Supplementary Data
Identification of microRNA activity by Targets’ Reverse
EXpression
Stefano Volinia1,2,3*, Rosa Visone3 , Marco Galasso1, Elda Rossi4 &
Carlo M Croce3
1DAMA,
Data Mining for Analysis of Microarrays, Dept of Morphology and Embryology,
University of Ferrara, Italy.
2Biomedical
Informatics, Ohio State University, Columbus, OH .
3Comprehensive
Cancer Center, Ohio State University, Columbus, OH.
4CINECA, Bologna, Italy
Supplementary Figure 1
A
B
C
D
Supplementary Figure 1
Supplementary Figure 2
Legends to Figures
Legend to Supplementary Figure 1. The cumulative distribution function (ECDF) plots and boxplots of the Kolmogorov-Smirnov test identify target coding genes specifically controlled by
microRNAs in a cellular context. T-test values from the miRNA assay vs. the control cells were
analyzed. A) miR-124 over-expression in mouse neuroblastoma (GDS2846). miR-124 was correctly
detected as the miRNA with the most down-regulated target genes. The blue curve (miR-124 target
genes) on the left and above the black non–targets curve indicates down-regulation of targets’
messenger RNAs. The red dotted curve is that expected by random association. B) The box-plots
also show an excess of repressed miR-124 target genes, indicated by a distribution of targets’ tvalues skewed towards negative values. C) miR-223 knock-out in mouse neutrophils (Baek et al
2008): miR-223 correctly detected as the miRNA with the most up-regulated target genes. The blue
curve (miR-223 target genes) on the right and below the black non–targets curve indicates upregulation of targets’ messenger RNAs. The red dotted curve is that expected by random
association. D) The box-plots also show an excess of up-regulated miR-223 target genes, indicated
by a distribution of targets’ t-values skewed towards positive values.
Legend to Supplementary Figure 2. The histogram of the TREX scores (-log10 of adjusted Pvalue). Only the significant p-values were measured (p<0.05). The cumulative frequency curve
shown a change in the slope for p-values < 0.0003 (scores larger than 3.50), indicating that from
this p-value to the most significant one there is an occurrence of miRNAs larger than expected by
chance.
Supplementary Table I
Luciferase vs. mock transfections.
miRNA
let-7a
let-7b
let-7c
let-7d
let-7e
let-7f
let-7g
let-7i
miR-1
miR-101
miR-103
miR-106b
miR-107
miR-124a
miR-125a
miR-125b
miR-128a
miR-128b
miR-130a
miR-130b
miR-132
miR-133a
miR-133b
miR-135a
miR-135b
miR-137
miR-139
miR-141
miR-1425p
miR-144
miR-145
miR-148a
miR-148b
miR-149
miR-152
miR-153
miR-155
UPregulated
Targets
Adjusted
p-value
0.994
0.994
0.994
0.994
0.994
0.994
0.994
0.994
0.899
0.994
0.926
0.899
0.926
0.899
0.926
0.926
0.899
0.899
0.899
0.899
0.899
0.635
0.635
0.95
0.95
0.899
0.899
0.899
Downregulated
Targets
Adjusted
p-value
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.926
0.926
0.994
0.899
0.899
0.994
0.899
0.994
0.899
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
miR-15a
miR-15b
miR-16
miR-17-5p
miR-181a
miR-181b
miR-181c
miR-182
miR-183
miR-186
miR-194
miR-195
miR-19a
miR-19b
miR-200b
miR-200c
miR-203
miR-204
miR-205
miR-206
miR-20a
miR-20b
miR-211
miR-212
miR-218
miR-219
miR-22
miR-23a
miR-23b
miR-24
miR-25
miR-26a
miR-26b
miR-27a
miR-27b
miR-29a
miR-29b
miR-29c
miR-301
miR-302a
miR-302b
miR-302c
0.899
0.899
0.899
0.994
0.994
0.994
0.994
0.994
0.899
0.899
0.899
0.899
0.656
0.656
0.994
0.994
0.994
0.971
0.899
0.899
0.899
0.994
0.971
0.899
0.953
0.899
0.899
0.926
0.926
0.994
0.899
0.899
0.899
0.899
0.899
0.994
0.994
0.994
0.899
0.656
0.606
0.454
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
miR-302d
miR-30a-3p
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-3p
miR-30e-5p
miR-32
miR-320
miR-330
0.656
0.994
0.454
0.454
0.454
0.454
0.994
0.454
0.899
0.994
0.899
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
miR-34a
miR-34b
miR-367
miR-372
miR-375
miR-7
miR-9
miR-92
miR-93
miR-96
miR-98
0.994
0.926
0.899
0.899
0.899
0.899
0.994
0.899
0.976
0.899
0.994
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
0.989
Negative control experiment: as expected, no miRNA was identified by transcriptome wide targets
analysis in Luciferase transfections. Dataset: AML Eto (GSM), prediction algorithm: microT
Supplementary Table II
Dataset: BartelMir223KoMouse2human prediction algorithm: microT
miRNA
UP-regulated
Targets
Adjusted
p-value
miRNA
UP-regulated
Targets
Adjusted
p-value
miR-223 <0.00001
miR-15a
0.01947
miR-101 0.00061
miR-15b 0.01947
miR-144 0.00259
miR-16
0.01947
miR-203 0.00259
miR-195 0.01947
miR-132 0.00288
miR-217 0.01947
miR-18a
0.00288
miR-31
0.01947
miR-18b 0.00288
miR-96
0.01947
miR-212 0.00288
miR-150 0.02474
miR-19a
0.00394
miR-200b 0.02495
miR-19b 0.00394
miR-200c 0.02495
miR-190 0.00458
miR-302c 0.02495
miR-106b 0.0048
miR-29a
0.02706
miR-20a
0.0048
miR-29b 0.02706
miR-369-3p 0.00663
miR-29c
0.02706
miR-153 0.00856
miR-182 0.02806
miR-302a 0.00856
miR-141 0.03306
miR-34a
0.00856
miR-149 0.03457
miR-302d 0.00916
miR-125a 0.03473
miR-103 0.01069
miR-125b 0.03473
miR-107 0.01069
miR-188 0.03574
miR-33
0.0108
miR-28
0.03593
miR-372 0.01166
miR-330 0.04227
miR-140 0.01341
miR-30a-3p 0.04312
miR-34b 0.01341
miR-30e-3p 0.04312
miR-124a 0.01392
miR-27a
0.04464
miR-218 0.01544
miR-27b 0.04464
miR-299-5p 0.01628
miR-302b 0.04464
miR-17-5p 0.01719
miR-194 0.04857
miR-20b 0.01719
miR-223 is correctly identified by transcriptome wide targets analysis as the most down-regulated
miRNA in miR-223 KO mice (adjusted Benjamini- Hochberg p-value <0.05). It should be noted
that here were no significant down-regulated targets inferred from this experiment.
Supplementary Table III. Significant miRNAs in liver from Dicer KO mice are all downregulated.
miRNA
miR-205
miR-23a
miR-23b
miR-302a
miR-302b
miR-302c
miR-302d
miR-15a
miR-15b
miR-16
miR-195
let-7d
miR-372
miR-34a
miR-142-3p
UP-regulated
Targets
0.00816
0.00816
0.00816
0.00816
0.00816
0.00816
0.00816
0.01044
0.01044
0.01044
0.01044
0.01498
0.01498
0.01606
0.04968
*GSE11899 GEO series. Fifteen miRNAs were down-regulated in the Dicer KO cells, but none was
up-regulated. This unbalanced profile is consistent with the deficiency in the processing
mechanisms for the production of mature miRNAs in these cells. To be noted that the number of
differentially regulated mRNA for the coding genes was roughly balanced, i.e. 3000 up-regulated
and 3000 down-regulated mRNAs (Chi square, p-value<0.001).
Supplementary Table IV. miRNAs associated to Overall Survival in Acute Myeloid Leukemia.
UP-regulated Down-regulated
Targets
Targets
Adjusted
Adjusted
miRNA
p-value
p-value
miR-216
0.999
0.0165
miR-302a
0.999
0.0165
miR-323
0.999
0.0165
miR-7
0.999
0.0165
miR-302d
0.999
0.0178
miR-139
0.999
0.0186
miR-10a
0.999
0.0308
miR-10b
0.999
0.0308
miR-137
0.999
0.0308
miR-155
0.999
0.0308
miR-181a
0.999
0.0308
miR-181b
0.999
0.0308
miR-181c
0.999
0.0308
miR-219
0.999
0.0308
miR-24
0.999
0.0378
miR-128a
0.999
0.0469
miR-128b
0.999
0.0469
miR-144
0.999
0.0469
miR-93
0.999
0.0469
miR-96
0.999
0.0469
miR-149
0.999
0.049
miR-372
0.999
0.049
*Cox analysis was performed using overall survival data. The log2 of hazard ratio was used to
performed the KS test on the miRNA targets. miR-181 and miR-155 were both previously
associated to prognosis in AML.
Supplementary Table V. Significant miRNAs (adjusted p-value <0.05) identified in 66
experiments by reverse miRNA profiling, ordered by cellular condition. Score is -log10 of
adjusted p-value.
miRNA
miR-10a
miR-10b
miR-29a
miR-29b
miR-29c
miR-133b
miR-133a
miR-339
miR-122a
miR-26a
miR-26b
miR-27a
miR-27b
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-98
miR-181a
miR-181b
miR-181c
miR-221
miR-222
miR-29a
miR-29b
miR-29c
miR-9
miR-32
let-7d
miR-21
miR-130a
miR-130b
miR-342
miR-301
miR-106b
miR-20a
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-92
miR-29a
miR-29b
miR-29c
Condition
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Asbestos late times
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Basal Vs Non Basal Breast Cancer
Breast DCIStoIDCprogression
Breast DCIStoIDCprogression
Breast DCIStoIDCprogression
Score
1.85
1.85
1.85
1.85
1.85
1.61
1.54
1.54
1.34
4.40
4.40
2.50
2.50
2.33
2.33
2.33
2.33
2.33
2.33
2.32
2.07
2.02
2.02
2.02
1.90
1.90
1.88
1.88
1.88
1.86
1.71
1.70
1.67
1.51
1.51
1.51
1.50
1.43
1.43
1.33
1.33
1.33
1.33
1.33
1.33
4.70
4.70
4.70
Regulation
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
active
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
miR-338
miR-9
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-129
miR-19a
miR-19b
miR-205
miR-27a
miR-27b
miR-29a
miR-29b
miR-29c
miR-98
miR-124a
miR-339
miR-188
miR-221
miR-222
miR-129
miR-29a
miR-29b
miR-29c
miR-30a-3p
miR-30e-3p
miR-299-3p
miR-133a
miR-133b
miR-375
miR-194
miR-149
miR-153
miR-1
miR-206
miR-128a
miR-128b
miR-181a
miR-181b
miR-181c
miR-186
miR-25
miR-330
miR-34c
miR-9
miR-27a
miR-27b
miR-150
Breast DCIStoIDCprogression
Breast DCIStoIDCprogression
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CA lung age
CCRC Metastasis DFI
CCRC Metastasis DFI
CCRC Metastasis DFI
CCRC Metastasis DFI
CCRC MetastasisNo
CCRC MetastasisNo
CCRC MetastasisNo
CCRC MetastasisNo
CCRC MetastasisNo
CCRC MetastasisNo
CCRC MetastasisNo
ccRCC
ccRCC
CD133 PosVsNeg
CD133 PosVsNeg
CD133 PosVsNeg
CD133 PosVsNeg
Cigarette Smoke Large Airwys
Cigarette Smoke Large Airwys
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
2.43
1.64
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.46
2.68
2.67
1.87
1.87
1.80
1.80
1.80
1.80
1.80
1.80
1.63
1.46
1.46
2.96
2.20
2.04
1.45
1.91
1.91
2.40
2.40
1.98
1.98
1.98
1.89
1.87
1.87
1.87
1.87
1.74
1.74
1.66
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
repressed
repressed
active
repressed
repressed
repressed
active
active
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
active
active
repressed
miR-200b
miR-200c
miR-15a
miR-15b
miR-16
miR-183
miR-195
miR-129
miR-134
miR-203
miR-106b
miR-20a
miR-367
miR-10a
miR-10b
miR-194
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-130a
miR-130b
miR-301
miR-375
miR-98
miR-101
miR-144
miR-181a
miR-181b
miR-181c
miR-23a
miR-23b
miR-32
miR-9
miR-92
miR-129
miR-19a
miR-19b
miR-182
miR-130a
miR-130b
miR-142-3p
miR-15a
miR-15b
miR-16
miR-195
miR-25
miR-27a
miR-27b
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Del13q
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
1.66
1.66
1.58
1.58
1.58
1.58
1.58
1.55
1.55
1.55
1.53
1.53
1.53
1.45
1.45
1.41
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
5.00
5.00
5.00
5.00
5.00
5.00
5.00
4.52
4.22
4.22
4.10
4.10
4.10
4.05
3.66
3.66
3.66
3.66
3.66
3.66
3.66
3.66
3.66
3.66
repressed
repressed
active
active
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-301
miR-338
miR-367
miR-324-3p
miR-128a
miR-128b
miR-200b
miR-200c
miR-217
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-323
miR-219
miR-106b
miR-148a
miR-148b
miR-152
miR-204
miR-20a
miR-211
miR-26a
miR-26b
miR-302d
miR-96
miR-141
miR-302a
miR-137
miR-155
miR-1
miR-206
miR-335
miR-103
miR-124a
miR-132
miR-212
miR-7
miR-320
miR-107
miR-299-5p
miR-18a
miR-18b
miR-342
miR-302c
miR-135a
miR-135b
miR-17-5p
miR-20b
miR-194
miR-188
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
3.66
3.66
3.66
3.29
3.07
3.07
3.07
3.07
3.07
3.05
3.05
3.05
3.05
3.05
3.05
2.96
2.85
2.85
2.85
2.85
2.85
2.85
2.85
2.85
2.85
2.63
2.61
2.55
2.53
2.49
2.49
2.47
2.47
2.47
2.46
2.44
2.41
2.41
2.40
2.39
2.37
2.23
2.22
2.22
2.22
2.17
2.16
2.16
1.96
1.96
1.92
1.76
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-145
miR-190
miR-34b
miR-21
miR-330
miR-139
miR-30a-3p
miR-30e-3p
miR-10a
miR-10b
miR-302b
miR-153
miR-183
miR-28
miR-299-3p
miR-372
miR-1
miR-206
miR-34c
miR-369-3p
miR-148a
miR-148b
miR-152
miR-9
miR-302c
miR-132
miR-155
miR-194
miR-200b
miR-200c
miR-212
miR-218
miR-29a
miR-29b
miR-29c
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-32
miR-369-3p
miR-92
miR-181a
miR-181b
miR-181c
miR-183
miR-199b
miR-330
miR-15a
miR-15b
miR-16
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CLL Zap70 CD38prognosis
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CP cancer immune resistance
CPES IPSvsMEFs
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
1.75
1.72
1.71
1.69
1.59
1.50
1.50
1.50
1.49
1.49
1.49
1.40
1.40
1.35
1.34
1.31
3.04
3.04
2.01
1.71
1.56
1.56
1.56
1.56
1.50
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
4.70
4.70
4.70
4.70
4.70
4.40
4.10
4.10
4.10
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
miR-195
miR-199a
miR-223
miR-22
miR-106b
miR-20a
miR-214
miR-143
miR-107
miR-103
miR-146a
miR-146b
miR-129
miR-133a
miR-133b
miR-367
miR-324-3p
miR-339
miR-137
miR-25
miR-320
miR-34b
miR-150
miR-142-5p
miR-148a
miR-148b
miR-152
miR-7
let-7i
miR-17-5p
miR-20b
miR-34a
miR-139
miR-18a
miR-18b
miR-186
miR-190
miR-21
miR-301
miR-335
miR-130a
miR-130b
miR-135a
miR-135b
miR-221
miR-222
miR-302a
miR-302d
miR-30a-3p
miR-30e-3p
miR-196a
miR-196b
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
4.10
4.10
4.05
4.00
3.66
3.66
3.49
3.47
3.46
3.37
3.24
3.24
3.10
3.05
3.05
2.95
2.88
2.88
2.82
2.82
2.82
2.75
2.67
2.59
2.59
2.59
2.59
2.56
2.53
2.46
2.46
2.13
2.07
2.07
2.07
2.03
2.03
2.03
2.03
2.02
2.01
2.01
2.01
2.01
1.87
1.87
1.86
1.81
1.74
1.74
1.70
1.70
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
miR-342
miR-122a
miR-299-3p
miR-34c
miR-205
miR-149
miR-31
miR-326
miR-302c
miR-33
miR-153
miR-328
miR-188
miR-216
miR-302b
miR-219
miR-346
miR-205
miR-23a
miR-23b
miR-302a
miR-302b
miR-302c
miR-302d
miR-15a
miR-15b
miR-16
miR-195
let-7d
miR-372
miR-34a
miR-142-3p
miR-128a
miR-128b
miR-200b
miR-200c
miR-27a
miR-27b
miR-9
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-98
miR-367
miR-25
miR-19a
miR-19b
miR-30a-5p
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
CRC mucosa
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
Dicer KO
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EB vs hES
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
1.68
1.67
1.67
1.67
1.66
1.63
1.62
1.58
1.57
1.57
1.50
1.44
1.42
1.39
1.32
1.31
1.31
2.09
2.09
2.09
2.09
2.09
2.09
2.09
1.98
1.98
1.98
1.98
1.82
1.82
1.79
1.30
1.45
1.45
1.45
1.45
1.45
1.45
1.45
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
3.80
3.39
2.69
2.69
2.69
repressed
repressed
repressed
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-218
miR-32
miR-190
miR-137
miR-194
miR-200b
miR-200c
miR-92
miR-150
miR-26a
miR-26b
miR-142-5p
miR-18a
miR-18b
miR-323
miR-106b
miR-17-5p
miR-20a
miR-20b
miR-139
miR-32
miR-302a
miR-93
miR-183
miR-153
miR-302d
miR-372
miR-9
miR-92
miR-335
miR-302b
miR-27a
miR-27b
miR-367
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-19a
miR-19b
miR-25
miR-30a-3p
miR-30e-3p
miR-219
miR-128a
miR-128b
miR-138
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
EGFR InhibitorResist GSE9599
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
2.69
2.69
2.69
2.69
2.29
2.29
2.11
1.80
1.80
1.75
1.75
1.72
1.39
1.39
1.39
1.36
1.36
1.36
1.33
5.00
5.00
5.00
5.00
3.85
3.85
3.70
3.70
3.51
3.37
3.37
3.37
3.37
3.37
3.34
3.30
3.14
3.14
3.08
3.07
3.07
3.07
3.07
3.07
3.03
3.03
3.03
2.50
2.50
2.35
2.34
2.34
2.27
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
miR-141
miR-144
miR-26a
miR-26b
miR-103
miR-200b
miR-200c
miR-125a
miR-125b
miR-107
miR-129
miR-142-5p
miR-193a
miR-193b
miR-186
miR-223
miR-299-5p
miR-29a
miR-29b
miR-29c
miR-148a
miR-148b
miR-152
miR-323
miR-218
miR-221
miR-222
miR-132
miR-212
miR-302c
miR-96
miR-342
miR-101
miR-216
miR-26a
miR-26b
miR-194
miR-9
miR-188
miR-106b
miR-19a
miR-19b
miR-20a
miR-200b
miR-200c
miR-22
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
ErythroidDifferentiationCA
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
2.27
2.27
2.22
2.22
2.06
2.05
2.05
1.92
1.92
1.89
1.87
1.87
1.87
1.87
1.86
1.81
1.65
1.65
1.65
1.65
1.54
1.54
1.54
1.53
1.51
1.51
1.51
1.49
1.49
1.49
1.41
1.31
1.31
1.31
3.51
3.51
3.19
2.44
2.26
2.19
2.19
2.19
2.19
2.01
2.01
2.01
1.90
1.90
1.90
1.90
1.90
1.90
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
let-7i
miR-101
miR-143
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-98
miR-145
miR-7
miR-130a
miR-130b
miR-301
miR-137
miR-148a
miR-148b
miR-152
miR-27a
miR-27b
miR-128a
miR-128b
miR-31
miR-21
miR-103
miR-107
miR-24
miR-34b
miR-183
miR-203
miR-218
miR-17-5p
miR-20b
miR-1
miR-206
miR-214
miR-302c
miR-32
miR-155
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-149
miR-101
miR-144
miR-28
miR-214
miR-19a
miR-19b
miR-302a
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
Estradiol MCF7
FoxO def myeloid prec
FoxO def myeloid prec
FoxO def myeloid prec
FoxO def myeloid prec
FoxO def myeloid prec
FoxO def myeloid prec
GDS3162 PolGmutMouse
GDS3162 PolGmutMouse
GDS3162 PolGmutMouse
GDS3162 PolGmutMouse
GDS3162 PolGmutMouse
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
1.90
1.90
1.90
1.90
1.90
1.90
1.90
1.90
1.90
1.85
1.75
1.65
1.65
1.65
1.61
1.61
1.61
1.61
1.61
1.61
1.54
1.54
1.52
1.51
1.49
1.49
1.49
1.47
1.46
1.46
1.45
1.39
1.39
1.36
1.36
1.36
1.36
1.36
1.82
1.82
1.82
1.82
1.82
1.82
2.43
1.83
1.83
1.74
1.33
2.27
2.27
2.27
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
repressed
active
active
active
repressed
repressed
repressed
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
repressed
repressed
repressed
miR-302d
miR-372
miR-93
miR-129
miR-375
miR-15a
miR-15b
miR-16
miR-195
miR-302b
miR-302c
miR-221
miR-222
miR-339
miR-190
miR-205
miR-150
miR-98
miR-27a
miR-27b
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-122a
miR-302a
miR-302d
miR-302c
miR-106b
miR-20a
miR-302b
miR-372
miR-93
miR-17-5p
miR-20b
miR-21
miR-30a-3p
miR-30e-3p
miR-223
miR-375
miR-34b
miR-302c
miR-302a
miR-302d
miR-21
miR-302b
miR-372
miR-93
miR-183
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
GSE11375TraumaOutcome
HepG2 Azacytidin
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hES
hESCvsDiff
hESCvsDiff
hESCvsDiff
hESCvsDiff
hESCvsDiff
hESCvsDiff
hESCvsDiff
IL15 NK
2.27
2.27
2.27
1.88
1.87
1.86
1.86
1.86
1.86
1.86
1.86
1.76
1.76
1.66
1.50
1.50
1.40
1.40
1.35
1.35
1.34
1.34
1.34
1.34
1.34
1.34
1.34
1.41
5.00
5.00
4.70
2.98
2.98
2.98
2.98
2.98
2.13
2.13
2.05
2.05
2.05
1.68
1.43
1.40
2.47
2.33
2.29
1.51
1.51
1.51
1.51
3.39
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-205
miR-106b
miR-20a
miR-181a
miR-181b
miR-181c
miR-144
miR-17-5p
miR-20b
miR-141
miR-150
miR-101
miR-186
miR-23a
miR-23b
miR-27a
miR-27b
miR-302a
miR-302d
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-330
miR-372
miR-323
miR-9
miR-145
miR-132
miR-212
miR-214
miR-339
miR-143
miR-190
miR-302b
miR-194
miR-200b
miR-200c
miR-103
miR-107
miR-124a
miR-125a
miR-125b
miR-19a
miR-19b
miR-26a
miR-26b
miR-302c
miR-93
miR-130a
miR-130b
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
2.94
2.65
2.65
2.43
2.43
2.43
2.18
2.18
2.18
2.16
2.16
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.15
2.12
2.07
2.03
2.00
2.00
2.00
2.00
1.89
1.89
1.89
1.85
1.81
1.81
1.76
1.76
1.76
1.76
1.76
1.76
1.76
1.76
1.76
1.76
1.76
1.69
1.69
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-15a
miR-15b
miR-16
miR-195
miR-204
miR-211
miR-216
miR-223
miR-128a
miR-128b
miR-142-3p
miR-30a-3p
miR-30e-3p
miR-301
miR-182
miR-96
miR-142-5p
miR-129
miR-10a
miR-10b
miR-218
miR-155
miR-18a
miR-18b
miR-1
miR-206
miR-34b
miR-203
miR-1
miR-143
miR-206
miR-92
miR-32
miR-128a
miR-128b
miR-149
miR-214
miR-26a
miR-26b
miR-27a
miR-27b
miR-302c
miR-302a
miR-302b
miR-302d
miR-372
miR-96
miR-22
miR-106b
miR-20a
miR-124a
miR-182
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL15 NK
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
IL20familyVsUntreated
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
1.66
1.66
1.66
1.66
1.65
1.65
1.65
1.63
1.59
1.59
1.57
1.51
1.51
1.50
1.47
1.47
1.44
1.41
1.39
1.39
1.36
1.35
1.35
1.35
1.30
1.30
1.30
1.81
1.69
1.69
1.69
1.69
1.43
1.33
1.33
1.33
1.33
1.33
1.33
1.33
1.33
3.85
3.72
3.72
3.72
3.72
3.72
3.59
3.49
3.49
3.18
2.91
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-218
miR-299-5p
miR-194
miR-323
miR-17-5p
miR-20b
miR-221
miR-222
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-375
miR-93
miR-26a
miR-26b
miR-369-3p
miR-142-3p
miR-190
miR-204
miR-211
miR-19a
miR-19b
miR-148a
miR-148b
miR-152
miR-128a
miR-128b
miR-183
miR-98
miR-149
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
miR-141
let-7i
miR-199b
miR-30a-3p
miR-30e-3p
miR-219
miR-200b
miR-200c
miR-326
miR-223
miR-330
miR-301
miR-150
miR-335
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
2.91
2.91
2.86
2.83
2.69
2.69
2.69
2.69
2.69
2.69
2.69
2.69
2.69
2.50
2.47
2.43
2.43
2.43
2.28
2.24
2.24
2.24
2.22
2.22
2.21
2.21
2.21
2.04
2.04
2.04
1.92
1.91
1.90
1.90
1.90
1.90
1.90
1.90
1.86
1.82
1.80
1.80
1.80
1.69
1.60
1.60
1.55
1.52
1.52
1.49
1.46
1.42
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-130a
miR-130b
miR-27a
miR-27b
miR-1
miR-142-5p
miR-196a
miR-196b
miR-199a
miR-206
miR-31
miR-181a
miR-181b
miR-181c
miR-219
miR-92
miR-335
miR-183
miR-330
miR-32
miR-7
miR-1
miR-206
miR-133a
miR-133b
miR-137
miR-141
miR-146a
miR-146b
miR-25
miR-323
miR-367
miR-186
miR-155
miR-138
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-96
miR-10a
miR-10b
miR-216
miR-23a
miR-23b
miR-299-5p
miR-155
miR-217
miR-137
miR-369-3p
miR-143
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
iPS vs NSC
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDS vs NormalCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
1.41
1.41
1.40
1.40
1.39
1.39
1.39
1.39
1.39
1.39
1.33
2.60
2.60
2.60
2.52
2.52
2.04
1.96
1.95
1.91
1.77
1.68
1.68
1.66
1.66
1.66
1.66
1.66
1.66
1.66
1.66
1.66
1.43
1.41
1.38
1.38
1.38
1.38
1.38
1.38
1.38
1.32
1.32
1.32
1.32
1.32
1.32
2.87
2.67
1.69
1.69
1.68
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-141
let-7d
miR-101
miR-103
miR-107
miR-182
miR-29a
miR-29b
miR-29c
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-144
miR-17-5p
miR-19a
miR-19b
miR-20b
miR-330
miR-98
miR-106b
miR-130a
miR-130b
miR-194
miR-204
miR-20a
miR-211
miR-299-5p
miR-301
miR-338
miR-34b
miR-9
miR-23a
miR-23b
miR-128a
miR-128b
miR-137
miR-27a
miR-27b
miR-1
miR-15a
miR-15b
miR-16
miR-195
miR-206
miR-10a
miR-10b
let-7a
let-7b
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MDSringedVsRefractoryCD34
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
1.61
1.57
1.57
1.57
1.57
1.57
1.57
1.57
1.57
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.55
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.39
1.37
1.37
3.68
3.68
3.68
3.68
3.68
3.06
3.06
3.06
3.06
3.06
3.06
2.40
2.40
2.30
2.30
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
let-7c
let-7e
let-7f
let-7g
let-7i
miR-98
miR-203
miR-21
miR-23a
miR-23b
miR-145
miR-182
miR-29a
miR-29b
miR-29c
miR-335
miR-9
miR-132
miR-199b
miR-212
miR-302d
miR-192
miR-200b
miR-200c
miR-302a
miR-369-3p
miR-134
miR-183
miR-215
miR-194
miR-302b
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-302c
miR-124a
miR-96
miR-137
miR-182
miR-124a
miR-96
miR-15a
miR-15b
miR-16
miR-195
miR-19a
miR-19b
miR-23a
miR-23b
miR-182
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
MelanomaVsNevi
miR-124 overexpression mouse neuroblastoma
miR-124 overexpression mouse neuroblastoma
miR-124 overexpression mouse neuroblastoma
miR-124 overexpression mouse neuroblastoma
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
2.30
2.30
2.30
2.30
2.24
2.10
2.06
2.04
1.92
1.92
1.69
1.69
1.69
1.69
1.69
1.69
1.60
1.57
1.57
1.57
1.57
1.55
1.55
1.55
1.55
1.55
1.45
1.45
1.45
1.43
1.42
1.40
1.40
1.40
1.40
1.40
1.39
5.00
2.04
1.68
1.31
5.00
4.22
3.96
3.96
3.96
3.96
3.96
3.96
3.92
3.92
3.85
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
active
active
active
active
active
active
active
active
active
repressed
repressed
active
miR-145
miR-26a
miR-26b
miR-29a
miR-29b
miR-29c
miR-21
miR-218
miR-1
miR-206
miR-130a
miR-130b
miR-301
miR-34b
miR-128a
miR-128b
miR-219
miR-148a
miR-148b
miR-152
miR-132
miR-212
miR-155
miR-181a
miR-181b
miR-181c
miR-27a
miR-27b
miR-142-3p
miR-129
miR-25
miR-141
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-369-3p
miR-98
miR-204
miR-211
miR-125a
miR-125b
miR-133a
miR-133b
miR-150
miR-103
miR-107
miR-299-5p
miR-24
let-7a
let-7b
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
3.77
3.66
3.66
3.62
3.62
3.62
3.51
3.32
3.25
3.25
2.40
2.40
2.40
2.40
2.37
2.37
2.36
2.32
2.32
2.32
2.23
2.23
2.03
1.94
1.94
1.94
1.91
1.91
1.89
1.76
1.72
1.65
1.65
1.65
1.65
1.65
1.65
1.62
1.60
1.52
1.52
1.48
1.48
1.44
1.44
1.44
1.42
1.42
1.42
1.37
1.35
1.35
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
repressed
repressed
active
repressed
repressed
repressed
active
active
active
active
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
let-7c
let-7e
let-7f
let-7g
let-7i
miR-153
miR-203
miR-9
miR-223
miR-101
miR-144
miR-203
miR-132
miR-18a
miR-18b
miR-212
miR-19a
miR-19b
miR-190
miR-106b
miR-20a
miR-369-3p
miR-153
miR-302a
miR-34a
miR-302d
miR-103
miR-107
miR-33
miR-372
miR-140
miR-34b
miR-124a
miR-218
miR-299-5p
miR-17-5p
miR-20b
miR-15a
miR-15b
miR-16
miR-195
miR-217
miR-31
miR-96
miR-150
miR-200b
miR-200c
miR-302c
miR-29a
miR-29b
miR-29c
miR-182
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
miR-124 Transfection
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
1.35
1.35
1.35
1.35
1.35
1.35
1.35
1.35
5.00
3.21
2.59
2.59
2.54
2.54
2.54
2.54
2.40
2.40
2.34
2.32
2.32
2.18
2.07
2.07
2.07
2.04
1.97
1.97
1.97
1.93
1.87
1.87
1.86
1.81
1.79
1.76
1.76
1.71
1.71
1.71
1.71
1.71
1.71
1.71
1.61
1.60
1.60
1.60
1.57
1.57
1.57
1.55
active
active
active
active
active
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
miR-141
miR-125a
miR-125b
miR-149
miR-188
miR-28
miR-30a-3p
miR-30e-3p
miR-330
miR-27a
miR-27b
miR-302b
miR-194
miR-29a
miR-29b
miR-29c
miR-135a
miR-135b
miR-96
miR-182
miR-23a
miR-23b
miR-26a
miR-26b
miR-137
miR-155
miR-27a
miR-27b
miR-219
miR-145
miR-30a-3p
miR-30e-3p
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-144
miR-148a
miR-148b
miR-152
miR-29a
miR-29b
miR-29c
miR-98
miR-375
miR-19a
miR-19b
miR-34a
miR-1
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
mir223 KO
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
miR-29 Transf
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
1.48
1.46
1.46
1.46
1.45
1.44
1.37
1.37
1.37
1.35
1.35
1.35
1.31
5.00
5.00
5.00
2.95
2.95
2.95
2.93
2.66
2.66
2.12
2.12
2.05
1.91
1.91
1.91
1.54
1.45
1.32
1.32
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
4.15
3.96
3.96
3.80
3.74
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-206
miR-25
miR-367
let-7d
miR-96
miR-107
miR-128a
miR-128b
miR-181a
miR-181b
miR-181c
miR-103
miR-302a
miR-369-3p
miR-145
miR-218
miR-219
miR-9
miR-372
miR-302d
miR-320
miR-93
miR-26a
miR-26b
miR-23a
miR-23b
miR-182
miR-34c
miR-92
miR-186
miR-139
miR-130a
miR-130b
miR-299-3p
miR-302c
miR-196a
miR-196b
miR-188
miR-338
miR-301
miR-21
miR-24
miR-7
miR-221
miR-222
miR-153
miR-302b
miR-133a
miR-133b
miR-223
miR-204
miR-211
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
3.74
3.68
3.68
3.66
3.66
3.54
3.54
3.54
3.43
3.43
3.43
3.24
3.17
3.15
3.14
3.12
2.97
2.93
2.91
2.89
2.89
2.89
2.86
2.86
2.68
2.68
2.59
2.53
2.46
2.41
2.34
2.32
2.32
2.29
2.28
2.26
2.26
2.19
2.11
2.09
2.03
1.81
1.80
1.76
1.76
1.70
1.64
1.63
1.63
1.63
1.59
1.59
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
repressed
active
active
active
active
active
active
active
repressed
active
active
active
active
active
active
active
active
active
active
miR-18a
miR-18b
miR-185
miR-28
miR-22
miR-199b
miR-150
miR-132
miR-212
miR-34c
miR-27a
miR-27b
miR-32
miR-132
miR-143
miR-200b
miR-200c
miR-203
miR-212
miR-24
miR-92
miR-19a
miR-19b
miR-27a
miR-27b
miR-15a
miR-15b
miR-16
miR-195
miR-10a
miR-10b
miR-17-5p
miR-20b
miR-106b
miR-20a
let-7a
let-7b
let-7c
let-7e
let-7f
let-7g
let-7i
miR-98
miR-135a
miR-135b
miR-128a
miR-128b
miR-153
miR-30a-5p
miR-30b
miR-30c
miR-30d
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MSC LagLogVsStationary
MyoD Wt vs Mut pair time
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
NanoG Oct4 siRNA
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
1.55
1.55
1.51
1.51
1.50
1.48
1.46
1.40
1.40
2.79
1.77
1.77
1.77
1.36
1.36
1.36
1.36
1.36
1.36
1.36
1.36
4.52
4.52
4.05
4.05
3.70
3.70
3.70
3.70
3.28
3.28
2.67
2.67
2.63
2.63
2.44
2.44
2.44
2.44
2.44
2.44
2.44
2.44
2.20
2.20
2.08
2.08
2.00
1.98
1.98
1.98
1.98
active
active
active
active
active
active
repressed
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-30e-5p
miR-339
miR-150
miR-9
miR-124a
miR-29a
miR-29b
miR-29c
miR-7
miR-372
miR-32
miR-92
miR-141
miR-342
miR-138
miR-26a
miR-26b
miR-186
miR-204
miR-211
miR-93
miR-330
miR-183
miR-302d
miR-302b
miR-129
miR-190
miR-219
miR-145
miR-18a
miR-18b
miR-128a
miR-128b
miR-19a
miR-19b
miR-106b
miR-20a
miR-27a
miR-27b
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-32
miR-129
miR-1
miR-17-5p
miR-206
miR-20b
miR-34b
miR-92
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53 in TGFbeta
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
1.98
1.98
1.93
1.93
1.81
1.81
1.81
1.81
1.81
1.77
1.76
1.76
1.71
1.68
1.64
1.64
1.64
1.59
1.59
1.59
1.57
1.56
1.50
1.50
1.49
1.45
1.43
1.41
1.31
1.31
1.31
5.00
5.00
5.00
5.00
4.52
4.52
4.22
4.22
4.22
4.22
4.22
4.22
4.22
4.22
4.15
4.00
4.00
4.00
4.00
4.00
3.92
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-15a
miR-15b
miR-16
miR-195
miR-138
miR-9
miR-139
miR-183
miR-7
miR-150
miR-34a
miR-10a
miR-10b
miR-200b
miR-200c
miR-137
miR-182
miR-25
miR-367
miR-124a
miR-26a
miR-26b
miR-153
miR-29a
miR-29b
miR-29c
miR-22
miR-369-3p
miR-101
miR-217
miR-142-5p
miR-143
miR-93
miR-141
miR-372
miR-302b
miR-96
miR-302d
let-7b
let-7c
let-7f
let-7g
let-7i
miR-98
miR-185
miR-190
let-7a
let-7e
miR-302a
miR-34c
miR-140
miR-144
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
p53NoTGF
3.74
3.74
3.74
3.74
3.28
3.28
2.87
2.84
2.79
2.76
2.72
2.63
2.63
2.47
2.47
2.45
2.45
2.45
2.45
2.42
2.41
2.41
2.37
2.24
2.24
2.24
2.02
2.02
1.93
1.93
1.92
1.86
1.78
1.64
1.64
1.58
1.52
1.49
1.48
1.48
1.48
1.48
1.48
1.48
1.44
1.44
1.43
1.43
1.42
1.33
1.32
1.31
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
active
miR-132
miR-212
miR-34b
miR-302d
miR-29a
miR-29b
miR-29c
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-129
miR-203
miR-219
miR-9
miR-188
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-9
miR-155
miR-129
miR-132
miR-182
miR-212
miR-182
miR-203
miR-30a-5p
miR-30b
miR-30c
miR-30d
miR-30e-5p
miR-21
miR-96
miR-200b
miR-200c
miR-29a
miR-29b
miR-29c
p53NoTGF
p53NoTGF
p63 depletion
p63 depletion
ParvoVirusDilatedHeart
ParvoVirusDilatedHeart
ParvoVirusDilatedHeart
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
Propofol CABG Atrium
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
PTEN KO
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
Sevoflurane CABG Atrium
VIN
VIN
VIN
VIN
zfx ko in SC
zfx ko in SC
zfx ko in SC
1.30
1.30
1.40
1.36
1.96
1.96
1.96
1.56
1.56
1.56
1.56
1.56
1.31
1.31
1.31
1.31
2.75
1.73
1.73
1.73
1.73
1.73
1.73
1.63
1.48
1.48
1.48
1.48
1.37
1.37
1.37
1.37
1.37
1.37
1.37
1.75
1.75
1.39
1.39
1.68
1.68
1.68
active
active
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
repressed
active
active
active
active
active
active
active
active
active
active
active
repressed
repressed
repressed
Supplementary Table VI. Target mRNAs for miR-221/222 correlate positively to disease free
interval in metastatic renal cancer
Gene Symbol score
PHF2
0.652
MESDC1
0.647
TIMP3
0.634
FOS
0.579
IRF2
0.53
CDKN1C
0.459
GNAI2
0.457
ANGPTL2
0.456
ARID1A
0.437
MEIS1
0.425
ATXN1
0.404
SEMA6D
0.356
MYLIP
0.305
NAP1L5
0.304
UBE2J1
0.303
ETS1
0.3
CDC2L6
0.263
HIPK1
0.262
PBX3
0.255
CDKN1B
0.249
BMF
0.228
DACH1
0.213
ESR1
0.21
PAIP2
0.166
VASH1
0.158
ZFPM2
0.154
ETS2
0.151
SLC4A4
0.135
ANKHD1
0.133
TCF12
0.115
TRPS1
0.112
INSIG1
0.093
SHANK2
0.083
VAPB
0.082
PPARGC1A 0.072
PGGT1B
0.064
VGLL4
0.059
PAK1
0.054
PPP6C
0.052
TMCC1
0.042
FNDC3A
0.041
 In bold the two CDK inhibitors experimentally validated as targets.
Supplementary Table VII. Target mRNAs for miR-29a are repressed in metastatic renal
cancer
SESTD1
BCL2L2
COL11A1
SIDT1
KIAA1166
SBF2
MFAP3
MFAP2
MAFB
CCNT2
CAV2
ANKRD13C
RARB
CALM3
CALM1
NDST1
EML4
EML5
NAV1
NAV3
NAV2
SPTLC2
TTYH2
MTMR4
TSPAN14
ENTPD7
AQP4
NFAT5
IFNG
SP1
IFI30
PER3
REV3L
LPL
PALM
TSPAN4
ARRDC3
ATP2B1
ABHD4
OSBPL11
PCGF3
KCTD15
CCND2
SPEN
PTEN
STARD8
HDAC4
DBT
SNX4
SPTAN1
GAB1
SLC31A1
ITGA11
SCHIP1
DNM3
C1orf21
PRKAB2
-0.335
-0.134
-0.287
-0.254
-0.23
-0.151
-0.118
-0.481
-0.069
-0.182
-0.136
-0.08
-0.462
-0.112
-0.136
-0.036
-0.037
-0.348
-0.073
-0.647
-0.158
-0.128
-0.167
-0.477
-0.14
-0.234
-0.652
-0.092
-0.174
-0.428
-0.368
-0.166
-0.123
-0.318
-0.101
-0.084
-0.28
-0.039
-0.373
-0.337
-0.283
-0.321
-0.156
-0.039
-0.292
-0.182
-0.106
-0.201
-0.044
-0.249
-0.093
-0.254
-0.309
-0.301
-0.449
-0.068
-0.272
SKI
KLHDC3
JARID1B
CHIC2
AHR
PPM1D
BMF
BACH2
SOX12
TFEB
PPARGC1A
KBTBD8
NID2
PRKG1
DIO2
CAMTA1
FRAS1
KIAA1199
FOS
COL1A1
SFPQ
GPAM
COL4A3
DAG1
HMCN1
PKNOX2
STRN3
C5orf13
PMP22
PEX5
ETV6
AP1G1
COL4A5
CAMKK2
COL4A4
WDFY3
NPTXR
WDFY1
CFL2
GAS7
ATXN1
PDGFRB
COL4A2
EHD2
EPHA3
AKAP13
ADAMTS18
FSTL1
NCOR2
CNR1
NCOA3
STRN4
BTG2
SMARCC1
SPARC
CDK6
PTP4A1
PRELP
ANKRD28
BCL7A
-0.319
-0.118
-0.258
-0.161
-0.176
-0.255
-0.1
-0.333
-0.084
-0.226
-0.079
-0.32
-0.034
-0.364
-0.237
-0.05
-0.32
-0.496
-0.416
-0.3
-0.207
-0.22
-0.202
-0.251
-0.63
-0.397
-0.346
-0.089
-0.345
-0.068
-0.281
-0.28
-0.109
-0.05
-0.489
-0.081
-0.317
-0.208
-0.066
-0.305
-0.291
-0.134
-0.083
-0.468
-0.047
-0.094
-0.244
-0.158
-0.161
-0.329
-0.523
-0.202
-0.222
-0.055
-0.204
-0.038
-0.119
-0.145
-0.056
-0.124
HAS3
KIAA1128
PPP1R13B
ZFP36L1
COL5A2
CAPN7
SLC43A2
DNMT3A
C13orf23
DICER1
PLXNA1
ZFP36
COL1A2
C17orf39
EMP1
TAF5
DUSP2
PPIC
CDC42
PHF17
TRIB2
BCL11A
CPEB3
BCL11B
FRMD4A
OXR1
MCL1
COL3A1
ADAM19
RERE
QKI
RAB30
COL16A1
TFAP2C
NAP1L3
RND3
DPP4
HS3ST3B1
KLF13
PDGFB
PDGFC
APPBP2
HOOK3
PSME4
TMPRSS3
PDIK1L
FBN1
LUZP1
GTPBP2
BACE1
NFIA
SPAST
SLC16A7
EPC1
NKTR
SNX24
COL6A3
GNG12
MMP2
-0.515
-0.176
-0.21
-0.38
-0.321
-0.104
-0.228
-0.106
-0.032
-0.212
-0.354
-0.246
-0.287
-0.362
-0.191
-0.185
-0.066
-0.193
-0.167
-0.198
-0.226
-0.128
-0.236
-0.319
-0.178
-0.231
-0.05
-0.194
-0.345
-0.32
-0.252
-0.084
-0.151
-0.577
-0.382
-0.075
-0.074
-0.444
-0.149
-0.277
-0.178
-0.252
-0.195
-0.137
-0.178
-0.45
-0.242
-0.35
-0.068
-0.162
-0.052
-0.032
-0.154
-0.121
-0.238
-0.228
-0.376
-0.124
-0.532