ENDOCRINOLOGY EXPECTED VA LUES AND S. I . UNIT CONVERSION TAB L ES TABLE OF CON TE NTS Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 – 3 Expected Values. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 – 73 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74-77 S.I. Unit Conversion Table. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78-89 (E) = Esoterix Test Number (L) = LabCorp Test Number Esoterix is a wholly owned subsidiary of LabCorp where its Endocrine Sciences laboratory operates as a Center of Excellence for specialized endocrinology. Endocrine Sciences' testing can be accessed directly from Esoterix or through LabCorp and any of its regional facilities. 1 E X P E C T E D VA LU E S I N T R O D U CT I O N I N T RODUCT I ON It is essential that a clinical laboratory establish reference ranges appropriate for its own methods. The practice of using normal values obtained from the literature, or from other laboratories may often be misleading. Confusion over test results often occurs because significant variations exist in individual patient values and normal ranges reported by different clinical laboratories.This variability is likely the result of dissimilar standard preparations, assay reagents, sample purification procedures or other methodological factors. As a specialized laboratory, Endocrine Sciences has long recognized the need for comprehensive normal values for hormone tests. In response to this need, we have maintained an active program to determine hormone levels in healthy individuals at all ages and over a broad range of physiologic conditions.The value of this information is readily apparent to physicians who because of the nature of endocrine disease, tend to rely heavily on laboratory results for diagnosis. Diagnostic problems in pediatric endocrinology are further complicated by dramatic changes in hormone levels which occur during the neonatal and prepubertal periods, at adrenarche, and during pubertal development. Comprehensive normal values are indispensable to the assessment of hormonal dysfunction in children. Since its founding in 1972, we have maintained a continuous program to obtain normal ranges in children. 2 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Through collaborative studies conducted with pediatricians, hospitals and university research centers, we have obtained comprehensive pediatric normals for the majority of our tests. The information we have accumulated over the past several years is summarized in this section to facilitate the interpretation of endocrine test results on pediatric patients.We would like to express our gratitude to the many clinicians and researchers who have participated in our program by generously contributing their time and patient samples. The difficult nature of certain studies has made it impossible to collect all of the data through our own program, necessitating that we obtain some values from research publications. This was done only after extensive review and careful examination to insure that methods demonstrated adequate specificity and that values were comparable to those determined at Endocrine Sciences. In the future, it will be necessary to collect data in a few areas where we were previously unsuccessful. Also, as new tests become available, we will need to establish normal values for them as well.We cordially invite interested physicians to join us in this continuing project. (E) Esoterix Test Number (L) LabCorp Test Number 3 E X P E C T E D VA LU E S E N DO C RI NO LO G Y A ci d L a b i l e S u b u n i t ( A LS ) 5 0 00 1 2 (E ) BLOOD ASSAYS 5 00 1 20 (L ) R a n g e ( m g /L ) I N FA N TS 0 – 2 Months: 3 – 6 Months: 7 – 12 Months: 0.2 – 5.1 0.7 – 5.6 0.7 – 7.9 P R E P U B E RTA L 1 – 2 Years: 3 – 4 Years: 5 – 7 Years: 8 – 10 Years: 0.9 – 9.3 1.9 – 10 2.3 – 11 4.2 – 13 P U B E RTA L 11 – 13 Years: 14 – 18 Years: 5.6 – 16 5.6 – 16 A D U LT S 19 – 25 Years: 26 – 35 Years: 36 – 45 Years: 46 – 55 Years: 56 – 65 Years: 7.0 – 16 7.0 – 16 7.0 – 16 7.0 – 16 7.0 – 16 4 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Al d o ste ron e BLOOD ASSAYS 5 00 0 14 (E) 5 00 4 67 (L ) SUPINE ( n g/ d L ) UP RI GH T ( n g/ d L ) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 5 – 635 19 – 141 not applicable not applicable FU LL-T ERM I NFA N TS 3 Days: 7 Days: 1 – 11 Months: 7 – 184 5 – 175 5 – 90 not applicable not applicable not applicable C HILD RE N 12 – 23 Months: 24 Months – 9 Years: 10 – 14 Years: 7 – 54 3 – 35 2 – 22 not applicable 5 – 80 4 – 48 3 – 16 7 – 30 Ad Lib Sodium Intake A D ULT S Values are based on early morning samples from subjects on ad lib sodium intake. Diurnal variations and values in pediatric patients on different sodium diets are currently unavailable. (E) Esoterix Test Number (L) LabCorp Test Number 5 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Ad renocor ticot ropic Ho rmone (ACTH) 5 0 00 1 1 (E ) BLOOD ASSAYS 50 0 47 1 ( L ) C HI LDRE N: ACTH levels in infants after one day, prepubertal and pubertal children are not significantly different from adults. A D U LT S R A NG E 6 – 48 pg/mL 6 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S A l d o s t e r o n e, U r i n e ( I n c l u d e s C r e a t i n i n e ) 5 00 0 18 (E) 50 0 76 0 ( L ) R A NG E (u g / 2 4 h our s ) Ad Lib Sodium Intake N EW B O R N 1 – 3 Days: URINE ASSAYS 0.5 – 5 R A NG E ( u g /g c re a t i n i n e ) 20 – 140 P R E P U B E RTAL C HIL DREN 4 – 10 Years: 1–8 4 – 22 Normal Sodium Intake A D ULT S 1.5 – 20 3 – 19 Aldosterone excretion rates in infants and children on high and low sodium intake are not available. Aldosterone excretion rates in newborns correlate highly with potassium: sodium ratios but not with sodium intake. (E) Esoterix Test Number (L) LabCorp Test Number 7 E X P E C T E D VA LU E S E N DO C RI NO LO G Y A lpha Su bu nit URINE ASSAYS 5 0 00 1 6 (E ) 1 4 02 6 9 (L ) R A NG E ( ng / m L) A D U LT Males: < 50 Years >/= 50 Years 0.05 – 0.53 0.09 – 0.76 Females: Premenopausal Postmenopausal 0.04 – 0.38 0.09 – 1.23 A n d ro s t a n e d i o l G l u c u r o n i d e 5 0 00 2 6 (E ) BLOOD ASSAYS 5 0 08 8 1 (L ) R A NG E ( ng / d L ) P R E P U B E RTA L C HILDRE N 0-10 Years: < 5 – 42 A D U LT S Males: Females*: 190 – 900 35 – 200 *Occasionally, normal females with no evidence of hirsutism may have levels well above the normal range. 8 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S A n d r o s te n e d i o n e BLOOD ASSAYS 5 0 00 3 0 (E ) 5 0 01 5 2 (L ) R A NG E ( ng / d L ) R E MAT UR E IN FA NTS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 92 – 892 80 – 446 FU LL–TE RM I NFA N TS 1 – 7 Days: 20 – 290 Levels decrease rapidly to a range of 18 – 80 ng/dL after one week. 1 – 11 Months: 6 – 68 Androstenedione gradually decreases during the first six months to prepubertal levels. P R E P U B E RTA L C HILDRE N 1 – 10 Years: 8 – 50 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) TANNER STAGE FEMALE AGE (years) RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 8 – 50 31 – 65 50 – 100 48 – 140 65 – 210 24 45 67 82 105 1 2 3 4 5 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 8 – 50 42 – 100 80 – 190 77 – 225 80 – 240 24 65 123 131 160 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 A D U LT S 18 – 40 Years: Postmenopausal: (E) Esoterix Test Number R A NG E ( ng / d L ) MALE 75 – 205 (L) LabCorp Test Number R A NG E ( ng / d L ) FEMALE (entire cycle) 60 – 245 30 – 120 9 E X P E C T E D VA LU E S E N DO C RI NO LO G Y A n t i d i u r e t ic H o r m o n e ( A D H ) * RUO * 5 0 00 3 5 (E ) BLOOD ASSAYS 5 0 08 4 6 (L ) R A N G E ( p g /m L ) A D U LT S 0.7 – 3.8 With normal serum osmolality 10 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S A n t i - M u l l e r i an Ho r m o ne ( A M H ) , S e r u m * RU O * 5 00 0 43 (E) BLOOD ASSAYS 5 00 1 83 (L ) R A NG E ( ng / m L) MA LE S 0 – 13 Days 14 Days -11 Months 12 Months – 6 Years 7 – 8 Years Adult 15.5 – 48.7 39.1 – 91.1 48.0 – 83.2 33.8 – 60.2 3.0 – 5.4 F EM A LE S 0 – 8 Years Adult 0.0 – 7.1 0.0 – 6.9 B o n e S p e c i f i c A l k a l i n e P h o s p h a t a s e, S e r u m 5 00 0 74 (E) BLOOD ASSAYS 5 0 06 0 2 (L ) R A NG E A D ULT S 20 – 79 Years: (E) Esoterix Test Number < 2 – 24 u/L (L) LabCorp Test Number 11 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Ca l c i t o n i n BLOOD ASSAYS 5 0 00 4 7 (E ) 50 0 63 6 ( L ) R A N G E ( p g / mL ) MALES 0 – 150y < 8.4 F EMAL ES 0 – 150y < 5.0 Catecholamines, Fr ac tionated, P las m a BLOOD ASSAYS 5 0 00 5 2 (E ) 5 0 08 8 3 (L ) N OR E P IN E P HR IN E R A N G E ( p g / mL ) E PI N E PHR I NE R A N G E ( p g / mL ) N EW B O R N 1 – 7 Days: 200 – 420 20 – 130 C H IL DR EN 1 – 16 Years: Basal: 150 – 400 20 – 115 A D U LT S 20 – 55 Years: Basal: Standing: 125 – 310 167 – 515 20 – 97 20 – 109 Values were obtained from samples collected under optimal, basal conditions whenever possible. Catecholamine levels are elevated by many variables, including the stress of venipuncture and by numerous pharmacological agents. 12 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Catecholamines, Fr ac tion ated, Ur ine URINE ASSAYS 5 00 0 62 (E) 50 0 52 0 ( L ) R A N GE ( u g/ 2 4 h o u r s ) R A N GE ( ug / g c r e a t i n i n e ) I NFA N TS < 1 Year: Not Determined 37 – 195 C HILD RE N 1 – 10 Years: Not Determined 24 – 140 O L DE R CHI L D R E N AND ADU LT S 16 – 125 12 – 110 I NFA N TS < 1 Year: Not Determined 2 – 180 C HILD RE N 1 – 10 Years: Not Determined 20 – 149 O L DE R CHI L D R E N AND ADU LT S 3 – 38 9 – 25 N OR EP I N EP HRI N E E P I N EP HRI N E Pediatric values were determined on both random and 8 hour urine collections. (E) Esoterix Test Number (L) LabCorp Test Number 13 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Catecholamines, Tot al, Ur ine (Includes Cr e atinine) 5 0 00 6 0 (E ) 5 0 04 7 3 (L ) R AN G E (u g / 2 4 h our s ) R A NG E ( u g /g c re a t i n i n e ) I N FA N TS < 1 Year: Not Determined 34 – 286 C H IL DR EN 1 – 10 Years: Not Determined 16 – 255 O L D E R C HI L DR E N AND AD ULT S 30 – 118 22 – 115 14 URINE ASSAYS Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Co r ticoste roid Binding Globulin (CBG) 5 00 0 76 (E) BLOOD ASSAYS 5 00 1 30 (L ) R A N G E (m g / d L) N EW B O R N 0 – 3 Weeks: 1.6 – 2.5 I NFA N TS 4 Weeks – 11 Months: 2.2 – 8.3 F EM A LE S 12 Months – 8 Years 4.3 – 10 MA LE S 12 Months – 9 Years 4.3 – 10 O L DE R CHI L D R E N AND ADU LT S 2.3 – 3.9 E S T R O GE N T H E R A P Y AN D P R EG NA NCY > 6.0 (E) Esoterix Test Number (L) LabCorp Test Number 15 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Co r ticos te rone BLOOD ASSAYS 5 0 00 8 4 (E ) 5 0 01 35 (L ) R A N GE ( n g/ d L ) R A N GE ( n g/ d L ) P R E M ATU RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 235 – 1108 150 – 1700 N EW B O R N 1 – 7 Days: 30 Days – 11 Months: 70 – 850 80 – 1500 C H IL DR EN 1 – 16 Years: 8 : 0 0 a. m . 135 – 1860 4 :0 0 p. m . 70 – 620 A D U LT S 130 – 820 60 – 220 Co r tis ol, Fr ee, Ur ine (Includes Cr e atinine ) URINE ASSAYS 5 0 01 0 2 (E ) 5 0 04 10 (L ) P R E P U B E RTA L C HI LD REN R A NG E ( ug / 2 4 ho u r s ) 3–9 R A NG E ( u g/g c r e a t i n i n e ) 7 – 25 A D U LT MALE 11 – 84 7 – 45 A D U LT FEMA LE 10 – 34 9 – 32 P R E GN A NC Y 16 – 60 14 – 59 16 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Co r tis ol, S a li va BLOOD ASSAYS 5 0 00 9 4 (E ) 5 0 01 7 9 (L ) R A NG E ( u g / d L) C HILDREN AND AD ULT S 8:00 a.m. 0.025 – 0.600 4:00 p.m. 0.010 – 0.200 Midnight <0.010 – 0.090 (E) Esoterix Test Number (L) LabCorp Test Number 17 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Co r tis ol, S e rum BLOOD ASSAYS 5 0 00 9 2 (E ) 5 0 01 5 4 (L ) R A NG E ( u g / d L) P R E M AT U RE I N FA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 1 – 11 2.5 – 9.1 FU LL–TE RM I NFA N TS Day 3: Day 7: 31 Days – 11 Months: 1.7 – 14 2.0 – 11 2.8 – 23 C H IL DR EN 12 Month – 15 Years: 8 :0 0 a . m . 3.0 – 21 4 : 0 0 p. m . A D U LT S 8.0 – 19 4.0 – 11 18 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S C - Pe p t i d e , P l a s m a BLOOD ASSAYS 5 0 01 0 4 (E ) 5 0 06 4 2 (L ) R A N GE ( n g / m L ) C H IL DR EN 8:00 a.m. Fasting: 0.4 – 2.2 A D U LT S 8:00 a.m. Fasting: 2 Hours Post Prandial (Sustacal): 2 Hours Post Glucose: 1.2 – 3.4 2.0 – 4.5 (E) Esoterix Test Number (L) LabCorp Test Number 0.4 – 2.1 19 E X P E C T E D VA LU E S E N DO C RI NO LO G Y D e hy d r o e p i a n d r o s t e r o n e ( D H E A ) BLOOD ASSAYS 5 00 1 16 (E) 5 00 1 56 (L ) R A N G E (n g / d L) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 236 – 3640 80 – 3150 FUL L–T ERM INFA N TS 3 Days: 8 – 30 Days: 31 Days – 5 Months: 6 – 11 Months: 65 – 1250 50 – 760 26 – 385 20 – 100 P R E P U B E RTAL C HIL DREN 12 Months – 5 Years: 20 – 130 6 – 7 Years: 20 – 275 8 – 10 Years: 31 – 345 Values begin to increase progressively at about six years of age prior to any physical evidence of puberty. P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 31 – 345 110 – 495 170 – 585 160 – 640 250 – 900 156 300 390 395 505 1 2 3 4 5 31 – 345 150 – 570 200 – 600 200 – 780 215 – 850 156 330 385 430 540 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 A D ULT S 20 – 50 Years: 20 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 160 – 800 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S D e hy d r o e p i a n d r o s t e r o n e S u l f a t e ( D H E A - S ) BLOOD ASSAYS 5 0 01 2 0 (E ) 5 0 01 6 1 (L ) R A N G E (ug / d L ) P R E M ATU RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: FU LL–TE RM I NFA N TS 3 Days: 1 – 12 Months: 123 – 882 122 – 710 88 – 356 5 – 111 ug/dL by first month, 5 – 48 ug/dL by 6 months. P R E P U B E RTAL 1 – 5 Years: C H IL DR EN 6 – 7 Years: 8 – 10 Years: P U B E RT Y < 5 – 57 9 – 72 13 – 115 TANNER AGE STAGE (years) MALE RANGE (ug/dL) MEAN (ug/dL) TANNER AGE STAGE (years) FEMALE RANGE (ug/dL) MEAN (ug/dL) 1 2 3 4 5 13 – 83 42 – 109 48 – 200 102 – 385 120 – 370 36 93 122 206 230 1 2 3 4 5 19 – 144 34 – 129 32 – 226 58 – 260 44 – 248 40 72 88 120 148 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 A D U LT S 21 – 30 Years: 31 – 40 Years: 41 – 50 Years: 51 – 60 Years: 61 – 70 Years: 71 – 80 Years: (E) Esoterix Test Number M A L E R A N G E ( u g/ d L ) 100 – 460 88 – 305 70 – 218 29 – 220 26 – 213 20 – 172 (L) LabCorp Test Number < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 F E M A L E R A N G E ( u g/ d L ) 76 – 255 48 – 247 19 – 210 20 – 157 10 – 115 not determined 21 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Deox y cor ticoste rone (DOC) 5 00 1 24 (E) BLOOD ASSAYS 5 00 1 38 (L ) R A NG E ( ng / d L ) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 34 – 36 Weeks, Day 4 20 – 105 28-78 N EW B O R N Levels are markedly elevated at birth and decrease rapidly during the first week to the range of 7-49 as found in older infants. FUL L–T ERM INFA N TS 1 – 11 Months: P R E P U B E RTAL C HIL DREN 2 – 10 Years: P U B E RTAL CHILDREN AND ADU LT S 8:00 a.m.: 22 7 – 49 2 – 34 2 – 19 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Deox y py ridin olin es, Ur ine (Includes Cr e atinine) 5 0 01 2 7 (E ) URINE ASSAYS 5 0 02 11 (L ) R A NG E A D U LT S Males: up to 5.4 nmole/mmole creatinine Females: Premenopausal: Postmenopausal: up to 7.4 nmole/mmole creatinine up to 8.5 nmole/mmole creatinine Results higher than the above ranges indicate an accelerated bone resorption rate. Des ox y cor tis ol, 1 1- , (Compound S for M ety ra pone Test) 5 0 01 3 6 (E ) BLOOD ASSAYS 5 0 05 5 0 (L ) R A NG E ( u g / d L) C HILDREN AND AD ULT S Baseline: <1 Post Metyrapone: Single Dose Test: Multiple Dose Test: (E) Esoterix Test Number 7 – 18 10 – 25 (L) LabCorp Test Number 23 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Desox yco r tis ol, 1 1-, ( Specific Compound S) 5 00 1 32 (E) BLOOD ASSAYS 5 00 1 71 (L ) R A N G E (n g / d L) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 110 – 1376 48 – 579 FUL L–T ERM INFA N TS 3 Days: 31 Days – 11 Months: 13 – 147 < 10 – 156 P R E P U B E RTAL C HIL DREN 8:00 a.m.: 20 – 155 P U B E RTAL CHILD REN AND ADU LT S 8:00 a.m.: 24 12 – 158 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S D ex am e t h a s o n e BLOOD ASSAYS 5 0 01 4 0 (E ) 50 0 11 8 ( L ) R A N G E ( n g /d L ) A D U LT S Baseline: < 30 8:00 a.m. 140 – 295 Following 1 mg Dexamethasone, Previous Evening 8:00 a.m. 1600 – 2850 Following 8 mg Dexamethasone, (4 x 2 mg Doses) Previous Day (E) Esoterix Test Number (L) LabCorp Test Number 25 E X P E C T E D VA LU E S E N DO C RI NO LO G Y D i hy d r o t e s t o s t e r o n e ( D H T ) BLOOD ASSAYS 5 00 1 44 (E) 5 00 1 42 (L ) M A L E R A N G E ( n g/ d L ) 10 – 53 5 – 60 P RE MAT U RE IN FA N TS F ULL– T ERM NEW B O RN S F E M A L E R A N GE ( n g/ d L ) 2 – 13 < 2 – 15 R A NG E ( ng / d L) F ULL– T ERM NEW B O RN S 2 Weeks – 6 Months: Male: DHT decreases rapidly the first week, then increases to 12–85 ng/dL between 30–60 days. Levels then decrease gradually to prepubertal values by seven months. Female: Levels decrease during the first month to < 3 ng/dL and remain there until puberty. P R E P U B E RTAL C HILD REN <3 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) 1 2 3 4 5 <3 3 – 17 8 8 – 33 19 22 – 52 36 24 – 65 43 R A N GE ( n g/ d L ) A DU LT S Male: Female: 26 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 MEAN (ng/dL) TANNER STAGE FEMALE AGE (years) RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 <3 5 – 12 7 – 19 4 – 13 3 – 18 8 12 7 9 30 – 85 4 – 22 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S E s t ra d i o l BLOOD ASSAYS 5 0 01 5 2 (E ) N EW B O R N 1 – 6 Months: Male: 1 – 11 Months: Female: 50 0 10 8 ( L ) R A NG E ( ng / d L ) Levels are markedly elevated at birth and fall rapidly during the first week to prepubertal values of < 1.5 ng/dL. Levels increase to 1.0 – 3.2 ng/dL between 30 and 60 days, then decline to prepubertal levels of < 1.5 ng/dL by six months. Levels increase to 0.5 – 5.0 ng/dL between 30 and 60 days, then decline to prepubertal levels of < 1.5 ng/dL during the first year. P R E P U B E RTA L C HILDRE N 1 – 10 Years: < 1.5 ng/dL P U B E RT Y TANNER STAGE MALE AGE (years) RANGE (ng/dL) MEAN (ng/dL) TANNER STAGE FEMALE AGE (years) RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 0.5 – 1.1 0.5 – 1.6 0.5 – 2.5 1.0 – 3.6 1.0 – 3.6 0.8 1.1 1.6 2.2 2.1 1 2 3 4 5 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 0.5 – 2.0 1.0 – 2.4 0.7 – 6.0 2.1 – 8.5 3.4 – 17 0.8 1.6 2.5 4.7 11 A D U LT S Male: 0.8 – 3.5 ng/dL Female: Follicular: Luteal: Postmenopausal: 3 – 10 ng/dL 7 – 30 ng/dL < 1.5 ng/dL (E) Esoterix Test Number (L) LabCorp Test Number 27 E X P E C T E D VA LU E S E N DO C RI NO LO G Y E s trogens, Total BLOOD ASSAYS 5 00 1 48 (E) 5 00 7 14 (L ) R A NG E ( ng/ d L) FUL L–T ERM INFA N TS Newborn: 30 Days – 11 Months: Male: Female: Markedly elevated at birth and fall rapidly during the first week to < 2.5 by seven days. Levels increase to 1.0 – 4.0 between 30 – 60 days then decline to < 2.5 by 12 months Levels increase to 1.0 – 6.0 between 30 – 60 days then decline to < 2.5 by 12 months P R E P U B E RTAL C HILD REN 1 – 10 Years: < 2.5 ng/dL P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 1.0 – 3.8 1.7 – 4.5 2.2 – 5.5 2.7 – 8.0 2.5 – 8.0 2.0 3.0 4.1 5.3 5.0 1 2 3 4 5 1.0 – 4.6 2.2 – 6.3 2.4 – 11 4 – 18 6 – 28 2.3 4.1 6.1 9.1 17 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 A DU LT S Male: 2 – 8 ng/dL Female: Follicular: 6 – 20 ng/dL Luteal: 16 – 40 ng/dL Postmenopausal: < 5 ng/dL * Esoterix’ assay is specific for estrone and estradiol, and does not measure estriol. 28 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S E s t ro n e BLOOD ASSAYS 5 0 01 7 2 (E ) 5 0 06 3 4 (L ) R A N G E ( n g /d L ) N EW B O R N Values are strikingly elevated at birth, then decrease rapidly during the first week to prepubertal levels of < 1.5. P R E P U B E RTA L C HILDRE N 1 – 10 Years: < 1.5 ng/dL P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 0.5 – 1.7 1.0 – 2.5 1.5 – 2.5 1.5 – 4.5 2.0 – 4.5 1.1 1.6 2.1 3.3 3.2 1 2 3 4 5 0.4 – 2.9 1.0 – 3.3 1.5 – 4.3 1.6 – 7.7 2.9 – 10.5 1.3 2.1 3.0 3.6 6.1 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 A D U LT S Male: 1.0 – 5.0 ng/dL Female: Follicular: Luteal: 3.0 – 10 ng/dL 9.0 – 16 ng/dL Postmenopausal: < 4.0 ng/dL (E) Esoterix Test Number (L) LabCorp Test Number < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 29 E X P E C T E D VA LU E S E N DO C RI NO LO G Y F o l l i c l e St i m u l a t i n g H o r m o n e ( F S H ) I C M A BLOOD ASSAYS 500192 (E) (Expressed in terms of W.H.O. International Standard, 5 00 09 7 (L ) Human Pituitary FSH 83/575) R AN GE ( mIU/mL ) I NFA N TS 4 Weeks – 11 Months: Male: 0.16 – 4.1 Levels are for infants from 4 weeks of age to one year. FSH in males declines to prepubertal levels by the end of the first year. Female: 0.24 – 14.2 Levels are for infants from 4 weeks of age to one year. FSH declines more slowly than in males to reach prepubertal levels by the end of the second year. P R E P U B E RTAL C HILD REN MAL E FE M A LE 12 Months – 8 Years: 0.26 – 3.0 1.0 – 4.2 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (mIU/mL) MEAN (mIU/mL) TANNER AGE STAGE (years) FEMALE RANGE (mIU/mL) MEAN (mIU/mL) 1 2 3 4 5 0.26 – 3.0 1.8 – 3.2 1.2 – 5.8 2.0 – 9.2 2.6 – 11.0 0.98 2.5 2.9 4.4 6.1 1 2 3 4 5 1.0 – 4.2 1.0 – 10.8 1.5 – 12.8 1.5 – 11.7 1.0 – 9.2 2.1 4.0 5.1 6.4 4.9 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 16.2 12.8 – 17.3 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 A D ULT Males 20 – 50 Years: 2.0 – 9.2 Females 18 – 34 Years: Follicular & Luteal: 1.8 – 11.2 Mid–cycle: 6 – 35 Post Menopausal: 30 – 120 30 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Fr uc tos am ine BLOOD ASSAYS 5 0 06 0 8 (E ) R A NG E < 285 umol/L Glutamic Acid Deca r box ylase (GAD-65) Autoantibodies 5 0 02 3 6 (E ) A L L AG E S 50 0 61 1 ( L ) R AN G E < 0.5 U/mL G l y co M a r k BLOOD ASSAYS 5 0 06 0 9 (E ) 50 0 11 5 ( L ) R ANG ES R E F E R E N C E I N T E R VA L (ug/mL) 1 , 5 AG ME A N ( S D ) ( u g / m L) 1 , 5 A G M ALE : FE MALE : 10.7-32.0 6.8-29.3 22.5 (5.8) 17.7 (6.2) (E) Esoterix Test Number BLOOD ASSAYS (L) LabCorp Test Number 31 E X P E C T E D VA LU E S E N DO C RI NO LO G Y G r o w t h H o r m on e A n t i b o d i e s 5 00 2 14 (E) A L L AG E S BLOOD ASSAYS 50 0 14 4 ( L ) R A N GE Negative G r o wt h H o r m o n e B i n d i n g Pr o t e i n ( G H B P ) 5 00 2 09 (E) BLOOD ASSAYS 5 00 1 77 (L ) R A N G E ( pm o l / L) C HILD RE N Under 2 Years: 3 – 10 Years: 10 – 15 Years: <125 – 762 267 – 1638 431 – 1892 A D ULT S 20 – 50 Years: 686 – 2019 L A RON DWA R F I S M < 125 32 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S G r o w t h H o r m o n e, I C M A 5 0 02 1 3 (E ) A L L AG E S BLOOD ASSAYS 5 00 6 47 (L ) R AN G E 0 – 6 ng/mL NOTE: GH is secreted episodically. An individual may have levels ranging from undetectable to elevated over the course of a day. RESPONSE TESTING (CHILDREN AND ADULTS): GH response to provocative stimuli among normal individuals is highly variable. Response values greater than 6 ng/mL using two-site assays have historically been considered to reflect normal GH secretory function, while values below 6 ng/mL have been considered to indicate some degree of GH deficiency. However, it should be noted that this limit is arbitrarily derived. A significant percentage of normal controls exhibit response values well below this 6 ng/mL limit.The clinical research literature should be consulted for a more recent detailed review of the interpretation of GH response data. (E) Esoterix Test Number (L) LabCorp Test Number 33 E X P E C T E D VA LU E S E N DO C RI NO LO G Y G r o wt h H o r m o ne, R I A 5 00 2 12 (E) BLOOD ASSAYS 50 0 63 2 ( L ) R A N G E ( n g/ m L ) N EW B O R N 1 Day: 2 – 7 Days: 31 Days – 11 Months: 5 – 53 5 – 27 2 – 10 Following an 8 – 12 hour overnight fast: C HILD RE N 0–6 A D ULT S 0–6 RESPONSE TESTING (CHILDREN AND ADULTS): The assessment of GH secretory capacity is complicated because of the episodic nature of GH release from the pituitary. Basal GH levels can exhibit considerable variability throughout a 24-hour period, thus limiting their clinical utility. Alternatively, measurement of GH response to various stimuli has commonly been used to improve the diagnostic assessment of GH secretion. GH response to provocative stimuli among normal individuals, however, is highly variable. Response values greater than 10 ng/mL have historically been considered to reflect normal GH secretory function, while values below 10 ng/mL have been considered to indicate some degree of GH deficiency. However, it should be noted that this limit is arbitrarily derived. A significant percentage of normal controls exhibit response values well below this 10 ng/mL limit.The clinical research literature should be consulted for a more recent detailed review of the interpretation of GH response data. 34 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S G r o w t h H o r m o n e, U r i n e ( I n c l u d e s C r e a t i n i n e ) 5 0 02 1 1 (E ) URINE ASSAYS 5 00 3 30 (L ) R A NG E ( n g/ g c r e a t i n i n e ) O v e r n i g h t Co l l e c t i o n P R E P U B E RTA L C HILDRE N 1 – 8 Years 7.5 – 42 P U B E RTAL C HILD REN 9 – 18 Years 6.7 – 39 A D U LT S 19 – 43 Years 0.2 – 14.8 2 4 h r Co l l e c t i o n P R E P U B E RTA L C HILDRE N 1 – 8 Years 10.2 – 30.1 P U B E RTAL C HILD REN 9 – 18 Years 9.3 – 29 A D U LT S 19 – 43 Years 0.2 – 13 H e m o g l ob in A 1 c BLOOD ASSAYS 5 0 20 8 0 (E ) A D U LT S (E) Esoterix Test Number 5 01 2 70 (L ) R AN G E 4.2% – 5.9% (L) LabCorp Test Number 35 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Hyd rox yco r ticoste roids, 1 7 , Ur ine (Includes Cr e atinine) 5 00 2 16 (E) URINE ASSAYS 5 00 8 52 (L ) Glenn–Nelson Procedure R A NG E ( m g/ 2 4 ho u r s ) R A NG E ( mg / g cr e a t i n i n e ) P R E P U B E RTAL C HIL DREN 1 – 4 Years: 5 – 9 Years: 0.2 – 2.5 0.5 – 2.5 1.7 – 6.4 2.2 – 6.0 P U B E RTAL CHILD REN AND ADU LT S Male: Female: 3 – 10 2–6 2.4 – 4.3 1.6 – 3.6 36 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Hy d rox yco r ticos te rone, 1 8 BLOOD ASSAYS 5 0 00 8 8 (E ) 50 0 77 8 ( L ) 1 8 – O H – C o r t i co s t e r o n e R A N GE ( n g/ d L ) 1 8 – O H – C o r t i c o s t e r o n e/ A l d o s te r o ne R a t i o R A N GE ( n g/ d L ) P R E M ATU RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 10 – 670 57 – 410 1.0 – 4.5 1.1 – 5.2 FU LL–TE RM I NFA N TS 3 Days: 31 Days – 11 Months: 31 – 546 5 – 220 2.6 – 5.3 2.3 – 6.0 C H IL DR EN 12 – 23 Months: 24 Months – 9 Years: 10 – 14 Years: 18 – 155 6 – 85 10 – 72 1.7 – 5.0 2.4 – 10.5 2.0 – 8.3 9 – 58 4 – 21 5 – 46 1.7 – 8.8 A D U LT S 8:00 a.m. Supine 8:00 a.m. Upright Samples were collected without regard to posture from subjects on ad lib sodium intake. For additional information on the effects of posture and sodium intake, contact the laboratory. (E) Esoterix Test Number (L) LabCorp Test Number 37 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Hyd rox yindoleacetic Acid, 5- ( 5-HIAA), Ur ine ( Inc l udes Cr e ati n i n e ) 5 00 2 15 (E) A D ULT S 38 URINE ASSAYS 5 00 7 20 (L ) R AN GE( mg/24 h ou r) < 16.0 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S H y d r o x y p r e g n e n o l o n e, 1 7 - BLOOD ASSAYS 5 0 02 6 2 (E ) 14 0 71 5 ( L ) R A NG E ( ng / d L ) P R E M ATU RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 375 – 3559 64 – 2380 FU LL–TE RM I NFA N TS 3 Days: 1 – 5 Months: 6c11 Months: 10 – 829 36 – 763 42 – 540 P R E P U B E RTA L C HILDRE N 12 – 23 Months: 24 Months – 5 Years: 6 – 9 Years: 14 – 207 10 – 103 10 – 186 P U B E RTAL AGE GROU P S 44 – 235 A D U LT S 53 – 357 (E) Esoterix Test Number (L) LabCorp Test Number 39 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Hyd rox y p rogeste rone, 17 a- , (17-OHP) BLOOD ASSAYS 5 00 2 70 (E) 5 00 1 63 (L ) R A N G E (n g / d L) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 124 – 841 26 – 568 FUL L–T ERM INFA N TS 3 Days: Male 1 – 11 Months: Female 1 – 11 Months : 7 – 77 Levels increase after the first week to peak values ranging from 40 – 200 ng/dl between 30 and 60 days. Values then decline to prepubertal range before one year. 13 – 106 P R E P U B E RTAL C HIL DREN 1 – 10 Years: 3 – 90 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) 1 < 9.8 3 – 90 38 2 9.8 – 14.5 5 – 115 51 3 10.7 – 15.4 10 – 138 57 4 11.8 – 16.2 29 – 180 80 5 12.8 – 17.3 24 – 175 97 A D ULT S M A L E R A N G E ( n g/ d L ) 27 – 199 40 TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) 1 < 9.2 3 – 82 2 9.2 – 13.7 11 – 98 3 10.0 – 14.4 11 – 155 4 10.7 – 15.6 18 – 230 5 11.8 – 18.6 20 – 265 F E M A L E R AN G E ( n g / d L ) Follicular: Luteal: MEAN (ng/dL) 31 49 70 290 108 15 – 70 35 – 290 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S I C A - 5 12 Au t o a nt i b o d i e s * R U O * 5 0 02 5 5 (E ) BLOOD ASSAYS 1 41 5 31 (L ) R A NG E < 1.0 U/mL A L L AG E S I G F B i n d i n g Pr o t e i n - 1 ( I G F B P - 1 ) 5 0 02 8 3 (E ) BLOOD ASSAYS 14 0 82 2 ( L ) R A N GE ( n g / m L ) P R E P U B E RTA L C HILDRE N Fasting: Random: 30 – 1000 10 – 500 P U B E RTAL C HILD REN Fasting: Random: 20 – 200 20 – 100 A D U LT S Fasting: Random: 10 – 150 0 – 40 (E) Esoterix Test Number (L) LabCorp Test Number 41 E X P E C T E D VA LU E S E N DO C RI NO LO G Y I G F B i n d i n g Pr o t e i n - 2 ( I G F B P - 2 ) 5 00 2 84 (E) 0 – 11 Months: 12 – 23 Months: 24 Months – 5 Years: 6 – 9 Years: 10 – 14 Years: 15 – 24 Years: 25 – 44 Years: 45 – 64 Years: 65 – 74 Years: 75 – 85 Years: 42 BLOOD ASSAYS 5 0 01 3 3 (L ) R A N G E ( n g/ m L ) 348 – 922 280 – 750 275 – 700 255 – 540 200 – 470 215 – 518 220 – 570 225 – 710 225 – 850 300 – 1038 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S I G F B i n d i n g Pr o t e i n - 3 ( I G F B P - 3 ) BLOOD ASSAYS 5 0 02 8 1 (E ) 5 00 6 44 (L ) R A NG E ( m g/ L ) M EA N ( m g/ L ) P R E M ATU RE I NFA N TS 0 Days – 1 Month: 2 – 3 Months: 4 – 5 Months: 6 –11 Months: 0.3 – 1.4 0.9 – 2.3 0.4 – 2.2 1.0 – 2.3 0.9 1.6 1.5 1.5 FU LL- TE RM INFA N TS 0 Days – 1 Month: 2 – 3 Months: 4 – 5 Months: 6 –11 Months: 0.4 – 1.7 0.5 – 2.1 0.6 – 2.4 0.5 – 2.4 0.9 1.3 1.4 1.4 C H IL DR EN 12 Months – 4 Years: 5 – 6 Years: 7 – 8 Years: 9 – 11 Years: 12 – 13 Years: 14 – 15 Years: 16 – 18 Years: 0.8 – 3.0 1.5 – 3.4 2.1 – 4.2 2.0 – 4.8 2.1 – 6.2 2.2 – 5.9 2.5 – 4.8 2.1 2.4 3.0 3.3 3.8 4.2 3.8 A D U LT S 19 – 30 Years: 31 – 70 Years: 2.0 – 4.2 1.9 – 3.6 3.0 2.7 (E) Esoterix Test Number (L) LabCorp Test Number 43 E X P E C T E D VA LU E S E N DO C RI NO LO G Y IGF- I BLOOD ASSAYS 5 00 2 82 (E) 5 00 4 85 (L ) T ERM R A NG E ( ng / m L) P R E – T E R M* R A NG E ( ng / m L) 15 – 109 15 – 109 7 – 124 7 – 93 15 – 101 21 – 93 23 – 163 23 – 171 15 – 132 15 – 179 N EWBORNS A ND INFA N TS Birth: 1 Day – 2 Months: 3 – 4 Months: 5 – 6 Months: 7 – 11 Months: * Values from preterm infants were determined at these ages from expected term gestation MAL E F EM A LE CHILD REN AND YOUNG AD ULT S 1 – 2 Years: 3 – 4 Years: 5 – 6 Years: 7 – 8 Years: 9 – 10 Years: 11 – 12 Years: 13 – 14 Years: 15 – 16 Years: 17 – 18 Years: 19 – 20 Years: 30 – 122 54 – 178 60 – 228 113 – 261 123 – 275 139 – 395 152 – 540 257 – 601 236 – 524 281 – 510 56 – 144 74 – 202 82 – 262 112 – 276 140 – 308 132 – 376 192 – 640 217 – 589 176 – 452 217 – 475 A D ULT S 21 – 30 Years: 31 – 40 Years: 41 – 50 Years: 51 – 60 Years: 61 – 70 Years: 71 – 80 Years: 155 – 432 132 – 333 121 – 237 68 – 245 60 – 220 36 – 215 87 – 368 106 – 368 118 – 298 53 – 287 75 – 263 54 – 205 44 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S I GF-I I BLOOD ASSAYS 5 0 02 2 8 (E ) 14 1 77 0 ( L ) P R E P U B E RTA L R A NG E ( ng / m L) 334 – 642 P U B E RTA L 245 – 737 A D U LT S 288 – 736 I nsu l i n BLOOD ASSAYS 5 0 02 2 0 (E ) 50 0 56 4 ( L ) R A NG E ( u U / m L ) Following a 4 –12 hour fast: 0 – 8 Years 0 – 13 P U B E RTAL C HILDREN AND AD ULT S 0 – 17 A D U LT S 2 Hours Post Meal (Sustacal): 7.6 – 26 2 Hours Post Glucose (75 gm): 15 – 53 (E) Esoterix Test Number (L) LabCorp Test Number 45 E X P E C T E D VA LU E S E N DO C RI NO LO G Y I n s u l i n An t i b o d i e s BLOOD ASSAYS 5 00 2 25 (E) 1 4 15 9 8 (L ) BINDING C A PAC I T Y (uU/mL) C HIL D RE N: 4 – 19 Years: < 5.0 A D ULT S : 20 – 40 Years: < 5.0 T Y P E I D IA B ET E S 5 – 420 46 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S I ns ulin , Fr ee and Tot al BLOOD ASSAYS 5 0 02 2 6 (E ) R A N G E ( u U / m L) N O N – DI ABE TI C In the absence of insulin–binding antibodies, the free and total insulin assays are equivalent. However, this assay is intended for use in diabetics with insulin autoantibody present. Measurement is performed on acid–treated samples and,therefore,the sensitivity and absolute values by this method may differ from our direct insulin RIA. Following a 4 – 12 hour fast: I N FA N TS A ND PR EP U BERTAL C H IL DR EN 0 -13 uU/mL P U B E RTAL C HILDREN AND AD ULT S 0 -17 uU/mL I NSULI N D EP END ENT D I AB ET IC PAT I E N TS Total insulin levels are dependent on the binding capacity of circulating antibodies and the patient’s insulin dose.Values range from about 50 uU/mL to more than 1000 uU/mL. Free insulin levels vary depending on the capacity and affinity of circulating insulin–binding antibodies and the dose of insulin given to the patient.Values range from non–diabetic levels up to about 100 uU/mL. (E) Esoterix Test Number (L) LabCorp Test Number 47 E X P E C T E D VA LU E S E N DO C RI NO LO G Y K e t o s t e r o i d s, 1 7 - , ( 1 7 - K S ) , U r i n e (I n cl u d e s C r e a t i n i n e ) URINE ASSAYS 5 00 2 30 (E) C HILD RE N 1 – 4 Years 5 – 9 Years: 10 – 12 Years: 13 – 14 Years: 15 – 16 Years: Male: Female: A D ULT S Male: Female: 48 R A N GE (m g / 2 4 ho u r s ) R A N GE (m g / g c r e a t i n i n e ) < 1.0 – 2.0 < 1.0 – 3.2 1.0 – 5.0 1.0 – 5.5 Not Determined Not Determined Not Determined Not Determined 3.0 – 13 2.5 – 8.0 Not Determined Not Determined 10 – 25 6 – 14 6 .7 – 12 5.6 – 10 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S L e p ti n BLOOD ASSAYS 5 0 02 3 7 (E ) 5 00 7 16 (L ) R A NG E ( ng / m L) M ALE R A NG E ( ng / m L) F EM A LE 0.7 – 5.3 3.3 – 18.3 A D U LT S (BMI = 22) Range is 5th – 95th percentile. NOTE: Leptin values are gender–dependent and highly correlated with the Body Mass Index (BMI).This reference range is provided only for an average BMI value. Contact Esoterix to obtain reference ranges correlated with other BMI’s.To obtain appropriate data, please furnish patient’s age and sex, plus height and weight, or BMI. (E) Esoterix Test Number (L) LabCorp Test Number 49 E X P E C T E D VA LU E S E N DO C RI NO LO G Y L u t e i ni z i n g H o r m o n e ( L H ), I C M A BLOOD ASSAYS 5 00 2 34 (E) 5 0 00 9 4 (L ) R A NG E (m I U / m L ) (Expressed In Terms of W.H.O. 2ND International Standard, Human Pituitary LH 80/552) I NFA N TS 2 Weeks – 11 Months: Values begin to increase about two weeks after birth to a range of 0.02 – 7.0 mIU/mL within the first three months, then decline to prepubertal values by the end of the first year. P R E P U B E RTAL C HIL DREN 12 Months – 8 Years: 0.02 – 0.3 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (mIU/mL) MEAN (mIU/mL) TANNER AGE STAGE (years) FEMALE RANGE (mIU/mL) MEAN (mIU/mL) 1 2 3 4–5 0.02 – 0.3 0.2 – 4.9 0.2 – 5.0 0.4 – 7.0 0.09 1.8 1.9 2.6 1 2 3 4–5 0.02 – 0.18 0.02 – 4.7 0.10 – 12.0 0.4 – 11.7 0.06 0.72 2.3 3.3 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 17.3 A D ULT S Male: Female: Follicular: Mid–cycle: Luteal: Postmenopausal: 50 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 18.6 1.5 – 9.0 mIU/mL 2.0 – 9.0 mIU/mL 18.0 – 49.0 mIU/mL 2.0 – 11.0 mIU/mL 20.0 – 70.0 mIU/mL Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S M a cro prola c t i n BLOOD ASSAYS 5 0 03 7 5 (E ) 50 0 32 4 ( L ) R A NG E < 50% (E) Esoterix Test Number (L) LabCorp Test Number 51 E X P E C T E D VA LU E S E N DO C RI NO LO G Y M e t a n e p h r i n e s , F r ac t i o n a t e d U r i n e URINE ASSAYS 5 00 2 40 (E) 501533(L) R A N GE ( u g/ 2 4 h o u r s ) R A N GE ( ug / g c r e a t i n i n e ) N OR ME TA NE P H RI N E C HILD RE N < 1 Year: 1 – 2 Years: 2 – 8 Years: 8 – 15 Years: Not Determined Not Determined Not Determined Not Determined 180 – 1900 250 – 830 150 – 735 95 – 705 A D ULT S : 110 – 720 109 – 596 M E TA N E P HR IN E C HILD RE N < 1 Year: 1 – 2 Years: 2 – 8 Years: 8 – 15 Years: Not Determined Not Determined Not Determined Not Determined 150 – 310 60 – 250 55 – 460 70 – 380 A D ULT S 35 – 278 22 – 205 Pediatric values were determined on both random and overnight urine collections. 52 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S M etaneph rines, Total , Ur ine (Includes Cr eatinine) 5 0 02 4 2 (E ) URINE ASSAYS 50 0 48 0 ( L ) R AN G E (u g / 2 4 h our s ) R AN G E ( u g /g c re a t i n i n e ) C H IL DR EN Birth – 1 Year: 1 – 2 Years: 2 – 8 Years: 8 – 15 Years: Not Determined Not Determined Not Determined Not Determined 410 – 2000 300 – 1200 200 – 900 140 – 830 A D U LT S 300 – 900 180 – 700 Pediatric values were determined on both random and overnight collections. M i c r o a l b u m i n , U r i ne ( Incl u d e s Cr e a t i n i n e ) 5 0 24 4 0 (E ) A D U LT S Overnight Collection: 24 Hour Collection: (E) Esoterix Test Number URINE ASSAYS 5 0 08 7 0 (L ) R AN G E ( m g/ 2 4 ho u r s ) R AN G E ( mg / g cr e a t i n i n e ) < 25 < 15 < 20 (L) LabCorp Test Number 53 E X P E C T E D VA LU E S E N DO C RI NO LO G Y N-Telopeptides, Ur ine (Includes Cr eatinine) 5 00 2 47 (E) URINE ASSAYS 5 00 1 88 (L ) R A NG E ( n m o l e s BC E / m m o l e c r e a t i n i n e ) A D ULT S Males and Premenopausal Females: Postmenopausal Females: Post Therapy: 10 – 65 25 – 110 Three to six months following effective therapy, N-Telopeptide values should decline to ≤ 35 nmoles BCE/mmole creatinine or decrease by ≥ 40% of base line value BCE = Bone Collagen Equivalents NOTE: Individuals exhibit significant daily variation in N-Telopeptide excretion. Postmenopausal values also vary over a wide range depending upon the stage of menopause and the rate of bone resorption. Results are most useful when compared to a baseline value. 54 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S O s t e o ca l c i n BLOOD ASSAYS 5 0 02 4 5 (E ) 50 0 71 8 ( L ) 0 – 11 Months: R A N GE ( n g / m L ) 5 – 25 P R E P U B E RTA L C HILDRE N 12 Months – 7 Years: 5 – 60 P U B E RTAL C HILD REN 8 – 9 Years: 10 – 11 Years: 12 – 15 Years: 30 – 103 37 – 154 42 – 225 A D U LT S 2 – 22 P a r a t hy r o i d H o r m o n e, I n t a c t ( I P T H ) ( I n c l u d e s C a l c i u m ) 5 0 02 4 6 (E ) C HILDREN AND AD ULT S (E) Esoterix Test Number BLOOD ASSAYS 5 00 6 92 (L ) R A NG E <10 – 65 pg/mL (L) LabCorp Test Number 55 E X P E C T E D VA LU E S E N DO C RI NO LO G Y P r e g n a n e t r i o l , U r i n e ( I n c l u d e s C r e at i n i n e ) 5 00 2 56 (E) 5 0 03 4 0 (L ) I NFA N TS R AN GE ( m g/ g c r e a t i n i n e ) Not determined C HILD RE N 0.1 – 0.9 A D ULT S 0.1 – 1.6 56 URINE ASSAYS Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S P r e g n en o l o ne BLOOD ASSAYS 5 0 02 5 8 (E ) 14 0 70 7 ( L) R A NG E ( ng / d L ) P R E M ATU RE I NFA N TS 26 – 28 Weeks, Day 4: 260 – 2104 N EONAT E S 1 – 7 Days: 150 – 2000 Levels decrease after birth, and are within the prepubertal range by three months. P R E P U B E RTA L C HILDRE N 20 – 140 P U B E RTAL AND ADULT S < 20 – 150 (E) Esoterix Test Number (L) LabCorp Test Number 57 E X P E C T E D VA LU E S E N DO C RI NO LO G Y P r o g e s t e ro n e BLOOD ASSAYS 5 00 2 66 (E) 5 00 1 67 (L ) MA LE S 1-16 Years Adults R A N G E ( n g /d L ) <10 – 15 <10 – 11 F EM A LE S 1 – 10 Years 11 Years 12 Years 13 Years 14 Years 15 Years 16 Years R A NG E <10 – 26 <10 – 255 <10 – 856 <10 – 693 <10 – 1204 <10 – 1076 <10 – 1294 A D ULT C YCLE DAYS 1–6 7 – 12 13 – 15 16 – 28 R A NG E <10 – 17 <10 – 135 <10 – 1563 <10 – 2555 P OST MENOPAU S A L <10 Note: Luteal progesterone peaked from 350 to 3750 ng/dL on days ranging from 17 to 23. 58 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S P r o i ns u l i n, P l a s ma BLOOD ASSAYS 5 0 02 7 2 (E ) 5 00 7 22 (L ) P RO I N S U L I N R A NG E (p M / L) P RO I N S U L I N / I N S U L I N * ( M o l a r R a ti o As % ) R A NG E N O R MA L CH I L DR E N Fasting: 1.8 – 10 6.4 – 16 NORMA L AD ULT S Fasting: 1.7 – 12 3.4 – 21 * Ratio calculated using actual insulin value, not the sum of insulin and proinsulin in the denominator. P r o lac t i n BLOOD ASSAYS 5 0 02 7 4 (E ) 5 00 5 57 (L ) R A NG E ( ng / m L) N EW B O R N 1 – 7 Days: 1 – 8 Weeks: 30 – 495 Values decline during the first two months of life to those observed in adult males 3-18 and females 3-24. C HILDREN AND AD ULT S Male: 3 – 18 Female: 3 – 24 (E) Esoterix Test Number (L) LabCorp Test Number 59 E X P E C T E D VA LU E S E N DO C RI NO LO G Y R e n i n , P l a s m a ( P l a s m a R e n i n Ac t i v i t y ) 5 00 2 78 (E) BLOOD ASSAYS 5 00 4 58 (L ) R A N G E ( n g/ d L / hr ) P R E MAT U R E 1 – 7 Days: 1100 – 16, 700 FU L LT E R M 1 – 7 Days: 200 – 3500 Plasma renin activity in newborns is elevated and highly variable. Premature infants generally exhibit substantially higher values ranging from 1100 – 16,700 ng/dL/hr. C HILD RE N* 31 Days – 11 Months: 12 Months – 2 Years: 3 – 4 Years: 5 – 9 Years: 10 – 14 Years: 235 – 3700 171 – 1115 100 – 650 50 – 585 50 – 330 A D ULT S ** S U PI NE UPR IGHT R A N G E ( n g/ d L / hr ) R A N G E ( n g/ d L / hr ) 20 – 160 70 – 330 * Normal Sodium Diet, Supine Posture ** Normal Sodium Diet NOTE: Normal studies of plasma renin activity in young children and adolescents are incomplete. 60 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S S ex Ho r m o n e B i n d i ng G l o b u l i n ( S H B G ) , I R M A 5 0 02 9 9 (E ) BLOOD ASSAYS 5 00 8 48 (L ) R A N G E (n m o l / L) I N FA N TS 1 Month – 2 Years: 60 – 252 P R E P U B E RTA L C HILDRE N 2 – 8 Years: 72 – 220 P U B E RTAL AG E S Males: Females: 16 – 100 36 – 125 A D U LT S Males: Females: Premenopausal Postmenopausal (E) Esoterix Test Number 20 – 60 40 – 120 28 – 112 (L) LabCorp Test Number 61 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Tes toste rone, B io available BLOOD ASSAYS 5 00 2 88 (E) 5 00 6 50 (L ) R A N G E (n g / d L) I NFA N TS AN D P RE P UB ERTAL C HILD RE N 1 – 9 Years: < 0.2 – 1.3 ng/dL P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) 1 2 3 4–5 < 0.2 – 3.4 2 – 58 12 12 – 70 30 84 – 350 210 < 9.8 9.8 – 14.5 10.7 – 15.4 11.8 – 17.3 MEAN (ng/dL) A D ULT S Male: 20 – 39 Yrs: 40 – 49 yrs 50 – 69 yrs 70 – 79 yrs 128 – 430 95 – 350 95 – 285 60 – 240 Female: 1.1 – 14.3 TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) 1 2 3 4–5 < 0.2 – 3.4 0.8 – 4.7 3.6 1.1 – 9.6 4.7 2.3 – 13.9 6.1 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 18.6 MEAN (ng/dL) R A NG E ( ng / d L ) NOTE: For additional information on interpretation of Bioavailable Testosterone levels, contact the laboratory. 62 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Testoste rone, Fr ee BLOOD ASSAYS 5 0 02 9 0 (E ) FU LL–TE RM I NFA N TS 1 – 15 Days: 1 – 2 Months: 3 – 4 Months: 5 – 6 Months: 50 0 10 2 ( L ) M A L E R A N G E ( p g / mL ) F E M A L E R A N G E ( p g/ m L) 1.5 – 31 3.3 – 18 0.7 – 14 0.4 – 4.8 0.5 – 2.5 0.1 – 1.3 0.3 – 1.1 0.2 – 0.6 P R E P U B E RTA L C HILDRE N 1 – 10 Years: 0.15 – 0.6 P U B E RT Y Same as males Comprehensive values for free testosterone by dialysis for both males and females throughout puberty are currently unavailable. A D U LT S 52 – 280 % F R E E T E S TO S T E R O N E M AL E RA NG E (%) FU LL–TE RM I NFA N TS 1 – 15 Days: 0.9 – 1.7 1 – 2 Months: 0.4 – 0.8 3 – 4 Months: 0.4 – 1.1 5 – 6 Months: 0.4 – 1.0 P R E P U B E RTA L C HILDRE N 1 – 10 Years: 0.4 – 0.9 1.1 – 6.3 FE M AL E RA NG E (% ) 0.8 – 1.5 0.4 – 1.1 0.5 – 1.0 0.5 – 0.8 Same as males P U B E RT Y Comprehensive values for free testosterone by dialysis for both males and females throughout puberty are currently unavailable. A D U LT S 1.5 – 3.2 (E) Esoterix Test Number (L) LabCorp Test Number 0.8 – 1.4 63 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Tes toste rone, Total BLOOD ASSAYS 5 00 2 86 (E) P R E MAT U RE I NFA N TS 26 – 28 Weeks, Day 4: 31 – 35 Weeks, Day 4: 5 00 1 59 (L ) M A L E R A N G E ( n g/ d L ) F E M A L E R A NG E ( ng / d L) 59 – 125 37 – 198 R A NG E ( ng / d L ) 5 – 16 5 – 22 FUL L–T ERM INFA N TS Newborns 1 – 7 Months: 75 – 400 20 – 64 Male: Levels decrease rapidly the first week to 20 – 50 ng/dL, then increase to 60 – 400 ng/dL (Mean = 190) between 20 – 60 days. Levels then decline to prepubertal range of < 3 – 10 by seven months. Female: Levels decrease during the first month to <10 ng/dL and remain there until puberty. P R E P U B E RTAL C HIL DREN 1 – 10 Years: < 3 – 10 P U B E RT Y TANNER AGE STAGE (years) MALE RANGE (ng/dL) MEAN (ng/dL) 1 < 9.8 < 3 – 10 4.9 2 9.8 – 14.5 18 – 150 42 3 10.7 – 15.4 100 – 320 190 4 11.8 – 16.2 200 – 620 372 5 12.8 – 17.3 350 – 970 546 A D ULT S 20 – 50 Ye a r s R A N G E (n g / d L) Male: 350 – 1030 Female: Premenopausal: 10 – 55 Postmenopausal: 7 – 40 64 TANNER AGE STAGE (years) FEMALE RANGE (ng/dL) MEAN (ng/dL) 1 2 3 4 5 < 3 – 10 7 – 28 15 – 35 13 – 32 20 – 38 4.9 18 25 22 28 < 9.2 9.2 – 13.7 10.0 – 14.4 10.7 – 15.6 11.8 – 18.6 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S T h y r o g l o b u l i n ( w / A n t i - t hy r o g l o b u l i n S c r e e n ) , Com prehe nsive BLOOD ASSAYS 5 0 03 1 6 (E ) 5 0 05 4 0 (L ) R A N GE ( n g / m L ) M EA N ( n g / m L ) T H Y ROGLOBULI N ICMA P R E P U B E RTA L C HILDRE N 2.9 – 56 17 P U B E RTAL C HILD REN AND AD ULT S 1.3 – 37 8.5 T H Y ROGLOBU LI N RI A I N FA N TS 1 – 12 Months 12 –113 42 P R E P U B E RTA L C HILDRE N 5 – 72 29 P U B E RTAL C HILD REN AND AD ULT S < 3 – 39 16 T h y ro g l o b u l i n An t i b o d i es ( A n t i - T g ) 5 0 00 3 8 (E ) BLOOD ASSAYS 5 0 05 5 5 (L ) R A N G E (I U / m L ) A L L AG E S (E) Esoterix Test Number 0 – 100 (L) LabCorp Test Number 65 E X P E C T E D VA LU E S E N DO C RI NO LO G Y T h y r o i d Pe r o x i d a s e A n t i b o d i e s ( A n t i - T P O ) 5 00 0 42 (E) ALL AG E S BLOOD ASSAYS 5 00 6 38 (L ) R AN GE ( IU/mL ) 0 – 20 T h y r o i d S t i m u l a t i n g H o r mon e ( T S H ) , I C M A 5 00 3 05 (E) BLOOD ASSAYS 5 00 4 77 (L ) R A NG E ( u U / m L ) P R E MAT U RE I NFA N TS 26 – 32 Weeks, 3 – 4 Days: FULL T E RM IN FA N TS 4 Days: Newborns: 0.8 – 6.9 1 – 11 Months: 1.3 – 16 TSH surges within the first 15 – 60 minutes of life reaching peak levels between 25 – 60 at about 30 minutes.Values then decline rapidly and after one week are within the dult normal range. 0.9 – 7.7 P R E P U B E RTAL C HIL DREN 0.6 – 5.5 P U B E RTAL CHILD REN AND ADU LT S 0.5 – 4.8 66 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S T h y rox i n e ( T - 4 ) BLOOD ASSAYS 5 0 03 1 0 (E ) 50 0 34 8 ( L ) R A N G E (ug / d L ) P R E M ATU RE I NFA N TS 26 – 30 Weeks, 3 – 4 Days: 2.6 – 14.0 FU LL–TE RM I NFA N TS 1 – 3 Days: 1 Week: 1 – 11 Months: 8.2 – 19.9 6.0 – 15.9 6.1 – 14.9 P R E P U B E RTA L C HILDRE N 12 Months – 2 Years: 3 – 9 Years: 6.8 – 13.5 5.5 – 12.8 P U B E RTAL C HILD REN 11 – 17 Years: 4.9 – 13.0 A D U LT S 4.2 – 13.0 (E) Esoterix Test Number (L) LabCorp Test Number 67 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Thy roxine Binding Globulin ( T B G ) BLOOD ASSAYS 5 00 3 18 (E) 5 00 7 24 (L ) R A N G E (m g / d L) T-4 /TBG R AT I O P R E MAT U RE I NFA N TS 26 – 30 Weeks, 3 – 4 Days: 1.2 – 3.8 2.2 – 3.7 I NFA N TS 31 Days – 23 Months: 2.1 – 6.0 2.1 – 4.3 P R E P U B E RTAL C HIL DREN 2 – 9 Years: 2.0 – 5.3 1.7 – 4.0 P U B E RTAL CHILD REN AND ADU LT S 1.8 – 4.2 1.8 – 4.5 T BG DE F IC IE N CY 0.1 – 0.9 4 – 42 68 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S T h y r o x i n e, F r ee BLOOD ASSAYS 5 0 03 1 4 (E ) 50 0 45 4 ( L ) R A N GE ( n g/ d L ) P R E M ATU RE I NFA N TS 26 – 30 Weeks, 3 – 4 Days: 0.4 – 2.8 FU LL–TE RM I NFA N TS 3 Days: 1 – 11 Months: 2.0 – 4.9 0.9 – 2.6 P R E P U B E RTA L C HILDRE N 0.8 – 2.2 P U B E RTAL C HILDREN AND AD ULT S 0.8 – 2.3 (E) Esoterix Test Number (L) LabCorp Test Number 69 E X P E C T E D VA LU E S E N DO C RI NO LO G Y Tr iiodothy ronine ( T-3) BLOOD ASSAYS 5 00 3 22 (E) 5 00 5 63 (L ) R A NG E ( ng / d L ) P R E MAT U RE I NFA N TS 26 – 30 Weeks, 3 – 4 Days: 24 – 132 FUL L–T ERM INFA N TS 1 – 3 Days: 1 Week: 1 – 11 Months: 89 – 405 91 – 300 85 – 250 P R E P U B E RTAL C HIL DREN 119 – 218 P U B E RTAL CHILD REN 11 – 17 Years: 80 – 185 A D ULT S 55 – 170 Tr iiodothy ronine, Fr ee Only 5 00 3 23 (E) A D ULT S 70 BLOOD ASSAYS 5 00 8 34 (L ) R A N G E ( p g /m L ) 2.3 – 4.2 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S Tr iiodothy ronine, R ever se *RUO* 5 0 03 2 6 (E ) BLOOD ASSAYS 50 0 87 5 ( L ) R A NG E ( ng / d L ) N EW B O R N S 90 – 250 Reverse T–3 levels are elevated at birth and during the first few days of life. Values then decrease rapidly and are within the adult range by one week. C HILDREN AND AD ULT S 10 – 50 T S H Rec ep to r A nt i b o d y ( T R A b) 5 0 03 0 8 (E ) A L L AG E S BLOOD ASSAYS 5 0 05 3 8 (L ) R A NG E ( U / L) Antibody Titer <1 U/L = Negative 1.1 - 1.5 U/L = Equivocal >1.5 U/L = Positive (E) Esoterix Test Number (L) LabCorp Test Number 71 E X P E C T E D VA LU E S E N DO C RI NO LO G Y V a n i l l y l m a n d e l i c Ac i d ( V M A ) , U r i n e ( I n c l u d e s C r e a t i n i n e ) 5 00 3 30 (E) BLOOD ASSAYS 5 00 4 96 (L ) R A N GE (m g / 2 4 ho u r s ) R A N GE (m g / g c r e a t i n i n e ) C HILD RE N Birth – 1 Year: 1 – 2 Years: 2 – 8 Years: 8 – 15 Years: Not Determined Not Determined Not Determined Not Determined 3 – 17 4 – 12 2 – 11 2 – 11 A D ULT S 0.7 – 6.8 1.5 – 7.0 Pediatric values were determined on both random and 8 hour urine collections. Vitamin D, 1 , 25-Dihyd rox y 5 00 3 42 (E) BLOOD ASSAYS 5 0 06 0 0 (L ) R A N G E ( p g /m L ) N EW B O R NS 0 – 30 Days 8 – 72 I NFA N TS AND CHILD REN 31 Days – 17 Years 15 – 90 A D ULT S > 18 Years 21 – 65 72 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y E XP E CT E D VA LU E S V itamin D, 25-Hyd rox y BLOOD ASSAYS 5 0 03 3 8 (E ) 50 0 51 0 ( L ) N E W B O R NS R A NG E ( ng / m L ) 5 – 42 C HILDREN AND AD ULT S 10 – 55 Note: Adult target levels are 32-100 ng/mL Expected values apply to assays performed at Endocrine sciences only. 73 E X P E C T E D VA LU E S E N DO C RI NO LO G Y 1. Cacclari, E., Cicognani, A., Pirazoli, P., Dallacosa, P., Mazzaracchio, M.A.,Tassoni, P., Bernardi, F., Salardi, S., and Zappulle, F. GH, ACTH, LH and FSH Behaviour in the First Seven Days of Life. Acta Paediatr. Scan. 65: 337, 1976. 2. Forest, M.G., and Bertrand, J. Sexual Steroids in Neonatal Period. Abstracts of the 7th Congress of the International Study Group for Steroids. J. Steroid Blochem. 6: xxiv, 1975. 3. Tanner, J.M., and Whitehouse, R.H. Clinical Longitudinal Standards for Height, Weight, Height Velocity, and the Stages of Puberty. Arch. Dis. Childhood 51: 170, 1976. As used herein, Tanner stages in males encompass development of both pubic hair and genitalia. In females, each stage encompasses both pubic hair and breast development. While this expands the chronological age range for each stage of pubertal development, it results in a better correlation with hormonal values. 4. Day of cycle not determined for pubertal females. 5. Data adapted from De Peretti, E., and Forest, M.G. Unconjugated Dehydroepiandrosterone Plasma Levels in Normal Subjects from Birth to Adolescence in Human:The Use of a Sensitive Radioimmunoassay. J. Clin. Endocrinol. Metab. 43: 982, 1976. 6. De Peretti, E., and Forest, M.G. Unconjugated Dehydroepiandrosterone Plasma Levels in Normal Subjects from Birth to Adolescence in Human: The Use of a Sensitive Radioimmunoassay. J. Clin. Endocrinol. Metab. 43: 982, 1976. 74 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y RE FE RE N C E S 7. Results in children are not significantly different than those found in adults. See Limal, J.M., Basmaciogullari, and Rapaport, R. Evaluation of Single Oral Dose Metyrapone Tests in Children with Hypopituitarism. Acta Paed. Scand. 65: 177, 1976. 8. Data adapted from Pang, S., Levine, L.S., Chow, D., Sagiani, F., Saenger, P., and New, M.I. Dihydrotestosterone and Its Relationship to Testosterone in Infancy and Childhood. J. Clin. Endocrinol. Metab. 48: 821, 1979. 9. Data adapted from Ducharme, J-R., Forest, M.G., De Peretti, E., Sempe, M., Collu, R., and Bertrand, J. Plasma Adrenal and Gonadal Sex Steroids in Human Pubertal Development. J. Clin. Endocrinol. Metab. 42: 468, 1976. 10. Bidlingmaier, F., Versmold, H., and Knorr, D. Sex Differences in Plasma Estrogen Concentrations in Infancy. 21 Symp. Dtsch. Ges. Endokrin Abstract 103. Acta Endoc. Suppl. 193: 103, 1975. 11. Data adapted from Bidlingmaier, F., Wagner-Barnack, M., Butenandt, O., and Knorr, D. Plasma Estrogens in Childhood and Puberty under Physiologic and Pathologic Conditions. Pediat. Res. 7: 901, 1973. 12. Sann, L., Chayvialle, J.A.P., Bremond, A., and Lambert, R. Serum Gastrin Level in Early Childhood. Arch. Dis. Childhood 50: 782, 1975. 13. Data adapted from Janik, J.S., Akbar, A.M., Burrington, J.D., and Burke, G. Serum Gastrin Levels in Infants and Children. Pediatrics 60: 60, 1977. 14. Luna, A.M., Wilson, D.M., Wibbeisman, C.J., Brown, R.C., Nagashima, R.J., Hintz, R.L., and Rosenfeld, R.G. Somatomedins in Adolescence: A CrossSectional Study of the Effect of Puberty on Plasma Insulin-Like Growth Factor I and II Levels. J. Clin. Endocrinol. Metab. 57: 268, 1983. (E) Esoterix Test Number (L) LabCorp Test Number 75 REFERENCES E N DO C RI NO LO G Y 15. Arnaud, S.B., Goldsmith, R.S., Stickler, G.B., McCall, J.T., and Arnaud, C.D. Serum Parathyroid Hormone and Blood Minerals: Interrelationships in Normal Children. Pediat. Res. 7: 485, 1973. 16. Hillman, L.S., Rojanasathit, S., Slatopolsky, E., and Haddad, J.G. Serial Measurements of Serum Calcium, Magnesium, Parathyroid Hormone, Calcitonin, and 25-Hydroxy-Vitamin D in Premature and Term Infants During the First Week of Life. Pediat. Res. 11: 739, 1977. 17. Guyda, H.J., and Friesen, H.G. Serum Prolactin Levels in Humans from Birth to Adult Life. Pediat. Res. 7: 534, 1973. 18. Aubert, M.L., Grumbach, M.M. and Kaplan, S.L. Heterologous Radioimmunoassay for Plasma Human Prolactin (hPRL) Values in Normal Subjects, Puberty, Pregnancy and in Pituitary Disorders. Acta Endocrinol. 77: 460, 1974. 19. Stark, P., Beckerhoff, R., Leumann, E.P., Veter, W., and Siegenthaler, W. Control of Plasma Aldosterone in Infancy and Childhood. Helv. Paediat. Acta 30: 349, 1975. 20. Dillon, M.J., and Ryness, J.M. Plasma Renin Activity and Aldosterone Concentration in Children. Brit. Med. Journ. 4: 316, 1975. 21. Sassard, J., Sann, L., Vincent, M., Francois, R., and Cier, J.F. Plasma Renin Activity in Normal Subjects from Infancy to Puberty. J. Clin. Endocrinol. Metab. 40: 524, 1975. 22. Data adapted from Forest, M.G., Cathiard, A.M., and Bertrand, J.A. Evidence of Testicular Activity in Early Infancy. J. Clin. Endocrinol. Metab. 37: 148, 1973. 76 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y RE FE RE N C E S 23. Forest, M.G., Sizonenko, P.C., Cathiard, A.E., and Bertrand, J. Hypophysio- Gonadal Function in Humans During the First Year of Life. J. Clin. Invest. 53: 819, 1974. 24. Forest, M.G., Cathiard, A.M., and Bertrand, J.A. Total and Unbound Testosterone Levels in the Newborn and in Normal and Hypogonadal Children: Use of a Sensitive Radioimmunoassay for Testosterone. J. Clin. Endocrinol. Metab. 36: 1132, 1973. 25. Ket, J.L., De Vijlder, J.M., Bikker, H., Gons, M.H., and Tegelaers, W.H.H. Serum Thyroglobulin Levels: The Physiological Decrease in Infancy and the Absence in Athyroidism. J. Clin. Endocrinol. Metab. 53: 1301, 1981. 26. Penny, R., Spencer, C.A., Frasier, S.D., and Nicoloff, J.T. ThyroidStimulating Hormone and Thyroglobulin Levels Decrease with Chronological Age in Children and Adolescents. J. Clin. Endocrinol. Metab. 56: 177, 1983. 27. Chopra, I.J., Sach, J., and Fisher, D.A. Circulatory Reverse T-3 in the Human Newborn. J. Clin. Invest. 55: 1137, 1975. 28. Raux-Eurin, M.G., Pham-Huu-Trung, M.T., Marrec, D., and Girard, F. Plasma Aldosterone Concentrations during the Neonatal Period. Pediat. Res. 11: 182, 1977. 29. Aperia, A., Broberger, O., Herin, P., and Zefterstrom, R. Sodium Excretion in Relation to Sodium Intake and Aldosterone Excretion in Newborn Pre-Term and Full-Term Infants. Acta Paediatr. Scand. 68: 813, 1979. 30. Follicular and luteal phases only; does not include midcycle peak. (E) Esoterix Test Number (L) LabCorp Test Number 77 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW ACTH (Corticotropin) Antidiuretic Hormone (ADH) Albumin Aldosterone, Serum Aldosterone, Urine Aldosterone/Creatinine Androstanediol Androstanediol Glucuronide Androstenedione Androsterone, Urine Androsterone/Creatinine Angiotensin I Angiotensin II Angiotensin III Angiotensin I Converting Enzyme Atrial Natriuretic Peptide (ANP) C-Peptide C-Peptide, Urine C-Peptide/Creatinine Calcitonin Calcium Calcium, Urine pmol/L 4.5000 pmol/L 1.0840 g/L 0.1000 pmol/L 0.0360 nmol/d 0.3604 nmol/mmol 3.1859 pmol/L 0.0292 pmol/L 0.0469 pmol/L 0.0286 umol/d 0.2905 umol/mmol 2.5680 pmol/L 1.2960 pmol/L 1.0460 pmol/L 0.9310 U/L 1.0000 pmol/L 3.0800 nmol/L 3.0210 nmol/L 3.0210 nmol/mmol 26.7109 pmol/L 3.4180 mmol/L 4.0080 mmol/d 40.0800 78 M U LT I P LY BY TO FIND pg/mL pg/mL g/dL ng/dL ug/24 h ug/g ng/dL ng/dL ng/dL mg/24 h mg/g pg/mL pg/mL pg/mL mU/mL pg/mL ng/mL ng/mL ug/g pg/mL mg/dL mg/24 h Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE WHEN YO U K N OW Catecholamines, Urine Catecholamines/Creatinine Corticosterone 18-Hydroxycorticosterone Cortisol, Serum Cortisol, Urine Cortisol/Creatinine Cortisone Creatinine, Urine Cyclic Amp, Urine Cyclic Amp/Creatinine Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone-Sulfate (DHEA-S) Deoxycorticosterone (DOC) 18-Hydroxydeoxycorticosterone (18-OH-DOC) 11-Desoxycortisol (Compound S) Dexamethasone Dihydrotestosterone (DHT) Dopamine, Plasma Dopamine, Urine nmol/d 0.1762 nmol/mmol 1.5572 pmol/L 0.0347 pmol/L 0.0362 nmol/L 0.0363 nmol/d 0.3625 nmol/mmol 3.2045 pmol/L 0.0361 umol/d 0.1131 umol/L 1.0000 nmol/mmol 0.0088 pmol/L 0.0288 nmol/L 0.0368 ug/24 h ug/g ng/dL ng/dL ug/dL ug/24 h ug/g ng/dL mg/24 h nmol/mL umol/g ng/dL ug/dL pmol/L pmol/L 0.0331 0.0347 ng/dL ng/dL pmol/L pmol/L pmol/L pmol/L nmol/d 0.0346 0.0393 0.0290 0.1530 0.1530 ng/dL ng/dL ng/dL pg/mL ug/24 h (E) Esoterix Test Number (L) LabCorp Test Number M U LT I P LY TO BY F IN D 79 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW Dopamine/Creatinine Endorphin, Beta Epinephrine, Plasma Ephinephrine, Urine Epinephrine/Creatinine Estradiol Estriol Estrogens, Serum Estrone Estrone Sulfate Folic Acid Follicle Stimulating Hormone (FSH) Follicle Stimulating Hormone, Urine FSH/Creatinine Gastrin Glucagon Growth Hormone Human Chorionic Gonadotropin (HCG) HCG, Urine HCG/Creatinine 5-Hydroxyindoleacetic Acid (5-HIAA), Urine nmol/mmol 1.3528 pmol/L 4.0000 pmol/L 0.1831 nmol/d 0.1831 nmol/mmol 1.6186 pmol/L 0.0272 pmol/L 0.0288 pmol/L 0.0271 pmol/L 0.0270 pmol/L 0.0350 pmol/L 0.0441 IU/L 1.0000 IU/d 1.0000 IU/mmol 8.8420 ng/L 1.0000 ng/L 1.0000 ug/L 1.0000 IU/L 1.0000 ug/g pg/mL pg/mL ug/24 h ug/g ng/dL ng/dL ng/dL ng/dL ng/dL ng/dL mIU/mL IU/24 h IU/g pg/mL pg/mL ng/mL mIU/mL IU/d IU/mmol nmol/d IU/24 h IU/g ug/24 h 80 M U LT I P LY BY 1.0000 8.8420 0.1912 TO FIND Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE WHEN YO U K N OW M U LT I P LY TO BY F IN D 5-HIAA/Creatinine nmol/mmol 1.6906 Homovanillic Acid (HVA), Urine nmol/d 0.1822 HVA/Creatinine nmol/mmol 1.6110 17-Hydroxycorticosteroids, Urine nmol/d 0.3625 17-Hydroxycorticosteroids/Creatinine nmol/mmol 3.2045 IGF-I (Somatomedin C) nmol/L 7.6490 IGF-II nmol/L 7.5000 Inhibin U/L 0.0010 Insulin pmol/L 0.1394 17-Ketosteroids, Urine umol/d 0.2884 17-Ketosteroids/Creatinine umol/mmol 2.5495 Luteinizing Hormone (LH) IU/L 1.0000 Luteinizing Hormone, Urine IU/d 1.0000 LH/Creatinine IU/mmol 8.8420 Metanephrine, Urine nmol/d 0.1972 Metanephrine/Creatinine nmol/mmol 1.7432 Metanephrines,Total, Urine nmol/d 0.1902 Metanephrines,Total/Creatinine nmol/mmol 1.6814 Methoxytyramine, Urine nmol/d 0.1672 Methoxytyramine/Creatinine nmol/mmol 1.4786 Norepinephrine, Plasma pmol/L 0.1692 Norepinephrine, Urine nmol/d 0.1692 Norepinephrine/Creatinine nmol/mmol 1.4957 (E) Esoterix Test Number (L) LabCorp Test Number ug/g ug/24 h ug/g ug/24 h ug/g ng/mL ng/mL U/mL uU/mL mg/24 h mg/g mIU/mL IU/24 h IU/g ug/24 h ug/g ug/24 h ug/g ug/24 h ug/g pg/mL ug/24 h ug/g 81 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW Normetanephrine, Urine Normetanephrine/Creatinine Osteocalcin Parathyroid Hormone Prednisolone Prednisone Pregnanediol, Urine Pregnanediol/Creatinine Pregnanetriol, Urine Pregnanetriol/Creatinine Pregnenolone 17-Hydroxypregnenolone Progesterone 17-Hydroxyprogesterone 20-Hydroxyprogesterone Prolactin Renin (Plasma Renin Activity) Reverse T-3 Secretin Sex Hormone Binding Globulin (SHBG) nmol/d 0.1832 nmol/mmol 1.6195 nmol/L 6.5000 pmol/L 9.5000 pmol/L 0.0361 pmol/L 0.0358 umol/d 0.3205 ng/dLumol 2.8332 umol/d 0.3365 umol/mmol 2.9747 pmol/L 0.0317 pmol/L 0.0333 pmol/L 0.0315 pmol/L 0.0331 pmol/L 0.0317 ug/L 1.0000 ng/L/s 3.6000 pmol/L 0.0651 pmol/L 3.0550 nmol/L 0.0288 82 M U LT I P LY BY TO FIND ug/24 h ug/g ng/mL pg/mL ng/dL pmol/L mg/24 h mg/g/mmol mg/24 h mg/g ng/dL ng/dL ng/dL ng/dL ng/dL ng/mL ng/mL/h ng/dL pg/mL ug/dL Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE WHEN YO U K N OW (Binding Capacity) Somatostatin-14 Somatostatin-28 Testosterone Free Testosterone Testosterone, Urine Testosterone/Creatinine Thyroglobulin Thyroid Stimulating Hormone (TSH) Thyroxine (T-4) Thyroxine Binding Globulin Thyrotropin Releasing Hormone (TRH) Triiodothryonine (T-3) Vanillylmandelic Acid (VMA), Urine VMA/Creatinine Vitamin B-12 25-Hydroxy-Vitamin D 1, 25-Dihydroxy-Vitamin D (E) Esoterix Test Number (L) LabCorp Test Number M U LT I P LY TO BY F IN D pmol/L 1.6380 pmol/L 3.2760 pmol/L 0.0288 pmol/L 0.2884 nmol/d 0.2884 nmol/mmol 2.5495 ug/L 1.0000 mU/L 1.0000 pg/mL pg/mL ng/dL pg/mL ug/24 h ug/g ng/mL uU/mL nmol/L mg/L pmol/L ug/dL mg/dL pg/mL 0.0777 0.1000 0.3620 pmol/L 0.0651 nmol/d 0.1982 nmol/mmol 1.7525 pmol/L 0.1355 nmol/L 0.4006 pmol/L 0.4166 ng/dL ug/24 h ug/g ng/dL ng/mL pg/mL 83 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW M U LT I P LY BY TO FIND ACTH (Corticotropin) Antidiuretic Hormone (ADH) Albumin Aldosterone, Serum Aldosterone, Urine Aldosterone/Creatinine Androstanediol Androstanediol Glucuronide Androstenedione Androsterone, Urine Androsterone/Creatinine Angiotensin I Angiotensin II Angiotensin III Angiotensin I Converting Enzyme Atrial Natriuretic Peptide (ANP) C-Peptide C-Peptide, Urine C-Peptide/Creatinine Calcitonin Calcium Calcium, Urine pg/mL pg/mL g/dL ng/dL ug/24 h ug/g ng/dL ng/dL ng/dL mg/24 h mg/g pg/mL pg/mL pg/mL mU/mL pg/mL ng/mL ng/mL ug/g pg/mL mg/dL mg/24 h 0.2222 0.9225 10.0000 27.7469 2.7747 0.3139 34.1997 21.3447 34.9162 3.4423 0.3894 0.7716 0.9560 1.0741 1.0000 0.3247 0.3310 0.3310 0.0374 0.2926 0.2495 0.0250 pmol/L pmol/L g/L pmol/L nmol/d nmol/mmol pmol/L pmol/L pmol/L umol/d umol/mmol pmol/L pmol/L pmol/L U/L pmol/L nmol/L nmol/L nmol/mmol pmol/L mmol/L mmol/d 84 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE WHEN YO U K N OW M U LT I P LY TO BY F IN D Catecholamines, Urine Catecholamines/Creatinine Corticosterone 18-Hydroxycorticosterone Cortisol, Serum Cortisol, Urine Cortisol/Creatinine Cortisone Creatinine, Urine Cyclic Amp, Urine Cyclic Amp/Creatinine Dehydroepiandrosterone (DHEA) Dehydroepiandrosterone-Sulfate (DHEA-S) Deoxycorticosterone (DOC) 18-Hydroxydeoxycorticosterone (18-OH-DOC) 11-Desoxycortisol (Compound S) Dexamethasone Dihydrotestosterone (DHT) Dopamine, Plasma Dopamine, Urine Dopamine/Creatinine ug/24 h ug/g ng/dL ng/dL ug/dL ug/24 h ug/g ng/dL mg/24 h nmol/mL umol/g ng/dL ug/dL 5.6770 0.6422 28.8600 27.5938 27.5862 2.7586 0.3121 27.7393 8.8420 1.0000 113.1000 34.6741 27.2109 nmol/d nmol/mmol pmol/L pmol/L nmol/L nmol/d nmol/mmol pmol/L umol/d umol/L nmol/mmol pmol/L nmol/L ng/dL ng/dL 30.2572 28.8600 pmol/L pmol/L ng/dL ng/dL ng/dL pg/mL ug/24 h ug/g 28.8684 25.4777 34.4353 6.5359 6.5359 0.7392 pmol/L pmol/L pmol/L pmol/L nmol/d nmol/mmol (E) Esoterix Test Number (L) LabCorp Test Number 85 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW M U LT I P LY BY TO FIND Endorphin, Beta Epinephrine, Plasma Ephinephrine, Urine Epinephrine/Creatinine Estradiol Estriol Estrogens, Serum Estrone Estrone Sulfate Folic Acid Follicle Stimulating Hormone (FSH) Follicle Stimulating Hormone, Urine FSH/Creatinine Gastrin Glucagon Growth Hormone Human Chorionic Gonadotropin (HCG) HCG, Urine HCG/Creatinine 5-Hydroxyindoleacetic Acid (5-HIAA), Urine pg/mL pg/mL ug/24 h ug/g ng/dL ng/dL ng/dL ng/dL ng/dL ng/dL mIU/mL IU/24 h IU/g pg/mL pg/mL ng/mL mIU/mL 0.2500 5.4615 5.4615 0.6178 36.7107 34.6741 36.8450 36.9822 28.6123 22.6552 1.0000 1.0000 0.1131 1.0000 1.0000 1.0000 1.0000 I pmol/L pmol/L nmol/d nmol/mmol pmol/L pmol/L pmol/L pmol/L pmol/L pmol/L IU/L IU/d IU/mmol ng/L ng/L ug/L U/L IU/24 h IU/g ug/24 h 1.0000 0.1131 5.2301 IU/d IU/mmol nmol/d 86 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE WHEN YO U K N OW Homovanillic Acid (HVA), Urine ug/24 h HVA/Creatinine ug/g 17-Hydroxycorticosteroids, Urine ug/24 h 17-Hydroxycorticosteroids/Creatinine ug/g IGF-I (Somatomedin C) ng/mL IGF-II ng/mL IGF-II ng/mL Inhibin U/mL Insulin uU/mL 17-Ketosteroids, Urine mg/24 h 17-Ketosteroids/Creatinine mg/g Luteinizing Hormone (LH) mIU/mL Luteinizing Hormone, Urine IU/24 h LH/Creatinine IU/g Metanephrine, Urine ug/24 h Metanephrine/Creatinine ug/g Metanephrines,Total, Urine ug/24 h Metanephrines,Total/Creatinine ug/g Methoxytyramine, Urine ug/24 h Methoxytyramine/Creatinine ug/g Norepinephrine, Plasma pg/mL Norepinephrine, Urine ug/24 h Norepinephrine/Creatinine ug/g (E) Esoterix Test Number (L) LabCorp Test Number M U LT I P LY TO BY F IN D 5.4885 0.6207 2.7586 0.3121 0.1307 0.1333 0.1333 1000.0 7.1750 3.4674 0.3922 1.0000 1.0000 0.1131 5.0710 0.5736 5.2576 0.5948 5.9809 0.6764 5.9100 5.9100 0.6686 nmol/d nmol/mmol nmol/d nmol/mmol nmol/L nmol/L nmol/L U/L pmol/L umol/d umol/mmol IU/L IU/d IU/mmol nmol/d nmol/mmol nmol/d nmol/mmol nmol/d nmol/mmol pmol/L nmol/d nmol/mmol 87 S . I . UNI T CO NV E R S I O N TA B L E E N DO C RI NO LO G Y H O R MO NE WHEN YO U K N OW M U LT I P LY BY TO FIND Normetanephrine, Urine Normetanephrine/Creatinine Osteocalcin Parathyroid Hormone Prednisolone Prednisone Pregnanediol, Urine Pregnanediol/Creatinine Pregnanetriol, Urine Pregnanetriol/Creatinine Pregnenolone 17-Hydroxypregnenolone Progesterone 17-Hydroxyprogesterone 20-Hydroxyprogesterone Prolactin Renin (Plasma Renin Activity) Reverse T-3 Secretin Sex Hormone Binding Globulin (SHBG) ug/24 h ug/g ng/mL pg/mL ng/dL ng/dL mg/24 h mg/g mg/24 h mg/g ng/dL ng/dL ng/dL ng/dL ng/dL ng/mL ng/mL/h ng/dL pg/mL ug/dL 5.4585 0.6175 0.1538 0.1053 27.7393 27.9018 3.1201 0.3530 2.9718 0.3362 31.5956 30.0752 31.7965 30.2572 31.5956 1.0000 0.2778 15.3610 0.3273 34.6741 nmol/d nmol/mmol nmol/L pmol/L pmol/L pmol/L umol/d umol/mmol umol/d umol/mmol pmol/L pmol/L pmol/L pmol/L pmol/L ug/L ng/L/s pmol/L pmol/L nmol/L 88 Expected values apply to assays performed at Endocrine Sciences only. EN D O C RI N O LO G Y S . I . UNI T CO N VE R S I O N TA B L E HOR M O NE (Binding Capacity) Somatostatin-14 Somatostatin-28 Testosterone Free Testosterone Testosterone, Urine Testosterone/Creatinine Thyroglobulin Thyroid Stimulating Hormone (TSH) Thyroxine (T-4) Thyroxine Binding Globulin Thyrotropin Releasing Hormone (TRH) Triiodothryonine (T-3) Vanillylmandelic Acid (VMA), Urine VMA/Creatinine Vitamin B-12 25-Hydroxy-Vitamin D 1, 25-Dihydroxy-Vitamin D (E) Esoterix Test Number (L) LabCorp Test Number WHEN YO U K N OW M U LT I P LY TO BY F IN D pg/mL pg/mL ng/dL pg/mL ug/24 h ug/g ng/mL uU/mL ug/dL mg/dL pg/mL 0.6105 0.3053 34.6741 3.4674 3.4674 0.3922 1.0000 1.0000 12.8717 10.0000 2.7624 pmol/L pmol/L pmol/L pmol/L nmol/d nmol/mmol ug/L mU/L nmol/L mg/L pmol/L ng/dL ug/24 h ug/g ng/dL ng/mL pg/ml 15.3610 5.0454 0.5706 7.3779 2.4963 2.4004 pmol/L nmol/d nmol/mmol pmol/L nmol/L pmol/L 89
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