Steam Sterilisation - Liquid Filters
dh
Intermediate Level
Module 21A
dh
domnick hunter ltd.
PROCESS DIVISION
Objectives
m Represent a typical LIQUID filter Steam In
Place (SIP) procedure
m Highlight potential problems and offer
solutions
dh
dh
domnick hunter ltd.
PROCESS DIVISION
Some Questions
m Why Steam?
To STERILISE the filter and probably
downstream pipework
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m Minimum Requirements?
Time = 20 mins
Temperature = 1210C
Pressure = 1.0 bar g
dh
domnick hunter ltd.
PROCESS DIVISION
CAUTION !!
m All cartridge filters will have a finite steam life under
optimum steaming conditions. Poor steaming
conditions WILL reduce the steam life of a cartridge
filter
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m Filter cartridges with a polypropylene core are more
susceptible to damage at high temperature
m To prevent cartridge filter damage during steaming
avoid excess differential pressure at high
temperature
dh
domnick hunter ltd.
PROCESS DIVISION
“How To” Guide
m These guides give step by step instructions for
the SIP of a typical LIQUID filter system
m They can be used to check actual SIP methods
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m They should be used as the basis for writing
customer-specific SIP procedures
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domnick hunter ltd.
PROCESS DIVISION
LIQUID FILTER
SIP
dh
PHOTO OF
BLOCKED/DAMAGED
PALL
THE PROBLEM
!
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domnick hunter ltd.
PROCESS DIVISION
Liquid filters - The Ideal Set-up
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
Remember
m It is very unlikely the existing system will exactly
match the “ideal” layout
m Use the principles and procedures from this
training to evaluate or constructively evaluate an
existing system
dh
m Practically adapt the typical system to meet the
system requirements
dh
domnick hunter ltd.
PROCESS DIVISION
Note
m Liquid filters should be steamed in the
FORWARD direction only
m Details of maximum steam temperatures and
steam life for specific filters are given in the
relevant data sheets
dh
dh
domnick hunter ltd.
PROCESS DIVISION
Valve Sequence for Product Liquid Flow
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
Drain the Product This is best achieved using a compressed air chase
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
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V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Drain the Product. This is best achieved using a compressed
air chase
Isolate the filter system for Steam In Place (SIP)
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
Valve positions Pre SIP
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
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V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
Open valves V 4, V 6 and V7
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
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V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
Open valves V 4, V 6 and V7
= Pipework HOT
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
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V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
When the steam trap (ST 2) below V 5 closes, slowly open V 5
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
When the steam trap below V 5 closes, slowly open V 5
Note the steam flow across the filter
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
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V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
When the steam trap below V 5 closes, slowly open V 5
Note the steam flow across the filter
When LIVE steam flows from valve V 4, slowly close V 4
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
When LIVE steam flows from valve V 4, slowly close V 4
This will direct the steam flow through the filter
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
When LIVE steam flows from valve V 4, slowly close V 4
This will direct the steam flow through the filter
The differential pressure (dp) must not exceed 0.2-0.34 bar g
(3-5psi)
dp = P1- P2
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
The differential pressure (dp) must not exceed 0.2-0.34 bar g
(3-5psi)
When the Steam Trap (ST 3) below valve V7 closes
the system pressure will begin to rise
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
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domnick hunter ltd.
PROCESS DIVISION
When the Steam Trap (ST 3) below valve V7 closes
the system pressure will begin to rise.
Sterilisation = 1210C for 20mins Reduced time and or temperature would NOT guarantee sterility
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Sterilisation = 1210C for 20mins.Reduced time and or temperature
would NOT guarantee sterility
Sensor T 1 must maintain 1210C for the 20 mins
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Sensor T 1 must maintain 1210C for the 20 mins
The differential pressure (dp) must not exceed 0.2-0.34 bar g
(3-5psi)
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
On completion of the steam sterilisation cycle, close
valves V 2, V 5 and V 7
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
On completion of the steam sterilisation cycle, close
valves V 2, V 5 and V 7
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
On completion of the steam sterilisation cycle, close
valves V 2, V 5 and V 7
Slowly open valve V 4
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
On completion of the steam sterilisation cycle, close
valves V 2, V 5 and V 7.
Slowly open valve V 4
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Slowly open valve V 4
Allow the steam to exit the system until pressure gauges P1 and
P2 display 0 bar g
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Allow the steam to exit the system until pressure gauges P1 and
P2 display 0 bar g
During this process the differential pressure (dp) must not exceed
0.2-0.34 bar g (3-5psi)
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valve V 4
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valve V 4
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valve V 4
Allow the filter temperature to fall to the normal
operating temperature
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valve V 4
Allow the filter temperature to drop to the normal
operating temperature
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Allow the filter temperature to drop to the normal
operating temperature
During the cooling period ensure a vacuum in excess of 0.34 bar g
(5psi) is not produced
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
During the cooling period ensure a vacuum in excess of 0.34 bar g
(5psi) is not produced
Close valve V 6
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
During the cooling period ensure a vacuum in excess of 0.34 bar g
(5psi) is not produced .
Close valve V 6
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
During the cooling period ensure a vacuum in excess of 0.34 bar g
(5psi) is not produced
Close valve V 6
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
For PROCESS sterilisation
Ensure valve V 2 is closed and V 3 and V 7 are open
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
For PROCESS sterilisation
Ensure valve V 2 is closed and V 3 and V 7 are open.
This PREVENTS the filter and the process being steam sterilised
at the same time
STEAM
P1
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Open valve V 8
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Open valve V 8
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Open valve V 8
Allow the temperature to increase to the sterilisation minimum
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Allow the temperature to increase to the sterilisation minimum.
Hold the minimum temperature for the minimum time
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Hold the minimum temperature for the minimum time
Close valves V 3, V 7 and V 8
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Hold the minimum temperature for the minimum time
Close valves V 3, V 7 and V 8
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valves V 3, V 7 and V 8
Allow the process to cool
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Close valves V 3, V 7 and V 8
Allow the process to cool
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Valve Sequence for Product Liquid Flow
P1
STEAM
V4
V8
PRODUCT
LIQUID
V1
STEAM
ST 1
T1 P2
V2
dh
V6
V5
ST 2
V3
V7
ST 3
PROCESS
dh
domnick hunter ltd.
PROCESS DIVISION
Liquid Filter SIP - Check List
m Ensure the system is fully drained prior to
starting the SIP
m Flow steam across the filter to an open vent or
drain before attempting to flow steam through
the filter
m Monitor the differential pressure during SIP
m Do not generate high steam flow through the
filter by steaming to an ‘open end’
dh
dh
domnick hunter ltd.
PROCESS DIVISION
Liquid Filter SIP - Check List
m Do not generate high steam flow through the
filter by steaming high volume downstream
systems through the filter
dh
m Vent the steam slowly to avoid pressure surges
m Avoid the formation of a vacuum during cooling
post SIP
dh
domnick hunter ltd.
PROCESS DIVISION
Steam Sterilisation - Liquid Filters
dh
Intermediate Level
Module 21A
dh
domnick hunter ltd.
PROCESS DIVISION