Exposure Outcome Probability of Causation Disease

Exposure
Outcome
Probability of
Causation
Polybrominateddiphenyl ethers (PBDE)
IQ Loss and Intellectual Disability
70-100%
Organophosphate pesticides
IQ Loss and Intellectual Disability
70-100%
29,736 lost IQ points; 112 additional cases of intellectual disability
441,890 lost IQ points; 2,022 additional cases of intellectual
disability
Dichlorodiphenytrichloroethane (DDE)
Childhood obesity
40-69%
83 additional cases of obesity at age 10
Dichlorodiphenytrichloroethane (DDE)
Adult diabetes
20-39%
975 additional cases of diabetes among 50-64 year olds
Di-2-ethylhexylphthalate (DEHP)
Adult obesity
40-69%
1,835 additional cases of obesity among 50-64 year old women
Di-2-ethylhexylphthalate (DEHP)
Adult diabetes
40-69%
709 additional cases of diabetes among 50-64 year old women
Bisphenol A
Childhood obesity
20-69%
1,470 additional cases of obesity at age 4
Polybrominateddiphenyl ethers (PBDE)
Testicular cancer
0-19%
279 additional cases of testis cancer
Polybrominateddiphenyl ethers (PBDE)
40-69%
40-69%
160 additional cases of cryptorchidism
25,500 additional cases of infertility requiring assisted reporductive
technology
Phthalates
Multiple exposures
Cryptorchidism
Male Infertility, Resulting in Increased
Assisted Reproductive Technology
Low testosterone, Resulting in Increased
Early Mortality
ADHD
40-69%
20-69%
7,161 deaths among 55-64 year old men
1,165 12-year olds with ADHD
Multiple exposures
Autism
20-39%
11 additional 8-year olds with autism
Benzyl and butylphthalates
Total Costs (accounting for probability)
Disease Burden in Netherlands
€5.770.000.000