO Reports 3:274-279.
65.
Gudikote, J.P. & Wilkinson, M.F. (2002) T-cell Receptor Sequences that elicit Strong
Downregulation of Premature Termination Codon-bearing Transcripts. EMBO J. 21:125-134.
Commentaries on this paper:
 Targeting Nonsense mRNA (2002) Nature Immunology 3:119.
 Faculty of 1000 (“Recommended”)
66.
Wilkinson, M.F. & Shyu, A-B. (2002) RNA Surveillance by Nuclear Scanning? Nature Cell
Biology 4: E144-147.
67.
Wang, J., Chang, Y.-F., Hamilton, J.I & Wilkinson, M.F. (2002) Nonsense-Associated
Altered Splicing: A Frame-Dependent Response Distinct from Nonsense-Mediated Decay.
Mol. Cell 10:951-957.
Commentary on this paper:
 Moore, M.J. (2002) No End to Nonsense. Science 298:370-371.
68.
Wang, J., Hamilton, J.I., Carter, M.S., Li, S. & Wilkinson, M.F. (2002) Alternatively Spliced
TCR mRNA Induced by Disruption of Reading Frame. Science 297:108-110.
Commentaries on this paper:
 Alfred, J. (2002) Gene Expression: Escaping Silence. Nature Reviews Genetics 2:9.
 Maquat, L.E. (2002) NASty Effects on Fibrillin pre-mRNA Splicing: Another Case of ESE
Does it, but Proposals for Translation-Dependent Splice-Site Choice Live On. Genes and
Development 16:1743-1753.
 Dahlberg, J.E., Lund, E. & Goodwin, E.B. (2003) Nuclear Translation: What is the
Evidence? RNA 9:1-8.
 Faculty of 1000 (“Must Read”)
69.
Gudikote, J. & Wilkinson, M.F. (2003) Regulation of mRNA Splicing, Export, and Decay by
RNA-Binding Proteins. In: “Encyclopedia of the Human Genome,” Nature Publishing Group.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
11
70.
Rao, M.K., Wayne, C.M., Meistrich, M.L. & Wilkinson, M.F. (2003) Pem Homeobox Gene
Promoter Sequences that Direct Transcription in a Sertoli Cell-Specific, Stage-Specific, and
Androgen-Dependent Manner in the Testis In Vivo. Mol. Endocrinol. 17:223-233.
71.
Wilkinson, M.F. (2003) The Cycle of Nonsense. Mol. Cell 12: 1059-1061.
72.
Inoue, K., Khajavi, M., Ohyama, T., Hirabayashi, S., Wilson, J., Reggin, J.D., Mancias, P.,
Butler, I.J., Wilkinson, M.F., Wegner, M. & Lupski, J.R. (2004) Molecular Mechanism for
Distinct Neurological Phenotypes Conveyed by Allelic Truncating Mutations. Nature Genetics
36: 361-369.
Commentaries on this paper:
 Chin, G. (2004) Location, Location, Location. Science 303:1731.
 Faculty of 1000 (“Exceptional”).
 Haigh, B. (2004) Making Sense out of Nonsense: the Role of Nonsense-Mediated Decay in
Phenotypic Variation. Clin. Genet. 66: 17-22.
73.
Li, S., Wilkinson M.F., Xia, X., David, M., Xu, L., Purkel-Sutton, A. & Bhardwaj, A. (2005)
Induction of IFN-Regulated Factors and Antitumoral Surveillance by Transfected Placebo
Plasmid DNA. Molecular Therapy 11:112-119.
74.
Sims-Mourtada, J.C., Bruce, S., McKeller, M.R., Rangel, R., Guzman-Rojas, L., Cain, K.,
Lopez, C., Zimonjic D.B., Popescu, N.C., Gordon, J., Wilkinson, M.F. & Hector MartinezValdez (2005) The Human AKNA Gene Expresses Multiple Transcripts and Protein Isoforms
as a Result of Alternative Promoter Usage, Splicing, and Polyadenylation. DNA & Cell
Biology 24:325-328.
75.
MacLean, J.A., Rao, M.K., Doyle, M.H., Richards, J.S. & Wilkinson, M.F. (2005) Regulation
of the Rhox5 Homeobox Gene in Primary Granulosa Cells: Preovulatory Expression and
Dependence on Sp1/Sp3 and Gabp. Biology of Reproduction 73:1126-1134.
76.
Wilkinson, M.F. (2005) A New Function for Nonsense-Mediated Decay Factors. Trends in
Genetics 21:143-148.
77.
MacLean, J.A., Chen, M.A., Wayne, C.M., Bruce, S.R., Meistrich, M.L., Macleod, C.L. &
Wilkinson, M.F. (2005) Rhox: A New Homeobox Gene Cluster. Cell 120:369-382.
Commentaries on this paper:
 Hogeveen, K.N. & Sassone-Corsi, P. (2005) Homeobox Galore: When Reproduction Goes
Rhox and Roll. Cell 120:287-288.
 Spitz, F. & Duboule D. (2005) Reproduction in Clusters. Nature 434:715-716.
 Faculty of 1000 (“Recommended”)
 Reported as “research news” by United Press International (UPI), Bio.com,
ScienceDaily.com, EurekAlert, Medical News Today, The Doctor’s Lounge.net, Blogchina,
Diario Medico.com
78.
Gudikote, J.P., Imam, J.S., Garcia, R.F. & Wilkinson, M.F. (2005) RNA Splicing Promotes
Translation and RNA Surveillance. Nature Structural & Molecular Biology 12:801-809.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
79.
12
Rao, M., Pham, J., Imam, J.S., MacLean, J.A., Murali, D., Furuta, Y., Sinha-Hikim, A.P. &
Wilkinson, M.F. (2006) Tissue-Specific RNAi Reveals that WT1 Expression in Nurse Cells
Controls Germ-Cell Survival and Spermatogenesis Genes & Development 20:147-12.
Commentaries on this paper:
 Nature (2006) 439:372.
 Nature Reviews Genetics (2006) 7:159.
 Reported as “research news” by Medi Lexicon (www.medilexicon.com), EurkAlert!
(www.eurkalert.org), Medical News Today (www.medicalnewstoday.com), News-Medical Net
(www.newsmedicalnet.com),
Knockout
and
Transgenic
Research
(www.knockoutscience.com), Health Topics (www.health-topics.org), Biological Procedures
Online (www.biologicalprocedures.com), Medcompare (www.medcompare.com), Small
Interfering RNA Resources (www.si-rna.com), BrightSurf (www.BrightSurf.com), and many
other web sites.
80. MacLean, J.A., Lorenzetti, D., Hu, Z., Salerno, W.J., Miller, J. & Wilkinson, M.F. (2006) The
Rhox Homeobox Gene Cluster: Recent Duplication of Three Family Members. Genesis
44:122-129.
81. Wang, W., Cajigas, I.J., García, E.J., Peltz, S.W., Wilkinson, M.F. & González, C.I. (2006) A
Role for Upf2p Phosphorylation in Saccharomyces cerevisiae Nonsense-Mediated mRNA
Decay. Molecular & Cellular Biology 26:3390-3400.
82. Bruno, I. & Wilkinson, M.F. (2006) P-bodies React to Stress and Nonsense. Cell 125:10361038.
83. Rao, M. & Wilkinson, M.F. (2006) Tissue- and Cell Type-Specific RNA Interference In Vivo.
Nature Protocols 1:1494-1501.
84. Chang, Y.-F., Imam, J.S. & Wilkinson, M.F. (2007) “The Nonsense-Mediated Decay RNA
Surveillance Pathway,” Annual Review of Biochemistry, Ed.: Kornberg, R., Annual Reviews
Inc.
85. Chan W.-K., Huang L., Gudikote J.P., Chang Y.-F., Imam J.S., MacLean J.A. & Wilkinson M.F.
(2007) An Alternative Branch of the Nonsense-mediated Decay Pathway. EMBO J. 26:18201830.
86. Chang Y.-F., Chan W.-K., Imam J.S. & Wilkinson M.F. (2007) Alternatively Spliced T-Cell
Receptor Transcripts are Upregulated in Response to Either Disruption of Splicing Elements
or Reading Frame. J. Biol. Chem. 282:29738-29747.
87. Hu Z., Shanker S., MacLean J.A., Ackerman S.L. & Wilkinson M.F. (2007) The RHOX5
Homeodomain Protein Mediates Transcriptional Repression of the Netrin-1 Receptor Gene
Unc5c. J. Biol. Chem. 283:3866-3876.
88. Bharadwaj A., Rao M.K., Kaur R., Buttigieg M.R. & Wilkinson M.F. (2008) GATA Factors and
Androgen Receptor Collaborate to Transcriptionally Activate the Rhox5 Homeobox Gene in
Sertoli Cells. Mol. Cell. Biol. 28:2138.
89. Shyu A.B., Wilkinson M.F. & van Hoof A. (2008) Messenger RNA Regulation: To Translate or
to Degrade. EMBO J. 27:471-481.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
13
90. Karam R., Carvalho J., Bruno I., Graziadio C., Senz J., Huntsman D., Carneiro F. Seruca R.,
Wilkinson M.F.* & Oliveira C.* (2008) The NMD mRNA Surveillance Pathway Downregulates
Aberrant E-Cadherin Transcripts in Gastic Cancer Cells and in CDH1 Mutation Carriers.
Oncogene 27:4255-4260. *co-senior authors
91. Zhu K., Chan W.-K., Heymach J.V., Wilkinson M.F. & McConkey D.J. Control of HIF-1
expression by eIF2 phosphorylation-mediated translational repression. Cancer Research
69: 1836-1843 (2009).
92. Bhalla A.D., Gudikote J.P., Wang J., Chan W.-K., Chang Y.-F., Olivas R. & Wilkinson M.F.
Nonsense Codons Induce a RNA Partitioning Shift. J. Biol. Chem. 284: 4062-4072 (2009).
93. Chan W.-K., Bhalla A., Gecz J., Huang L. & Wilkinson M.F. A UPF3-Mediated Regulatory
Switch that Maintains RNA Surveillance. Nature Structural & Molecular Biology 16:747-753
(2009).
94. Estrella L.A., Wilkinson M.F. & Gonzalez C.I. The Shuttling Protein Npl3 Promotes Translation
Termination Accuracy in Saccharomyces cerevisiae. J. Mol Biol. 394:410-422 (2009)
95. Hu Z., Dandekar D, O’Shaughnessy P.F., De Gendt K., Verhoeven G. & Wilkinson M.F.
Androgen-Induced Rhox Homeobox Genes Modulate the Expression of AR-Regulated
Genes. Molecular Endocrinology 24:60-75 (2010).
96. Imam J.S., Gudikote J.P., Chan W.-K. & Wilkinson M.F. Frame-Disrupting Mutations Elicit PremRNA Accumulation Independently of Frame Disruption. Nucleic Acids Research 38: 15591574 (2010).
97. MacLean, J.A., Bettegowda A., Kim B.J., Lou C-H., Yang S-M., Bhardwaj A., Shanker, S., Hu Z.,
Fan Y., Eckardt S., McLaughlin K.J., Skoultchi A.I. & Wilkinson M.F. The Rhox Homeobox
Gene Cluster is Imprinted and Selectively Targeted for Regulation by Histone H1 and DNA
Methylation. Molecular Cellular Biology 31:1275-1287 (2011).
98. Bruno I.G., Karam R., Huang L., Bhardwaj A., Lou C.-H., Shum E.Y., Song H-W., Corbett M.A.,
Gifford W.D., Gecz J., Phaff S. & Wilkinson M.F. Identification of a MicroRNA that Activates
Gene Expression by Repressing Nonsense-Mediated RNA Decay. Molecular Cell 42:500-510
(2011).
Commentaries on this paper:




Kulozik (2011) Stay tuned: miRNA expression and nonsense-mediated decay in brain
development. Molecular Cell 42:407-8.
Faculty of 1000 – highlighted
Nature Review Genetics highlight: vol. 12, pg. 455 (2011).
Science Daily (http://www.sciencedaily.com/releases/2011/05/110519122236.htm)
99. De Gendt K, Denolet E, Willems A, Daniels VW, Clinckemaile L, Denayer S, Wilkinson MF,
Claessens F, Swinnen JV, Verhoeven G. Expression of Tubb3, a Beta-Tubulin Isotype, is
Regulated by Androgens in Mouse and Rat Sertoli Cells. Biol. Reprod. 85:934-45 (2011).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
14
100. Huang L, Chan W-K, Lou C-H, Shao A, Stone E, Karam R, Song H-W & Wilkinson MF. RNA
Surveillance Homeostasis Governed by Tissue-Specific and Branched Feedback Loops. Mol
Cell 43:950-61 (2011).
Commentary on this paper: UCSD News Center
(http://ucsdnews.ucsd.edu/archive/newsrel/health/2011_09wilkinson-nmd.asp)
101. Ramaiah M., Shum EY & Wilkinson MF. How to Activate a Gene: Decap its Associated Noncoding RNA. Mol Cell 45:271-3 (2012).
102. Karam R. & Wilkinson MF. A Conserved MicroRNA/NMD Regulatory Circuit Controls Gene
Expression. RNA Biology 9:22-26 (2012).
103. Nguyen LS, Jolly L, Shoubridge C, Chan WK, Huang L, Laumonnier F, Raynaud M, Hackett
A, Field M, Rodriguez J, Srivastava AK, Lee Y, Long R, Addington AM, Rapoport JL, Suren S,
Hahn CN, Gamble J, Wilkinson MF, Corbett MA, Gecz J. Transcriptome profiling of
UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual
disability. Mol Psychiatry 17:1103-15 (2012).
104. Bhardwaj A, Song H-W, Beildeck M, Kerkhofs S, Castoro R, Shanker S, De Gendt K,
Claessens F, Issa JP & Wilkinson MF. DNA Demethylation-Dependent AR Recruitment and
GATA Factors Drive Rhox5 Homeobox Gene Transcription in the Epididymis." Molecular
Endocrinology 26:538-549 (2012).
105. Song H-W, Dann CT, McCarrey J., Meistrich M., Cornwall & Wilkinson MF. Dynamic
expression pattern and subcellular localization of the RHOX10 homeobox transcription factor
during germ cell development. Reproduction 143:611-624 (2012).
106. MacLean JA, Hayashi K., Turner TT & Wilkinson MF. The Rhox5 Homeobox Gene
Regulates the Region-Specific Expression of its Paralogs in the Rodent Epididymis. Biol.
Reproduction 86: 189- (2012).
Commentary on this paper:
Hammond GL, Rhox5 Rules in an Evolving Saga of Reproductive Diversity. Biol Reprod
86:188- (2012).
107. Huang L & Wilkinson MF. Regulation of Nonsense-Mediated RNA Decay. WIRES RNA 3:
807-828 (2012).
108. Song H-W & Wilkinson MF. In Vitro Spermatogenesis: A Long Journey to Get Tails.
Spermatogenesis 2:238-244 (2012).
109. Song H-W, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent
LC, de Rooij DG, Hsieh TC & Wilkinson MF. The RHOX homeobox gene cluster is
selectively expressed in human male germ cells and oocytes. Human Reproduction 28:163546 (1013).
110. Karam R, Wengrod J, Gardner LB, Wilkinson MF. Regulation of Nonsense-Mediated mRNA
Decay: Implications for Physiology and Disease. Biochim Biophys Acta 1829:624-33 (2013).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
15
111. Richardson ME, Bleiziffer A, Tüttelmann F, Gromoll J, Wilkinson MF. Epigenetic Regulation
of the RHOX Homeobox Gene Cluster and its Association with Human Male Infertility. Hum
Mol Genet 23:12-23 (2013).
Commentary
on
article.cfm/4774826)
this
paper:
MDLinx
(http://www.mdlinx.com/urology/news-
112. Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander
JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK. Targeted DNA
Demethylation and Activation of Endogenous Genes Using Programmable TALE-TET1
Fusion Proteins. Nature Biotechnology 31:1137-42 (2013).
113.
Lasalde C, Rivera AV, Leon A, Gonzalez JA, Estrella LA, Rodriguez-Cruz EN, Correa ME,
Cajigas IJ, Bracho DP, Vega IE, Wilkinson MF, Gonzalez CI. Identification and Functional
Analysis of Novel Phosphorylation Sites in the RNA Surveillance Protein Upf1. Nucleic Acids
Research 42:1916-29 (2014).
114. MacLean JA 2nd, Hu Z, Welborn JP, Song HW, Rao MK, Wayne CM, Wilkinson MF. The
RHOX Homeodomain Proteins Regulate the Expression of Insulin and Other Metabolic
Regulators in the Testis. J Biol Chem 288:34,809-25 (2013).
115. Lou C-H, Shao A, Shum EY, Espinoza JL, Huang L, Karam R & Wilkinson MF.
Posttranscriptional Control of the Stem and Neurogenic Programs by the Nonsense-Mediated
RNA Decay Pathway. Cell Reports 6:748-64 (2014).
Selected commentaries on this paper:

CIRM
cells.html)

Flower of Life – Support to Children with autism (http://www.fl-life.com.ua/wordpress/)

Beyond the Dish (https://beyondthedish.wordpress.com/tag/miles-f-wilkinson/)

Mesenchymal Stem Cells (http://www.mesenchymalstemcells.net/cell-medicine/proteinswitch-dictates-cellular-fate-stem-cell-or-neuron.php)
(http://cirmresearch.blogspot.com/2014/02/how-single-protein-helps-keep-our-
116. Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao
Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF*, Lu Y.* The UPF1 RNA
Surveillance Gene is Commonly Mutated in Pancreatic Adenosquamous Carcinoma. Nature
Medicine 20:596-8 (2014). *co-corresponding authors
Selected commentaries on this paper:
 Science Daily (http://www.sciencedaily.com/releases/2014/05/140525154720.htm)
 ASCO Post (http://www.ascopost.com/ViewNews.aspx?nid=16260)
Revised July 29, 2017
Miles Wilkinson, Ph.D.
16
 Medical Press (http://news360.com/article/240483164)
 Cancer Discovery Research Watch (http://cdnews.aacrjournals.org/)
117. De Gendt K, Verhoeven G, Amieux PS & Wilkinson MF. Genome-wide Identification of ARRegulated Genes Translated in Sertoli Cells In Vivo Using the RiboTag Approach. Mol
Endocrinology 28:575-91 (2014).
118.
Nguyen LS, Wilkinson MF & Gecz J. Nonsense-Mediated mRNA Decay: Inter-Individual
Variability and Human Disease. Neuroscience and Biobehavioral Reviews 2013 Nov 14. pii:
S0149-7634(13)00270-4. doi: 10.1016/j.neubiorev.2013.10.016. [Epub ahead of print].
119. Song H-W & Wilkinson MF. Transcriptional Control of Spermatogonial Maintenance and
Differentiation.
Seminars
Cell
Dev
Biol.
2014
Jun;30C:14-26.
doi:
10.1016/j.semcdb.2014.02.005. Epub 2014 Feb 19.
Invited journal articles:
1.
Lindsey, S., & Wilkinson, M.F. (1996) Homeobox Genes and Male Reproductive Development.
J. Assist. Reprod. & Genetic 13:182-192.
2.
Wayne, C. & Wilkinson, M.F. (1998) Pem: An Androgen-Dependent Homeodomain Gene
Expressed in Testi and Epididymis. In: “Testicular Function: From Gene Expression to Genetic
Manipulation,” pp. 213-234, Eds: Stefanini, M. et al., Springer-Verlag.
3.
MacLean, J.A. & Wilkinson, M.F. (2005) Gene Regulation in Spermatogenesis. In: “Current
Trends in Developmental Biology” 71:131-197.
4.
Bhardwaj, A. & Wilkinson M.F. (2005), A Metabolic Enzyme Doing Double Duty as a
Transcription Factor. BioEssays 27:467-471.
5.
Rao M. & Wilkinson M.F. (2006) “RNAi as a Tool to Silence Genes of Interest in Specific Tissues
or Cell Types,” in Touch Briefings/Drug Discovery 2006: pp 35-36.
6.
Hu Z., MacLean J.A., Bhardwaj A. & Wilkinson M.F. (2007) Regulation and Function of the
Rhox5 Homeobox Gene. Annals of the New York Academy of Science 1120:72-83.
7.
Shanker S., Hu Z. & Wilkinson M.F. (2008) Epigenetic Regulation and Downstream Targets
of the Rhox5 Homeobox Gene. International Journal of Andrology 31: 462-470.
8.
Bettegowda A. & Wilkinson M.F. (2009) Transcriptional and Post-transcriptional Regulation
of Spermatogenesis. In “Biology of Spermatogenesis,” Philosophical Transactions of the
Royal Society B-Biological Sciences 365:1637-1651.
9.
MacLean J.A. & Wilkinson M.F. (2010) The Rhox Genes. Reproduction 140:195-213.
Book chapters:
Revised July 29, 2017
Miles Wilkinson, Ph.D.
17
1.
Wilkinson, M.F. & Morris, A. (1983) Interferon and the Immune System 1: Induction of
Interferon and the Immune System (30 pg.) In: "Interferons: From Molecular Biology to
Clinical Application", Burke and Morris, eds., Society for General Microbiology Ltd.
2.
Wilkinson, M.F. & Morris, A. (1983) Partial Purification and Some Biological Properties of an
Interferon with Novel Characteristic Produced by Human Mononuclear Leukocytes. In: "The
Biology of the Interferon System". DeMaeyer & Schellenkens, ed., Elsevier Science
Publishers, B.V.
3.
Wilkinson, M.F. & Morris, A.G. (1985) The Interaction between Interferon and Macrophages
(19 pg.). In: “Mononuclear Phagocytes: Physiology and Pathology”, Jessup & Dean, eds.,
Elsevier/North Holland.
4.
Wilkinson, M.F. & Morris, A.G. (1986) Preparation and Partial Purification of Human
Interferon-delta. In: “Interferons: A Volume of Methods in Enzymology”, Colowick & Kaplan,
eds.
5.
Wilkinson, M.F. (1991) Purification of RNA (chapter 4). In: Volume 1 of "Basic Molecular
Biology: A Practical Approach", Brown, T.A., ed., IRL Press, Oxford.
6.
Wilkinson, M.F. (2000) Purification of RNA (chapter 4). In: Volume 1 of "Essential Molecular
Biology", 2nd Edition; Brown, T.A., ed., Oxford University Press, Oxford.
7.
Rao, M. & Wilkinson, M.F. (2002) Homeobox Genes and the Male Reproductive System
(chapter 15). In “The Epididymis: A Comprehensive Survey of the Efferent Ducts, the
Epididymis, and the Vas Deferens,” Robaire, B. and Hinton, B.T., eds., Kluwer
Academic/Plenum Publishers.
8.
Rao, M., Wayne, C. & Wilkinson, M.F. (2003) Expression and Regulation of the Pem
Homeobox Gene in the Epididymis. In "Third International Conference on the Epididymis,"
Hinton, B.T. & Turner, T.T., ed., Van Doren Press.
9.
Bruce, S. & Wilkinson, M.F. (2003) Nonsense-Mediated Decay: a Surveillance Pathway that
Detects Faulty TCR and BCR Transcripts.
In "Recent Research Developments in
Immunology," Pandalai, S.G., ed., Research Signposts Publishers.
10.
Bruce, S. & Wilkinson, M.F. (2005) RNA Stability. In “Genomics and Proteomics in
Molecular Medicine,” Ganten, D. & Ruckpaul, K., ed., Springer International.
11.
Gudikote J. & Wilkinson, M.F. (2005) Nonsense-Mediated Decay and the Immune System.
In: “The Nonsense-Mediated Decay RNA Surveillance Pathway,” Maquat, L.E., ed., Landes
Biosciences.
12.
Gudikote J. & Wilkinson M.F. (2005) RNA-Binding Proteins: Regulation of mRNA Splicing,
Export, and Decay, in “Encyclopedia of Life Sciences” (John Wiley and Sons, Ltd.).
Abstracts: (only those since 1993 are listed)
Revised July 29, 2017
Miles Wilkinson, Ph.D.
18
1. Carter, M., Qian, L., Vu, M., & Wilkinson, M.F. Post-Transcriptional Regulation of T Cell
Receptor- mRNA, MidWinter Conference of Immunologists, Asilomar, CA, January 8, 1993.
2.
Ganji, A.,Vu, M., Carter, M., & Wilkinson, M.F. A Molecular Mechanism that Selectively
Inhibits Expression of Transcripts Derived from Non-Productively Rearranged TCR- Genes,
MidWinter Conference of Immunologists, Asilomar, CA, January 8, 1993.
3.
Qian, L., Vu, M., Carter, M., & Wilkinson, M.F. A Spliced Intron Accumulates as a Lariant in
the Nucleus of T Cells, MidWinter Conference of Immunologists, Asilomar, CA, January 8, 1993.
4.
Qian, L. & Wilkinson, M.F. Characterization and Putative Functional Role of a Stable Intron
From the TCR- Gene, MidWinter Conference of Immunologists, Asilomar CA, January 8, 1993
5. Lindsey, J. S. & Wilkinson, M.F. An Oncofetal Homeobox Gene Expressed During Epididymis
and Spermatocyte Development, Development Biology Conference, University of British
Columbia, Vancouver, B.C., May 6 - 8, 1993.
6.
Carter, M. S., Vu, M.N. & Wilkinson, M.F. A Nuclear Mechanism Mediates the Down
Regulation of T cell Receptor- Transcripts that Possess Premature Termination Codons. RNA
Processing Conference, Cold Spring Laboratory, Cold Spring New York, May 19 – 23, 1993.
7.
Wilkinson, M.F. & Qian, L.. Nuclear Retention of Spliced mRNAs Dervied from Pre-mRNAs
that Encode a Stable Intron, RNA Processing Conference, Cold Spring Laboratory, Cold Spring,
New York, May 19 – May 23, 1993.
8.
Carter, M. S. & Wilkinson, M.F. A Nuclear Regulatory Mechanism is Engaged by Premature
Translation Termination (Nonsense) Codons, Keystone Symposia on Molecular and Cellular
Biology, Journal of Cellular Biochemistry, 18c: M504, February 13-19, 1994.
9. Wilkinson, M.F. & Qian, L. A Stable Intron may Regulate the Nuclear-to-Cytoplasmic Transport
of Mature Transcripts, Keystone Symposia on Molecular and Cellular Biology, Journal of
Cellular Biochemistry, 18c: M532, February 13 – 19, 1994.
10. Qian, L., Ding, Q., Kaplinsky, N., & Wilkinson, M.F. A Stable Intron may Regulate the Nuclearto-Cytoplasmic Transport of Mature Transcripts, International RNA Society Annual Meeting,
University of Wisconsin, Madison, Wisconsin, May 24 – 29, 1994.
11. Carter, M. S. & Wilkinson, M.F. A Nuclear Regulatory Mechanism is Engaged by Premature
Translation Termination (Nonsense) Codons, International RNA Society Annual Meeting,
University of Wisconsin, Madison, Wisconsin, February 13 – 26, 1994.
12. Carter, M. S., Doskow, J., Nhim, R. & Wilkinson, M.F. A Nuclear Proof-Reading Mechanism
Down Regulates Transcripts Harboring Premature Nonsense Codons, INSERM Conference,
Stransbourg-LeBischenberg (France), September 25-29, 1994.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
19
13. Ding, Q., Qian, L., & Wilkinson, M.F. Characterization and Potential Function of a Stable Intron
from the T Cell Receptor- Gene, RNA Processing Meeting, Cold Spring Harbor Laboratory,
Cold Spring Harbor, New York, May 17 – 21, 1995.
14. Carter, M. S., Doskow, J., Nhim, R. & Wilkinson, M.F. T Cell Receptor mRNA Regulation: A
Proof-Reading Mechanism, Thirteenth Annual Texas Regional Immunology Conference,
Galveston, Texas, November 17 – 19, 1995.
15. Carter, M. S., Li, S. & Wilkinson, M.F. A Downstream Intron is Essential for Nonsense CodonMediated Regulation in the Nucleus, International RNA Society Annual Meeting, University of
Wisconsin, Madison, Wisconsin, May 28 to June 2, 1996.
16.
Li, S. Carter, M. S. & Wilkinson, M.F. Multiple Exon Skipping and Alternative Splice
Donor/Acceptor Usage induced by Nonsense Codons, International RNA Society Annual
Meeting, University of Wisconsin, Madison, Wisconsin, May 28 to June 2, 1996.
17. Maiti, S.M., Doskow, J., Li, S., Nhim, R., Lindsey, J. S. & Wilkinson, M.F. The Pem Homeobox
Gene Displays Androgen-Dependent Alternative Promoter Usage and Tissue-Specific RNA
Splicing, 10th International Congress of Endocrinology, San Francisco, CA, June 12 – 13, 1996.
18. Lindsey, J.S. & Wilkinson, M.F. Pem: A Candidate Transcription Factor to Regulate AndrogenDependent Events in the Proximal Cauda Region of the Epididymis, 10th International Congress
of Endocrinology, San Francisco, CA, June 12 –13, 1996.
19.
Maiti, S.M., Doskow, J., Li, S., Nihm, M., Lindsey, J.S., & Wilkinson, M.F. The Pem
Homeobox Gene Displays Androgen-Dependent Alternative Promoter Usage and Tissue-Specific
RNA Splicing, Gordon Research Conference, Plymouth, N.H., July 7 – 12, 1996.
20. Carter, M. S., Li, S. & Wilkinson, M.F. Premature Nonsense Codons Affect Nuclear Metabolism
of T Cell Receptor-Beta Transcripts, International Meeting on Translational Control, Cold Spring
Harbor, New York, September 4 – 8, 1996.
21. Li, S., Carter, M. S. & Wilkinson, M.F. T Cell Receptor mRNA Regulation: A Scanning
Mechanism that Detects Premature Nonsense Codons, Fourteenth Annual Texas Regional
Immunology Conference, San Antonio, Texas, November 15 – 17, 1996.
22. Sutton, K. A. & Wilkinson, M.F. Evolution of the Pem Homebox Gene, Keystone Molecular and
Cellular Biology Symposia, Santa Fe, New Mexico, February 16 – 21, 1997.
23. Li, S. & M.F. Wilkinson. A Putative Surveillance Mechanism that Down Regulates Aberrant
Transcripts Bearing Premature Termination Codons, International RNA Society Annual Meeting,
Banff Centre, Banff, Alberta, Canada, May 27 – June 1, 1997.
24. Li, S. & Wilkinson, M.F. Nonsense Surveillance in Lymphocytes, 15th Annual Texas Regional
Immunology Conference, Galveston, Texas, November 21 – 23, 1997.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
20
25. Maiti, S.N. & Wilkinson, M.F. An Oncogene Response Element (ORE) Containing ETS, NFB,
and SP 1 Binding Sites is Essential for Pem Homeodomain Gene Transcription, Keystone
Symposia on Molecular and Cellular Biology, Taos, New Mexico, February 21 – 26, 1998.
26. Wayne, C.M. & Wilkinson, M.F. Pem: An Androgen-Dependent Homeodomain Gene Expressed
in Testis and Epididymis, 10th European Workshop on Molecular and Cellular Endocrinology of
the Testis, Ernst Schering Research Foundation, Capri, Italy, March 28 - April 1, 1998.
27. Mock-Casagrande, C.S., Mühlemann, O., Li, S., Wilkinson, M.F. Carmo-Fonseca, M. & Moore,
M. J. Dynamic Organization of Nuclear Function, Cold Spring Harbor, New York, October 7-11,
1998.
28.
Vock, V., Li, S. & Wilkinson, M.F. Nonsense Surveillance in Lymphocytes, Midwinter
Conference of Immunologists, Asilomar, California, January 23 – 26, 1999.
29. Maiti, S.N.& Wilkinson, M.F. A 15nt Oncogene Response Element (ORE) Containing Ets,
F, and Sp1 Binding Sites is Essential for Pem Homeodomain Gene Transcription, Keystone
Meeting: TransAmerican Association for Cancer Biology, “The Mutant Mouse: New Methods,
New Models, New Insights,” Keystone, Colorado, January 31 – February 5, 1999.
30. Mühlemann, O., Mock-Casagrande, C. S., Custódio, N., Carmo-Fonseca, M., Wilkinson, M.F. &
Moore, M. Nonsense codon-containing immunoglobulin mu and TCR RNAs accumulate at the
site of transcription. International RNA Society Annual Meeting, University of Edinburgh,
Scotland, June 23-29, 1999.
31. Gudikote, J., Li, S., Wilkinson, M.F. Is Nonsense Codon-Mediated Decay (NMD) Regulated by
Nonsense Promoting Elements (NPEs)?, Eukaryotic mRNA Processing Meeting, Cold Spring
Harbor, New York, August 25 – 29, 1999.
32. Mock-Casagrande, C., Mühlemann, O., Custódio, N., Carmo-Fonseca, M., Wilkinson, M.F. &
Moore, M. Investigating the Accumulation of Nonsense-Codon Containing mRNA at the Site of
Transcription, Eukaryotic mRNA Processing Meeting, Cold Spring Harbor, New York, August
25- 29, 1999.
33. Wayne, C. M. & Wilkinson, M.F., The Pem Homeodomain Protein: A Potential Regulator of
Germ Cell Apoptosis in the Testis, Recent Progress in Hormone Research 55th Conference,
Skamania Lodge, Stevenson, Washington, August 7 – 11, 1999.
34. Wilkinson, M.F. Pem: A Homeodomain Protein that may Regulate Events in the Testis and
Epididymis, Homeobox Workshop, Schloss Elmau, Germany, September 30 – October 3, 1999.
35. Wang, J. & Wilkinson, M.F., T-Cell Receptor Pre-mRNAs are Upregulated in Response to
Nonsense Condons, 18th Annual Texas Regional Immunology Conference, Galveston, Texas, 19 –
21 November, 1999.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
21
36. Hamilton, J.I., Carter, M. S., Li, S., Wang, J. & Wilkinson, M.F. A T-Cell Receptor Surveillance
Mechanism, 18th Annual Texas Regional Immunology Conference, Galveston, Texas, November
19 – 21, 1999.
37. Gudikote, J. ,Li, S., & Wilkinson, M.F. Is Nonsense Codon-Mediated Decay (NMD) Regulated
by Nonsense Promoting Elements (NPEs)?, 18th Annual Texas Regional Immunology
Conference, Galveston, TX, November 19 – 21, 1999.
38. Rao, M., Maiti, S. & Wilkinson, M.F. Transcriptional Regulation of the Homeobox Gene Pem
by Ets and Sp-1 Family Members in Reproductive Tissues. 6th Annual Texas Forum on Female
Reproduction. Houston, TX, May 18-19, 2000.
39.
Hamilton, J.I., Wang, J. & Wilkinson, M.F., Nonsense Codon-Dependent Upregulation of
Alternative Splice-Site Usage in TCR-Beta Transcripts. 5th Annual International RNA Meeting,
Madison, WI, May 30 – June 4, 2000.
40. Vock, V.M., Wang, J., Li, S. & Wilkinson, M.F., The Involvement of Ribosomes in NonsenseMediated Downregulation (NMD). 5th Annual International RNA Meeting, Madison, WI, May 30
– June 4, 2000.
41. Wang, J., Carter, M.S., Li, S. & Wilkinson, M.F., A Translation-Like Scanning Mechanism that
Induces Alternatively Spliced Transcripts. 5th Annual International RNA Meeting, Madison, WI,
May 30 – June 4, 2000.
42. Bruce, S. & Wilkinson, M.F., The Role of the Nucleus in Nonsense-Mediated Downregulation
(NMD). 5th Annual International RNA Meeting, Madison, WI, May 30 – June 4, 2000.
43. Gudikote, J., Li,, S. & Wilkinson, M.F., NPEs: Cis Elements that Promote Nonsense CodonMediated Downregulation. 5th Annual International RNA Meeting, Madison, WI, May 30 – June
4, 2000.
44. Chen, M., Wayne, C., Zhang, K., Maiti, S. & Wilkinson, M.F., Biochemical Characterization and
In Vivo Functional Analysis of Pem: a Homeodomain Protein Expressed in Adult Reproductive
Tissues. Gordon Research Conference, Reproductive Tract Biology, 1 July – 6 July, 2000.
45. Rao, M.K., Maiti, S. & Wilkinson, M.F., Transcriptional Regulation of the Androgen-Dependent
Homeobox Gene Pem by Ets and Sp1 Family Members in Reproductive Tissues. Society for the
Study of Reproduction (SSR), Madison, WI, 15 July – 18 July, 2000.
46. Gudikote, J. & Wilkinson, M.F., Identification of a Cis Element Essential for Super Nonsense
Codon-Mediated Decay (NMD), Cold Spring Harbor Translation meeting, Cold Spring Harbor,
NY, 6 September – 10 September, 2000.
47. Wang, J., Li, S., Carter, M., Hamilton, J. & Wilkinson, M.F., Nonsense Codon-Dependent
Induction of Alternatively Spliced Transcripts, Cold Spring Harbor Translation meeting, Cold
Spring Harbor, NY, 6 September – 10 September, 2000.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
22
48. Wang, J. & Wilkinson, M.F., A T-Cell Receptor Surveillance Mechanism. 19th Annual Texas
Regional Immunology Conference, Galveston, TX, November 17 – 19, 2000.
49.
Gudikote, J., Li, S. & Wilkinson, M.F. Regulation of T-cell Receptor Expression by the
Nonsense-Mediated Decay (NMD) RNA Surveillance Pathway. Midwinter Conference of
Immunologists, Asilomar, CA, 27-30 January, 2001.
50. Gudikote, J., Li, S. & Wilkinson, M.F. RNA-Binding Proteins that Interact with a Cis Element
that Promotes Nonsense Codon-Mediated Decay (NMD). 2nd International Conference: Proteins
that Bind RNA, Austin, TX, 4-8 March, 2001.
51. Wang, J., Hamilton, J., Carter, M., Li, S. & Wilkinson, M.F., Nonsense-Mediated Altered
Splicing (NMAS): A Translation-Like RNA-Correction Mechanism. C.N.R.S. Conference
Jacques Monod EMBO Workshop: mRNA Enigmas: Transport, Silencing, Decay, and their
Interplay with Translation, Aussois, France, 27 March – 1 April, 2001.
52. Rao, M.K., Maiti, S., MacLean, J.A. & Wilkinson, M.F., Transcriptional Regulation of the Pem
Homeobox Gene by Ets and Sp-1 Family Members in Ovarian Granulosa Cells. Texas Forum on
Female Reproduction, Seventh Annual Meeting, Houston, TX, 3-4 May, 2001.
53. Bruce, S.R., Li, S., Garrard, W.T. & Wilkinson, M.F., NMD is Elicited in Transgenic Mice In
Vivo by a Nonsense Codon the Terminal Exon of Ig Kappa Genes. 6th Annual International RNA
Meeting, Banff, Canada, May 29 – June 3, 2001.
54. Muhlemann, O., Mock-Casagrande, C.S., Wang, J., Li, S., Custodio, N., Carmo-Fonseca, M.,
Wilkinson, M.F. & Moore, M.J. Precursor RNAs Harboring Nonsense Codons Accumulate Near
the Site of Transcription. 6th Annual International RNA Meeting, Banff, Canada, May 29 – June
3, 2001.
55. Wang, J. Gudikote, J.P., Olivas, R. & Wilkinson, M.F. The NMD-Promoting Element (NPE) in
a TCR Gene Permits Intron-Proximal Nonsense Codons to Trigger NMD. 6th Annual International
RNA Meeting, Banff, Canada, May 29 – June 3, 2001.
56. Wang, J., Hamilton, J.I., Carter, M., Shulin, L. & Wilkinson, M.F. Nonsense Codons Induce
Alternatively Spliced Transcripts by a Translation-Like Mechanism. 6th Annual International
RNA Meeting, Banff, Canada, May 29 – June 3, 2001.
57. Wang, J., Hamilton, J.I., Olivas, R. & Wilkinson, M.F. Nonsense Codons Upregulate Unspliced
TCR Transcripts. 6th Annual International RNA Meeting, Banff, Canada, May 29 – June 3, 2001.
58. Wayne, C.M., Sutton, K. & Wilkinson, M.F. Ectopic Expression of a Sertoli-specific Homeobox
Gene Increases DNA-Strand Breaks in Adjacent Germ Cells. International Society for the Study
of Reproduction Annual Meeting, University of Ottawa, 28 July - 1 August, 2001.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
23
59. Rao, M.K., Sutton, K., Pagani, R.L., Lamb, D.J. & Wilkinson, M.F. Identification of Pem
Homeobox Gene Promoter Sequences Sufficient to Drive High Transcription Levels in Sertoli
Cells and Principal Cells of Caput Epididymis In Vivo. International Society for the Study of
Reproduction Annual Meeting, University of Ottawa, 28 July - 1 August, 2001.
60. Wilkinson, M.F., Rao, M.K., Maiti, S. & MacLean, J.A. Transcriptional Regulation of the Pem
Homeobox Gene by Ets and Sp-1 Family Members in Primary Granulosa Cells and Diverse
Tumor Cell Types. International Society for the Study of Reproduction Annual Meeting,
University of Ottawa, 28 July - 1 August, 2001.
61. Wang, J., Gudikote, J.P., Olivas, R. & Wilkinson, M.F. Nonsense Codons Induce Alternatively
Spliced Transcripts by a Translation-like Mechanism. Meeting on mRNA Stability and
Translation, U. Washington, Seattle, WA, 14-16 October, 2001.
62. Bruce, S.B. & Wilkinson, M.F. Developmental Regulation of the NMD RNA Surveillance
Pathway in B-Cell and Plasma Cell Lines. 20th Annual Texas Regional Immunology Conference,
Galveston, TX, 9-11 November, 2001.
63. Wang, J., Hamilton, J.I., Carter, M.C., Li, S. & Wilkinson, M.F. An RNA Surveillance
Mechanism that Detects Aberrant Transcripts. 11th International Workshop on Beyond the
Identification of Transcribed Sequences: Functional Expression and Evolutionary Analysis,
Reston, Virginia, 9-12 November, 2001.
64. Wilkinson, M.F. & Gudikote, J. A Surveillance Pathway that Detects Aberrant TCR Transcripts
Generated from Non-Productively Rearranged TCR Genes. Annual Meeting of the American
Association of Immunologists, New Orleans, LA, 20-24 April, 2002.
65. Clement, J.Q. & Wilkinson, M.F. The Effect of Nonsense Codons on Pre-mRNA Splicing and
mRNA Stability. Annual Meeting of the American Association of Immunologists, New Orleans,
LA, 20-24 April, 2002.
66. Rao, M.K., Wayne, C. & Wilkinson, M.F. Regulatory Sequences that Direct Developmentallly
Regulated Androgen-Dependent Expression in Sertoli Cells and Different Subregions of the
Epididymis In Vivo. The 3rd International Conference on the Epididymis, Charlottesville,
Virginia, 29 May - 1 June 2002.
67. Rao, M.K., Wayne, C. & Wilkinson, M.F. Identification of Promoter Sequences Necessary to
Drive Androgen-Dependent and Basal Expression from the Pem Homeobox Gene. The 3rd
International Conference on the Epididymis, Charlottesville, Virginia, 29 May - 1 June 2002.
68. Bruce, S.R. & Wilkinson, M.F. Developmental Regulation of the NMD RNA Surveillance
Pathway in B-Cell and Plasma Cell Lines. 7th Annual International RNA Meeting, Madison,
Wisconsin, 28 May – 1 June, 2002.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
24
69. Gudikote, J.P., Hamilton, J. & Wilkinson, M.F. T-Cell Receptor Regulatory Elements that
Promote mRNA Downregulation in Response to Nonsense Codons. 7th Annual International RNA
Meeting, Madison, Wisconsin, 28 May – 1 June, 2002.
70. Wang, J., Olivas, O.R. & Wilkinson, M.F. Nonsense Codons Cause Retention of Mature T-Cell
Receptor Transcripts in the Nuclear Fraction of Cells. 7th Annual International RNA Meeting,
Madison, Wisconsin, 28 May – 1 June, 2002.
71. Wang, J., Olivas, O.R. & Wilkinson, M.F. Rapid Decay and Partial Retention of Nonsense
Codon-Containing Transcripts in the Nuclear Fraction of Cells. Post-Transcriptional Control of
Gene Expression: Effectors of mRNA Decay FASEB meeting, Tucson, AZ, 6-11 July, 2002.
72. Rao, M.K., Wayne, C. M., Meistrich, M.L. & Wilkinson, M.F. A Promoter that Directs
Transcription in a Sertoli Cell-Specific, Stage-Specific, and Androgen-Dependent Manner In
Vivo. International Society for the Study of Reproduction Annual Meeting, Baltimore, MD, 28 31 July, 2002.
73. Chen, M. & Wilkinson, M.F. Inactivation of the Pem Gene Causes Reduced Caudal Sperm and
Subfertility. International Society for the Study of Reproduction Annual Meeting, Baltimore,
MD, 28 - 31 July, 2002.
74. MacLean J.A., Rao M.K. & Wilkinson M.F. Transcriptional Regulation of the Pem Homeobox
Gene by Ets and Sp-1 Family Members in Ovarian Granulosa Cells. International Society for the
Study of Reproduction Annual Meeting, Baltimore, MD, 28 - 31 July, 2002.
75. Wilkinson M.F., Imam J.S., Gudikote J.P. & Olivas O.R. Nonsense-Mediated Upregulation of
Pre-mRNA. 8th Annual International RNA Meeting, Vienna, Austria, 1 - 6 July , 2003.
76. MacLean J.A., Wayne C.M., Chen M. A., Bruce S. & Wilkinson M.F. The RhoX Genes: A New
Homeobox Gene Cluster on the X Chromosome Expressed Selectively in Reproductive Tissues.
International Society for the Study of Reproduction Annual Meeting, Cincinnati, Ohio, 19 - 22
July, 2003.
77. Rao M.J. & Wilkinson M.F. Regulation of Androgen Receptor Recruitment and Chromatin
Conformation by Androgen. International Society for the Study of Reproduction Annual Meeting,
Cincinnati, Ohio, 19 - 22 July, 2003.
78. Imam J.S., Gudikote J.P., Olivas O.R. & Wilkinson M.F. Nonsense-Mediated Upregulation of
Pre-mRNA. Cold Spring Harbor Conference: Eukaryotic mRNA Processing. Cold Spring
Harbor, NY, 20-24 August, 2003.
79. Bruce, S. & Wilkinson, M.F. Cell Type-Specific NMD. FASEB Research Conference, PostTranscriptional Control of Gene Expression: Mechanisms of mRNA Decay, Tucson, AZ, 26 June
– 1 July, 2004.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
25
80. MacLean, J.A., Chen, M.A., Wayne, C.M., Bruce, S.R., Meistrich, M.L., MacLeod, C.L. &
Wilkinson, M.F. Rhox: A New Homeobox Gene Cluster. International Society for the Study of
Reproduction Annual Meeting, Vancouver, B.C., 1-4 August, 2004.
81. Rao, M., Pham J. & Wilkinson, M.F. The Tumor Suppressor Wilms’ Tumor 1 (WT1) Gene is
Essential for Spermatogenesis. International Society for the Study of Reproduction Annual
Meeting, Vancouver, B.C., 1-4 August, 2004.
82. Shanker, S., Rao, M. & Wilkinson, M.F. Regulation of the Pem Homeobox Gene Distal
Promoter by Ets and Sp1 Factors Depends on Ras-Mediated DNA Methylation. International
Society for the Study of Reproduction Annual Meeting, Vancouver, B.C., 1-4 August, 2004.
83. Bhardwaj, A., Rao, M. & Wilkinson, M.F. Sertoli Cell-Specific Expression in the Testis
Directed by Regulatory Sequences in the Pem Proximal Promoter. International Society for the
Study of Reproduction Annual Meeting, Vancouver, B.C., 1-4 August, 2004.
84. Gudikote, J. & Wilkinson, M.F. Surveillance Mechanisms Discriminating Between Functional
and Mutant Transcripts. Environmental Mutation Society Annual Meeting: Genes, Mutations,
and Disease, Pittsburgh, PA, 2-6 October, 2004.
85. Shanker, S., Rao, M. & Wilkinson, M.F. Discrete DNA Methylation Boundaries Between
Promoters Expressed in Male and Female Reproductive Tissues,” Lost Pines Conference / U.
Texas M.D.A.C.C. Science Park, Smithville, TX, 22-24 October, 2005.
86. Bhalla, A., Gukikote, J., Wang, J. & Wilkinson, M.F. Nonsense Mediated Decay (NMD): an
RNA Surveillance Mechanism that Degrades Aberrant mRNAs Harboring Nonsense Codons.
Lost Pines Conference / U. Texas M.D.A.C.C. Science Park, Smithville, TX, 22-24 October,
2005.
87. Rao, M., Pham, J., MacLean III, J. & Wilkinson, M.F. The Transcription Factor Wilms’ Tumor
1 (WT1) is Essential for Normal Spermatogenesis. 28th North American Testis Workshop,
Seattle, WA, 30 March – 2 April, 2005.
88. MacLean III, J., Chen, M.A., Wayne, C.M., Rao, M., Bruce, S.R., Meistrich, M.L. & Wilkinson,
M.F. Rhox: A Homeobox Gene Cluster that Regulates Spermatogenesis. 28th North American
Testis Workshop, Seattle, WA, 30 March – 2 April, 2005.
89. MacLean III, J., Rao, M.K., Doyle, K.M.H., Richards, J.S. & Wilkinson, M.F., Transcriptional
Regulation of the Rhox5 Homeobox Gene by Ets and Sp1 Family. Annual Texas Forum on
Female Reproduction, Houston, TX, 14 – 15 April, 2005.
90. Shanker, S., Rao, M.K. & Wilkinson, M.F., The Identification of a Transcriptional Insulator
Between Alternative Promoters Expressed in Female and Male Reproductive Tissues. Annual
Texas Forum on Female Reproduction, Houston, TX, 14 – 15 April, 2005.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
26
91. Lorenzetti, D., MacLean III, Wayne, C.M., Rao, M.K. & Wilkinson, M.F., The Rhox Cluster: a
Novel Class of X-linked Homeobox Genes Expressed in Placenta and Adult Reproductive Organs.
Annual Texas Forum on Female Reproduction, Houston, TX, 14 – 15 April, 2005.
92. Rao, M., Pham, J.A., Murali, D., MacLean, J., Furuta & Wilkinson, M.F., Role of WT1 in
Spermatogenesis Revealed by RNAi- and Dominant Negative-Mediated Knockdown in
Transgenic Mice, Society for the Study of Reproduction, Quebec City, Canada, 23 – 28 July,
2005.
93. Wilkinson, M.F., Bhardwaj, J. & Rao, M. AR and GATA Factors Collaborate to Drive Sertoli
Cell-Specific Expression of the Pem (Rhox5) Proximal Promoter in the Testis. Society for the
Study of Reproduction, Quebec City, Canada, 23 – 28 July, 2005.
94. Hu, Z., MacLean, J.A. & Wilkinson, M.F. Genes Regulated by the Pem (Rhox5) Homeodomain
Prrotein in Sertoli Cells. Society for the Study of Reproduction, Quebec City, Canada, 23 – 28
July, 2005.
95. MacLean, J.A., Wayne, C.M., Rao, M.K., Chaillet, R. & Wilkinson, M.F. Rhox5 Regulates
Adjacent Homeobox Genes on the X Chromosome during Development. Society for the Study of
Reproduction, Quebec City, Canada, 23 – 28 July, 2005.
96. Imam, J.S., Gudikote, J.P. & Wilkinson, M.F. Nonsense Codons Upregulate Precursor RNA in a
Frame-Dependent Manner. Lost Pines Conference / U. Texas M.D.A.C.C. Science Park,
Smithville, TX, 21-23 October, 2005.
97. Gudikote, J.P., Imam, J.S., Garcia, R.F. & Wilkinson, M.F. Efficient RNA Splicing Promotes
Translation and RNA Surveillance. Cold Spring Harbor Conference: Eukaryotic mRNA
Processing. Cold Spring Harbor, NY, 24-28 August, 2005.
98. Imam, J.S., Gudikote, J.P. & Wilkinson, M.F. Nonsense Codons Upregulate Precursor RNA in a
Frame-Dependent Manner. Cold Spring Harbor Conference: Eukaryotic mRNA Processing. Cold
Spring Harbor, NY, 24-28 August, 2005.
99. Chang, Y-F. & Wilkinson, M.F. T-Cell Receptor Nonsense-Associated Altered Splicing. Cold
Spring Harbor Conference: Eukaryotic mRNA Processing. Cold Spring Harbor, NY, 24-28
August, 2005.
100. Chan, W., Gudikote, J.P. & Wilkinson, M.F. TCR Nonsense-Mediated Decay is Insensitive to
UPF3b Depletion. Cold Spring Harbor Conference: Eukaryotic mRNA Processing. Cold Spring
Harbor, NY, 24-28 August, 2005.
101. Bruno, I., Chan, W. & Wilkinson, M.F. Analysis of the Effects of Depleting the NMD Factors
BTZ and eIF4A3 by Inducible RNAi. Cold Spring Harbor Conference: Eukaryotic mRNA
Processing. Cold Spring Harbor, NY, 24-28 August, 2005.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
27
102. Bhalla, J. Wang, J. Gudikote, J.P., Olivas, O.R. & Wilkinson, M.F. Premature Termination
Codons Elicit a Nuclear-to-Cytoplasmic Partitioning Shift. Cold Spring Harbor Conference:
Eukaryotic mRNA Processing. Cold Spring Harbor, NY, 24-28 August, 2005.
103. Shanker, S., Rao, M.K. & Wilkinson, M.F. Identification of a Methylation Boundary Region
that Serves as an Insulator Between Alternative Tissue-Specific Promoters. Keystone Symposia:
Epigenetics & Chromatin Remodeling in Development, Keystone, CO, 19-24 January, 2006.
104. MacLean, J.A. & Wilkinson, M.F. Homeobox Genes and Male Reproduction. American
Society of Andrology Annual Meeting, Chicago, 8-11 April, 2006.
105. MacLean, J.A., Hu, Z., Bhardwaj, A., Wayne, C.M., Rao, M.K. & Wilkinson, M.F. RHOX5
Regulates Key Regulators of Metabolism During Testis Development. Texas Forum for
Reproductive Sciences. Houston, TX, 20-21 April, 2006.
106. Bhardwaj, A., Rao, M.K. & Wilkinson, M.F. Sertoli Cell-Specific Transcription Achieved by a
Collaboration of Androgen Receptor and GATA Transcription Factors. Texas Forum for
Reproductive Sciences. Houston, TX, 20-21 April, 2006.
107. Chang Y.-F. & Wilkinson M.F. Nonsense-Associated Altered Splicing Can Be Both Reading
Frame and Exonic Splicing Enhancer Dependent. 11th Annual International RNA Meeting,
Seattle, WA 20-25 June, 2006.
108. Gudikote J., Bhalla A., Wang J., Chan, W.-K., Chang Y.-F., Olivas O.R. & Wilkinson M.F.
Retention of Nonsense Codon-Bearing mRNAs in the Nuclear Fraction of Mammalian Cells.
11th Annual International RNA Meeting, Seattle, WA 20-25 June, 2006.
109. Huang, L., Chan W.-K., Gudikote J., Chang Y.-F., Imam J.S., MacLean J.S., Rao M. &
Wilkinson M.F. Evidence for an Alternative Branch of the Nonsense-Mediated Decay Pathway.
11th Annual International RNA Meeting, Seattle, WA 20-25 June, 2006.
110. Imam J.S. & Wilkinson M.F. NMD Degrades Inefficiently Spliced Mammalian Pre-mRNA.
11th Annual International RNA Meeting, Seattle, WA 20-25 June, 2006.
111. MacLean J.A., Hu Z., Bhardwaj A., Wayne C.M., Rao M.K. & Wilkinson M.F. Rhox5
Regulates Key Regulators of Metabolism During Testis Development, Society for the Study of
Reproduction, Omaha, Nebraska (29 July – 1 August 2006).
112. Shanker S., Rao M.K. & Wilkinson, M.F. Identification of a CpG-Free Methylation Boundary
that Serves as an Insulator Between Alternative Sex-Specific Promoters, Society for the Study of
Reproduction, Omaha, Nebraska (29 July – 1 August 2006).
113. Wilkinson M.F. Cell Type- and Tissue-Specific RNAi, Fourth Annual RNAi Conference,
Boston, MA, (25-26 October).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
28
114. Wilkinson M.F., Shanker S., MacLean J. & Rao M. Developmental Regulation of the X-Linked
Rhox Homeobox Gene Cluster, American Society for Biochemistry & Molecular Biology:
Transcriptional Regulation by Chromatin and RNA Polymerase II, Kiawah Island, SC (2-5
November).
115. Guzzardo P.M., Cajigas I.J., Krebber H., Wilkinson M.F. & Gonzalez C.I. Characterization of
the Role of the Upf Proteins in the Activation of the NMD Pathway in Yeast. Annual Biomedical
Research Conference for Minority Students (ABRCMS), Anaheim, CA (8-11 November 2006).
116. Wilkinson M.F., Bhardwaj A., Song H.-W., Shanker S., Turner T.T. & MacLean J. Rhox
Homeobox Genes and the Epididymis. Fourth International Workshop on the Epididymis, ChatelGuyon, Auvergne, France (4-7 December).
117. Bhalla A., Gudikote J., Wang J., Chan W.-K., Chang Y.-F., Olivas O.R. & Wilkinson M.F. Two
Levels of mRNA Quality Control: Nuclear-Fraction Decay and Nuclear-Fraction Decay. 12th
Annual International RNA Meeting, Madison, WI (29 May – 3 June, 2007).
118. Huang L., Wilkinson M.F., Chan W.-K., Rao M. & Buttigieg M. In Vivo Role of the NMD
RNA Surveillance Pathway Elucidated Using a Conditional RNA Interference Approach. 12th
Annual International RNA Meeting, Madison, WI (29 May – 3 June, 2007).
119. MacLean J., Turner T. & Wilkinson M.F. The RHOX5 Homeodomain Protein Directs RegionSpecific Gene Expression in the Epididymis. Society for the Study of Reproduction, San Antonio,
TX (21-25 July, 2007).
120. Rao M., Shanker S., Matsumoto Y., Bhardwaj A. & Wilkinson M.F. Hormone- and StressInduced Relief of a Tissue-Specific Transcriptional Elongation Block. Society for the Study of
Reproduction, San Antonio, TX (21-25 July, 2007).
121. Shanker S., Hu Z. & Wilkinson M.F. The Rhox Homeobox Genes and Reproduction.
International Symposium on Genetics and Male Infertility, Florence, Italy (14-16 September,
2007).
122. Karam R., Carneiro F., Oliveira C. & Wilkinson M.F. The NMD RNA Surveillance Pathway
Degrades Aberrant E-Cadherin Transcripts in Hereditary Diffuse Gastric Cancer. Keystone
Symposia on Gastrointestinal Cancer, Beijing, China (14-19 October 2007).
123. Agosto, A., Cajigas, I.J., Guzzardo, P., Gross, T., Krebber, H., Wilkinson, M.F. and Gonzalez,
C.I. An interaction between Mex67 and Upf1 at the terminal step of mRNA export facilitates
mRNA translation. 4th RISE Area Conference; Studies in Structural Biology: Understanding
Nature’s Own Nanotechnology, University of Puerto Rico-Río Piedras, March 2008.
124. Agosto, A., Cajigas, I.J., Guzzardo, P., Gross, T., Krebber, H., Wilkinson, M.F. and Gonzalez,
C.I. An interaction between Mex67 and Upf1 at the terminal step of mRNA export facilitates
mRNA translation. 28th Puerto Rico Interdisciplinary Scientific Meeting 43rd Junior Technical
Meeting, University of Puerto Rico-Arecibo, March 2008.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
29
125. Lasalde, C., Cajigas, I.J., León, A., González R., Cardé-Serrano, J., Vega, I.E., Wilkinson, M.F.
and González, C. I. Understanding the Role of Phosphorylation of the Upf Proteins in the Activity
of the Nonsense-Mediated mRNA Decay (NMD) Pathway. 4th RISE Area Conference: Studies in
Structural Biology. March 2008, San Juan, P.R.
126. González R., Lasalde, C., Cajigas, I.J., León, A., Cardé-Serrano, J., Vega, I.E., Wilkinson, M.F.
and González, C. I. Understanding the Role of Phosphorylation of the Upf Proteins in the Activity
of the Nonsense-Mediated mRNA Decay (NMD) Pathway. 28th Puerto Rico Interdisciplinary
Scientific Meeting 43rd Junior Technical Meeting, University of Puerto Rico-Arecibo, March
2008.
127. Cajigas, I.J., Guzzardo, P., Agosto, A., Gross, T., Krebber, H., Wilkinson, M.F. and González,
C.I. An interaction between Mex67p and Upf1p at the terminal step of mRNA export facilitates
mRNA translation. American Society for Biochemistry and Molecular Biology (ASBMB) Annual
Meeting, April 2008, San Diego Convention Center, San Diego, CA.
128. Lasalde, C., Cajigas, I.J., León, A., González R., Cardé-Serrano, J., Vega, I.E., Wilkinson, M.F.
and González, C. I. Understanding the Role of Phosphorylation of the Upf Proteins in the Activity
of the Nonsense-Mediated mRNA Decay (NMD) Pathway. ASBMB Annual Meeting. April
2008, San Diego, CA (oral presentation).
129. Bhardwaj A., Shanker S., Song H.-W., Suzuki K., Orgebin-Crist M.-C. & Wilkinson M.F.
Spatial and Temporal Expression of the Rhox5 Homeobox Gene in the Epididymis is Controlled
by DNA Methylation, Androgen Receptor, and GATA Transcription Factors. Society for the
Study of Reproduction, Kailua-Kona, Hawaii (27-30 May, 2008).
130. Huang L. & Wilkinson M.F. The Role of the NMD RNA Surveillance Pathway in Sertoli Cells
Elucidated Using a Tissue-Specific RNA Interference Approach. Society for the Study of
Reproduction, Kailua-Kona, Hawaii (27-30 May, 2008).
131. Chan W.-K., Bhalla A., Gecz J. & Wilkinson M.F. Cross-Regulation and Redundancy of the
Nonsense-Mediated Decay Factors UPF3A and UPF3B. FASEB conference on “Posttranscriptional Gene Regulation.” Colby College, ME (29 June-4 July 2008).
132. Bhalla A.D., Gudikote J.P., Wang J., Chan W.-K., Chang Y.-F., Olivas O.R. & Wilkinson M.F.
Nonsense Codons Elicit Retention and Decay in the Nuclear Fraction of Cells. FASEB
conference on “Post-transcriptional Gene Regulation.” Colby College, ME (29 June-4 July 2008).
133. Lasalde, C., Cajigas, I.J., León, A., González R., Cardé-Serrano, J., Vega, I.E., Wilkinson, M.F.
and González, C. I. Understanding the Role of Phosphorylation of the Upf Proteins in the Activity
of the Nonsense-Mediated mRNA Decay (NMD) Pathway. 2nd Biennial NISBRE Symposium,
Washington, DC (August 2008).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
30
134. Bhardwaj A., Rao M.K., Matsumoto Y., Shanker S. & Wilkinson M.F. Hormone- and DNA
Demethylation-Induced Relief of a Tissue-Specific Transcriptional Elongation Block. Texas
Forum for Reproductive Sciences. Houston, TX, (16-17 April, 2009).
135. Bruno I., Huang L., Bhardwaj A. & Wilkinson M.F. “MicroRNA-Mediated Regulation of
RNA Surveillance,” 4th Annual M.D. Anderson/Baylor College of Medicine Symposium on
Development of Non-Coding RNAs for Cancer Therapy (22 January, 2009).
136. Bruno I., Huang L., Bhardwaj A. & Wilkinson M.F. “A Brain-Specific miRNA
Regulates mRNA Surveillance Pathways,” Keystone Symposia on Therapeutic Modulation
of RNA Using Oligonucleotides, Lake Louise, Alberta, CA (8-13 February, 2009).
137. Wilkinson M.F. “Short RNAs as Tools,” 9th International Congress on Andrology,
Barcelona, Spain (7-10 March, 2009)
138. Bhardwaj A., Rao M.K., Matsumoto Y., Shanker S. & Wilkinson M.F. “Hormone- and
DNA Demethylation-Induced Relief of a Tissue-Specific Transcriptional Elongation
Block,” Texas Forum for Reproductive Sciences, Houston, TX (16-17 April, 2009).
139. Wilkinson M.F. “Rhox5: A New Model of Transcriptional Control,” Annual Society for
the Study of Reproduction conference, Pittsburgh, PA (18-22 July, 2009).
140. Wilkinson M.F. “Rhox Genes: Mediators of Androgen Action?,” Reseau Quebecois en
Reproduction Symposium, Montreal (18-19 November, 2009).
141. Wilkinson M.F., Huang L., Bhalla A.D., Bhardwaj A., Song H.W., Karam R. & Bruno
I.G. “A MicroRNA Upregulates Neuron-Specific Transcripts Through the NMD Pathway,”
Experimental Biology 2010, Anaheim, CA (24-28 April, 2010).
142. Wilkinson M.F. “Rhox Genes: Targets and Mediators of Androgen Action,” 16th European
Workshop on Molecular and Cellular Endocrinology of the Testis, Elba Island, Italy (8-12 May
2010).
143. Karam R., Bruno I., Huang L, Bhardwaj A. & Wilkinson M.F. “The Convergence of Two
Negative Post-Transcriptional Pathways Elicits Activation of Gene Expression,” Annual RNA
Society Meeting, Seattle, WA (22-26 June, 2010).
144. Lasalde C., Estrella L., Correa M., Wilkinson M.F. & Gonzalez C. “The Shuttling Protein Npl3
Promotes Translation Termination Accuracy in Saccharomyces cerevisiae,” Annual RNA Society
Meeting, Seattle, WA (22-26 June, 2010).
145. Lasalde C., Rivera A., Rodriguez-Cruz E., Leon A., Vega I., Wilkinson M.F. & Gonzalez C.
“Understanding the Role of Upf1 Phosphorylation in the NMD Pathway,” Annual RNA Society
Meeting, Seattle, WA (22-26 June, 2010).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
31
146. Bettegowda A & Wilkinson MF, “The Rhox3 Homeobox Gene is Required for Male Germ Cell
Progression In Vivo,” XXI North American Testis Workshop, Montreal, Canada (30 March-2
April, 2011).
147. Bettegowda A & Wilkinson MF, “The Rhox3 Homeobox Gene Paralogs are Essential for
Spermatogenesis In Vivo,” Annual Society for the Study of Reproduction (SSR) conference,
Portland, OR (18-22 July, 2011).
148. Richardson (Beildeck) & Wilkinson MF, “DNA Methylation Controls Tissue-Specific and
Developmentally Regulated Expression of Rhox Genes,” Gordon conference: Epigenetics
Mechanisms, Development and Disease, Easton, MA (7-11 August, 2012)
149. Ramaiah M & Wilkinson MF, “Rapidly Evolving MicroRNAs Retain their Targets by a CoEvolution Mechanism,” ASBMB Annual Meeting, San Diego, CA (21-25 April, 2012).
150. Shum EY & Wilkinson MF, “A MicroRNA Upregulates Neuron-Specific Transcripts Through
the NMD Pathway,” ASBMB Annual Meeting, San Diego, CA (21-25 April, 2012).
151. Huang L, Shum EY, Karam R, Ngyuen, Gecz J & Wilkinson MF, “NMD-Deficient Upf3b-null
Mice Display Behavioral and Neuropathological Defects,” ASBMB Annual Meeting, San Diego,
CA (21-25 April, 2012).
152. Lou CH, Schultheisz HL, Boscolo FS, Huang L, Laurent LC & Wilkinson MF, “The RNA Decay
Pathway, NMD, Promotes the Stem-Like Stage,” 10th Annual International Society for Stem Cell
Research (ISSCR), Yokohama, Japan (13-16 June, 2012).
153. Shum EY, Huang L & Wilkinson MF, “Physiological Role of NMD in Neuronal Development
In Vivo,” EMBO/EMBL Symposia: Complex Life of mRNA, Heidelberg, Germany (7-10
October, 2012).
154. Shao A, Shum EY, Lou C-H & Wilkinson MF, “A microRNA-NMD Regulatory Network in the
Brain,” EMBO/EMBL Symposia: Complex Life of mRNA, Heidelberg, Germany (7-10 October,
2012).
155. Song H-W & Wilkinson MF, “The Role of the Homeobox Transcription Factor, RHOX10, in
Early Development of Mouse Male Germ Cells,” CSHL Symposia: Germ Cells, Cold Spring
Harbor, NY (2-6 October, 2012)
156. Stumpo DJ, Blackshear PJ, and Wilkinson MF, "Maternal mRNA Stability during the Oocyte to
Embryo Transition,” Women's Reproductive Health Research Symposium; Philadelphia,
Pennsylvania (October 2012).
157. Shum EY, Huang L, Nguyen LS, Gecz J & Wilkinson MF, “Nonsense-Mediated Decay: An
RNA-Based Switch Controlling Development,” 34th Annual Lorne Conference, Lorne, Australia
(17-19 February, 2013)
Revised July 29, 2017
Miles Wilkinson, Ph.D.
32
158. Song HW & Wilkinson MF, “Evidence that the Homeobox Transcription Factor, RHOX10,
Promotes Spermatogonial Stem Cell Self-Renewal and Meiotic Progression,” XXII North
American Testis Workshop, San Antonio, TX (10-13 April, 2013).
159. Shum EY, Huang L & Wilkinson MF, “Role of Nonsense-Mediated Decay In Vivo,” HHMI
Janelia Conference: Sensory Signaling in Model Organisms, Ashburn, VA (21-24 April, 2013).
160. Ramaiah M, King CC & Wilkinson MF, “An X-Linked MicroRNA with the Unique Ability to
Promote Translation,” CSHL Symposia: Eukaryotic mRNA Processing, Cold Spring Harbor, NY
(20-24 August, 2013)
161. Cook-Andersen H, Howe MC, Shum E, Stumpo DJ, Blackshear PJ, and Wilkinson MF. "Posttranscriptional Regulation of Maternal mRNA during Early Embryogenesis," Women's
Reproductive Health Research Symposium; Denver, CO (October, 2013)
162. Song H-W & Wilkinson MF, “The Role of the Rhox Gene Cluster in Spermatogonial Stem
Cells,” European Testis Workshop, Elsinore, Denmark (13-17 May, 2014)
163. Shao A, Lou C-H & Wilkinson MF, “Stem Cell Self-Renewal and Differentiation is Controlled
by an Intricate RNA Decay Circuit,” 12th Annual International Society for Stem Cell Research
(ISSCR), Vancouver, BC (18-21 June, 2014).
164. Lou R & Wilkinson MF, “A NMD-microRNA Circuit that Serves as a Switch to Dictate Stem
Cell Self-Renewal and Differentiation,” FASEB Symposia: Post-Transcriptional Control of Gene
Expression: Mechanisms of mRNA Decay, Big Sky, Montana (6-11 July, 2014)
165. Song H-W, Bettegowda A, Shum EY, Richardson M, Sukhwani M, Orwig KE & Wilkinson MF,
“The Rhox Homeobox Gene Cluster Acts through Rhox10 to Promote Spermatogonial Stem Cell
Maintenance,” Society for the Study of Reproduction, Grand Rapids, Michigan (19-23 July,
2014).
Patents Pending and Granted:
UCSD Case 2012-346, entitled “Non-invasive Molecular Diagnosis of Male-Factor Infertility”
(Wilkinson laboratory), filed on June 28, 2013
Grant and Contract Support (since 1996):
NATIONAL INSTITUTES OF HEALTH, “The Role of NMD in Olfactory Neurogenesis” (R01GM111838) P.I., Wilkinson, MF, 07/01/14 – 06/30/18, $1,059,263 (total DIRECT costs).
CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE, “New Regulators of
Spermatogonial Stem Cells: RHOX Homeobox Transcription Factors,” P.I. P.I., Wilkinson, MF,
05/01/14 – 04/30/16, $400,000 (total DIRECT costs).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
33
CALIFORNIA INSTITUTE FOR REGENERATIVE MEDICINE, “Role of the NMD RNA
Decay Pathway in Maintaining the Stem-Like State,” P.I. P.I., Wilkinson, MF, 11/01/12 –
10/31/15, $1,050,000 (total DIRECT costs).
NATIONAL INSTITUTES OF HEALTH, “Regulation and Function of the Rhox5 Homeobox
Gene” (R01-HD45595) P.I., Wilkinson, MF, 07/01/09 – 06/30/15, $1,602,938 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Androgen-Dependent Rhox Homeobox Genes” (R01
HD053808) P.I., Wilkinson, MF, 05/01/07 – 04/30/13, $1,593,750 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Regulation of RNA Surveillance” (R01-GM58595) P.I.,
Wilkinson, MF, 07/01/09 – 06/30/13, $1,514,100 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Regulation of RNA Surveillance” (R01-GM58595)
P.I., Wilkinson, MF, 07/01/08 – 06/31/09, $120,000 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Conditional Knockout of WT1 in Sertoli Cells In
Vivo” (1-R01 HD042714), P.I., Wilkinson, MF, 03/01/03 – 02/28/10 (no-cost extension),
$1,698,750 (total costs).
NATIONAL INSTITUTES OF HEALTH, "Training Program in Cancer Immunobiology," (2
T32CA09598-17A1, Program Director, Ananthaswamy H., Program Coordinator, McIntyre, B.
W., Co-investigator, Wilkinson, MF, 0/31/89-2/28/10, $334,686 (total direct costs).
NATIONAL INSTITUTES OF HEALTH, "Training Program in Mammalian Reproduction,"
(5T32HD07324), P.I., Sanborn, B., Co-investigator, Wilkinson, MF, 9/30/86-4/30/07, $153,023
(annual direct costs).
NATIONAL SCIENCE FOUNDATION, “Linkage of Nonsense Condons and RNA Splicing”
(MCB-9808936), P.I., Wilkinson, MF, 10/01/98-09/09/02, $188,700 (total costs).
NATIONAL INSTITUTES OF HEALTH, "The Pem Homeobox Gene", (RO1-CA78023), P.I.,
Wilkinson, MF, 02/01/99-03/31/04; $889,365 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Nonsense Surveillance of Rearranging Gene Transcript”
(RO1-GM58595 Supplement), P.I., Wilkinson, MF, 01/01/00-12/31/02, $163,399 (total costs).
NATIONAL INSTITUTES OF HEALTH, “TCR RNA Surveillance” (5-R01 GM058595) P.I.,
Wilkinson, MF, 01/01/03 – 12/31/07, $1,328,800 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Activation of Spermatogenic Recovery after Toxic
Insult”, (RO1-ES508075), P.I., Meistrich, M.L.; Collaborator, Wilkinson, MF, 08/01/9607/31/01, $164,136 (annual direct costs).
Revised July 29, 2017
Miles Wilkinson, Ph.D.
34
HUMAN CANCER GENETICS PROGRAM, “Nonsense Surveillance”, P.I., Wilkinson, MF,
12/01/98-11/30/01, $98,104 (total costs).
UNIVERSITY CANCER FOUNDATION, “A Genetic Correction Mechanism”, P.I., Wilkinson,
MF, 11/01/98-10/31/01, $100,000 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Nonsense Surveillance of Rearranging Gene
Transcript” (RO1-GM58595), P.I., Wilkinson, MF, 12/01/98-12/31/02, $823,677 (total costs).
NATIONAL INSTITUTES OF HEALTH, “Function and Regulation of the Pem Homeobox
Gene” (9-R01 HD45595) P.I., Wilkinson, MF, 07/01/03 – 06/30/09, $1,359,000 (total costs).
NATIONAL SCIENCE FOUNDATION, “Linkage of Nonsense Codons & RNA Splicing,”
(MCB-0316793) P.I., Wilkinson, MF, 09/01/03 – 08/31/08, $640,000 (total costs).
NATIONAL INSTITUTES OF HEALTH, “The Role of Phosphorylation in the NMD RNA
Surveillance,” U54-CA96297 (partnership between M.D.A. and U. Puerto Rico), P.I., Wilkinson,
MF & Gonzalez C, 08/01/04 – 07/31/08, $133,350 (total direct costs to Wilkinson laboratory).
NATIONAL INSTITUTES OF HEALTH, “The Role of Phosphorylation in the NMD RNA
Surveillance,” U54-CA96297 (partnership between M.D.A. and U. Puerto Rico), P.I., Wilkinson,
MF & Gonzalez C, 10/01/08 – 09/31/11, $220,128 (total direct costs to Wilkinson laboratory).
NATIONAL INSTITUTES OF HEALTH, “Pem - A Novel Gene Expressed In Embryos and
Tumor Cells,” (RO1-HD27233), P.I., Wilkinson, MF, 05/01/91-06/30/97, $105,000 (annual
direct costs).
NATIONAL SCIENCE FOUNDATION, “A Stable Intron from the T cell Receptor Gene”:
Characterization and Function Role” (MCB-9307963), P.I., Wilkinson, MF, 09/01/93-12/31/96,
$65,000 (annual total costs).
NATIONAL INSTITUTES OF HEALTH, “Regulation of T cell receptor gene expression” (RO1GM39586), P.I., Wilkinson, MF, 10/01/93-08/31/99: $110,000 (annual direct costs).
Invitations for Oral Presentation at Conferences (only since 1994):
1994 “Nuclear Proof-Reading Mechanism Down-Regulates Transcripts Harboring Premature
Nonsense Codons?” INSERM Conference, mRNA Processing and Nuclear Organization,
LeBischenberg, France
1994
“A Nuclear Regulatory Mechanism is Engaged by Premature Translation Termination
(Nonsense) Codons,” Keystone Symposium (The Eukaryotic Nucleus), Tammarron,
Colorado
Revised July 29, 2017
Miles Wilkinson, Ph.D.
1995 “T-cell Receptor mRNA Regulation: a Proof-Reading Mechanism,” Texas Immunology
Conference, Galveston, TX (regional conference)
1996 “Premature Nonsense Codons Affect Nuclear Metabolism of TCR-transcripts,” Cold
Spring Harbor Meeting (Translational Control), Cold Spring Harbor, NY
1996 “Pem: An Androgen-Regulated Homeobox Gene in Sertoli Cells,” Tenth International
Congress of Endocrinology, San Francisco, CA
1996 “T-cell Receptor mRNA Regulation: A Scanning Mechanism that Detects Premature
Termination Codons,” Texas Immunology Conference, San Antonio, TX (regional
conference)
1997 “T-Cell Receptor Alternative Spliced Transcripts Regulated by Nonsense Codons,”
International RNA Society Meeting, Banff, Canada
1997 “Nonsense Surveillance in Lymphocytes,” (speaker and session chair) Texas
Immunology Conference, Galveston, TX (regional conference)
1998 “Pem: An Androgen-Dependent Homeodomain Gene,” Ernst Schering Research
Foundation Workshop, Capri, Italy
1999 “A T-Cell Receptor Surveillance Mechanism,” Texas Regional Immunology Conference,
Galveston, TX (regional conference)
1999 “Pem: An Oncofetal Gene,” Ernst Schering Research Foundation Workshop, Schloss
Elmau, Germany
2000 “A T-Cell Receptor Surveillance Mechanism,” Texas Immunology Conference, Austin, TX
(speaker and session chair).
2000 “Identification of a Cis Element Essential for Super Nonsense Codon-Mediated Decay
(NMD),” Cold Spring Harbor Translation Meeting, Cold Spring Harbor, NY
2000 “Transcriptional Regulation of the Androgen-Dependent Homeobox Gene Pem by Ets and
Sp1 Family Members in Reproductive Tissues,” Society for the Study of Reproduction
(SSR), Madison, WI
2000 “Transcriptional Regulation of the Homeobox Gene Pem by Ets and Sp-1 Family Members
in Reproductive Tissues,” 6th Annual Texas Forum on Female Reproduction. Houston, TX
(regional conference)
2000 “Nonsense Codon-Dependent Upregulation of Alternative Splice-Site Usage in TCR-Beta
Transcripts,” 5th Annual International RNA Meeting, Madison, WI
Revised July 29, 2017
35
Miles Wilkinson, Ph.D.
2001 "Developmental Regulation of the NMD RNA Surveillance Pathway in B-Cell and Plasma
Cell Lines," 20th Annual Texas Regional Immunology Conference, Galveston, TX.
2001
"An RNA Surveillance Mechanism that Detects Aberrant Transcripts," 11th International
Workshop on Beyond the Identification of Transcribed Sequences: Functional Expression
and Evolutionary Analysis, Reston, Virginia
2001 "Nonsense Codons Induce Alternatively Spliced Transcripts by a Translation-like
Mechanism," Conference on mRNA Stability and Translation, U. Washington, Seattle, WA
2001 "Identification of Pem Homeobox Gene Promoter Sequences Sufficient to Drive High
Transcription Levels in Sertoli Cells and Principal Cells of Caput Epididymis In Vivo,"
Society for the Study of Reproduction (SSR) Annual Meeting, University of Ottawa,
Canada
2001 "Ectopic Expression of a Sertoli-specific Homeobox Gene Increases DNA-Strand Breaks in
Adjacent Germ Cells," Society for the Study of Reproduction (SSR) Annual Meeting,
University of Ottawa, Canada
2001 "Transcriptional Regulation of the Pem Homeobox Gene by Ets and Sp-1 Family Members
in Ovarian Granulosa Cells," Texas Forum on Female Reproduction, Seventh Annual
Meeting, Houston, TX
2001 "Precursor RNAs Harboring Nonsense Codons Accumulate Near the Site of Transcription,"
6th Annual International RNA Meeting, Banff, Canada
2001 “NMD-Promoting Element (NPE) in a TCR Gene Permits Intron-Proximal Nonsense
Codons to Trigger NMD," 6th Annual International RNA Meeting, Banff, Canada
2001
"Nonsense Codons Induce Alternatively Spliced Transcripts by a Translation-Like
Mechanism," 6th Annual International RNA Meeting, Banff, Canada
2001 “Nonsense-Mediated Altered Splicing (NMAS): A Translation-Like RNA-Correction
Mechanism,” C.N.R.S. Conference Jacques Monod EMBO Workshop: mRNA Enigmas:
Transport, Silencing, Decay, and their Interplay with Translation, Aussois, France
2002 “A Surveillance Pathway that Detects Aberrant TCR Transcripts Generated from NonProductively Rearranged TCR Genes," Annual Meeting of the American Association of
Immunologists, New Orleans, LA.
2002 "Inactivation of the Pem Gene Causes Reduced Caudal Sperm and Subfertility," Society
for the Study of Reproduction (SSR) Annual Meeting, Baltimore, MD.
Revised July 29, 2017
36
Miles Wilkinson, Ph.D.
37
2002 "A Promoter that Directs Transcription in a Sertoli Cell-Specific, Stage-Specific, and
Androgen-Dependent Manner In Vivo," Society for the Study of Reproduction (SSR)
Annual Meeting, Baltimore, MD.
2002 "Rapid Decay and Partial Retention of Nonsense Codon-Containing Transcripts in the
Nuclear Fraction of Cells," FASEB Research Conference: Post-Transcriptional Control of
Gene Expression: Effectors of mRNA Decay, Tucson, AZ.
2002 "Regulatory Sequences that Direct Developmentallly Regulated Androgen-Dependent
Expression in Sertoli Cells and Different Subregions of the Epididymis In Vivo," 3rd
International Conference on the Epididymis, Charlottesville, Virginia.
2002 "Nonsense Codons Cause Retention of Mature T-Cell Receptor Transcripts in the Nuclear
Fraction of Cells," 7th Annual International RNA Meeting, Madison, Wisconsin.
2003 “Cancer Immunity: Challenges for the Next Decade,” 56th Annual Symposium on
Fundamental Cancer Research, M. D. Anderson Cancer Center (session chair).
2003 “Nonsense-Mediated Upregulation of Pre-mRNA,” Cold Spring Harbor Conference: Eukaryotic
mRNA Processing, Cold Spring Harbor, NY.
2003 “Regulation of Androgen Receptor Recruitment and Chromatin Conformation by Androgen,”
Society for the Study of Reproduction (SSR) Annual Meeting, Cincinnati, OH.
2004 “Alternative Promoters Insulated by Tissue-Specific DNA Methylation Boundaries,”
Chromatin Remodeling and Gene Expression in Male Germ Cells, Banbury Center, Cold
Spring Harbor, NY, 14-17 November.
2004 “Surveillance Mechanisms Discriminating Between Functional and Mutant Transcripts,”
Environmental Mutation Society Annual Meeting, Pittsburgh, PA, 2-6 October.
2004 “Discrete DNA Methylation Boundaries Between Promoters Expressed in Male and
Female Reproductive Tissues,” Lost Pines Conference / U. Texas M.D.A.C.C. Science
Park, Smithville, TX, 22-24 October (presented by my postdoctoral fellow Sreenath
Shanker).
2004 “Nonsense Mediated Decay (NMD): an RNA Surveillance Mechanism that Degrades
Aberrant mRNAs Harboring Nonsense Codons,” Lost Pines Conference / U. Texas
M.D.A.C.C. Science Park, Smithville, TX, 22-24 October (presented by my Ph.D. student
Angela Bhalla).
2004 “Rhox: A New Homeobox Gene Cluster,” Society for the Study of Reproduction (SSR)
Annual Meeting, Vancouver, B.C. (presented by my postdoctoral fellow Jim MacLean).
2004 “The Tumor Suppressor Wilms’ Tumor 1 (WT1) Gene is Essential for Spermatogenesis,”
Society for the Study of Reproduction (SSR) Annual Meeting, Vancouver, B.C.
Revised July 29, 2017
Miles Wilkinson, Ph.D.
2004 “Regulation of the Pem Homeobox Gene Distal Promoter by Ets and Sp1 Factors Depends
on Ras-Mediated DNA Methylation,” Society for the Study of Reproduction (SSR) Annual
Meeting, Vancouver, B.C.
2004 “Cell Type-Specific NMD,” FASEB Research Conference: Post-Transcriptional Control of
Gene Expression: Mechanisms of mRNA Decay, Tucson, AZ
2004 “Homeobox Genes and the Male Reproductive Tract,” Gordon Research Conference,
Reproductive Tract Biology, New London, CT.
2005 “Efficient RNA Splicing Promotes Translation and RNA Surveillance,” Cold Spring
Harbor Conference: Eukaryotic mRNA Processing. Cold Spring Harbor, NY (24-28
August), presented by my postdoctoral fellow Jayanthi Gudikote.
2005 “AR and GATA Factors Collaborate to Drive Sertoli Cell-Specific Expression of the Pem
(Rhox5) Proximal Promoter in the Testis,” Society for the Study of Reproduction, Quebec
City, Canada, 23 – 28 July.
2005 “Role of WT1 in Spermatogenesis Revealed by RNAi- and Dominant Negative-Mediated
Knockdown in Transgenic Mice,” Society for the Study of Reproduction, Quebec City,
Canada (23 – 28 July), presented by my postdoctoral fellow Manjeet Rao.
2005 “Nonsense-Mediated Decay: an RNA Surveillance Pathway,” U.P.R. & M.D.A.C.C. U54
joint conference, University of Puerto Rico (18 May).
2005 “Transcriptional Regulation of the Rhox5 Homeobox Gene by Ets and Sp1 Family
Members in Primary Granulosa Cells,” Annual Texas Forum on Female Reproduction,
Houston, TX (14 – 15 April), presented by my postdoctoral fellow James MacLean.
2006 “Rhox5 Regulates Key Regulators of Metabolism During Testis Development,” Society
for the Study of Reproduction, Omaha, Nebraska (29 July – 1 August), presented by my
postdoctoral fellow James MacLean.
2006 “Identification of a CpG-Free Methylation Boundary that Serves as an Insulator Between
Alternative, Sex-Specific Promoters,” Society for the Study of Reproduction, Omaha,
Nebraska, (29 July – 1 August), presented by my postdoctoral fellow Sreenath Shanker.
2006 “Evidence for An Alternative Branch of the NMD Pathway,” FASEB Conference on
Posttranscriptional Regulation (24 - 29 June).
2006 “The Rhox Gene Cluster,” Gordon Research Conference, Mammalian Gametogenesis &
Embryo (18-23 June).
Revised July 29, 2017
38
Miles Wilkinson, Ph.D.
2006
“Sertoli Cell-Specific Transcription Achieved by a Collaboration of Androgen Receptor
and GATA Transcription Factors,” Texas Forum for Reproductive Sciences, Houston,
TX (20-21 April), presented by my postdoctoral fellow Anjana Bhardwaj.
2006 “Homeobox Genes and Male Reproduction,” American Society of Andrology, Annual
Meeting, Chicago (8-11 April), presented by my postdoctoral fellow James MacLean.
2006 “Cell Type- and Tissue-Specific RNAi,” Fourth Annual RNAi Conference, Boston, MA
(25-26 October).
2006 “Developmental Regulation of the X-Linked Rhox Homeobox Gene Cluster,” American
Society for Biochemistry & Molecular Biology: Transcriptional Regulation by Chromatin
and RNA Polymerase II, Kiawah Island, SC (2-5 November).
2006 “Rhox Homeobox Genes and the Epididymis,” Fourth International Workshop on the
Epididymis, Chatel-Guyon, Auvergne, France (4-7 December).
2007 Benchmark Lecture: “The Rhox Homeobox Gene Cluster,” American Society of
Andrology, North American Testis Workshop, Tampa, FL (18-21 April).
2007 “Hormone- and Stress-Induced Relief of a Tissue-Specific Transcriptional Elongation
Block,” Society for the Study of Reproduction, San Antonio, TX (21-25 July), presented
by my postdoctoral fellow Manjeet Rao.
2007 “The RHOX5 Homeodomain Protein Directs Region-Specific Gene Expression in the
Epididymis,” Society for the Study of Reproduction, San Antonio, TX (21-25 July),
presented by my postdoctoral fellow James MacLean.
2007 “The Rhox Homeobox Genes and Reproduction,” International Symposium on Genetics
and Male Infertility, Florence, Italy (14-16 September).
2007 “The NMD RNA Surveillance Pathway Degrades Aberrant E-Cadherin Transcripts in
Hereditary Diffuse Gastric Cancer,” Keystone Symposia on Gastrointestinal Cancer,
Beijing, China (14-19 October), presented by my PhD student Rachid Karam.
2008 “Hormones, Homeoboxes, and Transcriptional Control,” 5th Annual Gilbert S. Greenwald
Symposium on Reproduction, Kansas City, Missouri (10-11 October).
2009 “MicroRNA-Mediated Regulation of RNA Surveillance,” 4th Annual M.D.
Anderson/Baylor College of Medicine Symposium “Development of Non-Coding RNAs
for Cancer Therapy” (22 January), presented by my postdoctoral fellow Ivone Bruno.
2009 “A Brain-Specific miRNA Regulates mRNA Surveillance Pathways,” Keystone Symposia
on “Therapeutic Modulation of RNA Using Oligonucleotides,” Lake Louise, Alberta, CA
(8-13 February), presented by my postdoctoral fellow Ivone Bruno
Revised July 29, 2017
39
Miles Wilkinson, Ph.D.
2009 “Hormone- and DNA Demethylation-Induced Relief of a Tissue-Specific Transcriptional
Elongation Block,” Texas Forum for Reproductive Sciences, Houston, TX (16-17 April),
presented by my postdoctoral fellow Anjana Bhardwaj
2009 “Short RNAs as Tools,” 9th International Congress on Andrology, Barcelona, Spain (7-10
March)
2009 “Rhox5: A New Model of Transcriptional Control,” Annual Society for the Study of
Reproduction conference, Pittsburgh, PA (18-22 July)
2009 “Rhox Gene Networks,” Mammalian Gametogenesis Gordon Conference, Waterville,
Vermont (session chair and speaker) (2-7 August)
2009
“Rhox Genes: Mediators of Androgen Action?,” Reseau Quebecois en Reproduction
Symposium, Montreal (18-19 November)
2010
“A MicroRNA Upregulates Neuron-Specific Transcripts Through the NMD Pathway,”
Experimental Biology 2010, Anaheim, CA (24-28 April).
2010 “Rhox Genes: Targets and Mediators of Androgen Action,” 16th European Workshop on
Molecular and Cellular Endocrinology of the Testis, Elba Island, Italy (session chair and
speaker) (8-12 May 2010).
2010 “The Convergence of Two Negative Post-Transcriptional Pathways Elicits Activation of
Gene Expression,” Annual RNA Society Meeting, Seattle, WA (22-26 June), presented by
my postdoctoral fellow Rachid Karam.
2011 “The Rhox3 Homeobox Gene Paralogs are Essential for Spermatogenesis In Vivo,”
Annual Society for the Study of Reproduction conference, Portland, OR (18-22 July).
2011 “Epigenetic Regulation of RHOX Genes in Mouse and Human Testes,” presented by my
post-doctoral fellow Marcy Richardson, Southern California Germ Cell Club, UCLA
Harbor campus (18 June).
2012 “Do MicroRNAs and RNA Surveillance Converge to Regulate Neural Development?”
Winter Conference on Brain Research, Snowbird, Utah (21-26 January).
2012 “NMD-Deficient Upf3b-null Mice Display Behavioral and Neuropathological Defects,”
presented by my post-doctoral fellow Lulu Huang, ASBMB Annual Meeting, San Diego,
CA (21-25 April).
2012 “The Testes as Birthplace for New Genes,” Woods Hole Summer course: “Frontiers in
Reproduction,” Woods Hole, MA (17 May)
2012 “A Mouse Model for Cognitive Dysfunction Caused by Disrupted NMD?” FASEB: PostTranscriptional Control of Gene Expression, Steamboat Springs, CO (24-29 June).
Revised July 29, 2017
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Miles Wilkinson, Ph.D.
2012 “Physiological Role of NMD in Neuronal Development In Vivo,” presented by my predoctoral fellow Eleen Shum, EMBO/EMBL Symposia: Complex Life of mRNA,
Heidelberg, Germany (7-10 October).
2013 “Nonsense-Mediated Decay: An RNA-Based Switch Controlling Development,” Lorne
Genome conference (34th), Lorne, Australia (17-19 February, 2013).
2013 “Functional Coupling of IRE1 Signaling with the NMD RNA Decay Pathway Dictates the
Threshold and Dynamics of the Unfolded Protein Response,” presented by my
postdoctoral fellow Rachid Karam, ASBMB: The Multitasking Endoplasmic Reticulum in
Health and Disease, Warrenton, VA (1-4 May, 2013).
2013 “An X-Linked MicroRNA with the Unique Ability to Promote Translation,” presented by
my postdoctoral fellow Madhuvanthi Ramaiah, CSHL Symposia: Eukaryotic mRNA
Processing, Cold Spring Harbor, NY (20-24 August).
2014 “The Role of the Rhox Gene Cluster in Spermatogonial Stem Cells,” European Testis
Workshop, Elsinore, Denmark (13-17 May).
2014 “A NMD-microRNA Circuit that Serves as a Switch to Dictate Stem Cell Self-Renewal
and Differentiation” FASEB Symposia: Post-Transcriptional Control of Gene Expression:
Mechanisms of mRNA Decay, Big Sky, Montana (6-11 July).
2014 “The Rhox Homeobox Gene Cluster Acts through Rhox10 to Promote Spermatogonial
Stem Cell Maintenance,” presented by my postdoctoral fellow Hye-Song, Society for the
Study of Reproduction, Grand Rapids, Michigan (19-23 July).
Seminar Invitations from other Institutions (only since 1994):
1994 Randall Developmental Biology Institute, London, U.K.
Loyola University, Chicago, M and I Department
St. Louis University Medical Center, Mol. M and I Department
University of Illinois, Chicago, Biochemistry Department
Penn State University College of Medicine, M and I Department
Reed College, Biology Department
1995 Baylor Clinical Immunology Grand Rounds U. Texas Medical School, Department of
Biochemistry and Molecular Biology
1996 Baylor College of Medicine, Department of Cell Biology
1997 Baylor College of Medicine, Department of Immunology
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Miles Wilkinson, Ph.D.
42
1998 “A Surveillance Pathway that Detects Mutant TCR Transcripts,” European Molecular
Biology Organization (EMBL), Heidelberg, Germany
1998 “A Surveillance Pathway that Detects Mutant TCR Transcripts,” Sir Dunn School of
Pathology, University of Oxford, Oxford, U.K.,
2000 “The Pem Homeobox Gene: Regulation in Tumors and Reproductive Tissues,” Arkansas
Cancer Center, University of Arkansas, Little Rock, Arkansas
2000 “RNA Surveillance,” Developmental Biology & Molecular Biology Dept., University of
Texas Southwestern Medical Center, Dallas, TX
2000 “Nonsense-Mediated Decay (NMD): A Surveillance Mechanism that Detects Aberrant
Transcripts,” University of Texas Medical School, Human Cancer Genetics seminar
2001 “NMD: A Surveillance Pathway that Detects and Destroys Bad mRNAs," U.T. Medical
School Biochemistry and Molecular Biology Seminar Series (8 October)
2001 “Regulation and Function of the Pem Homeobox Gene,” R & D Workshop, Baylor College of
Medicine (1 March)
2001 “An RNA Surveillance Mechanism that Detects and Corrects Bad mRNAs,” Molecular
Virology Department, Baylor College of Medicine (27 February)
2002 “RNA Surveillance and the Nucleus,” University of Texas, Austin (20 November)
2002 “RNA Surveillance, RNA Splicing, and the Nucleus” and “A Novel Downregulatory
Response to Nonsense Codons” (two talks), Department of Genetics, Case-Western
Reserve University, Cleveland, Ohio (11-12 November)
2002 “T-Cell Receptor RNA Surveillance,” Department of Immunology, University of Toronto,
Toronto, Canada (29 April)
2002
“Function and Regulation of the Pem Homeobox Gene in the Reproductive Tract,”
University of Virginia, Charlottesville, Virginia (3 April)
2003 “RNA Surveillance, the Nucleus, and Translation,” Department of Biology, University of
Indiana, Bloomington, Indiana (1 October)
2003 “RNA Surveillance and the Nuclear Translation Paradox,” Molecular & Cell Biology
Program, University of California, Berkeley, CA (1 May)
2003 “RNA Surveillance and the Nuclear Translation Paradox,” Department of Biochemistry,
Oregon Health Sciences University, Portland, OR (22 April)
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Miles Wilkinson, Ph.D.
2004 “Nonsense Codons, Splicing, and the Nucleus,” Biochemistry Department, U. Texas
Southwestern Medical Center, Dallas (18 November)
2004 “A New Homeobox Gene Complex Expressed in the Male and Female Reproductive
Tract,” School of Molecular Sciences, Washington State University, Pullman, WA (21
October)
2004 “RNA Surveillance and the Nucleus,” Department of Microbiology and Molecular
Genetics, Medical College of Wisconsin, Milwaukee, WI (13 April)
2004 “Life During and After Transcription,” Department of Molecular Biology, Cell Biology,
and Biochemistry, Brown University, Providence, RI (24 March)
2005 “Germ-Cell Development, Transcriptional Regulation, and Tissue-Specific RNAi,”
University of Toronto / Sunnybrook Institute (1 December)
2005 “Germ-Cell Survival Mediated by Nurse-Cell Transcription Factors,” Northwestern
University, Evanston campus (30 November)
2005 “Germ-Cell Survival Mediated by Nurse-Cell Transcription Factors,” Northwestern
University Medical School (5 October)
2005 “Tissue-Specific RNAi Reveals Mechanisms Required for the Survival and Maturation of
Germ Cells” and “RNA Splicing, Translation, and RNA Surveillance,” Ohio State
University (10-11 October; 2 talks)
2005 “Germ-Cell Survival Mediated by Nurse-Cell Transcription Factors,” Penn State
University (4 October)
2005 “The Role of Homeobox and Zinc-Finger Transcription Factors in Reproduction,” B105
Institute, University of Arizona (14 June)
2005 “RNA Surveillance, Translation, and the Nucleus,” Department of Biochemistry, Duke
University Medical Center (26 April)
2006 “Germ Cells, Nurse Cells, and RNAi,” Center for Research on Reproduction and Women’s
Health, University of Pennsylvania (22 February)
2006 “RNA Surveillance and RNAi,” Department of Genetics and Developmental Biology,
University of Connecticut (20 September)
2007 “The Rhox Genes: Transcriptional Control and Gametogenesis,” Department of
Biochemistry and Molecular Biology, University of Texas Medical School (10 December)
2007 “Hormones, Homeoboxes, and Transcriptional Control,” Department of Biochemistry and
Molecular Biology, Baylor College of Medicine (13 December)
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Miles Wilkinson, Ph.D.
2008 “Hormones, Homeoboxes, and Transcriptional Control,” Department of Reproductive
Medicine, University of California, San Diego, San Diego, CA (11 February)
2008 “Hormones, Homeoboxes, and Transcriptional Control,” Department of Biochemistry and
Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University (10
March)
2008 “Regulation of RNA Surveillance,” Department of Biology, University of Puerto Rico, San
Juan, Puerto Rico (6 May)
2008 “Hormones, Homeoboxes, and Transcriptional Control, Texas A&M University, College
Station, TX (14 November)
2008
“Regulation of RNA Surveillance,” Institute of Molecular Pathology and Immunology,
University of Porto, Portugal (2 December)
2010 “Regulation of RNA Surveillance,” UCLA, Harbor Campus, Los Angeles (28 September)
2011 “MicroRNAs and RNA Surveillance Converge to Regulate Neural Development,”
Department of Biology, Johns Hopkins University (3 February)
2012 “Small RNAs and RNA Decay Mechanisms Collaborate in the Brain,” UPGG Seminar
Series, Duke University (20 November)
2013 “RNA Surveillance, MicroRNAs, and the Brain,” NHLBI, NIH (26 March)
2013 “The X-Linked Rhox Homeobox Gene Cluster: Epigenetic Regulation and Roles in
Spermatogonial Stem Cells,” Program in Reproductive Sciences Seminar Series,
University of Colorado School of Medicine, Anschutz, CO (10 December)
2013 “The X-Linked Rhox Homeobox Gene Cluster: Epigenetic Regulation and Roles in
Spermatogonial Stem Cells,” University of Turku, Finland (19 Dec)
2014 “RNA Nonsense Sheds Light on Malignancy and Stress Responses,” Sanford Burnham
Research Institute Symposia, keynote speaker, La Jolla, CA (30 July)
Institutional Service Responsibilities and Other Duties:
Service or duties:
 Radiation and Safety Committee (OHSU), 1987-1994
 Promotion and Tenure Committee (OSHU), 1990
 Core Curriculum Task Force: Cellular Disease Processes I (OHSU), 1991
 Core Curriculum Task Force: Cell Structure and Function I (OHSU), 1991
 Senior Immunologist Search Committee (OHSU), 1991-1992
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Miles Wilkinson, Ph.D.
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Core Curriculum Task Force: Cellular Disease Processes II (OHSU), 1992-1993
Mid-Tenure Review: Gilbert Cote, 1995
Institutional Research Support Committee: 1997 – July 1999
Institutional Animal Care and Use Committee: 1997 – 1999
Faculty Senate: 1997 – 2000
Faculty Senate, Finance Committee: 1999 - 2000
Faculty Achievement Awards Committee: 1999
Oversight of Institutional Research Programs Committee: 1999
Mid-Tenure Review: Bing Su, Stephanie Watowich, Faith Strickland, July 1999
Mid-Tenure Review: Hector Martinez-Valdez, September 1999
Study Section Review Committee, Basic Research Projects: Sep 1999 - Aug 2000
Program in Reproductive Biology, Curriculum and Graduate Studies Committee,
member: March 1999 -2003
Program in Reproductive Biology, Admissions/Recruiting Committee, chairman: Dec
1999 - 2003
Advisory Committee, Grants and Contracts Database, member: Jan 2000 - present
M.D.A. Research Report Advisory Group: June 2000
Summer Science Educators Advisory Committee on Immunology: July 2000
Knudsen Award Committee (U. Texas Ph.D. thesis competition): July 2000
Immunology Graduate Program, Steering Committee: March 2001 – present
Program in Reproductive Biology, Training Grant Steering Committee: March 2001 –
present
Sarcoma Multidisciplinary Research Program, grant reviewer: April 2001
American Legion Auxiliary Fellowship in Cancer Research Committee: August 2001
Program in Reproductive Biology, seminar series director: August 2001 – present
Postdoctoral Fellows Programs Advisory Committee, member: August 2001 – 2004
Cell and Regulatory Biology Seminar Program, member: September 2001 – 2005
GSBS (graduate program) Curriculum Committee, member: October 2001 – Sep. 2005
Multidisciplinary Research Advisory Committee (MRAC) (MDACC grant study
section, Tobacco & Goodwin funds), member: March 2001 – June 2007
"Cancer Immunity: Challenge of the Next Decade," M.D.A. Symposium, member of
the organizing committee: August 2002 – October 2003
Faculty Achievement Awards committee; chair of basic research subcommittee: April –
May 2004
Shared Resources Core Matching Committee, MDA/U. Puerto Rico Partnership: March
2005 – present
Mid-Tenure Review: Joya Chandra, April 2005
Genes & Development Graduate Program, Membership committee: July 2005 – present
GSBS (graduate program) Membership Committee, member: September 2005 - present
Promotion and Tenure Committee, MDACC: August 2005 – August 2008
Mid-Tenure Review: F. Xiao-Feng Qin: April 2006
CAO Search Committee (M.D.A.; replacement for Margaret Kripke): July 2006 - 2007
Biochemisty/Molecular Genetics MDACC Seminar Series, co-coordinator: August
2006 – present
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Miles Wilkinson, Ph.D.
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Mid-Tenure Review: Kimberley Schluns, April 2007
Structural Biology, M.D.A. Search Committee, Dec 2007 – 2009
MDACC Endowed Positions and Awards Committee, Nov 2008 – 2009
UCSD Hopkins Building Animal Committee, member, August 2009 – 2012
BMS Admissions Committee, member, Dec 2009 – present
Reproductive Medicine Department (REI) M.D. Fellowship Admissions Committee,
2010 - present
Reproductive Medicine faculty search committee, member, Feb 2010 – 2012
Institute of Genomic Medicine symposia committee, member, March 2011 – present
La Jolla Mesa “RNA Club,” organizer, Dec 2011 – present
CIRM training grant fellowship selection committee – 2011 - present
Sanford Consortium for Regenerative Medicine (SCRM) building space committee,
chair, Dec 2012 – present
Dept. Reproductive Medicine space committee, Feb 2013 – present
NIH (NHLBI) Site Visit, mid-tenure review chair, May 2014
Reproductive Medicine faculty search committee, member, July 2014 – present
Formal Teaching:
Courses taught:
1988 – 1990
1988 – 1992
1988 – 1992
1988 – 1993
1988 – 1993
1988 – 1993
1988 – 1994
1989 – 1994
1990 – 1993
1990 – 1994
1992
1993
1993
1994 – 2008
1995 – 2003
1995
1996 – 2008
1997 – 1999
1998 – 2002
1999 – 2006
2004 – 2006
2006 – 2009
Revised July 29, 2017
CON612, Graduate Student Molecular and Cellular Biology, Lecturer,
O.H.S.U.
MB610, Medical Microbiology, Laboratory, O.H.S.U.
MB610, Medical Microbiology, Lecturer, O.H.S.U.
MB22, Nursing Student Microbiology, Laboratory, O.H.S.U.
MB511, Graduate Student Pathogenesis, Lecturer, O.H.S.U.
MB211, Nursing Student Microbiology, Lecturer, O.H.S.U.
CON610, Medical Student Immunology, Lecturer, O.H.S.U.
MB511, Graduate Student Immunology, Lecturer, O.H.S.U.
CON610, Medical Student Immunology, Course Director, O.H.S.U.
Gene Expression Journal Club, co-director, O.H.S.U.
Molecular Genetics (424/524), Lecturer, Portland State University
BMB612, Graduate Student, Advanced Topics in Molecular Biology,
Lecturer, O.H.S.U.
Cell Structure and Function, Medical Student Course, Gene Therapy and
Molecular Genetics lectures, O.H.S.U.
GSO60014, Immunology I, Lecturer
GSO60014, Immunology I, Course Director
GSO40751, Seminars in Regulatory Biology, Lecturer
GSO30102, Immunology II, Lecturer
GSO40063, Cancer Biology, Lecturer
Core Curriculum, Immunology, Lecturer
GS120123 Advanced Reproductive Biology, Lecturer
GS12 0083 Reproductive Biology, Lecturer
GS04 0123 Eukaryotic Gene Expression, Lecturer
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Miles Wilkinson, Ph.D.
2006 – 2008
2008
2009
2010 - 2012
2011 - present
2014
GS040073 Developmental Biology, Lecturer
Baylor DB program, Evolutionary Conservation of Developmental
Mechanisms course, Lecturer
GS040123 Eukaryotic Gene Expression, Course Director
BIOM-201 (Seminars in Biomedical Research), BMS-UCSD, Discussion
Leader
BIOM-226 (Hormone Action), BMS-UCSD, Lecturer
Lecture for the Inter-institutional Core Course in Stem Cell Biology,
Medicine and Ethics
Training programs:
1993 – 1995
Training Program in Ophthalmology, O.H.S.U.
1993 – 1995
Training Program in Molecular Hematology, O.H.S.U.
1994 – 2005
Program in Cancer Immunology
1998 – 2006
Program in Reproductive Biology
Other educational programs:
2001
Cross-departmental M.D.A. seminar for Department of Molecular Genetics:
“NMD: An RNA Surveillance Pathway”
2002
Cross-departmental M.D.A. seminar for the GU Seminar Series: "Function and
Regulation of the Pem Homeobox Gene in Reproductive Tissues"
2004
Cross-departmental M.D.A. seminar for the Bioimmunotherapy Lecture Series:
“RNA Surveillance, Translation, and the Nucleus”
2004
M.D.A. Information exchange seminar for the Department of Molecular Genetics:
“RNA Surveillance, Translation, and the Nucleus”
2006
M.D.A. Information exchange seminar for the Department of Cancer Biology:
“Tissue-Specific RNAi and Germ-Cell Development”
2007
M.D.A. Institutional Grand Rounds: “RNA Surveillance”
2008
Monthly Faculty Seminar Series at M.D.A.: “Hormones, Homeoboxes, and
Transcriptional Control”
2009
Cross-departmental U.C.S.D. seminar for the Genetics and Genomics Seminar
Series: “Regulation of RNA Surveillance”
2010
Cross-departmental seminar for the UCSD Genetics Training Program, 3rd Annual
Retreat: “The Rhox Homeobox Gene Cluster”
Revised July 29, 2017
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Miles Wilkinson, Ph.D.
2010
Departmental seminar for the UCSD Reproductive Medicine Research Retreat:
“The Rhox Homeobox Genes”
2010
Cross-departmental seminar for the UCSD Moores Cancer Center: “NMD: A
Developmental and Tumor RNA Surveillance Regulator”
2011
Cross-departmental seminar for the Ludwig Institute/UCSD Cancer Research
Seminar Series: “RNA Surveillance, MicroRNAs, and the Brain”
2013
Urology Workshop for German-U.S. Male Fertility Consortium held at UCSD: “An
X-Linked Gene Cluster in Search of a Purpose”
2013
Cross-departmental seminar for the UCSD Pathology Department: “An X-Linked
Gene Cluster in Search of a Purpose”
Student/Postdoctoral Training/Committees:
Pre-Doctoral Students directly supervised*
1988 – 1993
Lian Qian (Ph.D. 1993)
1990 – 1996
Mark Carter (Ph.D. 1996)
1991 – 1996
Suzanne Lindsey (Ph.D. 1996)
1992 – 1993
Amir Ganji
1992 – 1998
Jade Clement (Ph.D. 1998)
1994
Dawn Hancock
1996 – 2002
Chad Wayne (Ph.D. 2002)
1995
Deana Leonard
1997 – 1998
Thomas Perrin
1998
Roberto Rangel
1999
Meena Tanwar
1999
Chi-Hui Tang
2000
Qing (Vicky) Xia
2000 – 2007
Yao-Fu (Joseph) Chang (Ph.D. 2007)
2000 – 2007
Jaafer Saadi Imam (Ph.D. 2007)
2000
Shankavaram Deepti Srinivas
2000
Ke Zhang
2001
Jubilee Stewart
2002 – 2005
Wai Kin Chan (Ph.D. 2005)
2003
Ran Xie
2003 – 2009
Angela Bhalla (Ph.D. 2009)
2003 – 2007
Zhiying Hu (Ph.D. 2007)
2003
Georgialina Rodriguez
2004 – 2009
Lulu Huang (Ph.D. 2009)
2004
Roxanna Irani (MD/PhD)
2004 – 2005
Hatice Duzkale
2005
Thang Van Nguy
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Miles Wilkinson, Ph.D.
2006
2006 – 2009
2006 – 2008
2007
2007
2007
2007
2007
2008
2009
2010 – present
2010
2010 – present
2010
2010
2012
2013
2013
2013 – 2014
2014 – present
2014
Corinne Bell
Hye-Won Song (Ph.D. 2009)
Rachid Karam (Ph.D. 2008)
William Munoz
Eun-Ah Kim
Fanmao Zhang
Ayako Ohno (Baylor College of Medicine)
Qin Li
Kae-Jiun Chang (Baylor College of Medicine)
Ian Huggins (BMS-UCSD)
Eleen Shum (BMS-UCSD)
Stephanie Dusaban (BMS-UCSD)
Ada Shao (BMS-UCSD)
Jacuqeline Ward (BMS-UCSD)
Matthew Poling (BMS-UCSD)
Andres Betancourt-Torres (BMS-UCSD)
Kendall Satterfield (BMS-UCSD)
Patrick Menzies (BMS-UCSD)
Matthew Krause (MS 2014)
Samantha Jones (BMS-UCSD)
Jennifer Dumdie (MD-PhD student, UCSD)
*Note: List does not include graduate students who rotated through my lab at O.H.S.U. (19871994)
Post-Doctoral Fellows/Research Associates supervised:
1994 – 1996
Phillip Morris, PhD
1994 – 1998
Sourindra Maiti, PhD
1994 – 1998
Shulin Li, PhD
1995 – 1997
Keith Sutton, PhD
1998 – 2000
John Hamilton, PhD
1998 – 2000
Gladis Shuttleworth, PhD (part time)
1999 – 2009
Jayanthi Gudikote, PhD (rose to the level of NT Assistant Professor)
1999 – 2002
Jun Wang, PhD
1999 – 2002
Mingang Chen, PhD
1999 – 2007
Manjeet Rao, PhD (rose to level of NT Assistant Professor)
2000 – 2004
Shirley Bruce
2001 – 2007
James MacLean, PhD (rose to the level of Instructor)
2003 – 2009
Anjana Bhardwaj, PhD
2003 – 2007
Sreenath Shanker, PhD
2004 – 2005
Diego Lorenzetti, PhD
2004 – 2009
Ivone Bruno, PhD
2006 – 2009
Wai Kin Chan, PhD
2006 – 2008
Dinesh Dandekar, PhD
2007 – 2012
Anilkumar Bettegowda, DVM/PhD
Revised July 29, 2017
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Miles Wilkinson, Ph.D.
2008 – 2009
2008 – 2014
2009 – present
2009 – present
2010 – 2014
2010 – 2012
2010 – present
2010 – 2012
2012 – present
2012
2014 – present
Zhiying Hu, PhD
Rachid Karam, MD/PhD
Chih-Hong (Robert) Lou, PhD
Madhuvanthi Ramaiah, PhD
Marcy Beildeck, PhD
Lulu Huang, PhD
Hye-Won Song, PhD
Karel De Gendt, PhD
Heidi Cook-Andersen, MD/PhD (WRHR Scholar/Assistant Professor)
Margaret Howe, MD (resident)
Terra-Dawn Plank, PhD
Visiting professors:
2010
2010
Dr. Joerg Gromoll (from University of Munster, Germany)
Dr. Sib Sanker Roy (from the Indian Institute of Chemical Biology, India)
Undergraduate Students:
1989 – 1990
Jessica Doskow, Reed College, senior thesis
1990 – 1991
David Zeoli, Reed College, senior thesis
1990 – 1991
Suzanne Lindsey, Pacific University, senior thesis
1991 – 1992
John Knight, Reed College, senior thesis
2009
Julia Peng (UCSD)
2012 – 2013
Adrienne Zhao (UCSD)
2012
Grace Gu (UCSD)
2012 – 2014
Josh Espinoza (SDSU-CIRM internship program)
2012 – 2014
Matt Krause (UCSD)
2013 – 2014
Eric Babajanian (UCSD)
2013 – present
Liang Tea (UCSD)
2014 – present
Kevin Dao (USCD)
2014 – present
Kevin Nguyen (UCSD)
Student (PhD/MS) Advisory committees (does not include my own students):
1988 – 1989
Greg Dietz, Microbiology, O.H.S.U.
1988 – 1989
Cole Nelson, Microbiology, O.H.S.U.
1989 – 1990
Qing Chen, Microbiology, O.H.S.U.
1990 – 1991
Larry Sherman, Cell Biology, O.H.S.U.
1990 – 1991
Yun-Cai Cai, Microbiology, O.H.S.U.
1990 – 1991
Greg Henkel, Microbiology, O.H.S.U.
1992 – 1993
Scott Schuetze, Biochemistry, O.H.S.U.
1993 – 1994
Tom Finn, Cell Biology, O.H.S.U.
1994 – 1995
Angela Downs, Immunology, M.D.A.
1994 – 1995
Darren Woodside, Immunology, M.D.A.
1995 – 1996
David Cooper, Immunology, M.D.A.
1995 – 1996
Dawn Chander, Molecular Genetics, M.D.
1995 – 1996
Leslie Elrich, Biochemistry, Baylor College of Medicine
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Miles Wilkinson, Ph.D.
1995 – 1996
1995 – 1996
1996 – 1997
1997 – 1999
1997 – 2002
1998
1998 – 2000
1999
1999 – 2000
1999 – 2000
1999 – 2000
1999
2000 – 2001
2001 – 2002
2001 – 2002
2001 – 2002
2001
2002 – 2004
2003 – 2004
2003 – 2004
2003 – 2004
2003 – 2004
2003 – 2004
2003
2003 – 2004
2003 – 2005
2003 – 2004
2004 – 2005
2004 – 2005
2004 – 2005
2004 – 2005
2005 – 2006
2005 – 2006
2005 – 2006
2005 – 2008
2006 – 2007
2006 – 2007
2006 – 2008
2007 – 2008
2007 – 2009
2007 – 2009
2007 – 2009
2007 – 2009
2007 – 2009
2007 – 2009
2008 – 2009
Revised July 29, 2017
Nianhua Xu, Biochemistry, U. T. Medical School
Henry Chan , Immunology, M.D.A.
David Schmitt, Immunology, M.D.A.
John Perez, GSBS
Jeff Walterscheid, Immunology, M.D.A.
Huanmei Wu, Biochemistry, U.T. Medical School
Cynthia Christian, Experimental Radiotherapy, M.D.A.
Hu-Hui Lee, Molecular Genetics, M.D.A.
Tsung-Cheng Chang, Biochemistry, U.T. Medical School
Eric Duffield, Immunology Dept., M.D.A.
Melissa Drysdale, U.T. Medical School
Asad Mian, Baylor College of Medicine
Melissa Aldrich, U. T. Medical School
Joanna Johnson (Koch), Molecular Genetics Dept., M.D.A.
Matthew Billard, Immunology Dept., M.D.A.
Ke Zhang, Biochemistry Dept., M.D.A.
Amanda Martinelli, Immunology Program affiliate, M.D.A
Menil Sinha, Immunology Program, M.D.A.
Jack Bevers III, Immunology Dept., M.D.A.
Ye Tao, Biochemistry & Molecular Biology, M.D.A.
Valerie Stone, Surgical Oncology Dept., M.D.A.
Ching-Ping Day, Molecular & Cellular Oncology, M.D.A.
Jianping Chen, Molecular Genetics Dept., M.D.A.
Angelica Gutierrez, Bioimmunotherapy Dept., M.D.A.
Marenda Wilson, Microbiology Dept., U. Texas Medical School
Morgan McKeller, Immunology Dept., M.D.A.
Steven Lopez, Immunology Dept., M.D.A.
Hye-Won Song, Molecular Genetics Dept., M.D.A.
Jason Jones, Immunology Dept., M.D.A.
Jun Yang, Surgical Oncology, M.D.A.
Julie Robertson, Diagnostic Science, Dental Branch, U. Texas Med School
Yongxing Wang, Molecular Genetics, M.D.A.
Dinghai Zheng, Biochemistry Dept., U. Texas Medical School
Shanzhi Wang, Molecular Genetics Dept., M.D.A.
Daneen Grossman, Microbiology Dept., U. Texas Medical School
Jesse Flynn, Biochemistry Dept., M.D.A.
Ryan Sowell, Immunology Dept., M.D.A.
Yufeng Li, Melanoma Dept., M.D.A.
Song Yi Ko, Department of Systems Biology, M.D.A.
Nam Tonthat, Department of Biochemistry & Mol. Biol., M.D.A.
Brian Pickering, Dept. of Molecular and Cellular Oncology, M.D.A.
Jason Ford, Dept. of Molecular Genetics, M.D.A.
Borislava Tsanova, Microbiology Dept., U. Texas Medical School
Yun Seong Jeong, Molecular Genetics Dept., M.D.A.
Tonthat Nam, Department of Biochemistry and Molecular Biol., M.D.A.
Sumaiyah Rehman, Dept. Molecular & Cellular Oncology, M.D.A.
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Student (PhD/MS) Examining committees:
1989
Greg Dietz, Microbiology, O.H.S.U.
1992
Chris Bond, Cell Biology, O.H.S.U.
1995
Shiela Peng, Biochemistry, U.T. Medical School
1996
Dawn Chander, Molecular Genetics, M.D.A.
1996
David Schmitt, Immunology, M.D.A.
1996
Leslie Elrich, Biochemistry, Baylor College of Medicine
1998
Nianhua Xu, Biochemistry, U.T. Medical School
1998
John Perez, GSBS
1999
Hu-Hui Lee, Molecular Genetics, M.D.A.
2000
Tsuing-Cheng Chang, U. T. Medical School
2000
Maribelis Ruiz, Cancer Biology, M.D.A.
2000
Cynthia R. Shirley, M.D.A.
2002
Joshua Vincentz, Biochemistry & Mol. Biol. Dept., M.D.A.
2002
Ke Zhang, Biochemistry Dept., M.D.A.
2002
Jennifer Sims, Immunology Dept., M.D.A.
2003
Matthew Billard, Immunology Dept., M.D.A.
2003
Joanna Koch, Molecular Genetics Dept., M.D.A.
2003
Jason Grier, Biochemistry & Mol. Biol. Dept., M.D.A.
2004
Valerie Stone, Surgical Oncology Dept., M.D.A.
2004
Marenda Wilson, Microbiology Dept., U. Texas Medical School
2004
Zhiying Hu, Immunology Dept., M.D.A.
2004
Ye Tao, Biochemistry & Molecular Biology, M.D.A.
2004
Athanasia Panopoulos, Immunology Dept., M.D.A.
2004
Weiyi Peng, Immunology Dept., Baylor College of Medicine
2004
Jack Bevers III, Immunology Dept., M.D.A.
2005
Morgan McKeller, Immunology Dept., M.D.A.
2005
Tom Lee, Biochemistry & Molecular Genetics Dept., M.D.A.
2005
Xueyao Fu, Biochemistry & Molecular Biology, M.D.A.
2005
Jun Yang, Surgical Oncology, M.D.A.
2005
Kyucheol Cho, Biochemistry & Molecular Biology, M.D.A.
2005
Hye-Won Song, Molecular Genetics Dept., M.D.A.
2005
Xueyao Fu, Biochemistry & Molecular Biology, M.D.A.
2006
Kendra Carmon, U. Texas Medical School
2006
Dustin Baldridge, Baylor College of Medicine
2006
Ivan Cajigas, University of Puerto Rico
2006
Daneen Grossman, Microbiology Dept., U. Texas Medical School
2007
Julie Robertson, Diagnostic Science, Dental Branch, U. Texas Med School
2007
Dinghai Zheng, Biochemistry Dept., U. Texas Medical School
2007
Shanzhi Wang, Biochemistry Dept., M.D.A.
2008
Yufeng Li, Immunology Dept., M.D.A.
2008
Margaret Wat, Molecular and Human Genetics Program, Baylor
2008
Mark Nolte, Genetics Dept., M.D.A.
2008
Yun Seong Jeong, Genetics Dept., M.D.A.
2008
Nam Tonthat, Biochemistry & Molecular Biology, M.D.A.
Revised July 29, 2017
52
Miles Wilkinson, Ph.D.
2010
2011
2012
2012, 2013
2013
2013
2013
thesis defense)
Brandon Taylor, BMS-UCSD
Chris Wall, BMS-UCSD
Julia Nussbacher, BMS-UCSD
Kanaga Rajan (minor and major props), BMS-UCSD
Alan Acab, BMS-UCSD
Jenna Richter, BMS-UCSD
Oliver Meikar, University of Turku, Finland (the sole “opponent” for his
Student (PhD) Supervisory committees (does not include my own students):
1990 – 1991
Greg Dietz, Microbiology, O.H.S.U.
1990 – 1992
Cole Nelson, Microbiology, O.H.S.U.
1991 – 1992
Chris Bond, Cell Biology, O.H.S.U.
1991 – 1992
Qing Chen, Microbiology, O.H.S.U.
1991 – 1993
John Shaskus, Biochemistry, O.H.S.U.
1992 – 1994
Greg Henkel, Microbiology, O.H.S.U.
1992 – 1993
Yun-Cai Cai, Microbiology, O.H.S.U.
1992 – 1993
Larry Sherman, Cell Biology, O.H.S.U.
1994 – 1996
Arun Nataraj, Immunology, M.D.A.
1995 – 1997
Shiela Peng, Biochemistry, U.T. Medical School
1996 – 2000
Leslie Elrich, Biochemistry, Baylor College of Medicine
1996 – 1999
Henry Chan , Immunology, M.D.A.
1996 – 1999
Nianhua Xu, Biochemistry, U.T. Medical School
1996 – 1998
Dawn Chander, Molecular Genetics, M.D.A.
1999 – 2000
Eric Duffield, Immunology Dept., M.D.A.
1998 – 2000
David Schmitt, Immunology, M.D.A.
2000 – 2003
Maribelis Ruiz, Cancer Biology, M.D.A.
2000 – 2003
Cynthia R. Shirley, M.D.A.
2000 – 2002
Marya McCarty, Cancer Biology Dept., M.D.A.
2001 – 2002
Laura Nelson, Cancer Biology, M.D.A.
2001 – 2004
Tsuing-Cheng Chang, U.T. Medical School
2002 – 2005
Ke Zhang, Biochemistry & Mol. Bio. Dept. M.D.A.
2002 – 2003
Zhenming Xu, Dept. Mol. & Cell. Oncology, M.D.A.
2002 – 2003
Amanda Martinelli, Immunology Program affiliate, M.D.A
2003 – 2005
Dat Nghiem, Immunology Dept., M.D.A.
2003 – 2006
Joanna Koch, Molecular Genetics Dept., M.D.A.
2003 – 2006
Jason Mitchell, Immunology Dept., M.D.A.
2003 – 2005
Chunlei Wu, Biostatistics Dept., M.D.A.
2003 – 2004
Karen Lafollette, Biochemistry & Mol. Bio. Dept., M.D.A.
2004 – 2007
Helen Huang, U.T. Medical School
2004 – 2005
Jason Grier, Biochemistry & Mol. Biol. Dept., M.D.A.
2005 – 2007
Marenda Wilson, Microbiology Dept., U. Texas Medical School
2005 – 2008
Hannah Cheung, Endocrine & Neoplasia Dept., M.D.A.
2005 – 2006
Valerie Stone, Surgical Oncology Dept., M.D.A.
2005 – 2007
Ye Tao, Biochemistry & Molecular Biology, M.D.A.
2005 – 2006
Chi-Ping Day, Mol. & Cellular Oncology Dept., M.D.A.
Revised July 29, 2017
53
Miles Wilkinson, Ph.D.
2005 – 2008
2005 – 2008
2006 – 2009
2006 – 2008
2006 – 2009
2007 – 2009
2007 – 2009
2007 – 2009
2008 – 2009
2008 – 2009
2008 – 2009
2008 – 2009
2010 – 2011
2010 – 2012
2010 – 2012
2010 – 2012
2010 – 2013
2012 – present
2012 – present
2012 – present
2013 – present
2013 – present
2013 – present
2013 – present
2013 – present
2013 – present
2013 – present
2014 – present
2014 – present
2014 – present
Revised July 29, 2017
Tom Lee, Biochemistry & Molecular Genetics Dept., M.D.A.
Morgan McKeller, Immunology Dept., M.D.A.
Rui Zhu, Biochemistry Dept., M.D.A.
Kendra Carmon, U. Texas Medical School
Amy Shore, Baylor College of Medicine
Christopher Bland, Pathology Dept., Baylor
Daneen Grossman, Microbiology Dept., U. Texas Medical School
Stephanie Greene, Baylor College of Medicine
Leon Lim, Baylor College of Medicine
Johanna Lee, Baylor College of Medicine
Bryce Vincent, Cancer Biology Dept., M.D.A.
Bon Quy Trinh, Department of Systems Biology, M.D.A.
Benjamin F. O’Conner, Division of Biology, UCSD
Stacy Erickson, Division of Biology, UCSD
Boris Reznik, Division of Biology, UCSD
Gloria Kuo, BMS, UCSD
Brandon Taylor, BMS, UCSD
Rui Fu, Division of Biology, UCSD
Polly Huang, BMS, UCSD
Kanaga Rajan, BMS-UCSD
Alan Acab, BMS-UCSD
Jacqueline Benthuysen, BMS-UCSD
Vanessa Mondol, Division of Biology, UCSD
Marco Arribas-Layton, Division of Biology, UCSD
Jacqueline Ward, BMS-UCSD
Claire Koechlein, BMS-UCSD
Julia Nussbacher, BMS-UCSD
Kelly Feldman, Division of Biology, UCSD (Masters student)
Kalodiah Toma, Division of Biology, UCSD (Masters student)
Jenna Richter, BMS-UCSD
54