GLOBAL PLASMA SUPPLY AND!
PRODUCT DEMAND!
IPFA/BCA Global Symposium on!
The Future for Blood and Plasma Donations!
Sacramento, CA!
23-24 September 2014!
Patrick Robert!
The Marketing Research Bureau, Inc.!
METHODOLOGY!
The data used to develop the charts and tables shown in
this presentation have been compiled from surveys
conducted by the Marketing Research Bureau in some fifty
countries, and published in various syndicated reports.!
All the data and information originate from sources
generally available to the public. Their accuracy is not
guaranteed, and the Marketing Research Bureau assumes
no liability for their use. © 2014!
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
•  Plasma Fractionation Projection!
•  Plasma Supply!
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
•  Plasma Fractionation Projection!
•  Plasma Supply!
THE WORLDWIDE PLASMA PROTEINS MARKET BY PRODUCT - 2012
WITHOUT RECOMBINANT FACTORS
Total Market $15,222 Million
All Others
22.2%
Hyperimmunes (IM &
IV)
3.8%
Factor VIII (Plasma
Derived)
10.6%
Albumin
13.3%
Factor IX (Plasma
Derived)
2.5%
Polyvalent IVIG/SCIG
47.6%
THE WORLDWIDE PLASMA PROTEINS MARKET BY COMPANY - 2012
WITHOUT RECOMBINANT FACTORS
Total Market 15,222.4 Million
Mitsubishi/Benesis
1.4%
All Others
9.2%
CSL Behring
22.6%
Kedrion
3.8%
Grifols
19.6%
Non-Profit Organizations
11.0%
Biotest
3.0%
Baxter
22.3%
Octapharma
7.1%
THE WORLDWIDE PLASMA PROTEINS MARKET BY REGION - 2012
WITHOUT RECOMBINANT FACTORS
Total Market $15,222 Million
Europe
30.8%
Middle-East
3.3%
Oceania
1.9%
Asia & Pacific
14.2%
South America
5.5%
Africa
1.1%
North America
43.2%
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
•  Plasma Fractionation Projection!
•  Plasma Supply!
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
1.  IV/Subcutaneous Immune Globulin (IVIG/SCIG)!
2. 
Albumin!
3.  Factor VIII!
4.  Market Drivers!
WORLDWIDE DEMAND FOR INTRAVENOUS & SUBCUTANEOUS IMMUNE
GLOBULIN (IVIG/SCIG) 1984 - 2014
Metric Tons
160.0
140.0
143.6
CAGR!
+10.2% per year since 1984!
+7.9% per year since 2000!
120.0
100.0
123.9
106.9
80.0
83.2
60.0
73.2
40.0
20.0
47.4
7.4
8.9
9.7
15.7
19.7
27.7
35.5
54.8
63.4
36.6
0.0
1984 1986
1988 1990
1992 1994
1996 1998
2000
2002
2004
2006
2008
2010
2012
2014
GLOBAL DEMAND FOR POLYVALENT INTRAVENOUS/SUBCUTANEOUS
IMMUNE GLOBULIN (IVIG/SCIG)
(Metric Tons) 2008 - 2020
250.0
Global annual growth 2012-­‐20: 7.7% 200.0
208.7
179.8
150.0
100.0
155.0
81.9
102.6
115.4
133.7
50.0
2008
2010
2012
2014
2016
2018
2020
THE POLYVALENT IVIG MARKET BY REGION
FROM 1986 TO 2020 (Est.)
(Kilograms)
120,000
Global annual growth 2012-­‐20: 7.7% 100,000
80,000
60,000
40,000
20,000
1986 1988 1990 1992 1994 1996 1998 2000 2003 2005 2008 2010 2012 2014 2016 2018 2020
South America
North America
Europe
Asia & Pacific
Middle East & Africa
Oceania
THE IV/SCIG MARKET BY MEDICAL SPECIALTY IN
THE UNITED STATES
2012 AND 2017 (Percentages)
100%
90%
80%
3%
5%
16%
3%
8%
13%
Pulmonology/Cardiology
Ophthalmology
Obstetrics/Neonatology
70%
Infectious Diseases
60%
28%
29%
Rheumatology/Nephrology
50%
Dermatology
40%
Transplant
30%
Hematology/Oncology
20%
41%
41%
Allergy/Immunology
10%
Neurology
0%
2012
2017
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
1.  IV/Subcutaneous Immune Globulin (IVIG/SCIG)!
2.  Albumin!
3.  Factor VIII!
4.  Market Drivers!
WORLDWIDE ALBUMIN DEMAND 1984 - 2014
Metric Tons
800.0
CAGR!
+3.6% per year since 1984!
+4.8% per year since 2000!
700.0
600.0
300.0
716.3
608.0
500.0
400.0
780.1
439.6455.7
414.4
427.0
433.8450.5
405.8
365.6
302.6
267.1
275.7
549.2
521.8
200.0
2014
2012
2010
2008
2006
2004
2002
2000
1998
1996
1994
1992
1990
1988
1986
0.0
1984
100.0
THE GLOBAL ALBUMIN MARKET
FROM 1986 TO 2020
(Metric Tons)
1200.0
Global annual growth 2012-­‐20: 5.3% 1000.0
1006.2
906.0
800.0
816.6
736.7
600.0
549.2
611.9
665.3
400.0
200.0
0.0
2008
2010
2012
2014
2016
2018
2020
THE ALBUMIN MARKET BY REGION
FROM 1986 TO 2020
(Kilograms)
500,000
450,000
Annual Growth Rates Assumptions!
• Asia & Pacific + 7%!
• South America + 6%!
• North America + 4%!
• Europe 3%!
• Middle East & North Africa 5%!
• Oceania 4%!
400,000
350,000
300,000
250,000
200,000
150,000
100,000
50,000
0
1986
1988
1990
1992
South America
1994
1996
1998
North America
2000
Europe
2003
2005
2008
Asia & Pacific
2010
2012
2014
ME & Africa
2016
2018
Oceania
2020
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
1.  IV/Subcutaneous Immune Globulin (IVIG/SCIG)!
2.  Albumin!
3.  Factor VIII!
4.  Market Drivers!
WORLDWIDE DEMAND FOR FACTOR VIII 1984 - 2014
Plasma-derived, Million International Units
4,000
3,942
CAGR!
+3.7% per year since 1984!
+4.5% per year since 2000!
3,500
3,000
3,617
3,319
2,881
2,500
2,129
2,000
1,500
1,308 1,438 1,481
1,612
1,837
2,124 2,115
1,878
2,375
2,496
1,663
1,000
500
0
1984 1986
1988 1990
1992 1994
1996 1998
2000 2002
2004 2006
2008 2010
2012 2014
5/55!
WORLDWIDE DEMAND FOR FACTOR VIII 1984 - 2014
Plasma-derived & Recombinant - Million International Units
10,000
9,760
8,956
9,000
8,000
7,000
CAGR!
+6.9% per year since 1984!
+7.2% per year since 2000!
6,000
4,943
4,000
2,000
6,908
6,020
5,000
3,000
8,000
3,705
2,664
2,129
1,837
1,3081,4381,4811,612
3,963
3,038
1,000
0
1984 1986 1988
1990 1992 1994
1996 1998 2000
2002 2004 2006
2008 2010
Total Market
5/55!
Plasma-Derived
2012
2014
THE WORLDWIDE FACTOR VIII MARKET
FROM 2008 TO 2020 Est.
(International Units x Million)
12,000
Global annual growth 2012-­‐20: 2.1% 10,566
10,000
9,990
9,455
8,952
8,959
8,114
8,000
6,905
6,000
5,192
5,241
3,759
3,718
5,553
5,888
4,693
4,000
4,024
3,421
3,902
4,102
6,246
4,320
2,881
2,000
0
2008
2010
2012
Plasma-derived
2014
Recombinant
2016
Total Market
2018
2020
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
1.  IV/Subcutaneous Immune Globulin (IVIG/SCIG)!
2.  Albumin!
3.  Factor VIII!
4.  Market Drivers!
WORLDWIDE ALBUMIN DEMAND 1974 - 2014
Metric Tons
780.1
800.0
716.3
700.0
608.0
600.0
549.2
521.8
500.0
455.7
439.6
433.8450.5
427.0
414.4
405.8
400.0
300.0
200.0
365.6
302.6
275.7
267.1
235.0
210.0
180.0
160.0
130.0
2014
2010
2012
2008
2006
2004
2002
2000
1996
1998
1994
1992
1990
1988
1984
1986
1982
1980
1978
1976
-
1974
100.0
PLASMA REQUIREMENTS FOR ALBUMIN, FACTOR & IVIG
1974 - 2014 - Million Liters
30.0
25.0
20.0
15.0
10.0
5.0
19
74
19
76
19
78
19
80
19
82
19
84
19
86
19
88
19
90
19
92
19
94
19
96
19
98
20
00
20
02
20
04
20
06
20
08
20
10
20
12
20
14
-
Plasma for Albumin
WORLDWIDE DEMAND FOR FACTOR VIII 1984 - 2014
Plasma-derived, Million International Units
4,000
3,942
3,500
3,617
3,319
3,000
2,881
2,500
2,129
2,000
1,500
1,612
1,308 1,438 1,481
1,837
2,124 2,115
1,878
2,375
2,496
1,663
1,000
500
0
1984 1986
1988 1990
1992 1994
1996 1998
2000 2002
2004 2006
2008 2010
2012 2014
PLASMA REQUIREMENTS FOR ALBUMIN, FACTOR & IVIG
1974 - 2014 - Million Liters
30.0
25.0
20.0
15.0
10.0
5.0
19
74
19
76
19
78
19
80
19
82
19
84
19
86
19
88
19
90
19
92
19
94
19
96
19
98
20
00
20
02
20
04
20
06
20
08
20
10
20
12
20
14
-
Plasma for Factor VIII
WORLDWIDE DEMAND FOR INTRAVENOUS & SUBCUTANEOUS IMMUNE GLOBULIN (IVIG/SCIG)
1984 - 2014
Metric Tons
160.0
140.0
143.6
120.0
123.9
100.0
106.9
80.0
83.2
60.0
73.2
63.4
40.0
47.4
20.0
7.4
8.9
9.7
15.7
19.7
27.7
35.5
54.8
36.6
0.0
1984 1986
1988 1990
1992
1994
1996
1998
2000
2002
2004
2006
2008
2010
2012
2014
PLASMA REQUIREMENTS FOR ALBUMIN, FACTOR & IVIG
1974 - 2014 - Million Liters
40.0
35.0
30.0
25.0
20.0
15.0
10.0
5.0
19
74
19
76
19
78
19
80
19
82
19
84
19
86
19
88
19
90
19
92
19
94
19
96
19
98
20
00
20
02
20
04
20
06
20
08
20
10
20
12
20
14
-
Plasma for IVIG
PLASMA REQUIREMENTS FOR ALBUMIN, FACTOR & IVIG
1974 - 2014 - Million Liters
40.0
35.0
30.0
25.0
20.0
15.0
10.0
5.0
19
74
19
76
19
78
19
80
19
82
19
84
19
86
19
88
19
90
19
92
19
94
19
96
19
98
20
00
20
02
20
04
20
06
20
08
20
10
20
12
20
14
-
Plasma for Albumin
Plasma for Factor VIII
Plasma for IVIG
Market Drivers!
•  From 1974 to 1980, albumin drove the plasma market
because neither factor VIII nor IVIG were available in large
quantities. One liter of plasma generated 28 grams of
albumin.!
•  In 1980, plasma-derived factor VIII became the market
driver: its global needs determined the quantity of plasma
to fractionate. Its production yield was 150-180
international units per liter of plasma.!
•  IVIG took over as the market driver in 2000, and will keep
this role in the foreseeable future. Its production yield is
about 4.5 grams per liter of plasma.!
Table of Contents!
•  Market Overview!
•  Plasma Products Demand!
•  Plasma Fractionation Projection!
•  Plasma Supply!
CAPACITY AND THROUGHPUT OF THE LARGEST
FRACTIONATORS 2013 - 2020
(Thousand Liters)
60,000
55,200
50,000
46,633
45,500
40,000
36,564
32,590
30,332
30,000
20,000
10,000
0
2013
Capacity
2016
2020
Throughput
PLASMA FRACTIONATION CAPACITY
BY REGION FROM 2002 TO 2012
(THOUSAND LITERS)
25,000
20,000
18,874
20,462
16,489
14,890
15,000
13,992
12,952
10,000
10,887
11,042
10,292
6,894
7,324
2,376
2,122
8,140
5,000
2,004
15,785
11,544
14,330
12,444
2,160
2,195
9,442
8,750
2,010
0
1999
2002
Europe
2004
North America
2007
Asia & Pacific
2010
All Others
2012
PLASMA FRACTIONATION THROUGHPUT
BY REGION FROM 2002 TO 2012
(THOUSAND LITERS)
20,000
18,420
18,000
16,660
16,000
14,000
12,000
12,201
11,035
10,000
8,000
11,700
11,637
9,671
8,781
6,898
6,000
7,115
5,726
4,000
4,550
5,226
5,028
2,000
1,644
1,338
1,520
5,038
1,586
1,634
0
2002
2004
Europe
2007
North America
2010
Asia & Pacific
All Others
2012
CAPACITY OF THE LARGEST FRACTIONATORS 2013 - 2020
16,000
14,000
12,000
Grifols
10,000
CLS Behring
Baxter
8,000
Octapharma
Kedrion
6,000
Biotest
Others *
4,000
2,000
0
2013
"Others" are LFB and BPL
2016
2020
Table of Contents!
•  Plasma Proteins Market Overview!
•  Plasma Products Demand!
•  Plasma Products Supply!
•  Plasma Supply!
TYPE OF PLASMA PROCESSED WORLDWIDE - 1996 TO 2012
COMMERCIAL COMPANIES & NON-PROFIT ORGANIZATIONS
(Thousand Liters)
Total in 2012: 36,792,000 Liters
Apheresis plasma is increasingly
fractionated in all regions!
30,000
27,855
25,583
25,000
20,000
17,648
15,000
18,633
18,157
16,328
14,925
10,000
7,398
8,471
8,542
8,169
7,768
8,060
8,937
5,000
1996
1999
2002
Source Plasma
2004
2007
Recovered Plasma
2010
2012
TYPE OF PLASMA PROCESSED IN EUROPE - 1996 TO 2012
NON-PROFIT ORGANIZATIONS
(Thousand Liters)
4,000
3,772
3,500
3,550
3,000
2,500
2,000
1,772
1,500
1,000
1,639
1,499
648
500
1,229
1,110
934
1,192
1,069
808
588
282
-
1996
1999
Source Plasma
2002
2004
2007
Recovered Plasma
2010
2012
TYPE OF PLASMA PROCESSED IN ASIA FROM 1996 TO 2012
NON-PROFIT ORGANIZATIONS
(Thousand Liters)
3,500
3,000
2,903
2,500
2,000
1,739
1,500
1,310
1,000
853
755
500
1,375
1,276
863
738
613
502
398
400
469
1996
1999
2002
Source Plasma
2004
2007
Recovered Plasma *
2010
2012
Chart 14
TYPE OF PLASMA FRACTIONATED IN NORTH AMERICA FROM 1996 TO 2012
COMMERCIAL COMPANIES & NON-PROFIT ORGANIZATIONS
(Thousand Liters)
12,000
10,050
10,000
8,000
8,396
8,097
7,273
7,731
6,000
5,308
5,925
4,000
2,000
670
1,275
1,120
1,590
1,050
1,650
1,190
1996
1999
2002
Source Plasma
2004
2007
Recovered Plasma
2010
2012
Plasma Supply - Conclusion!
•  In 2012, a total of about 36.8 million liters of source and
recovered plasma were fractionated worldwide - 27.9
million liters of source and 8.9 million liters of recovered.!
•  Between 1996 and 2012, on an annual basis (CAGR), the
global plasma supply for fractionation has increased by:!
Source plasma: 4% per year!
Recovered plasma:1.2%!
Overall plasma for fractionation: 3.2% !
•  Approximately 40% to 50% more plasma will be needed in
2020 than in 2013 (50 million liters vs. 36 million)!
Thank you!