Using Lidocaine and Benzocaine to Link Sodium Channel
Molecular Conformations to State-Dependent
Antiarrhythmic Drug Affinity
by Dorothy A. Hanck, Elena Nikitina, Megan M. McNulty, Harry A. Fozzard, Gregory
M. Lipkind, and Michael F. Sheets
Circulation Research
Volume 105(5):492-499
August 28, 2009
Copyright © American Heart Association, Inc. All rights reserved.
Figure 1. Q-V relationships for WT (A) and F1759K (B) channels before and after exposure to 10
mmol/L lidocaine.
Dorothy A. Hanck et al. Circ Res. 2009;105:492-499
Copyright © American Heart Association, Inc. All rights reserved.
Figure 2. Steady-state voltage-dependent Na channel availability protocol (A, bottom) showing
data for a representative cell expressing F1759K channels in control (left) and after exposure to
1 mmol/L lidocaine.
Dorothy A. Hanck et al. Circ Res. 2009;105:492-499
Copyright © American Heart Association, Inc. All rights reserved.
Figure 3. Q-V relationships for WT (A) and F1759K (B) channels exposed to 2 mmol/L
benzocaine.
Dorothy A. Hanck et al. Circ Res. 2009;105:492-499
Copyright © American Heart Association, Inc. All rights reserved.
Figure 4. Steady-state voltage-dependent Na channel availability of WT (A) and F1759K (B)
channels exposed to benzocaine.
Dorothy A. Hanck et al. Circ Res. 2009;105:492-499
Copyright © American Heart Association, Inc. All rights reserved.
Figure 5. Proposed location for lidocaine (A and B) and benzocaine (C and D) in the closed (A
and C) and open/inactivated Na channel (B and D).
Dorothy A. Hanck et al. Circ Res. 2009;105:492-499
Copyright © American Heart Association, Inc. All rights reserved.